GREMLIN Database
MIPA - MltA-interacting protein
UniProt: P0A908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13492
Length: 248 (238)
Sequences: 1535 (1262)
Seq/√Len: 81.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_W67_G5.8821.00
103_D180_E5.6241.00
219_Y236_W4.8101.00
171_E191_P3.8591.00
79_S114_S3.7861.00
161_G198_Y3.7401.00
154_L205_Y3.1601.00
81_T112_G3.0671.00
207_F213_V2.8471.00
76_D115_Y2.8051.00
105_R172_Y2.7771.00
227_T235_S2.6941.00
122_G145_W2.5011.00
102_L186_L2.4451.00
84_W107_S2.4431.00
154_L203_A2.4361.00
181_S188_G2.3891.00
216_T241_S2.3401.00
34_V44_T2.2291.00
214_Y243_G2.2141.00
128_L139_I2.0221.00
208_L211_W2.0171.00
61_F66_G2.0101.00
182_A185_G1.9771.00
156_V203_A1.9661.00
219_Y238_G1.9221.00
181_S185_G1.9181.00
159_G200_E1.9021.00
162_V195_W1.8131.00
175_G191_P1.8121.00
178_R188_G1.7951.00
134_D137_N1.7761.00
221_R235_S1.7531.00
125_R144_A1.7231.00
177_S180_E1.6891.00
38_P41_D1.6881.00
39_Y196_S1.6851.00
197_P223_S1.6751.00
111_A132_T1.6421.00
211_W244_I1.6251.00
191_P225_E1.6241.00
101_H186_L1.5951.00
85_S110_M1.5551.00
102_L231_M1.5421.00
194_S226_V1.5250.99
182_A186_L1.5050.99
108_T135_N1.5030.99
153_G205_Y1.4990.99
183_R186_L1.4940.99
85_S169_Q1.4920.99
200_E218_R1.4850.99
170_N226_V1.4710.99
50_P243_G1.4610.99
102_L176_V1.4430.99
194_S223_S1.4340.99
131_D136_S1.4250.99
27_S247_K1.4240.99
217_A238_G1.4100.99
76_D117_H1.4040.99
126_T143_M1.3980.99
181_S186_L1.3870.99
93_D104_D1.3850.99
7_L17_A1.3550.99
108_T133_L1.3470.99
176_V186_L1.3310.99
131_D135_N1.3220.98
165_N226_V1.3200.98
171_E175_G1.3060.98
101_H231_M1.3010.98
139_I166_S1.2670.98
138_G166_S1.2530.98
110_M136_S1.2430.98
164_W193_D1.2310.98
130_G166_S1.2030.97
33_G47_Y1.2000.97
59_F68_Y1.1920.97
29_G51_V1.1850.97
69_Y72_N1.1700.97
170_N194_S1.1680.97
34_V46_V1.1620.97
15_T18_G1.1580.96
118_F123_Y1.1490.96
11_V16_S1.1490.96
36_E40_K1.1480.96
165_N170_N1.1430.96
170_N191_P1.1300.96
32_V46_V1.1280.96
77_K116_A1.1240.96
26_F54_Y1.1160.96
167_E192_N1.1090.95
99_M231_M1.0990.95
128_L141_W1.0920.95
146_L157_T1.0890.95
8_A18_G1.0840.95
155_T204_S1.0790.95
33_G241_S1.0780.95
85_S140_V1.0700.94
30_A48_P1.0690.94
81_T129_A1.0590.94
141_W164_W1.0490.94
109_M132_T1.0480.94
99_M102_L1.0330.93
140_V165_N1.0320.93
139_I164_W1.0310.93
162_V197_P1.0290.93
51_V243_G1.0250.93
196_S226_V1.0080.93
99_M180_E1.0080.93
109_M133_L1.0040.92
24_G54_Y0.9990.92
55_E62_R0.9980.92
148_R157_T0.9900.92
211_W246_Y0.9830.92
10_G13_I0.9830.92
98_Q231_M0.9750.91
93_D101_H0.9610.91
58_N68_Y0.9590.91
38_P42_Y0.9570.90
15_T19_V0.9550.90
