GREMLIN Database
YCCT - UPF0319 protein YccT
UniProt: P0A8X4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13722
Length: 220 (208)
Sequences: 507 (407)
Seq/√Len: 28.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D57_H6.7551.00
203_D206_T6.4361.00
194_R197_Y3.5811.00
196_K213_W3.4371.00
142_I147_E3.3641.00
131_D151_Y3.1831.00
199_F214_A3.1591.00
194_R198_W3.0101.00
58_Q152_N2.9871.00
198_W202_A2.8581.00
63_V199_F2.5480.99
208_N215_E2.4980.99
192_E209_T2.3380.99
195_L210_F2.2300.98
199_F211_L2.1460.98
212_Q215_E2.1370.98
192_E203_D2.0800.97
162_Q167_M2.0590.97
110_F114_P2.0550.97
60_V133_L2.0340.97
208_N212_Q2.0140.97
139_A142_I1.9940.96
58_Q133_L1.9600.96
60_V148_V1.9010.95
53_D57_H1.9010.95
211_L214_A1.8940.95
83_V148_V1.7820.93
62_R79_S1.6990.91
139_A147_E1.6410.90
191_T198_W1.6300.90
194_R202_A1.6260.90
207_R213_W1.5700.88
192_E206_T1.5690.88
144_Y147_E1.5660.88
25_L31_L1.5490.87
212_Q216_K1.5440.87
58_Q199_F1.5210.86
120_D124_T1.5140.86
58_Q151_Y1.5020.85
61_F84_V1.4790.84
205_Q208_N1.4680.84
58_Q137_S1.4670.84
10_I182_A1.4500.83
143_D199_F1.4440.83
66_T214_A1.4020.81
58_Q83_V1.3920.81
52_L55_G1.3860.80
151_Y155_A1.3710.80
54_N57_H1.3700.80
56_P85_S1.3660.79
152_N199_F1.3580.79
197_Y202_A1.3540.79
103_N106_E1.3240.77
198_W201_L1.3160.77
63_V77_Y1.3140.77
133_L152_N1.3120.76
58_Q143_D1.3100.76
21_T51_E1.2870.75
89_Q92_N1.2860.75
52_L108_N1.2660.74
57_H203_D1.2530.73
54_N90_L1.2510.73
207_R215_E1.2230.71
79_S114_P1.2210.71
116_L199_F1.2180.71
156_K159_S1.2020.70
23_L31_L1.1890.69
133_L151_Y1.1750.68
54_N86_F1.1670.68
137_S152_N1.1640.67
48_D83_V1.1610.67
5_I13_C1.1520.67
61_F158_A1.1510.66
196_K214_A1.1340.65
195_L202_A1.1320.65
89_Q124_T1.1270.65
196_K210_F1.1190.64
28_D65_K1.1080.63
211_L215_E1.1060.63
197_Y209_T1.1050.63
67_I213_W1.1020.63
192_E196_K1.1010.63
191_T194_R1.0990.63
101_L110_F1.0930.62
12_L164_A1.0860.62
130_L140_K1.0860.62
135_I147_E1.0810.61
154_S158_A1.0770.61
80_P132_I1.0730.61
137_S142_I1.0720.61
208_N214_A1.0710.61
122_D161_P1.0580.60
169_D180_L1.0430.59
67_I107_A1.0400.58
131_D158_A1.0350.58
67_I214_A1.0200.57
39_V183_I0.9990.55
67_I116_L0.9980.55
165_T168_A0.9960.55
85_S96_F0.9860.54
143_D146_V0.9830.54
135_I139_A0.9700.53
36_G145_E0.9630.53
52_L57_H0.9580.52
198_W206_T0.9580.52
52_L182_A0.9570.52
65_K101_L0.9550.52
26_S63_V0.9550.52
203_D209_T0.9480.51
195_L198_W0.9470.51
101_L111_D0.9430.51
139_A144_Y0.9410.51
197_Y201_L0.9370.51
14_L108_N0.9270.50
60_V211_L0.9230.50
30_D63_V0.9220.49
133_L199_F0.9220.49
26_S141_T0.9220.49
32_L60_V0.9140.49
106_E215_E0.9130.49
61_F96_F0.9130.49
18_V207_R0.9090.48
9_L127_P0.9030.48
158_A203_D0.8950.47
116_L201_L0.8850.47
167_M170_D0.8800.46
84_V148_V0.8800.46
190_L194_R0.8790.46
119_L125_P0.8770.46
77_Y152_N0.8740.46
77_Y111_D0.8700.45
100_R200_K0.8620.45
207_R216_K0.8610.45
151_Y199_F0.8520.44
8_T14_L0.8500.44
76_L101_L0.8500.44
60_V81_P0.8470.44
94_V116_L0.8370.43
94_V199_F0.8360.43
35_D203_D0.8360.43
83_V126_I0.8350.43
83_V151_Y0.8330.43
171_S180_L0.8330.43
30_D46_G0.8210.42
60_V83_V0.8180.42
59_L211_L0.8120.41
161_P169_D0.8020.40
21_T53_D0.8000.40
106_E119_L0.7980.40
12_L16_V0.7970.40
189_V192_E0.7970.40
168_A185_P0.7950.40
14_L18_V0.7930.40
73_E196_K0.7880.39
131_D155_A0.7880.39
35_D60_V0.7850.39
23_L183_I0.7770.38
133_L147_E0.7740.38
143_D152_N0.7720.38
61_F148_V0.7710.38
77_Y97_R0.7630.37
135_I142_I0.7600.37
