GREMLIN Database
ENTH - Proofreading thioesterase EntH
UniProt: P0A8Y8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11105
Length: 137 (120)
Sequences: 3440 (2290)
Seq/√Len: 209.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_E97_K3.3321.00
83_T111_N2.5031.00
30_R37_E2.4131.00
38_A65_L2.4111.00
29_T39_E2.4101.00
27_V39_E2.3931.00
101_V119_F2.2451.00
91_R124_R2.2341.00
30_R35_V2.2171.00
65_L100_G2.1831.00
117_V125_R2.0351.00
120_D124_R2.0201.00
37_E101_V2.0081.00
40_M57_A1.9611.00
35_V101_V1.9421.00
106_H111_N1.9391.00
62_A129_C1.9371.00
66_G131_L1.9281.00
32_G35_V1.8751.00
104_P107_L1.8551.00
39_E99_R1.8111.00
59_A85_L1.7891.00
35_V103_Q1.7561.00
20_M57_A1.7081.00
70_G133_T1.7001.00
66_G116_I1.6931.00
20_M60_A1.5831.00
62_A116_I1.5761.00
59_A87_A1.5671.00
70_G112_Q1.5631.00
84_E88_T1.5041.00
74_T77_G1.4561.00
52_L81_V1.4221.00
37_E99_R1.4141.00
117_V128_T1.4131.00
44_T47_H1.3791.00
87_A127_C1.3751.00
103_Q117_V1.3691.00
103_Q115_E1.2861.00
58_S127_C1.2511.00
105_L128_T1.2441.00
75_R78_Q1.2271.00
58_S126_C1.2261.00
93_V126_C1.2141.00
115_E128_T1.2101.00
41_P97_K1.2091.00
119_F123_G1.1941.00
58_S118_V1.1461.00
43_D46_T1.1371.00
112_Q135_V1.1291.00
26_I38_A1.1161.00
50_F71_F1.1051.00
69_A114_W1.1011.00
88_T113_S1.0931.00
29_T37_E1.0771.00
34_D72_M1.0611.00
17_D22_A1.0321.00
105_L115_E1.0311.00
28_Y38_A1.0251.00
25_G45_R1.0201.00
56_G60_A1.0061.00
42_V53_L1.0041.00
23_H45_R1.0031.00
90_H113_S0.9881.00
63_E82_G0.9621.00
21_V64_T0.9581.00
97_K121_E0.9470.99
71_F80_V0.9460.99
53_L98_V0.9330.99
58_S89_H0.9280.99
86_N130_R0.9260.99
90_H106_H0.9210.99
61_L100_G0.9120.99
90_H125_R0.9110.99
100_G116_I0.9050.99
62_A118_V0.8910.99
24_L60_A0.8890.99
99_R119_F0.8850.99
47_H95_E0.8560.99
106_H113_S0.8540.99
52_L92_P0.8530.99
27_V97_K0.8420.99
90_H128_T0.8360.99
69_A102_C0.8350.99
34_D104_P0.8160.98
99_R121_E0.8130.98
84_E130_R0.8120.98
88_T132_G0.8100.98
80_V135_V0.8090.98
31_L72_M0.8090.98
87_A129_C0.8070.98
101_V123_G0.8040.98
85_L89_H0.8020.98
59_A89_H0.7990.98
40_M61_L0.7980.98
116_I131_L0.7960.98
104_P114_W0.7930.98
70_G80_V0.7830.98
55_G89_H0.7700.98
71_F79_C0.7700.98
91_R106_H0.7640.98
93_V98_V0.7100.96
40_M53_L0.7100.96
115_E130_R0.7060.96
119_F125_R0.7050.96
73_M107_L0.7020.96
53_L58_S0.6930.96
63_E67_S0.6900.96
98_V126_C0.6900.96
16_S22_A0.6880.96
111_N134_A0.6840.95
26_I40_M0.6790.95
28_Y68_M0.6790.95
26_I60_A0.6780.95
46_T57_A0.6740.95
19_T22_A0.6720.95
99_R120_D0.6690.95
49_P67_S0.6690.95
91_R120_D0.6680.95
112_Q133_T0.6650.95
33_D73_M0.6640.95
42_V98_V0.6610.95
52_L94_S0.6600.94
113_S132_G0.6520.94
81_V134_A0.6500.94
41_P46_T0.6460.94
78_Q135_V0.6420.94
36_L72_M0.6370.93
46_T53_L0.6370.93
102_C114_W0.6350.93
19_T46_T0.6340.93
101_V117_V0.6230.93
100_G118_V0.6220.93
28_Y31_L0.6170.92
59_A129_C0.6090.92
47_H94_S0.6080.92
73_M78_Q0.6050.91
26_I61_L0.6040.91
83_T134_A0.6000.91
69_A104_P0.5980.91
83_T132_G0.5950.91
83_T88_T0.5860.90
36_L69_A0.5850.90
70_G114_W0.5760.89
110_Q134_A0.5730.89
33_D107_L0.5710.89
99_R123_G0.5710.89
113_S130_R0.5700.89
58_S63_E0.5700.89
29_T38_A0.5630.88
67_S82_G0.5620.88
58_S93_V0.5620.88
74_T80_V0.5620.88
19_T23_H0.5600.88
59_A131_L0.5550.88
20_M23_H0.5530.87
105_L125_R0.5520.87
62_A87_A0.5520.87
50_F79_C0.5510.87
29_T97_K0.5500.87
25_G43_D0.5430.86
48_Q67_S0.5390.86
27_V41_P0.5390.86
88_T130_R0.5390.86
93_V120_D0.5340.86
66_G133_T0.5330.85
31_L68_M0.5320.85
73_M77_G0.5290.85
114_W133_T0.5250.85
18_N22_A0.5190.84
65_L116_I0.5190.84
34_D107_L0.5180.84
42_V46_T0.5160.84
48_Q52_L0.5150.83
48_Q66_G0.5130.83
103_Q119_F0.5130.83
105_L117_V0.5120.83
82_G85_L0.5090.83
33_D72_M0.5010.82
65_L102_C0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh5A 2 1 100 0.327 Contact Map
4k4cA 2 1 100 0.327 Contact Map
4qd8A 3 1 100 0.338 Contact Map
3lmbA 2 0.9854 100 0.339 Contact Map
4rmmA 2 0.9562 99.9 0.353 Contact Map
1sc0A 1 0.9927 99.9 0.363 Contact Map
3e8pA 3 0.9927 99.9 0.365 Contact Map
3gekA 3 0.8759 99.9 0.368 Contact Map
1yocA 4 0.9854 99.9 0.368 Contact Map
1t82A 2 0.9489 99.9 0.371 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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