100_R190_N0.9520.90
78_L115_Y0.9500.90
55_E69_Y0.9470.90
9_L18_G0.9450.90
146_L159_G0.9420.90
119_T122_G0.9340.89
165_N194_S0.9320.89
110_M129_A0.9280.89
142_D202_S0.9250.89
140_V169_Q0.9240.89
12_L19_V0.9230.89
80_I112_G0.9230.89
124_L145_W0.9230.89
130_G139_I0.9150.88
71_W78_L0.9110.88
169_Q173_Y0.9100.88
98_Q102_L0.8990.87
11_V17_A0.8920.87
39_Y174_Y0.8900.87
10_G16_S0.8850.87
29_G50_P0.8820.86
105_R180_E0.8820.86
98_Q186_L0.8780.86
60_W186_L0.8750.86
103_D177_S0.8700.86
165_N196_S0.8600.85
76_D122_G0.8550.85
97_H100_R0.8510.84
96_D102_L0.8480.84
171_E190_N0.8470.84
34_V240_I0.8460.84
40_K194_S0.8460.84
174_Y196_S0.8460.84
205_Y208_L0.8430.84
18_G21_H0.8430.84
170_N196_S0.8420.84
103_D183_R0.8410.84
179_K183_R0.8390.84
16_S19_V0.8360.83
13_I19_V0.8250.83
159_G218_R0.8220.82
111_A231_M0.8210.82
195_W223_S0.8210.82
166_S219_Y0.8200.82
221_R236_W0.8180.82
222_L232_V0.8180.82
37_H45_D0.8100.81
10_G104_D0.8090.81
12_L16_S0.8040.81
8_A13_I0.8010.81
123_Y146_L0.8010.81
9_L14_A0.7950.80
21_H149_Y0.7860.79
12_L22_A0.7840.79
7_L18_G0.7750.78
108_T136_S0.7740.78
215_G244_I0.7740.78
170_N223_S0.7730.78
130_G136_S0.7730.78
10_G14_A0.7720.78
114_S125_R0.7710.78
177_S186_L0.7690.78
202_S218_R0.7680.78
106_K167_E0.7620.77
9_L19_V0.7610.77
207_F211_W0.7570.77
54_Y112_G0.7550.77
31_G243_G0.7530.76
10_G17_A0.7530.76
99_M143_M0.7520.76
113_L128_L0.7510.76
35_V104_D0.7500.76
39_Y158_P0.7470.76
8_A97_H0.7420.75
59_F66_G0.7410.75
83_Y110_M0.7380.75
31_G241_S0.7300.74
7_L14_A0.7280.74
15_T20_A0.7220.73
62_R65_G0.7220.73
156_V201_L0.7210.73
96_D186_L0.7180.73
170_N193_D0.7150.73
160_I201_L0.7130.72
78_L113_L0.7130.72
106_K235_S0.7130.72
38_P88_Y0.7100.72
142_D163_Q0.7100.72
198_Y220_T0.7080.72
60_W65_G0.7010.71
36_E41_D0.7010.71
149_Y158_P0.7010.71
99_M181_S0.7000.71
28_L232_V0.6970.71
222_L237_T0.6950.71
176_V181_S0.6900.70
103_D179_K0.6880.70
138_G145_W0.6870.70
221_R237_T0.6850.69
177_S181_S0.6840.69
28_L86_P0.6840.69
218_R239_L0.6830.69
73_D123_Y0.6800.69
153_G156_V0.6780.69
194_S224_D0.6780.69
64_L200_E0.6760.68
105_R226_V0.6720.68
164_W195_W0.6710.68
180_E188_G0.6660.67
176_V230_P0.6660.67
207_F210_D0.6640.67
27_S212_S0.6530.66
154_L206_N0.6530.66
144_A161_G0.6520.66
18_G22_A0.6480.65
72_N113_L0.6420.64
161_G197_P0.6400.64
227_T236_W0.6380.64
78_L149_Y0.6370.64
15_T236_W0.6360.64
204_S212_S0.6330.63
31_G86_P0.6330.63
60_W183_R0.6320.63
54_Y57_D0.6300.63
51_V245_T0.6290.63
9_L12_L0.6280.63
214_Y218_R0.6270.63
14_A188_G0.6260.62
186_L231_M0.6260.62
77_K205_Y0.6250.62
97_H185_G0.6240.62
115_Y119_T0.6240.62