131_D152_N0.7550.37
6_V150_R0.7540.37
102_E139_A0.7470.36
83_V131_D0.7400.36
86_F152_N0.7390.36
99_P158_A0.7380.36
85_S160_L0.7350.35
59_L96_F0.7340.35
126_I200_K0.7300.35
137_S147_E0.7300.35
7_T34_L0.7290.35
15_P181_D0.7250.35
163_F167_M0.7240.35
113_A159_S0.7230.35
118_L201_L0.7220.35
36_G110_F0.7220.35
77_Y80_P0.7200.34
2_K5_I0.7170.34
30_D103_N0.7160.34
84_V112_A0.7150.34
29_V98_L0.7130.34
137_S199_F0.7110.34
199_F207_R0.7110.34
202_A210_F0.7080.34
35_D206_T0.7060.33
183_I189_V0.7050.33
161_P166_M0.7040.33
163_F178_S0.7030.33
68_H157_R0.7020.33
196_K200_K0.7000.33
6_V106_E0.6930.33
62_R114_P0.6920.32
35_D211_L0.6900.32
208_N213_W0.6860.32
4_G109_H0.6840.32
8_T124_T0.6740.31
16_V19_F0.6720.31
133_L137_S0.6700.31
166_M177_V0.6680.31
196_K209_T0.6670.31
101_L197_Y0.6610.30
44_L159_S0.6600.30
60_V82_L0.6590.30
7_T188_Q0.6580.30
28_D82_L0.6550.30
29_V86_F0.6550.30
24_R119_L0.6510.30
66_T199_F0.6500.30
137_S143_D0.6480.30
167_M183_I0.6480.30
189_V207_R0.6470.30
12_L203_D0.6460.29
206_T209_T0.6420.29
8_T16_V0.6420.29
60_V196_K0.6390.29
82_L199_F0.6380.29
87_N180_L0.6370.29
86_F126_I0.6360.29
33_V67_I0.6350.29
66_T76_L0.6340.29
195_L205_Q0.6270.28
110_F145_E0.6260.28
166_M170_D0.6230.28
194_R201_L0.6230.28
94_V151_Y0.6230.28
193_Q197_Y0.6200.28
141_T158_A0.6190.28
59_L142_I0.6160.28
57_H94_V0.6140.27
152_N159_S0.6130.27
160_L164_A0.6100.27
33_V76_L0.6090.27
56_P212_Q0.6090.27
150_R170_D0.6080.27
23_L52_L0.6040.27
62_R72_S0.6000.27
23_L35_D0.6000.27
124_T154_S0.6000.27
27_T94_V0.5980.26
188_Q204_P0.5970.26
65_K94_V0.5950.26
75_R107_A0.5910.26
21_T24_R0.5890.26
198_W214_A0.5880.26
210_F214_A0.5880.26
126_I130_L0.5880.26
40_S115_R0.5870.26
61_F99_P0.5870.26
81_P208_N0.5860.26
81_P123_A0.5840.26
197_Y213_W0.5830.26
25_L44_L0.5820.26
59_L165_T0.5800.25
32_L62_R0.5800.25
141_T144_Y0.5770.25
11_A167_M0.5720.25
206_T216_K0.5710.25
29_V33_V0.5710.25
196_K212_Q0.5700.25
71_N137_S0.5650.25
22_T184_P0.5650.25
58_Q138_T0.5640.24
193_Q204_P0.5600.24
165_T170_D0.5600.24
20_A46_G0.5590.24
33_V148_V0.5560.24
134_A201_L0.5520.24
92_N95_N0.5510.24
121_G167_M0.5470.24
66_T74_E0.5450.23
55_G207_R0.5430.23
155_A159_S0.5430.23
197_Y206_T0.5430.23
142_I194_R0.5400.23
29_V111_D0.5390.23
77_Y101_L0.5390.23
161_P170_D0.5390.23
171_S182_A0.5380.23
104_E127_P0.5360.23
143_D147_E0.5350.23
78_I140_K0.5350.23
33_V212_Q0.5350.23
10_I13_C0.5310.23
59_L134_A0.5310.23
188_Q191_T0.5310.23
72_S202_A0.5280.22
16_V88_T0.5250.22
65_K114_P0.5230.22
51_E181_D0.5210.22
192_E213_W0.5210.22
10_I166_M0.5200.22
4_G7_T0.5190.22
46_G127_P0.5180.22
73_E76_L0.5170.22
122_D165_T0.5170.22
35_D53_D0.5170.22
34_L53_D0.5160.22
19_F164_A0.5160.22
81_P85_S0.5150.22
30_D72_S0.5140.22
63_V67_I0.5130.22
25_L92_N0.5120.22
185_P189_V0.5100.22
34_L48_D0.5100.22
98_L101_L0.5090.21
157_R184_P0.5070.21
67_I196_K0.5060.21
9_L15_P0.5040.21
85_S107_A0.5020.21
82_L194_R0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fybB 1 0.6 50.1 0.938 Contact Map
2jttC 1 0.1364 22.8 0.948 Contact Map
2nocA 1 0.3227 18.1 0.951 Contact Map
2qbwA 1 0.7227 13.9 0.953 Contact Map
4uu4A 1 0.6409 11.8 0.955 Contact Map
3gknA 1 0.5545 11.3 0.955 Contact Map
2ggtA 1 0.5318 9.9 0.956 Contact Map
3zbiC 1 0.1273 9.1 0.957 Contact Map
4n4rB 1 0.5409 8.8 0.957 Contact Map
4hqzA 1 0.5273 8.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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