GREMLIN Database
YIHX - Alpha-D-glucose-1-phosphate phosphatase YihX
UniProt: P0A8Y3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11850
Length: 199 (183)
Sequences: 27262 (22667)
Seq/√Len: 1675.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_E125_R3.0501.00
149_H153_A3.0401.00
139_M143_E2.9681.00
174_A181_S2.5901.00
94_H127_A2.5611.00
111_R115_T2.5331.00
90_I94_H2.5131.00
149_H152_Q2.4851.00
165_D170_N2.4851.00
130_H153_A2.3051.00
102_R129_D2.2981.00
139_M145_R2.2881.00
104_V130_H2.2801.00
106_L146_I2.2671.00
151_L161_T2.2571.00
111_R136_D2.1981.00
151_L179_I2.0671.00
172_E176_Q1.9601.00
157_S160_D1.9571.00
5_F103_V1.9491.00
97_R127_A1.9421.00
107_S114_T1.8961.00
171_I181_S1.8881.00
163_F174_A1.7871.00
95_K99_Q1.7801.00
168_A172_E1.7501.00
4_I150_V1.7481.00
162_V182_I1.7131.00
97_R129_D1.6721.00
4_I106_L1.6301.00
156_F161_T1.6271.00
103_V128_A1.6201.00
3_Y101_H1.6151.00
151_L158_P1.5941.00
144_A148_Q1.5901.00
104_V154_E1.5581.00
4_I163_F1.5411.00
115_T125_R1.5181.00
73_Q77_G1.4941.00
7_L105_V1.4771.00
75_S79_Q1.4591.00
32_A35_K1.4321.00
77_G81_V1.4121.00
10_V164_F1.4081.00
132_Y153_A1.3871.00
3_Y164_F1.3821.00
71_Y75_S1.3781.00
78_W82_F1.3251.00
132_Y150_V1.3101.00
22_A26_L1.3091.00
95_K98_E1.3071.00
4_I161_T1.2821.00
145_R149_H1.2601.00
7_L12_V1.2571.00
115_T119_E1.2491.00
3_Y96_L1.2271.00
74_F78_W1.2271.00
11_I89_V1.2241.00
70_S73_Q1.2141.00
23_W27_T1.1971.00
147_Y163_F1.1921.00
74_F82_F1.1871.00
137_L149_H1.1811.00
175_N181_S1.1591.00
86_R186_D1.1491.00
73_Q76_H1.1491.00
97_R103_V1.1151.00
123_E126_D1.1131.00
148_Q152_Q1.1081.00
173_G177_L1.0991.00
147_Y173_G1.0971.00
44_F47_H1.0941.00
147_Y179_I1.0921.00
105_V128_A1.0901.00
150_V154_E1.0901.00
33_S36_K1.0831.00
116_F120_E1.0821.00
114_T133_L1.0721.00
88_E91_A1.0641.00
54_D57_F1.0581.00
70_S74_F1.0531.00
7_L109_T1.0511.00
22_A25_D1.0451.00
156_F160_D1.0441.00
7_L114_T1.0341.00
130_H154_E1.0331.00
106_L150_V1.0321.00
94_H98_E1.0231.00
107_S133_L1.0161.00
42_E46_Q1.0151.00
148_Q177_L1.0091.00
90_I127_A1.0071.00
161_T179_I1.0001.00
26_L77_G0.9901.00
147_Y165_D0.9891.00
54_D58_A0.9841.00
85_L124_I0.9811.00
145_R148_Q0.9791.00
62_C65_M0.9761.00
4_I179_I0.9731.00
169_D172_E0.9711.00
76_H80_A0.9671.00
32_A36_K0.9661.00
163_F179_I0.9621.00
59_E63_H0.9571.00
111_R133_L0.9511.00
25_D31_L0.9471.00
93_M128_A0.9471.00
21_G25_D0.9421.00
56_A59_E0.9381.00
171_I183_L0.9351.00
91_A94_H0.9331.00
111_R135_Q0.9211.00
62_C66_A0.9101.00
26_L73_Q0.9101.00
85_L90_I0.9081.00
94_H126_D0.8981.00
132_Y149_H0.8971.00
72_E76_H0.8961.00
4_I154_E0.8951.00
148_Q158_P0.8921.00
7_L117_W0.8831.00
46_Q49_R0.8791.00
77_G80_A0.8711.00
104_V150_V0.8691.00
164_F182_I0.8691.00
63_H66_A0.8661.00
56_A60_A0.8651.00
116_F119_E0.8631.00
33_S37_S0.8631.00
76_H79_Q0.8561.00
46_Q51_E0.8551.00
45_H48_E0.8531.00
78_W81_V0.8511.00
86_R89_V0.8481.00
19_V23_W0.8451.00
41_G45_H0.8411.00
133_L136_D0.8361.00
58_A61_L0.8341.00
96_L101_H0.8301.00
57_F61_L0.8291.00
138_G145_R0.8281.00
74_F77_G0.8251.00
