GREMLIN Database
YCIA - Acyl-CoA thioester hydrolase YciA
UniProt: P0A8Z0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11121
Length: 132 (118)
Sequences: 3219 (1779)
Seq/√Len: 163.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_M115_F3.4351.00
85_T128_A3.0581.00
52_G127_R2.7381.00
45_L78_A2.6741.00
42_G117_Y2.6131.00
39_D56_T2.5081.00
35_M59_V2.4561.00
66_R108_Y2.3521.00
23_T70_V2.2781.00
35_M62_M2.2431.00
29_I34_L2.1721.00
75_C107_R2.0901.00
81_V91_N2.0731.00
22_D33_W1.9031.00
82_Q89_S1.7671.00
109_K112_E1.7401.00
121_D125_K1.6271.00
30_F36_S1.6171.00
68_V110_A1.6031.00
18_A29_I1.6001.00
72_D108_Y1.5991.00
16_T40_I1.5961.00
72_D98_K1.5831.00
83_K129_L1.5421.00
96_V108_Y1.5411.00
10_G49_I1.5131.00
33_W36_S1.5001.00
50_A88_V1.4871.00
101_S105_G1.4311.00
98_K101_S1.4151.00
97_K107_R1.3871.00
93_E109_K1.3601.00
58_R116_K1.3541.00
76_C92_I1.3341.00
69_A72_D1.3191.00
48_E97_K1.3061.00
81_V89_S1.2841.00
49_I80_C1.2801.00
55_V120_V1.2281.00
44_I73_V1.2161.00
50_A54_V1.2121.00
89_S114_L1.2041.00
24_N31_G1.1971.00
77_Y95_W1.1901.00
45_L80_C1.1881.00
24_N30_F1.1631.00
68_V74_V1.1621.00
91_N114_L1.1601.00
11_D77_Y1.1541.00
79_R91_N1.1471.00
36_S40_I1.1391.00
13_V77_Y1.1231.00
60_E114_L1.1171.00
22_D37_Q1.1141.00
84_G87_S1.1031.00
72_D96_V1.0831.00
46_A54_V1.0811.00
101_S106_Q1.0730.99
49_I88_V1.0500.99
91_N112_E1.0430.99
80_C88_V1.0330.99
43_A47_K1.0280.99
45_L90_I1.0090.99
87_S118_V1.0070.99
16_T37_Q1.0050.99
26_N120_V1.0010.99
57_V63_T0.9830.99
89_S116_K0.9740.99
95_W109_K0.9590.99
92_I115_F0.9530.99
41_G78_A0.9380.99
95_W107_R0.9370.99
11_D79_R0.9340.99
37_Q40_I0.9030.98
29_I33_W0.8850.98
81_V114_L0.8660.98
38_M113_A0.8650.98
59_V115_F0.8500.97
49_I83_K0.8500.97
69_A124_G0.8490.97
13_V75_C0.8430.97
60_E116_K0.8420.97
34_L68_V0.8240.97
100_A105_G0.8210.97
88_V129_L0.8120.96
120_V126_P0.8090.96
39_D55_V0.8030.96
86_T126_P0.8020.96
34_L94_V0.7980.96
31_G64_F0.7970.96
34_L111_T0.7900.96
45_L49_I0.7730.95
98_K106_Q0.7710.95
98_K108_Y0.7690.95
29_I37_Q0.7660.95
14_L41_G0.7660.95
93_E112_E0.7630.95
80_C90_I0.7600.95
14_L40_I0.7570.95
12_L45_L0.7560.95
52_G119_A0.7550.95
75_C95_W0.7540.95
19_M25_A0.7530.95
41_G76_C0.7420.94
122_P127_R0.7390.94
79_R93_E0.7260.94
60_E89_S0.7190.93
34_L74_V0.7110.93
37_Q74_V0.7020.92
54_V88_V0.6960.92
82_Q116_K0.6910.92
28_D69_A0.6870.92
57_V87_S0.6860.91
37_Q76_C0.6770.91
42_G92_I0.6750.91
23_T71_G0.6690.90
19_M30_F0.6690.90
27_G71_G0.6610.90
51_H105_G0.6540.89
80_C83_K0.6530.89
93_E114_L0.6460.89
43_A117_Y0.6440.89
20_P116_K0.6410.89
121_D126_P0.6410.89
19_M40_I0.6410.89
42_G115_F0.6390.88
40_I44_I0.6380.88
57_V118_V0.6370.88
77_Y93_E0.6360.88
119_A127_R0.6350.88
33_W37_Q0.6340.88
120_V124_G0.6260.87
16_T62_M0.6220.87
73_V99_V0.6200.87
24_N27_G0.6200.87
85_T126_P0.6150.86
50_A53_R0.6140.86
58_R63_T0.6130.86
15_R18_A0.6110.86
55_V87_S0.6090.86
35_M115_F0.6060.86
46_A90_I0.6050.85
54_V117_Y0.6010.85
39_D84_G0.6010.85
21_A36_S0.5890.84
78_A92_I0.5820.83
42_G90_I0.5790.83
29_I68_V0.5780.83
26_N53_R0.5750.83
84_G118_V0.5720.82
49_I130_P0.5720.82
38_M94_V0.5670.82
46_A117_Y0.5650.81
73_V97_K0.5600.81
65_L82_Q0.5580.81
68_V94_V0.5460.79
38_M92_I0.5450.79
56_T59_V0.5400.78
86_T118_V0.5390.78
47_K99_V0.5380.78
123_E126_P0.5340.78
13_V78_A0.5320.77
100_A122_P0.5300.77
28_D111_T0.5280.77
51_H99_V0.5260.77
34_L59_V0.5240.76
49_I60_E0.5230.76
79_R114_L0.5170.75
123_E128_A0.5150.75
38_M76_C0.5140.75
83_K130_P0.5130.75
65_L112_E0.5130.75
64_F71_G0.5130.75
58_R61_G0.5110.75
57_V111_T0.5110.75
98_K127_R0.5030.73
97_K105_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mobA 3 0.9015 99.9 0.339 Contact Map
4ncpA 5 0.9621 99.9 0.36 Contact Map
4zv3A 3 0.9697 99.9 0.397 Contact Map
1y7uA 5 0.9621 99.8 0.446 Contact Map
2qq2A 5 0.9697 99.8 0.449 Contact Map
2q2bA 5 0.9091 99.8 0.455 Contact Map
1vpmA 5 0.9773 99.8 0.46 Contact Map
2gvhA 3 0.9318 99.8 0.469 Contact Map
3bjkA 5 0.9697 99.8 0.484 Contact Map
4ienA 5 0.9394 99.8 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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