GREMLIN Database
YJJG - Pyrimidine 5'-nucleotidase YjjG
UniProt: P0A8Y1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12115
Length: 225 (197)
Sequences: 29594 (23488)
Seq/√Len: 1673.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D170_R4.0091.00
158_Y162_Q2.8241.00
129_E134_R2.7931.00
148_V152_N2.7891.00
175_G181_D2.5711.00
185_G192_T2.5381.00
121_S125_Q2.4911.00
101_V105_N2.3781.00
105_N136_Y2.3521.00
5_W166_P2.3351.00
3_W191_A2.2451.00
114_G139_L2.2401.00
112_K138_D2.2271.00
158_Y161_E2.1851.00
121_S145_E2.1711.00
116_I155_I2.1481.00
139_L162_Q2.1001.00
8_F113_I2.0801.00
148_V154_K2.0621.00
160_L171_V2.0291.00
213_S217_E2.0221.00
117_T124_Q1.9901.00
182_I192_T1.9541.00
186_I209_T1.9151.00
167_D170_R1.8481.00
6_I111_A1.8371.00
183_L187_N1.8331.00
108_R136_Y1.7971.00
106_A219_E1.7771.00
191_A209_T1.7601.00
160_L190_L1.7011.00
7_F173_M1.6981.00
173_M185_G1.6801.00
172_L193_C1.6331.00
100_A215_L1.6271.00
108_R138_D1.6231.00
7_F159_A1.5671.00
86_F90_M1.5591.00
81_K85_A1.5431.00
113_I137_F1.5401.00
196_N213_S1.5111.00
160_L168_R1.5021.00
5_W163_A1.5011.00
35_T38_D1.4731.00
83_N87_I1.4661.00
97_L197_A1.4381.00
7_F116_I1.4301.00
166_P171_V1.4021.00
125_Q134_R1.3901.00
82_L86_F1.3801.00
3_W172_L1.3651.00
29_D85_A1.3581.00
114_G163_A1.3511.00
103_L215_L1.3481.00
10_A115_I1.3481.00
6_I107_I1.3441.00
153_K157_D1.3431.00
193_C212_V1.3251.00
25_R29_D1.3181.00
196_N211_T1.3141.00
6_I174_V1.3071.00
193_C210_W1.2881.00
214_S217_E1.2821.00
85_A88_N1.2821.00
10_A15_F1.2661.00
13_T174_V1.2631.00
85_A89_A1.2451.00
106_A109_G1.2401.00
14_L100_A1.2371.00
141_V162_Q1.2291.00
26_M30_Y1.2131.00
103_L219_E1.2061.00
125_Q129_E1.1821.00
99_G102_S1.1611.00
156_F184_G1.1501.00
156_F173_M1.1411.00
7_F171_V1.1351.00
5_W171_V1.1291.00
102_S216_H1.1001.00
82_L90_M1.0971.00
141_V159_A1.0861.00
124_Q142_I1.0841.00
108_R113_I1.0791.00
29_D81_K1.0761.00
25_R89_A1.0711.00
10_A124_Q1.0701.00
156_F190_L1.0551.00
154_K158_Y1.0521.00
5_W112_K1.0491.00
73_E76_N1.0481.00
157_D161_E1.0341.00
132_G135_D1.0341.00
21_T25_R1.0301.00
154_K157_D1.0271.00
72_A75_L1.0271.00
25_R85_A1.0221.00
96_P133_L1.0201.00
126_V130_R1.0191.00
105_N109_G1.0101.00
21_T24_Q1.0041.00
171_V190_L1.0031.00
10_A119_G0.9991.00
146_V158_Y0.9991.00
84_E88_N0.9961.00
104_L137_F0.9891.00
65_H69_E0.9761.00
186_I192_T0.9751.00
25_R28_L0.9691.00
43_Q46_N0.9691.00
173_M190_L0.9661.00
115_I137_F0.9611.00
66_G70_S0.9611.00
101_V136_Y0.9561.00
157_D188_A0.9531.00
116_I159_A0.9511.00
186_I207_A0.9501.00
126_V129_E0.9471.00
11_D17_F0.9471.00
159_A163_A0.9441.00
81_K84_E0.9351.00
121_S142_I0.9341.00
27_F32_V0.9221.00
24_Q28_L0.9161.00
5_W114_G0.9141.00
82_L85_A0.9131.00
156_F175_G0.9121.00
182_I208_P0.9091.00
121_S144_E0.9081.00
141_V158_Y0.9061.00
66_G69_E0.9061.00
96_P101_V0.9041.00
34_F39_F0.9021.00
139_L163_A0.9011.00
69_E73_E0.8931.00
172_L191_A0.8851.00
99_G214_S0.8841.00
36_A39_F0.8811.00
7_F190_L0.8761.00
191_A210_W0.8731.00
102_S105_N0.8701.00
212_V218_L0.8661.00
11_D119_G0.8641.00
21_T93_I0.8601.00
38_D41_D0.8581.00
184_G188_A0.8551.00
180_S183_L0.8441.00
157_D168_R0.8431.00
10_A127_R0.8391.00
147_G154_K0.8371.00
70_S73_E0.8261.00
163_A166_P0.8231.00
194_W211_T0.8211.00
117_T142_I0.8151.00
15_F127_R0.8141.00
