GREMLIN Database
YCEI - Protein YceI
UniProt: P0A8X2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11820
Length: 191 (166)
Sequences: 4319 (3145)
Seq/√Len: 244.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_D76_N2.9701.00
77_T105_A2.8761.00
98_N101_K2.8281.00
124_D131_T2.6251.00
74_T104_Q2.5371.00
72_N108_T2.4761.00
107_F123_G2.2941.00
120_D137_E2.2771.00
98_N128_N2.2121.00
82_T88_D2.1941.00
126_T131_T2.1801.00
120_D135_T2.1631.00
122_T135_T2.1161.00
53_K81_D2.0451.00
110_T124_D2.0361.00
132_K165_D2.0121.00
160_K178_E2.0081.00
121_I138_A1.9831.00
164_K177_Q1.9661.00
162_K165_D1.9531.00
76_N104_Q1.9511.00
122_T133_P1.9431.00
162_K177_Q1.9431.00
94_A98_N1.8581.00
90_H95_D1.8351.00
24_D60_T1.8331.00
72_N106_T1.8241.00
113_K122_T1.8111.00
86_E89_K1.8031.00
113_K120_D1.8001.00
102_Y128_N1.7751.00
65_N68_A1.7741.00
77_T99_T1.7491.00
111_S122_T1.6901.00
108_T124_D1.6651.00
58_T72_N1.6611.00
59_F187_G1.6411.00
85_A89_K1.5961.00
124_D133_P1.5581.00
160_K180_D1.5481.00
156_E184_S1.5311.00
71_V109_S1.4541.00
125_L134_V1.4011.00
157_A183_I1.3871.00
36_V55_F1.3801.00
39_R47_W1.3671.00
38_F50_G1.3541.00
34_A185_V1.3331.00
56_D74_T1.3281.00
136_L157_A1.3191.00
132_K166_F1.3151.00
70_K108_T1.3041.00
136_L159_G1.3011.00
28_D33_H1.2961.00
40_I179_V1.2741.00
115_D118_E1.2591.00
92_R99_T1.2081.00
102_Y129_G1.2081.00
27_I57_G1.2061.00
75_I105_A1.2001.00
82_T87_R1.1631.00
159_G181_L1.1601.00
40_I175_A1.1531.00
115_D120_D1.1391.00
80_V91_L1.1311.00
112_V121_I1.1231.00
152_R188_V1.1221.00
110_T133_P1.1181.00
114_K119_L1.1111.00
128_N168_I1.1071.00
158_E182_I1.1071.00
60_T70_K1.0991.00
57_G73_V1.0831.00
108_T126_T1.0821.00
143_Q153_A1.0661.00
52_F75_I1.0631.00
37_N49_Y1.0481.00
152_R186_E1.0441.00
20_A23_A1.0431.00
91_L97_L1.0421.00
54_D79_S1.0381.00
81_D88_D1.0281.00
24_D58_T1.0251.00
162_K178_E1.0121.00
89_K92_R1.0071.00
158_E180_D0.9981.00
105_A127_L0.9841.00
136_L183_I0.9711.00
170_T175_A0.9641.00
48_L87_R0.9641.00
109_S112_V0.9631.00
171_D174_P0.9571.00
78_T92_R0.9411.00
90_H96_F0.9401.00
29_K56_D0.9361.00
53_K79_S0.9351.00
25_Y153_A0.9341.00
145_D151_K0.9331.00
36_V183_I0.9191.00
59_F71_V0.9081.00
33_H186_E0.9021.00
32_Q84_H0.9011.00
94_A101_K0.8991.00
114_K117_D0.8981.00
62_D68_A0.8981.00
126_T129_G0.8941.00
51_T83_N0.8911.00
161_I181_L0.8881.00
134_V159_G0.8861.00
39_R49_Y0.8720.99
77_T97_L0.8710.99
88_D92_R0.8650.99
107_F135_T0.8560.99
118_E139_K0.8530.99
112_V119_L0.8430.99
27_I185_V0.8340.99
74_T106_T0.8330.99
73_V183_I0.8310.99
133_P137_E0.8300.99
66_P69_D0.8290.99
137_E159_G0.8240.99
25_Y187_G0.8220.99
62_D65_N0.8190.99
98_N102_Y0.8180.99
39_R182_I0.8140.99
96_F175_A0.8130.99
33_H42_H0.8090.99
37_N182_I0.8060.99
61_F119_L0.8040.99
140_L143_Q0.8010.99
52_F79_S0.7950.99
34_A55_F0.7900.99
