GREMLIN Database
YQGE - UPF0301 protein YqgE
UniProt: P0A8W5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13289
Length: 187 (171)
Sequences: 1933 (1297)
Seq/√Len: 99.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_H151_P4.3871.00
140_Q144_D4.1221.00
73_M162_I3.7351.00
88_T123_D3.6691.00
155_N159_K3.5091.00
37_I127_A3.2561.00
23_V39_V3.2451.00
153_D172_L3.0261.00
22_S41_K2.9761.00
22_S38_I2.8451.00
34_A139_E2.7901.00
25_Y103_T2.5651.00
21_R166_W2.4071.00
7_F39_V2.3841.00
14_L18_I2.3411.00
9_I150_A2.3171.00
23_V166_W2.2381.00
14_L146_A2.2031.00
96_S104_V2.1901.00
170_A177_I2.1751.00
161_P164_D2.1561.00
43_L74_L2.0371.00
48_I52_L1.9501.00
98_R101_D1.9201.00
6_H149_T1.8431.00
123_D159_K1.8241.00
15_Q20_R1.8061.00
38_I74_L1.7851.00
4_Q28_E1.7291.00
160_T168_E1.7241.00
29_H34_A1.7151.00
87_H121_P1.5931.00
166_W170_A1.5771.00
103_T157_L1.5521.00
87_H96_S1.5331.00
100_S103_T1.5021.00
176_D179_T1.4931.00
73_M125_L1.4741.00
150_A172_L1.4611.00
18_I41_K1.4411.00
26_I34_A1.4271.00
78_L132_S1.4151.00
162_I165_R1.3981.00
114_T120_Q1.3780.99
159_K168_E1.3270.99
37_I99_I1.2980.99
24_V36_G1.2680.99
109_R113_E1.2510.99
28_E32_N1.2480.99
5_H25_Y1.2460.99
150_A173_I1.2410.99
19_F137_Q1.2320.99
89_P104_V1.2320.99
39_V165_R1.2250.99
19_F77_P1.2160.99
11_M145_N1.1980.98
4_Q166_W1.1680.98
47_K50_G1.1640.98
150_A166_W1.1550.98
98_R104_V1.1500.98
159_K164_D1.1460.98
98_R102_N1.1130.98
24_V131_A1.1070.97
25_Y86_L1.1050.97
115_L124_V1.0610.97
102_N154_L1.0550.97
27_C158_F1.0420.96
79_A130_Y1.0360.96
24_V146_A1.0340.96
29_H139_E1.0320.96
7_F23_V1.0230.96
96_S106_T1.0220.96
93_F111_V1.0200.96
14_L20_R1.0180.96
142_I149_T1.0070.96
125_L165_R0.9930.95
119_K164_D0.9910.95
83_G107_T0.9840.95
25_Y157_L0.9840.95
134_E140_Q0.9790.95
170_A175_V0.9680.94
16_D19_F0.9640.94
170_A180_M0.9630.94
77_P129_G0.9550.94
72_V123_D0.9500.94
46_L181_P0.9440.94
39_V125_L0.9400.94
178_L181_P0.9400.94
9_I170_A0.9360.93
47_K69_D0.9250.93
114_T118_D0.9240.93
164_D168_E0.9050.92
55_L150_A0.9040.92
168_E171_K0.9010.92
13_A182_G0.8980.92
17_P74_L0.8930.92
7_F165_R0.8880.91
41_K74_L0.8810.91
42_P162_I0.8810.91
155_N168_E0.8770.91
148_L180_M0.8740.91
171_K176_D0.8620.90
153_D156_I0.8580.90
18_I22_S0.8520.90
170_A178_L0.8390.89
57_I118_D0.8350.89
37_I70_K0.8190.88
68_L71_P0.8190.88
165_R169_A0.8190.88
26_I100_S0.8020.87
136_G139_E0.8020.87
9_I51_I0.8020.87
83_G128_L0.7980.86
21_R167_R0.7920.86
21_R182_G0.7900.86
177_I181_P0.7830.85
84_F128_L0.7830.85
148_L170_A0.7800.85
87_H107_T0.7690.84
154_L164_D0.7680.84
59_P68_L0.7660.84
92_N104_V0.7550.83
169_A173_I0.7520.83
16_D77_P0.7510.83
19_F131_A0.7450.82
161_P165_R0.7450.82
11_M148_L0.7430.82
137_Q141_E0.7390.82
145_N173_I0.7350.82
24_V38_I0.7340.81
116_G120_Q0.7330.81
156_I175_V0.7320.81
38_I68_L0.7300.81
5_H127_A0.7280.81
21_R177_I0.7260.81
