GREMLIN Database
BLC - Outer membrane lipoprotein Blc
UniProt: P0A901 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12474
Length: 177 (163)
Sequences: 1854 (1401)
Seq/√Len: 109.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L78_G4.0321.00
122_D126_R3.8691.00
67_R71_G3.5561.00
65_S73_N3.4251.00
103_A117_N3.0631.00
152_K171_W2.8051.00
42_T63_T2.4941.00
71_G94_Y2.3971.00
138_L169_F2.3831.00
36_A72_L2.3791.00
45_E48_R2.3771.00
149_D153_Q2.2411.00
62_A76_N2.1571.00
34_F118_V2.1351.00
73_N90_E2.1141.00
35_D38_R2.0281.00
77_K86_W1.9771.00
158_V161_R1.9181.00
46_I142_S1.8401.00
131_C164_F1.7711.00
40_L66_L1.7601.00
158_V162_E1.7591.00
63_T77_K1.7581.00
80_N83_R1.7221.00
157_A161_R1.7001.00
37_K66_L1.6991.00
75_I90_E1.6941.00
120_A158_V1.6881.00
165_D168_K1.6491.00
16_V19_C1.6481.00
129_L159_A1.6451.00
97_G100_T1.6051.00
119_I129_L1.5661.00
71_G92_K1.5381.00
77_K88_Q1.5261.00
140_I155_M1.5061.00
42_T61_T1.5031.00
120_A155_M1.4751.00
48_R60_V1.4721.00
138_L159_A1.4531.00
151_V154_E1.4511.00
119_I131_C1.4091.00
129_L155_M1.3951.00
30_V103_A1.3731.00
120_A154_E1.3230.99
31_V121_L1.3110.99
40_L72_L1.3050.99
94_Y113_Y1.2940.99
28_V135_R1.2680.99
91_G108_F1.2650.99
142_S147_I1.2600.99
31_V102_A1.2590.99
34_F121_L1.2470.99
38_R124_E1.2160.99
62_A106_V1.2150.99
140_I147_I1.2060.99
64_Y76_N1.1960.99
120_A127_H1.1900.99
34_F101_R1.1900.99
152_K156_L1.1800.99
153_Q157_A1.1480.99
58_E81_P1.1470.99
54_E139_W1.1390.98
45_E139_W1.1350.98
147_I152_K1.1240.98
156_L166_V1.1210.98
15_L19_C1.1190.98
127_H155_M1.1020.98
46_I147_I1.0930.98
51_H137_Y1.0790.98
92_K113_Y1.0690.98
155_M158_V1.0660.98
58_E173_Q1.0650.98
65_S75_I1.0510.97
157_A160_T1.0500.97
67_R73_N1.0490.97
138_L164_F1.0450.97
39_Y62_A1.0160.97
126_R144_T1.0140.97
9_A12_A1.0090.97
103_A119_I1.0050.97
45_E172_V0.9960.96
61_T77_K0.9950.96
62_A104_L0.9890.96
154_E158_V0.9850.96
80_N87_Q0.9840.96
107_S110_G0.9750.96
76_N108_F0.9550.95
40_L65_S0.9530.95
48_R139_W0.9520.95
108_F114_G0.9430.95
14_F19_C0.9400.95
147_I155_M0.9290.95
30_V117_N0.9250.95
127_H151_V0.9230.95
91_G106_V0.9180.94
121_L128_A0.9040.94
97_G101_R0.8980.94
56_G80_N0.8920.94
129_L147_I0.8880.93
64_Y116_Y0.8840.93
107_S113_Y0.8830.93
97_G103_A0.8760.93
93_A106_V0.8740.93
149_D171_W0.8680.93
62_A74_V0.8660.92
102_A118_V0.8640.92
148_S151_V0.8620.92
76_N141_L0.8620.92
27_G135_R0.8610.92
48_R51_H0.8590.92
79_Y86_W0.8540.92
59_K174_Q0.8540.92
75_I88_Q0.8530.92
95_F101_R0.8440.92
131_C138_L0.8400.91
166_V169_F0.8380.91
123_R126_R0.8350.91
129_L158_V0.8280.91
149_D152_K0.8210.90
128_A141_L0.8190.90
74_V93_A0.8180.90
36_A95_F0.8050.89
29_T32_N0.8040.89
39_Y76_N0.7990.89
103_A115_G0.7990.89
60_V172_V0.7900.89
79_Y84_G0.7890.89
39_Y89_S0.7790.88
