GREMLIN Database
YIDA - Sugar phosphatase YidA
UniProt: P0A8Y5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11195
Length: 270 (256)
Sequences: 10974 (9017)
Seq/√Len: 563.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_K262_F4.0951.00
17_P256_L3.5431.00
217_A231_A3.1311.00
254_S257_E2.9771.00
228_I234_G2.8861.00
22_S258_D2.7681.00
4_K214_E2.7421.00
24_A258_D2.6031.00
205_A215_I2.5411.00
24_A265_E2.4711.00
8_I39_V2.4271.00
242_P246_E2.4081.00
43_T50_V2.4021.00
16_L20_T2.3471.00
229_E247_V2.2531.00
202_K230_Y2.1861.00
212_P230_Y2.0411.00
76_K79_D2.0241.00
196_N226_A2.0101.00
23_P27_N1.9331.00
31_A34_A1.9091.00
225_I244_V1.8881.00
84_A203_S1.8191.00
222_E243_S1.8111.00
253_K257_E1.8081.00
225_I247_V1.8021.00
236_A248_A1.7931.00
242_P245_K1.7911.00
5_L40_V1.7671.00
31_A265_E1.7611.00
29_I39_V1.7471.00
222_E241_I1.7451.00
26_K56_E1.7381.00
3_I216_M1.7281.00
234_G249_N1.7211.00
7_A201_V1.7151.00
32_A37_V1.7011.00
211_K214_E1.6981.00
202_K206_D1.6861.00
31_A35_R1.6841.00
89_S92_D1.6801.00
76_K81_S1.6211.00
203_S206_D1.6201.00
250_F267_Y1.5991.00
235_V263_A1.5881.00
244_V247_V1.5871.00
233_V249_N1.5791.00
203_S207_V1.5641.00
233_V250_F1.5591.00
10_M15_L1.5581.00
8_I218_I1.5431.00
199_T202_K1.5211.00
22_S25_V1.5131.00
38_N208_L1.5111.00
86_T203_S1.5101.00
3_I37_V1.5101.00
198_G230_Y1.5051.00
201_V227_M1.4941.00
218_I260_V1.4441.00
101_R118_A1.4421.00
27_N31_A1.4311.00
250_F263_A1.4301.00
217_A227_M1.4251.00
95_F177_K1.4221.00
100_S156_M1.4171.00
25_V258_D1.3991.00
167_I171_P1.3961.00
141_E144_K1.3731.00
33_R60_E1.3651.00
213_E232_G1.3581.00
24_A262_F1.3491.00
3_I214_E1.3461.00
236_A240_A1.3441.00
3_I233_V1.3431.00
218_I263_A1.3241.00
92_D177_K1.3211.00
26_K30_A1.3131.00
85_Q150_Q1.2901.00
238_D254_S1.2851.00
205_A212_P1.2811.00
92_D95_F1.2591.00
28_A261_A1.2561.00
228_I244_V1.2531.00
7_A42_T1.2491.00
103_V169_R1.2441.00
82_T85_Q1.2411.00
212_P215_I1.2401.00
225_I229_E1.2371.00
179_T226_A1.2311.00
99_L103_V1.2291.00
250_F266_K1.2291.00
90_Y94_R1.2221.00
243_S246_E1.2201.00
263_A267_Y1.2191.00
86_T192_D1.1971.00
92_D178_Y1.1951.00
216_M267_Y1.1911.00
24_A28_A1.1821.00
6_I264_I1.1771.00
73_L82_T1.1641.00
28_A265_E1.1631.00
162_I165_Q1.1561.00
245_K251_V1.1541.00
215_I231_A1.1541.00
30_A34_A1.1521.00
67_I200_G1.1491.00
164_D168_A1.1481.00
40_V204_L1.1271.00
85_Q152_L1.1151.00
164_D182_K1.1091.00
6_I32_A1.1091.00
179_T194_R1.1091.00
252_T259_G1.1061.00
217_A228_I1.1031.00
260_V264_I1.1021.00
5_L205_A1.1001.00
5_L210_I1.0931.00
7_A215_I1.0871.00
181_L191_L1.0861.00
252_T263_A1.0831.00
153_K189_E1.0811.00
239_N255_N1.0801.00
17_P255_N1.0751.00
231_A234_G1.0661.00
74_V203_S1.0621.00
6_I37_V1.0581.00
212_P232_G1.0561.00
23_P26_K1.0511.00
122_I126_T1.0511.00
