GREMLIN Database
YQIA - Esterase YqiA
UniProt: P0A8Z7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12186
Length: 193 (183)
Sequences: 870 (610)
Seq/√Len: 45.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_P50_L4.9811.00
76_T159_Y4.6021.00
22_L177_F4.0211.00
80_Q139_I3.8131.00
171_N175_T3.5081.00
140_W165_T3.4011.00
141_L164_Q2.9321.00
7_L51_L2.9281.00
64_G188_L2.7201.00
105_Q114_Q2.5721.00
145_T168_E2.5691.00
14_P39_Q2.5521.00
52_E81_C2.5141.00
96_F129_Q2.2371.00
108_N111_T2.1931.00
11_N115_Y2.1371.00
144_Q176_G2.0630.99
118_E121_H2.0540.99
94_R97_E2.0300.99
20_S24_N1.9590.99
89_V142_L1.9020.99
22_L66_V1.8510.99
123_Y127_V1.7760.98
144_Q167_I1.7050.98
4_L64_G1.6880.98
156_V164_Q1.6420.97
73_Y96_F1.6400.97
5_L65_I1.6050.97
77_W81_C1.5380.96
7_L75_A1.5340.96
52_E56_L1.5230.96
86_A139_I1.5210.96
48_A77_W1.4910.95
143_Q155_A1.4870.95
65_I84_L1.4600.95
25_W29_H1.4420.94
105_Q116_V1.4110.94
144_Q170_G1.4060.93
19_A37_I1.4010.93
56_L82_F1.3940.93
52_E82_F1.3870.93
123_Y126_K1.3870.93
107_E114_Q1.3840.93
36_I54_I1.3610.92
13_S16_S1.3540.92
11_N108_N1.3430.92
22_L181_F1.3290.91
80_Q138_L1.3180.91
26_L35_M1.2980.90
16_S92_A1.2870.90
144_Q174_F1.2780.90
120_R123_Y1.2590.89
97_E154_Q1.2400.88
170_G174_F1.2380.88
176_G179_D1.2280.88
22_L184_I1.2280.88
79_S139_I1.2240.87
144_Q175_T1.2170.87
141_L156_V1.2070.87
6_Y16_S1.1950.86
23_K35_M1.1940.86
14_P38_P1.1890.86
153_R157_A1.1820.86
142_L180_Y1.1760.85
89_V174_F1.1710.85
58_H63_L1.1510.84
44_P47_A1.1440.84
129_Q158_Y1.1430.84
140_W163_R1.1400.83
38_P54_I1.1250.83
152_Y156_V1.1210.82
5_L51_L1.1190.82
100_T126_K1.1110.82
143_Q156_V1.1020.81
119_S123_Y1.1010.81
23_K27_A1.0780.80
95_P102_Y1.0770.80
49_E53_S1.0740.80
87_V184_I1.0720.79
76_T93_V1.0640.79
6_Y12_S1.0580.78
5_L54_I1.0550.78
99_L122_I1.0270.76
79_S130_I1.0260.76
39_Q50_L1.0260.76
21_L178_E1.0190.76
124_D128_M1.0130.75
142_L174_F1.0100.75
103_L117_L1.0080.75
85_P138_L1.0040.75
144_Q177_F0.9910.74
63_L84_L0.9900.74
43_Y124_D0.9890.74
107_E111_T0.9690.72
45_S124_D0.9580.71
46_D124_D0.9480.70
92_A98_L0.9440.70
9_G12_S0.9420.70
79_S138_L0.9410.70
25_W182_N0.9360.69
143_Q164_Q0.9360.69
4_L188_L0.9310.69
77_W130_I0.9300.69
74_Y117_L0.9290.69
107_E112_G0.9250.68
167_I180_Y0.9240.68
165_T180_Y0.9120.67
7_L65_I0.9060.67
133_L136_P0.9050.67
23_K37_I0.8970.66
14_P19_A0.8900.65
183_P186_D0.8880.65
51_L78_L0.8860.65
15_R19_A0.8790.65
20_S23_K0.8780.64
3_T58_H0.8770.64
156_V166_V0.8750.64
167_I176_G0.8730.64
50_L53_S0.8710.64
29_H32_D0.8600.63
112_G118_E0.8560.62
8_H12_S0.8560.62
57_E126_K0.8480.62
145_T169_G0.8470.62
48_A74_Y0.8370.61
134_E138_L0.8340.60
144_Q152_Y0.8310.60
108_N113_Q0.8270.60
44_P125_L0.8200.59
76_T130_I0.8190.59
145_T152_Y0.8140.59
10_F104_G0.8130.58
33_V188_L0.8090.58
73_Y94_R0.8060.58
13_S173_A0.8030.57
70_L125_L0.7960.57
3_T36_I0.7960.57
21_L28_E0.7890.56
40_L50_L0.7880.56
117_L144_Q0.7870.56
96_F158_Y0.7790.55
11_N117_L0.7750.55
5_L38_P0.7690.54
118_E170_G0.7670.54