110_G113_Y0.7760.88
58_E79_Y0.7750.88
53_F137_Y0.7710.87
34_F102_A0.7700.87
54_E60_V0.7660.87
117_N133_P0.7580.86
20_S24_P0.7570.86
96_T105_K0.7530.86
31_V34_F0.7520.86
129_L140_I0.7500.86
92_K110_G0.7480.86
39_Y130_V0.7420.85
156_L169_F0.7380.85
72_L106_V0.7360.85
15_L18_A0.7350.85
156_L171_W0.7240.84
98_A101_R0.7220.84
16_V20_S0.7210.84
159_A166_V0.7170.83
94_Y105_K0.6940.81
67_R70_G0.6840.80
48_R54_E0.6830.80
148_S155_M0.6770.80
63_T75_I0.6710.79
41_G143_R0.6650.78
25_P59_K0.6610.78
96_T103_A0.6600.78
160_T167_S0.6600.78
74_V108_F0.6590.78
94_Y107_S0.6530.77
120_A129_L0.6500.77
10_A13_A0.6490.77
124_E153_Q0.6490.77
13_A16_V0.6490.77
76_N91_G0.6420.76
35_D40_L0.6420.76
56_G81_P0.6410.76
67_R94_Y0.6360.75
127_H147_I0.6310.75
13_A18_A0.6300.75
119_I162_E0.6290.74
46_I145_P0.6290.74
30_V102_A0.6280.74
122_D127_H0.6250.74
130_V141_L0.6240.74
52_R55_R0.6230.74
59_K79_Y0.6220.74
123_R127_H0.6210.74
123_R131_C0.6190.73
35_D125_Y0.6160.73
105_K115_G0.6130.73
33_N123_R0.6120.72
107_S112_F0.6080.72
100_T118_V0.6060.72
74_V91_G0.6040.71
49_F168_K0.5970.71
53_F116_Y0.5930.70
76_N93_A0.5920.70
60_V114_G0.5910.70
119_I138_L0.5910.70
39_Y64_Y0.5880.69
115_G131_C0.5870.69
17_V150_E0.5860.69
39_Y106_V0.5840.69
39_Y116_Y0.5830.69
44_Y174_Q0.5810.69
47_A50_D0.5790.68
62_A89_S0.5780.68
9_A16_V0.5780.68
33_N100_T0.5750.68
140_I159_A0.5730.67
62_A114_G0.5730.67
160_T166_V0.5730.67
13_A17_V0.5730.67
27_G162_E0.5710.67
93_A141_L0.5680.67
9_A13_A0.5620.66
36_A40_L0.5610.66
147_I151_V0.5600.66
38_R125_Y0.5600.66
54_E172_V0.5600.66
23_T123_R0.5570.65
123_R130_V0.5560.65
46_I144_T0.5550.65
44_Y172_V0.5550.65
142_S145_P0.5530.65
104_L116_Y0.5530.65
9_A15_L0.5450.64
32_N101_R0.5450.64
62_A93_A0.5450.64
155_M159_A0.5400.63
55_R87_Q0.5380.63
11_T16_V0.5380.63
121_L130_V0.5360.62
47_A169_F0.5350.62
20_S103_A0.5340.62
28_V34_F0.5310.62
37_K40_L0.5280.61
42_T75_I0.5240.61
47_A156_L0.5230.61
76_N116_Y0.5180.60
131_C162_E0.5160.59
80_N85_M0.5140.59
15_L20_S0.5120.59
66_L72_L0.5120.59
126_R151_V0.5120.59
116_Y130_V0.5060.58
69_D92_K0.5060.58
146_T167_S0.5060.58
28_V131_C0.5050.58
68_D124_E0.5040.58
135_R162_E0.5010.57
57_L80_N0.5010.57
76_N106_V0.5000.57
30_V33_N0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qwdA 1 0.9435 100 0.281 Contact Map
1gkaB 1 0.9153 100 0.323 Contact Map
1z24A 2 0.8927 100 0.324 Contact Map
2hzqA 1 0.8814 100 0.326 Contact Map
3ebwA 2 0.8362 100 0.327 Contact Map
1i4uA 2 0.9096 100 0.333 Contact Map
1kxoA 1 0.8757 100 0.339 Contact Map
4o9sA 3 0.8814 100 0.345 Contact Map
1kt6A 1 0.8814 100 0.353 Contact Map
4ge1A 1 0.8701 100 0.357 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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