192_D195_V1.0501.00
10_M53_Y1.0491.00
235_V252_T1.0431.00
16_L256_L1.0401.00
261_A265_E1.0331.00
241_I244_V1.0331.00
14_L25_V1.0211.00
177_K193_K1.0141.00
237_M259_G1.0121.00
158_D162_I1.0111.00
5_L215_I1.0051.00
74_V84_A1.0051.00
30_A33_R1.0041.00
196_N199_T1.0011.00
201_V231_A0.9951.00
98_K102_E0.9911.00
205_A230_Y0.9901.00
262_F266_K0.9821.00
235_V250_F0.9811.00
221_Q241_I0.9781.00
216_M233_V0.9751.00
240_A245_K0.9681.00
216_M263_A0.9671.00
30_A58_H0.9621.00
216_M235_V0.9601.00
165_Q168_A0.9561.00
51_H80_G0.9511.00
99_L102_E0.9511.00
204_L208_L0.9491.00
168_A171_P0.9441.00
237_M252_T0.9441.00
205_A232_G0.9381.00
238_D245_K0.9371.00
253_K259_G0.9371.00
86_T194_R0.9341.00
263_A266_K0.9301.00
198_G226_A0.9271.00
14_L29_I0.9271.00
85_Q112_R0.9241.00
32_A39_V0.9201.00
202_K212_P0.9191.00
47_Y68_T0.9181.00
236_A244_V0.9171.00
8_I260_V0.9141.00
94_R98_K0.9101.00
205_A210_I0.9081.00
222_E225_I0.9081.00
43_T68_T0.9041.00
238_D253_K0.8891.00
27_N30_A0.8881.00
191_L196_N0.8871.00
74_V200_G0.8851.00
72_A195_V0.8801.00
165_Q169_R0.8771.00
262_F265_E0.8721.00
7_A40_V0.8691.00
238_D257_E0.8631.00
87_A150_Q0.8601.00
158_D163_L0.8581.00
83_V207_V0.8561.00
25_V261_A0.8541.00
215_I232_G0.8521.00
16_L22_S0.8511.00
51_H55_K0.8471.00
88_L192_D0.8441.00
68_T73_L0.8371.00
232_G249_N0.8361.00
95_F98_K0.8341.00
228_I247_V0.8331.00
75_Q82_T0.8331.00
98_K143_E0.8301.00
91_D95_F0.8231.00
122_I125_Y0.8211.00
176_E193_K0.8201.00
243_S247_V0.8161.00
67_I204_L0.8151.00
99_L174_V0.8121.00
75_Q80_G0.8121.00
217_A234_G0.8081.00
42_T67_I0.8071.00
180_V190_I0.8051.00
8_I14_L0.8001.00
159_E162_I0.7901.00
167_I182_K0.7901.00
37_V216_M0.7881.00
6_I216_M0.7851.00
253_K266_K0.7841.00
32_A264_I0.7841.00
14_L21_I0.7831.00
215_I230_Y0.7811.00
47_Y75_Q0.7761.00
102_E169_R0.7761.00
10_M41_L0.7721.00
28_A31_A0.7711.00
87_A152_L0.7611.00
46_P69_Y0.7611.00
240_A244_V0.7571.00
68_T75_Q0.7571.00
25_V28_A0.7531.00
237_M240_A0.7511.00
160_P164_D0.7481.00
40_V61_Q0.7411.00
95_F99_L0.7411.00
24_A261_A0.7361.00
179_T196_N0.7351.00
142_A145_M0.7351.00
164_D167_I0.7341.00
97_E101_R0.7341.00
228_I248_A0.7281.00
18_D256_L0.7251.00
201_V217_A0.7241.00
81_S207_V0.7241.00
16_L255_N0.7151.00
50_V68_T0.7121.00
220_D240_A0.7091.00
220_D237_M0.7091.00
41_L50_V0.7061.00
103_V165_Q0.7051.00
214_E232_G0.7031.00
95_F174_V0.7001.00
94_R143_E0.6991.00
101_R107_F0.6981.00
111_D151_F0.6961.00
14_L255_N0.6951.00
135_I139_F0.6871.00
195_V199_T0.6851.00
199_T203_S0.6841.00
250_F262_F0.6841.00
234_G244_V0.6821.00
72_A192_D0.6821.00
179_T193_K0.6811.00
50_V66_C0.6801.00
140_C144_K0.6761.00
140_C143_E0.6751.00
12_G237_M0.6711.00
99_L169_R0.6701.00
202_K205_A0.6631.00
70_N189_E0.6601.00
250_F253_K0.6581.00
155_M189_E0.6571.00