75_A86_A0.7570.53
86_A150_L0.7530.53
10_F115_Y0.7420.52
117_L121_H0.7330.51
11_N106_N0.7330.51
52_E55_V0.7300.50
7_L74_Y0.7290.50
6_Y9_G0.7290.50
12_S18_K0.7250.50
17_A26_L0.7240.50
70_L75_A0.7230.50
25_W188_L0.7190.49
126_K133_L0.7170.49
174_F180_Y0.7160.49
40_L88_V0.7130.49
53_S57_E0.7130.49
72_G172_H0.7100.48
34_E61_D0.7070.48
93_V150_L0.7040.48
146_G170_G0.7030.48
5_L103_L0.7020.48
121_H124_D0.6970.47
70_L131_D0.6920.47
68_S173_A0.6870.46
99_L125_L0.6860.46
48_A55_V0.6830.46
21_L176_G0.6810.46
144_Q155_A0.6770.45
12_S72_G0.6760.45
5_L63_L0.6760.45
35_M173_A0.6750.45
15_R20_S0.6710.45
73_Y93_V0.6700.45
22_L179_D0.6630.44
27_A127_V0.6620.44
3_T34_E0.6600.44
33_V186_D0.6560.43
94_R154_Q0.6550.43
89_V127_V0.6520.43
55_V63_L0.6510.43
78_L82_F0.6450.42
4_L11_N0.6430.42
92_A149_V0.6400.42
24_N137_D0.6360.41
74_Y128_M0.6350.41
22_L149_V0.6330.41
40_L75_A0.6320.41
150_L177_F0.6320.41
95_P150_L0.6290.41
100_T119_S0.6270.41
89_V115_Y0.6260.40
63_L81_C0.6250.40
18_K72_G0.6240.40
5_L75_A0.6230.40
19_A108_N0.6200.40
22_L32_D0.6200.40
139_I161_S0.6160.39
17_A21_L0.6140.39
40_L54_I0.6130.39
36_I160_A0.6060.39
7_L55_V0.6050.38
95_P148_E0.6040.38
26_L100_T0.6020.38
89_V136_P0.5970.38
122_I182_N0.5920.37
64_G78_L0.5920.37
77_W164_Q0.5910.37
66_V107_E0.5910.37
57_E82_F0.5900.37
125_L150_L0.5890.37
24_N27_A0.5890.37
42_P74_Y0.5880.37
98_L110_Y0.5870.37
117_L122_I0.5870.37
33_V64_G0.5860.37
61_D160_A0.5860.37
14_P37_I0.5850.37
3_T63_L0.5830.36
56_L131_D0.5820.36
99_L115_Y0.5800.36
29_H57_E0.5790.36
103_L121_H0.5750.36
165_T174_F0.5740.36
89_V184_I0.5720.35
65_I75_A0.5700.35
103_L163_R0.5700.35
56_L137_D0.5700.35
69_S147_D0.5650.35
71_G147_D0.5650.35
108_N174_F0.5640.35
9_G18_K0.5640.35
130_I139_I0.5580.34
26_L33_V0.5570.34
70_L74_Y0.5510.34
44_P90_N0.5510.34
11_N99_L0.5510.34
45_S49_E0.5490.33
71_G91_P0.5490.33
91_P147_D0.5490.33
69_S91_P0.5490.33
65_I78_L0.5440.33
48_A140_W0.5390.33
85_P186_D0.5390.33
157_A161_S0.5380.33
79_S84_L0.5360.32
85_P142_L0.5350.32
75_A88_V0.5340.32
29_H188_L0.5320.32
13_S26_L0.5300.32
157_A160_A0.5300.32
18_K68_S0.5300.32
165_T183_P0.5280.32
23_K26_L0.5260.31
116_V121_H0.5250.31
70_L177_F0.5220.31
77_W128_M0.5220.31
20_S45_S0.5210.31
103_L106_N0.5200.31
40_L150_L0.5190.31
155_A170_G0.5150.31
90_N159_Y0.5150.31
95_P141_L0.5150.31
32_D83_M0.5120.30
109_P149_V0.5120.30
34_E63_L0.5110.30
120_R124_D0.5100.30
41_P106_N0.5090.30
47_A74_Y0.5090.30
140_W187_F0.5060.30
167_I179_D0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fleA 1 0.9948 100 0.588 Contact Map
2qjwA 2 0.8135 99.7 0.715 Contact Map
3llcA 1 0.9689 99.7 0.725 Contact Map
4z8zA 1 0.9741 99.7 0.733 Contact Map
1uxoA 1 0.8808 99.6 0.736 Contact Map
2wtmA 2 0.9845 99.6 0.738 Contact Map
3pfbA 2 0.9689 99.6 0.744 Contact Map
4k5qA 1 0.9689 99.6 0.745 Contact Map
2qs9A 1 0.8964 99.6 0.746 Contact Map
3o4hA 2 0.9637 99.6 0.747 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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