GREMLIN Database
YBGC - Acyl-CoA thioester hydrolase YbgC
UniProt: P0A8Z3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11110
Length: 134 (126)
Sequences: 5989 (4311)
Seq/√Len: 384.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K65_E3.1351.00
83_T93_T2.5471.00
68_A102_T2.4391.00
32_Y107_A2.3051.00
70_A104_L2.2271.00
70_A76_L2.2161.00
115_D118_K2.1671.00
7_R77_E2.1451.00
67_Y106_E2.1171.00
63_T108_E2.1151.00
7_R79_Q2.1101.00
9_P75_M2.0511.00
29_V62_M2.0181.00
27_S30_A2.0081.00
32_Y105_N1.8411.00
79_Q95_R1.8211.00
84_S91_V1.7661.00
79_Q97_V1.7631.00
9_P77_E1.7111.00
29_V64_V1.6701.00
81_E93_T1.6521.00
97_V103_L1.6351.00
74_D98_N1.6221.00
56_A116_P1.6081.00
95_R103_L1.5921.00
126_K130_A1.5621.00
64_V105_N1.5461.00
65_E106_E1.4891.00
11_R75_M1.4801.00
93_T108_E1.4791.00
91_V108_E1.4781.00
32_Y96_I1.4731.00
94_Q109_V1.4701.00
11_R41_R1.4651.00
78_I96_I1.4201.00
86_R89_S1.3811.00
23_V31_F1.3791.00
98_N102_T1.3731.00
95_R106_E1.3701.00
35_A80_T1.3611.00
88_T121_P1.3391.00
38_E42_H1.3241.00
11_R38_E1.3101.00
9_P99_A1.2981.00
75_M99_A1.2931.00
98_N104_L1.2921.00
60_R65_E1.2621.00
49_A53_E1.2551.00
83_T108_E1.2491.00
69_P119_M1.2481.00
15_E30_A1.2251.00
49_A52_A1.2181.00
89_S110_L1.2111.00
62_M109_V1.2031.00
33_E36_R1.1891.00
46_S49_A1.1881.00
125_P128_I1.1631.00
16_D30_A1.1421.00
41_R73_D1.1371.00
48_Q52_A1.1251.00
12_V23_V1.1231.00
13_Y16_D1.1221.00
114_V119_M1.1031.00
35_A78_I1.1011.00
88_T112_V1.0991.00
91_V110_L1.0921.00
77_E99_A1.0721.00
87_G123_A1.0671.00
26_A30_A1.0341.00
61_K110_L1.0221.00
6_F80_T1.0181.00
55_V113_C1.0131.00
67_Y103_L1.0001.00
58_V114_V0.9851.00
81_E95_R0.9811.00
54_R117_L0.9791.00
115_D122_R0.9521.00
76_L104_L0.9201.00
77_E101_N0.9001.00
10_V78_I0.8961.00
103_L106_E0.8951.00
60_R110_L0.8891.00
97_V101_N0.8861.00
25_H62_M0.8781.00
83_T91_V0.8591.00
41_R46_S0.8571.00
32_Y64_V0.8541.00
127_S130_A0.8381.00
14_Y17_T0.8361.00
25_H66_Y0.8341.00
20_G58_V0.8311.00
31_F76_L0.8151.00
13_Y34_R0.8051.00
16_D31_F0.8031.00
126_K129_V0.7941.00
6_F42_H0.7931.00
25_H29_V0.7901.00
93_T106_E0.7881.00
11_R73_D0.7881.00
17_T21_G0.7791.00
82_I92_F0.7741.00
39_M80_T0.7601.00
36_R59_V0.7521.00
23_V70_A0.7521.00
61_K108_E0.7491.00
8_W35_A0.7481.00
8_W34_R0.7461.00
8_W38_E0.7461.00
77_E97_V0.7431.00
38_E41_R0.7421.00
36_R94_Q0.7351.00
60_R67_Y0.7301.00
62_M107_A0.7141.00
13_Y30_A0.7141.00
24_Y33_E0.7141.00
10_V34_R0.7131.00
80_T94_Q0.7041.00
78_I94_Q0.7021.00
12_V31_F0.7011.00
30_A33_E0.6991.00
71_R119_M0.6950.99
14_Y19_A0.6920.99
10_V31_F0.6910.99
94_Q111_V0.6890.99
88_T123_A0.6820.99
20_G24_Y0.6790.99
12_V76_L0.6740.99
22_V58_V0.6690.99
48_Q73_D0.6670.99
80_T92_F0.6640.99
53_E127_S0.6570.99
25_H36_R0.6520.99
20_G25_H0.6490.99
22_V69_P0.6490.99
48_Q51_M0.6430.99
65_E108_E0.6420.99
87_G129_V0.6400.99
85_M129_V0.6380.99
60_R112_V0.6360.99
15_E24_Y0.6320.99
36_R111_V0.6300.99
127_S131_E0.6220.99
116_P119_M0.6220.99
34_R38_E0.6180.99
55_V122_R0.6150.99
59_V111_V0.6140.99
20_G56_A0.5990.98
90_L124_L0.5960.98
28_Y70_A0.5960.98
27_S31_F0.5950.98
46_S73_D0.5910.98
39_M82_I0.5900.98
60_R89_S0.5890.98
89_S112_V0.5850.98
14_Y72_L0.5850.98
39_M43_H0.5830.98
15_E34_R0.5760.98
124_L129_V0.5740.98
24_Y27_S0.5720.98
17_T27_S0.5670.98
86_R129_V0.5660.98
51_M56_A0.5650.98
36_R92_F0.5640.98
123_A126_K0.5610.98
98_N101_N0.5570.98
62_M66_Y0.5550.97
17_T72_L0.5500.97
74_D104_L0.5490.97
89_S129_V0.5460.97
22_V119_M0.5430.97
43_H131_E0.5390.97
54_R122_R0.5390.97
14_Y20_G0.5350.97
59_V109_V0.5350.97
57_F113_C0.5340.97
37_T72_L0.5320.97
85_M90_L0.5290.97
14_Y37_T0.5270.97
57_F92_F0.5240.96
113_C125_P0.5170.96
99_A102_T0.5170.96
36_R109_V0.5160.96
57_F124_L0.5110.96
113_C124_L0.5070.96
39_M92_F0.5050.96
113_C122_R0.5040.96
64_V107_A0.5020.96
16_D27_S0.5020.96
47_Q51_M0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ownA 3 1 100 0.223 Contact Map
2essA 2 0.9701 100 0.23 Contact Map
2hljA 2 0.9701 100 0.265 Contact Map
1s5uA 6 1 100 0.266 Contact Map
2hx5A 4 0.9925 100 0.267 Contact Map
3ck1A 4 0.9925 100 0.27 Contact Map
2w3xA 4 1 100 0.273 Contact Map
2nujA 3 0.9851 100 0.275 Contact Map
2gf6A 4 0.9851 100 0.278 Contact Map
1njkA 4 0.9627 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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