7_F163_A0.8121.00
99_G216_H0.8081.00
177_T180_S0.8061.00
174_V193_C0.8031.00
192_T209_T0.7991.00
97_L195_L0.7981.00
35_T39_F0.7961.00
104_L136_Y0.7851.00
114_G159_A0.7841.00
107_I113_I0.7841.00
166_P170_R0.7831.00
22_G26_M0.7831.00
30_Y81_K0.7821.00
113_I136_Y0.7781.00
107_I111_A0.7761.00
105_N135_D0.7691.00
64_Q67_R0.7691.00
101_V132_G0.7641.00
11_D117_T0.7571.00
168_R190_L0.7561.00
124_Q127_R0.7551.00
24_Q36_A0.7521.00
102_S106_A0.7491.00
4_D111_A0.7471.00
72_A76_N0.7461.00
15_F131_T0.7441.00
142_I145_E0.7401.00
118_N149_A0.7331.00
182_I194_W0.7281.00
83_N90_M0.7241.00
3_W111_A0.7231.00
97_L100_A0.7191.00
86_F89_A0.7061.00
37_E40_Q0.7031.00
119_G124_Q0.7021.00
4_D166_P0.7011.00
40_Q43_Q0.6971.00
174_V218_L0.6971.00
70_S74_R0.6941.00
13_T181_D0.6921.00
193_C218_L0.6921.00
145_E162_Q0.6911.00
6_I172_L0.6911.00
42_Y45_V0.6861.00
83_N86_F0.6831.00
68_F71_W0.6821.00
202_Q213_S0.6821.00
64_Q68_F0.6791.00
41_D44_A0.6781.00
101_V135_D0.6781.00
84_E87_I0.6731.00
112_K166_P0.6711.00
4_D112_K0.6711.00
96_P131_T0.6681.00
19_S95_T0.6661.00
183_L186_I0.6631.00
139_L159_A0.6631.00
156_F181_D0.6621.00
212_V215_L0.6611.00
11_D176_D0.6561.00
153_K187_N0.6471.00
118_N180_S0.6451.00
7_F114_G0.6421.00
128_L134_R0.6411.00
91_A126_V0.6411.00
195_L215_L0.6401.00
113_I138_D0.6351.00
173_M181_D0.6321.00
155_I159_A0.6301.00
16_T95_T0.6301.00
20_F94_C0.6291.00
197_A215_L0.6291.00
3_W170_R0.6291.00
82_L89_A0.6281.00
67_R71_W0.6251.00
73_E77_V0.6251.00
124_Q140_L0.6191.00
146_V155_I0.6181.00
118_N151_P0.6131.00
16_T19_S0.6091.00
125_Q140_L0.6081.00
141_V155_I0.6041.00
68_F72_A0.6031.00
17_F119_G0.6031.00
15_F94_C0.6001.00
64_Q69_E0.5991.00
23_L26_M0.5971.00
168_R171_V0.5891.00
71_W75_L0.5881.00
215_L219_E0.5871.00
124_Q128_L0.5861.00
23_L27_F0.5861.00
173_M184_G0.5801.00
69_E79_P0.5801.00
12_E18_D0.5791.00
216_H219_E0.5781.00
143_S155_I0.5771.00
11_D127_R0.5771.00
160_L166_P0.5741.00
196_N201_E0.5721.00
155_I184_G0.5711.00
72_A77_V0.5711.00
105_N108_R0.5701.00
160_L188_A0.5701.00
100_A104_L0.5691.00
157_D160_L0.5681.00
40_Q44_A0.5671.00
45_V70_S0.5641.00
137_F140_L0.5581.00
116_I173_M0.5581.00
79_P82_L0.5551.00
180_S184_G0.5531.00
119_G123_L0.5501.00
28_L33_T0.5501.00
21_T89_A0.5441.00
141_V163_A0.5431.00
100_A103_L0.5391.00
156_F185_G0.5371.00
103_L174_V0.5371.00
67_R72_A0.5341.00
122_A126_V0.5331.00
212_V219_E0.5301.00
8_F103_L0.5281.00
99_G103_L0.5271.00
184_G187_N0.5261.00
67_R70_S0.5241.00
16_T97_L0.5211.00
75_L78_E0.5211.00
82_L87_I0.5201.00
42_Y46_N0.5191.00
139_L142_I0.5181.00
69_E72_A0.5131.00
183_L206_I0.5121.00
103_L107_I0.5101.00
14_L115_I0.5061.00
87_I90_M0.5041.00
26_M29_D0.5041.00
79_P83_N0.5041.00
122_A125_Q0.5031.00
34_F37_E0.5021.00
108_R135_D0.5001.00
13_T195_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnmA 1 0.9822 100 0.29 Contact Map
3ed5A 1 1 100 0.292 Contact Map
1swvA 2 0.9867 100 0.311 Contact Map
3iruA 4 0.9911 100 0.314 Contact Map
3smvA 1 0.9778 100 0.318 Contact Map
2hdoA 1 0.9111 100 0.321 Contact Map
4uw9A 1 0.8667 100 0.325 Contact Map
2om6A 2 0.9911 100 0.328 Contact Map
3umcA 2 0.9778 100 0.328 Contact Map
3umgA 2 0.9778 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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