130_V167_N0.7890.99
33_H154_G0.7830.99
155_F185_V0.7790.99
40_I48_L0.7740.99
97_L163_L0.7700.99
97_L168_I0.7630.99
49_Y184_S0.7600.99
89_K93_S0.7590.99
38_F82_T0.7540.98
106_T129_G0.7540.98
156_E182_I0.7440.98
142_G155_F0.7430.98
154_G184_S0.7430.98
134_V166_F0.7420.98
29_K54_D0.7360.98
119_L138_A0.7260.98
35_F51_T0.7250.98
60_T69_D0.7120.98
114_K118_E0.7100.98
183_I187_G0.7070.98
138_A157_A0.7070.98
27_I187_G0.7050.98
115_D139_K0.7050.98
19_S23_A0.7030.98
154_G186_E0.6990.97
115_D119_L0.6990.97
140_L155_F0.6980.97
112_V138_A0.6970.97
28_D42_H0.6900.97
50_G87_R0.6810.97
41_Q47_W0.6790.97
128_N167_N0.6790.97
19_S22_A0.6780.97
77_T92_R0.6750.97
39_R180_D0.6750.97
140_L153_A0.6730.97
29_K32_Q0.6730.97
91_L96_F0.6710.97
45_Y144_G0.6710.97
129_G167_N0.6690.97
164_K171_D0.6690.97
26_K56_D0.6690.97
18_G22_A0.6590.96
47_W156_E0.6580.96
80_V92_R0.6560.96
52_F55_F0.6550.96
65_N69_D0.6510.96
42_H154_G0.6500.96
49_Y83_N0.6470.96
41_Q176_S0.6460.96
125_L166_F0.6400.96
107_F159_G0.6370.96
43_L46_S0.6350.96
125_L161_I0.6350.96
170_T174_P0.6320.95
90_H170_T0.6320.95
97_L177_Q0.6290.95
42_H46_S0.6260.95
143_Q151_K0.6260.95
169_K173_G0.6250.95
53_K83_N0.6190.95
97_L179_V0.6190.95
42_H186_E0.6060.94
110_T122_T0.6030.94
84_H88_D0.6020.94
51_T81_D0.6000.94
63_E68_A0.5960.94
87_R90_H0.5920.94
127_L166_F0.5870.93
83_N88_D0.5840.93
163_L175_A0.5820.93
35_F49_Y0.5800.93
77_T168_I0.5770.93
77_T102_Y0.5760.93
141_I156_E0.5740.93
73_V157_A0.5740.93
66_P119_L0.5730.92
87_R91_L0.5720.92
118_E137_E0.5710.92
127_L161_I0.5680.92
78_T99_T0.5670.92
34_A57_G0.5650.92
37_N51_T0.5650.92
84_H87_R0.5640.92
141_I154_G0.5590.92
80_V97_L0.5590.92
29_K33_H0.5570.91
26_K58_T0.5560.91
164_K172_L0.5550.91
50_G82_T0.5520.91
38_F80_V0.5510.91
33_H152_R0.5500.91
62_D66_P0.5480.91
63_E66_P0.5480.91
49_Y182_I0.5460.91
46_S154_G0.5450.90
69_D112_V0.5380.90
109_S121_I0.5340.90
27_I73_V0.5300.89
126_T130_V0.5290.89
161_I168_I0.5290.89
57_G185_V0.5290.89
62_D69_D0.5280.89
168_I171_D0.5260.89
110_T131_T0.5240.89
94_A128_N0.5230.89
33_H142_G0.5190.88
164_K169_K0.5170.88
127_L168_I0.5160.88
26_K188_V0.5140.88
144_G152_R0.5120.88
108_T131_T0.5120.88
29_K55_F0.5090.87
82_T91_L0.5070.87
33_H46_S0.5040.87
40_I176_S0.5030.87
23_A63_E0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y0gA 2 0.8743 100 0.074 Contact Map
1wubA 1 0.8691 100 0.176 Contact Map
2fgsA 2 0.8691 100 0.19 Contact Map
3hpeA 2 0.8429 100 0.216 Contact Map
3q34A 2 0.822 100 0.3 Contact Map
2x32A 1 0.8272 100 0.318 Contact Map
4uu4A 1 0.6597 39.8 0.927 Contact Map
2qguA 1 0.822 14.5 0.941 Contact Map
4wrtA 1 0.6963 12.8 0.942 Contact Map
3nb3A 2 0.6073 11.9 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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