86_R184_V0.8211.00
8_G14_I0.8181.00
147_Y170_N0.8151.00
162_V180_T0.8141.00
8_G107_S0.8141.00
43_A47_H0.8091.00
55_E59_E0.8091.00
108_N140_R0.8071.00
158_P179_I0.8071.00
12_V117_W0.8061.00
144_A176_Q0.7961.00
41_G46_Q0.7951.00
42_E48_E0.7881.00
75_S78_W0.7851.00
43_A46_Q0.7851.00
96_L103_V0.7851.00
44_F48_E0.7841.00
90_I123_E0.7821.00
103_V127_A0.7791.00
8_G109_T0.7791.00
114_T117_W0.7711.00
168_A183_L0.7621.00
45_H49_R0.7611.00
56_A62_C0.7591.00
24_S29_I0.7541.00
118_P125_R0.7471.00
91_A95_K0.7441.00
172_E175_N0.7371.00
102_R156_F0.7371.00
20_L24_S0.7351.00
60_A63_H0.7351.00
13_D86_R0.7251.00
61_L66_A0.7221.00
79_Q82_F0.7211.00
136_D153_A0.7201.00
89_V93_M0.7191.00
97_R100_G0.7161.00
90_I126_D0.7161.00
55_E58_A0.7141.00
130_H150_V0.7131.00
61_L65_M0.7101.00
12_V121_Y0.7081.00
42_E45_H0.7081.00
137_L146_I0.7071.00
121_Y124_I0.7061.00
53_S56_A0.7061.00
30_P33_S0.7051.00
16_F84_A0.6991.00
89_V92_I0.6961.00
17_N83_V0.6921.00
103_V129_D0.6891.00
114_T131_I0.6871.00
132_Y154_E0.6861.00
69_L73_Q0.6861.00
46_Q50_G0.6731.00
151_L156_F0.6721.00
151_L177_L0.6721.00
22_A77_G0.6721.00
43_A48_E0.6721.00
146_I150_V0.6611.00
59_E62_C0.6591.00
22_A81_V0.6571.00
93_M127_A0.6571.00
58_A62_C0.6551.00
3_Y162_V0.6501.00
13_D16_F0.6491.00
158_P161_T0.6491.00
48_E51_E0.6491.00
109_T113_H0.6491.00
163_F173_G0.6451.00
60_A64_E0.6381.00
70_S75_S0.6381.00
9_N15_D0.6331.00
114_T118_P0.6271.00
92_I95_K0.6261.00
109_T114_T0.6261.00
13_D84_A0.6251.00
43_A50_G0.6241.00
163_F170_N0.6221.00
75_S82_F0.6141.00
63_H67_L0.6131.00
5_F92_I0.6131.00
108_N169_D0.6081.00
44_F49_R0.6041.00
148_Q151_L0.6011.00
134_S146_I0.5991.00
115_T131_I0.5931.00
92_I164_F0.5931.00
109_T165_D0.5921.00
41_G44_F0.5861.00
180_T183_L0.5851.00
34_L37_S0.5831.00
10_V170_N0.5811.00
4_I104_V0.5811.00
47_H50_G0.5791.00
71_Y74_F0.5791.00
85_L121_Y0.5751.00
171_I175_N0.5751.00
10_V184_V0.5731.00
146_I173_G0.5701.00
12_V83_V0.5681.00
94_H97_R0.5651.00
77_G82_F0.5581.00
106_L163_F0.5531.00
130_H133_L0.5491.00
20_L23_W0.5491.00
112_L116_F0.5481.00
62_C67_L0.5431.00
147_Y174_A0.5371.00
21_G31_L0.5371.00
173_G176_Q0.5361.00
151_L157_S0.5361.00
18_R109_T0.5341.00
74_F81_V0.5331.00
88_E92_I0.5301.00
72_E75_S0.5291.00
71_Y79_Q0.5281.00
8_G166_D0.5281.00
75_S81_V0.5271.00
132_Y146_I0.5161.00
50_G53_S0.5141.00
113_H117_W0.5101.00
97_R126_D0.5101.00
14_I109_T0.5101.00
57_F62_C0.5091.00
128_A131_I0.5081.00
71_Y81_V0.5081.00
144_A177_L0.5061.00
175_N180_T0.5051.00
170_N173_G0.5041.00
145_R152_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b0cA 2 0.9899 100 0.262 Contact Map
4jb3A 1 0.9849 100 0.271 Contact Map
2i6xA 1 0.9698 100 0.282 Contact Map
4dccA 1 0.9698 100 0.313 Contact Map
5am2A 2 0.995 100 0.315 Contact Map
3cnhA 1 0.9749 100 0.351 Contact Map
2zg6A 2 0.9045 100 0.362 Contact Map
3iruA 4 0.9899 100 0.362 Contact Map
3ed5A 1 0.9899 100 0.364 Contact Map
1swvA 2 0.9899 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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