GREMLIN Database
SLYA - Transcriptional regulator SlyA
UniProt: P0A8W2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13408
Length: 144 (130)
Sequences: 23301 (17337)
Seq/√Len: 1520.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_Q91_K2.9921.00
122_E132_K2.9151.00
81_C89_R2.6021.00
46_D91_K2.5881.00
48_S87_A2.5501.00
77_S91_K2.5401.00
125_Q129_L2.3411.00
119_S122_E2.2851.00
125_Q128_T2.1671.00
80_T88_K2.1151.00
41_H100_I2.0331.00
48_S51_Q1.9711.00
117_G136_N1.9421.00
33_H73_K1.9401.00
122_E125_Q1.8501.00
118_I129_L1.8081.00
41_H92_L1.8061.00
81_C87_A1.7421.00
95_K99_L1.6261.00
74_G95_K1.6001.00
71_E78_R1.5771.00
8_D131_A1.5511.00
99_L102_E1.5111.00
49_Q67_L1.4781.00
126_L129_L1.4771.00
122_E128_T1.4591.00
95_K98_P1.4441.00
33_H69_Q1.4311.00
36_T66_T1.4281.00
67_L90_I1.4211.00
43_L55_A1.4171.00
68_D72_E1.3991.00
39_N55_A1.3981.00
30_T33_H1.3661.00
8_D134_E1.3641.00
23_R106_V1.3481.00
41_H97_E1.3381.00
27_L102_E1.3121.00
8_D127_I1.2911.00
129_L132_K1.2681.00
27_L106_V1.2291.00
122_E129_L1.2041.00
51_Q54_K1.1751.00
43_L47_Q1.1671.00
49_Q88_K1.1641.00
98_P102_E1.1601.00
12_L134_E1.1511.00
46_D89_R1.1501.00
68_D85_R1.1491.00
50_I60_Q1.1471.00
128_T132_K1.1441.00
59_E62_S1.1381.00
78_R88_K1.1371.00
75_L99_L1.1351.00
127_I131_A1.1141.00
50_I54_K1.1131.00
36_T63_L1.1131.00
11_R134_E1.1051.00
58_I62_S1.1051.00
106_V109_K1.0841.00
21_D25_K1.0831.00
123_L127_I1.0611.00
23_R109_K1.0571.00
49_Q90_I1.0211.00
121_E125_Q1.0121.00
111_R114_I1.0081.00
26_P106_V0.9831.00
10_A13_V0.9781.00
64_V68_D0.9781.00
23_R113_E0.9771.00
68_D71_E0.9641.00
12_L130_I0.9621.00
73_K99_L0.9511.00
49_Q60_Q0.9481.00
46_D79_Q0.9461.00
32_T66_T0.9411.00
61_P64_V0.9401.00
97_E101_S0.9391.00
47_Q55_A0.9311.00
49_Q63_L0.9261.00
47_Q51_Q0.9231.00
19_L110_T0.9231.00
75_L95_K0.9201.00
62_S65_R0.9171.00
13_V17_R0.9141.00
92_L96_A0.9111.00
58_I63_L0.9111.00
77_S93_T0.9051.00
51_Q55_A0.9031.00
59_E65_R0.8891.00
40_I76_I0.8841.00
94_E97_E0.8801.00
107_I111_R0.8731.00
94_E98_P0.8731.00
15_I134_E0.8631.00
80_T85_R0.8611.00
73_K95_K0.8611.00
120_A124_E0.8471.00
79_Q89_R0.8431.00
34_W103_M0.8341.00
37_L100_I0.8191.00
65_R69_Q0.8171.00
125_Q132_K0.8131.00
28_E73_K0.8111.00
84_D87_A0.8101.00
27_L103_M0.8011.00
102_E106_V0.7981.00
105_A109_K0.7951.00
23_R26_P0.7921.00
109_K112_A0.7901.00
65_R68_D0.7891.00
92_L97_E0.7881.00
81_C84_D0.7851.00
69_Q72_E0.7801.00
10_A14_R0.7781.00
115_L123_L0.7771.00
41_H104_E0.7731.00
67_L76_I0.7651.00
21_D31_Q0.7641.00
32_T62_S0.7511.00
45_P97_E0.7501.00
118_I133_L0.7501.00
36_T52_L0.7481.00
41_H101_S0.7471.00
9_L13_V0.7371.00
71_E76_I0.7361.00
82_A89_R0.7331.00
119_S123_L0.7331.00
113_E116_H0.7321.00
109_K113_E0.7311.00
71_E77_S0.7291.00
39_N56_I0.7281.00
67_L71_E0.7261.00
39_N43_L0.7131.00
108_N112_A0.7121.00
124_E127_I0.7081.00
53_A63_L0.7081.00
17_R21_D0.7061.00
23_R110_T0.7041.00
12_L133_L0.7001.00
19_L113_E0.6941.00
69_Q73_K0.6941.00
131_A135_H0.6901.00
53_A60_Q0.6821.00
14_R18_A0.6821.00
35_V56_I0.6821.00
43_L51_Q0.6811.00
39_N47_Q0.6721.00
68_D78_R0.6701.00
9_L12_L0.6651.00
45_P91_K0.6601.00
34_W107_I0.6601.00
98_P101_S0.6601.00
49_Q64_V0.6591.00
105_A108_N0.6501.00
132_K136_N0.6471.00
40_I92_L0.6461.00
124_E128_T0.6431.00
20_I23_R0.6411.00
39_N52_L0.6361.00
121_E124_E0.6351.00
38_H42_Q0.6261.00
36_T56_I0.6231.00
8_D11_R0.6231.00
70_L75_L0.6021.00
102_E105_A0.5921.00
40_I47_Q0.5851.00
63_L67_L0.5841.00
110_T113_E0.5821.00
50_I53_A0.5741.00
101_S104_E0.5741.00
38_H100_I0.5701.00
34_W100_I0.5681.00
38_H104_E0.5681.00
20_I107_I0.5641.00
104_E108_N0.5561.00
119_S132_K0.5531.00
31_Q35_V0.5461.00
8_D130_I0.5391.00
129_L136_N0.5371.00
9_L130_I0.5351.00
101_S105_A0.5341.00
118_I123_L0.5341.00
100_I104_E0.5331.00
19_L22_H0.5311.00
35_V39_N0.5311.00
78_R90_I0.5301.00
118_I132_K0.5281.00
128_T131_A0.5211.00
116_H136_N0.5201.00
33_H66_T0.5191.00
37_L41_H0.5191.00
52_L90_I0.5051.00
9_L16_W0.5021.00
118_I122_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3deuA 2 0.9167 99.9 0.205 Contact Map
3cjnA 2 0.9653 99.9 0.235 Contact Map
3e6mA 2 0.9653 99.9 0.239 Contact Map
4rguA 4 0.9861 99.9 0.24 Contact Map
3u2rA 4 0.9028 99.9 0.241 Contact Map
3cdhA 4 0.9236 99.9 0.243 Contact Map
4yifA 2 0.9722 99.9 0.248 Contact Map
3boqA 2 0.9097 99.9 0.248 Contact Map
3oopA 2 0.9236 99.9 0.252 Contact Map
2fbkA 2 0.9167 99.9 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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