169_R172_Q0.6551.00
234_G248_A0.6531.00
90_Y150_Q0.6521.00
42_T227_M0.6511.00
93_Y151_F0.6501.00
24_A27_N0.6481.00
10_M14_L0.6441.00
218_I235_V0.6431.00
91_D94_R0.6431.00
174_V177_K0.6371.00
104_G162_I0.6361.00
252_T262_F0.6301.00
47_Y51_H0.6301.00
5_L204_L0.6251.00
236_A247_V0.6221.00
226_A229_E0.6211.00
73_L152_L0.6181.00
94_R147_P0.6141.00
239_N245_K0.6131.00
10_M50_V0.6101.00
171_P180_V0.6101.00
168_A172_Q0.6101.00
112_R150_Q0.6071.00
258_D261_A0.6061.00
111_D149_T0.6051.00
33_R61_Q0.6041.00
153_K183_S0.6001.00
82_T112_R0.6001.00
233_V263_A0.5991.00
37_V214_E0.5951.00
97_E109_A0.5951.00
218_I252_T0.5941.00
163_L182_K0.5941.00
33_R58_H0.5921.00
179_T191_L0.5921.00
128_H134_T0.5921.00
52_N55_K0.5911.00
222_E244_V0.5911.00
14_L41_L0.5891.00
244_V248_A0.5861.00
76_K83_V0.5851.00
180_V188_L0.5841.00
28_A32_A0.5831.00
237_M255_N0.5811.00
160_P185_P0.5801.00
218_I264_I0.5791.00
22_S261_A0.5781.00
74_V204_L0.5751.00
109_A151_F0.5740.99
210_I215_I0.5730.99
123_S126_T0.5720.99
194_R199_T0.5710.99
198_G202_K0.5690.99
253_K263_A0.5680.99
112_R149_T0.5680.99
90_Y148_N0.5670.99
108_H155_M0.5660.99
54_L66_C0.5660.99
235_V249_N0.5640.99
41_L54_L0.5630.99
261_A264_I0.5620.99
128_H131_F0.5600.99
6_I218_I0.5580.99
210_I232_G0.5580.99
21_I26_K0.5580.99
132_V136_P0.5570.99
225_I228_I0.5560.99
74_V207_V0.5560.99
15_L255_N0.5550.99
184_A221_Q0.5530.99
112_R152_L0.5490.99
69_Y152_L0.5460.99
258_D262_F0.5440.99
155_M187_F0.5440.99
239_N254_S0.5420.99
119_N140_C0.5410.99
126_T129_E0.5400.99
29_I264_I0.5380.99
241_I245_K0.5380.99
76_K207_V0.5360.99
32_A261_A0.5350.99
8_I32_A0.5320.99
163_L188_L0.5320.99
50_V53_Y0.5320.99
105_S156_M0.5320.99
99_L170_I0.5310.99
25_V29_I0.5300.99
27_N265_E0.5300.99
4_K37_V0.5290.99
105_S166_A0.5280.99
69_Y187_F0.5280.99
93_Y97_E0.5250.99
161_A165_Q0.5240.99
127_V131_F0.5230.99
3_I38_N0.5220.99
69_Y72_A0.5210.99
212_P231_A0.5200.99
163_L167_I0.5200.99
17_P254_S0.5180.99
126_T130_S0.5180.99
73_L112_R0.5170.99
201_V205_A0.5120.99
5_L38_N0.5110.99
231_A249_N0.5100.99
70_N183_S0.5100.99
128_H132_V0.5090.99
198_G215_I0.5090.99
147_P150_Q0.5060.99
21_I45_R0.5030.99
12_G16_L0.5030.99
33_R39_V0.5020.99
107_F154_V0.5010.99
158_D166_A0.5010.99
42_T70_N0.5000.99
183_S189_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkqA 1 1 100 0.218 Contact Map
3pgvA 3 0.9519 100 0.225 Contact Map
2b30A 2 0.9926 100 0.233 Contact Map
3l7yA 1 0.9667 100 0.238 Contact Map
3mpoA 1 0.9889 100 0.242 Contact Map
1nrwA 1 0.963 100 0.243 Contact Map
3daoA 1 0.9704 100 0.25 Contact Map
1nf2A 4 0.9741 100 0.253 Contact Map
4dw8A 1 0.9852 100 0.255 Contact Map
1rlmA 1 0.9667 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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