152_G181_S0.6220.62
37_H43_D0.6190.62
102_L180_E0.6170.61
96_D99_M0.6150.61
36_E88_Y0.6120.61
126_T141_W0.6110.61
67_G76_D0.6090.60
175_G180_E0.6090.60
137_N173_Y0.6080.60
88_Y99_M0.6080.60
110_M131_D0.6080.60
161_G220_T0.6070.60
7_L11_V0.6060.60
32_V242_T0.6000.59
151_N155_T0.6000.59
43_D66_G0.5960.59
220_T239_L0.5950.59
29_G165_N0.5950.59
167_E225_E0.5950.59
31_G48_P0.5940.58
105_R165_N0.5920.58
26_F53_N0.5920.58
15_T45_D0.5920.58
189_Y242_T0.5910.58
42_Y46_V0.5900.58
111_A115_Y0.5890.58
12_L15_T0.5890.58
62_R163_Q0.5880.58
210_D246_Y0.5870.58
24_G56_G0.5870.58
222_L227_T0.5860.57
11_V15_T0.5860.57
11_V18_G0.5860.57
70_L136_S0.5860.57
102_L105_R0.5860.57
138_G248_F0.5850.57
10_G15_T0.5850.57
187_R190_N0.5790.57
11_V132_T0.5770.56
115_Y197_P0.5770.56
38_P105_R0.5760.56
67_G113_L0.5750.56
15_T187_R0.5740.56
82_A111_A0.5720.56
87_L138_G0.5710.56
105_R173_Y0.5710.56
106_K218_R0.5670.55
151_N206_N0.5650.55
152_G190_N0.5650.55
54_Y246_Y0.5630.54
207_F212_S0.5610.54
11_V14_A0.5590.54
29_G192_N0.5580.54
93_D103_D0.5530.53
37_H102_L0.5530.53
33_G77_K0.5520.53
35_V45_D0.5500.53
167_E187_R0.5490.53
14_A18_G0.5490.53
228_D234_K0.5490.53
9_L15_T0.5480.53
92_K96_D0.5460.52
14_A19_V0.5450.52
191_P194_S0.5430.52
74_A78_L0.5430.52
171_E247_K0.5430.52
68_Y108_T0.5420.52
39_Y172_Y0.5420.52
83_Y173_Y0.5400.51
218_R242_T0.5380.51
13_I17_A0.5370.51
132_T135_N0.5350.51
170_N192_N0.5330.51
79_S221_R0.5330.51
31_G156_V0.5310.50
232_V246_Y0.5310.50
74_A234_K0.5280.50
150_T155_T0.5250.49
38_P237_T0.5250.49
21_H71_W0.5250.49
104_D246_Y0.5250.49
24_G39_Y0.5250.49
79_S116_A0.5240.49
39_Y173_Y0.5230.49
101_H211_W0.5220.49
87_L107_S0.5210.49
69_Y79_S0.5210.49
176_V199_L0.5200.49
102_L211_W0.5190.49
84_W144_A0.5190.49
38_P165_N0.5170.48
25_K84_W0.5170.48
153_G208_L0.5140.48
123_Y148_R0.5130.48
75_T119_T0.5130.48
177_S183_R0.5130.48
139_I195_W0.5120.48
106_K109_M0.5110.48
94_S246_Y0.5100.48
65_G216_T0.5070.47
136_S166_S0.5070.47
105_R194_S0.5060.47
9_L177_S0.5060.47
57_D122_G0.5030.47
221_R227_T0.5010.46
207_F244_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nb3A 2 0.5363 99.1 0.786 Contact Map
2x27X 1 0.7621 98.6 0.82 Contact Map
2k0lA 1 0.7702 98.1 0.844 Contact Map
2f1vA 4 0.6492 97.5 0.865 Contact Map
1qjpA 1 0.5202 97.4 0.867 Contact Map
1p4tA 2 0.6008 97.3 0.87 Contact Map
2jmmA 1 0.5685 97.2 0.872 Contact Map
2lhfA 1 0.6492 97.1 0.873 Contact Map
3qraA 1 0.5726 96.8 0.879 Contact Map
2x9kA 1 0.8427 96.7 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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