35_M84_F0.7230.80
9_I169_A0.7190.80
142_I146_A0.7180.80
118_D121_P0.7160.80
69_D171_K0.7080.79
35_M105_M0.7080.79
121_P128_L0.7050.79
91_S135_K0.6960.78
17_P136_G0.6940.78
48_I112_L0.6880.77
167_R171_K0.6870.77
85_I111_V0.6840.77
27_C35_M0.6810.76
102_N122_S0.6760.76
142_I145_N0.6720.75
145_N149_T0.6680.75
77_P137_Q0.6680.75
116_G126_V0.6670.75
102_N163_A0.6670.75
18_I79_A0.6660.75
49_E58_T0.6620.74
11_M149_T0.6580.74
160_T164_D0.6550.74
37_I166_W0.6510.73
110_D118_D0.6500.73
52_L112_L0.6470.73
7_F156_I0.6460.73
119_K140_Q0.6430.72
11_M46_L0.6380.72
114_T117_T0.6360.71
165_R170_A0.6340.71
25_Y152_A0.6320.71
5_H23_V0.6300.71
5_H28_E0.6290.71
5_H37_I0.6280.70
53_E58_T0.6250.70
59_P86_L0.6240.70
31_T41_K0.6210.70
49_E68_L0.6190.69
178_L182_G0.6170.69
14_L17_P0.6160.69
93_F114_T0.6150.69
143_L182_G0.6140.69
89_P102_N0.6110.68
24_V54_K0.6060.68
82_R95_S0.6060.68
27_C112_L0.6010.67
82_R87_H0.6000.67
18_I88_T0.5960.66
153_D169_A0.5960.66
122_S153_D0.5950.66
120_Q171_K0.5930.66
85_I130_Y0.5930.66
23_V172_L0.5910.66
52_L83_G0.5910.66
113_E117_T0.5860.65
79_A109_R0.5850.65
28_E108_S0.5840.65
54_K111_V0.5840.65
129_G133_W0.5810.64
76_G147_W0.5790.64
7_F149_T0.5780.64
48_I126_V0.5780.64
112_L121_P0.5780.64
52_L116_G0.5770.64
115_L120_Q0.5760.64
37_I92_N0.5700.63
28_E46_L0.5700.63
55_L59_P0.5690.63
84_F106_T0.5690.63
72_V126_V0.5680.63
143_L160_T0.5660.62
33_G86_L0.5650.62
33_G109_R0.5650.62
133_W147_W0.5640.62
47_K140_Q0.5640.62
111_V114_T0.5620.62
48_I81_D0.5600.62
25_Y39_V0.5600.62
151_P172_L0.5580.61
38_I167_R0.5560.61
73_M156_I0.5560.61
24_V114_T0.5540.61
139_E145_N0.5540.61
80_E93_F0.5530.61
50_G59_P0.5520.61
41_K58_T0.5490.60
69_D159_K0.5490.60
106_T110_D0.5480.60
117_T120_Q0.5480.60
156_I172_L0.5470.60
21_R119_K0.5470.60
78_L146_A0.5450.60
42_P73_M0.5450.60
170_A179_T0.5430.59
84_F105_M0.5420.59
14_L19_F0.5420.59
20_R171_K0.5420.59
71_P156_I0.5410.59
114_T145_N0.5410.59
177_I182_G0.5400.59
29_H85_I0.5360.58
83_G96_S0.5310.58
114_T122_S0.5300.57
93_F107_T0.5290.57
6_H34_A0.5280.57
84_F87_H0.5260.57
25_Y100_S0.5240.57
151_P155_N0.5230.57
95_S114_T0.5230.57
35_M82_R0.5220.56
96_S107_T0.5180.56
119_K155_N0.5150.55
83_G108_S0.5130.55
87_H106_T0.5120.55
81_D107_T0.5090.55
83_G169_A0.5060.54
29_H52_L0.5060.54
122_S163_A0.5040.54
39_V53_E0.5010.53
24_V68_L0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hafA 1 0.9412 100 0.033 Contact Map
2gzoA 1 0.9947 100 0.038 Contact Map
2muiA 1 0.9786 100 0.047 Contact Map
2ew0A 1 0.9358 100 0.051 Contact Map
2do8A 1 0.9786 100 0.055 Contact Map
2gs5A 1 0.9412 100 0.123 Contact Map
3ug7A 4 0.492 15.7 0.951 Contact Map
3iekA 3 0.8289 15.7 0.951 Contact Map
4r3uC 1 0.5668 15 0.952 Contact Map
1vr6A 4 0.3904 8.9 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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