GREMLIN Database
NANR - Transcriptional regulator NanR
UniProt: P0A8W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12817
Length: 263 (206)
Sequences: 21668 (15912)
Seq/√Len: 1108.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_A230_R3.6281.00
137_R238_D3.3661.00
233_D236_E2.9261.00
159_S223_I2.7721.00
43_M48_E2.7611.00
50_G53_E2.6821.00
43_M64_F2.4211.00
130_F134_S2.4041.00
150_L178_V2.2911.00
58_E69_R2.2081.00
129_L246_N2.1431.00
123_H186_P2.0891.00
37_E78_A2.0481.00
86_Q96_S2.0371.00
141_E234_P2.0241.00
36_V67_V1.9891.00
41_E82_K1.9611.00
126_Q138_Y1.9581.00
148_I230_R1.9351.00
147_Q184_G1.8911.00
181_E189_M1.8711.00
36_V65_F1.8141.00
228_A236_E1.7891.00
178_V181_E1.7601.00
39_E43_M1.7441.00
133_S242_Q1.7311.00
144_T147_Q1.7301.00
87_I93_A1.7161.00
155_L226_V1.6751.00
221_Q247_S1.6751.00
137_R234_P1.6711.00
127_L191_I1.6441.00
236_E240_A1.6331.00
134_S137_R1.6031.00
133_S238_D1.5971.00
42_Q46_R1.5831.00
238_D242_Q1.5801.00
224_A240_A1.5721.00
30_K38_E1.5421.00
129_L242_Q1.4771.00
152_A226_V1.4751.00
157_I171_S1.4731.00
136_V237_A1.4421.00
177_R193_V1.4341.00
159_S219_Y1.4251.00
147_Q182_I1.4201.00
180_A192_H1.3991.00
187_I198_W1.3951.00
88_N91_E1.3871.00
227_D231_R1.3701.00
37_E82_K1.3691.00
190_A194_A1.3681.00
129_L249_S1.3651.00
143_A148_I1.3451.00
154_A171_S1.3421.00
231_R236_E1.3291.00
59_R63_A1.3181.00
223_I227_D1.3061.00
234_P238_D1.3031.00
176_H222_H1.2871.00
157_I174_D1.2831.00
57_S60_E1.2741.00
123_H187_I1.2721.00
122_A253_H1.2571.00
60_E64_F1.2481.00
155_L223_I1.2431.00
35_M39_E1.2381.00
153_K157_I1.2341.00
152_A156_E1.2331.00
143_A232_H1.2301.00
154_A178_V1.2211.00
129_L133_S1.2171.00
88_N94_R1.2101.00
61_L72_V1.2081.00
122_A249_S1.1901.00
174_D178_V1.1871.00
221_Q244_H1.1751.00
239_R243_S1.1711.00
136_V241_L1.1701.00
242_Q246_N1.1631.00
179_L229_I1.1601.00
39_E42_Q1.1541.00
39_E65_F1.1511.00
137_R235_D1.1511.00
133_S137_R1.1501.00
177_R181_E1.1501.00
54_Q94_R1.1301.00
80_K87_I1.1291.00
135_L180_A1.1221.00
154_A174_D1.1111.00
143_A182_I1.0941.00
30_K35_M1.0871.00
227_D230_R1.0871.00
148_I232_H1.0861.00
155_L158_N1.0831.00
155_L159_S1.0801.00
136_V140_A1.0731.00
43_M65_F1.0731.00
236_E239_R1.0711.00
123_H185_N1.0671.00
226_V230_R1.0661.00
148_I226_V1.0651.00
171_S174_D1.0601.00
178_V182_I1.0601.00
152_A223_I1.0571.00
49_F95_V1.0531.00
143_A147_Q1.0381.00
126_Q185_N1.0351.00
249_S253_H1.0351.00
86_Q94_R1.0351.00
138_Y142_H1.0311.00
80_K85_V1.0241.00
150_L153_K1.0151.00
128_R132_E1.0151.00
43_M49_F1.0091.00
76_L93_A1.0081.00
228_A233_D1.0081.00
172_D176_H1.0031.00
74_E77_A1.0011.00
150_L181_E1.0001.00
191_I194_A0.9991.00
150_L154_A0.9931.00
44_I95_V0.9901.00
156_E159_S0.9901.00
175_F226_V0.9861.00
134_S238_D0.9851.00
167_A170_R0.9751.00
170_R174_D0.9711.00
189_M193_V0.9581.00
224_A236_E0.9351.00
149_D153_K0.9311.00
224_A243_S0.9281.00
58_E73_R0.9241.00
78_A81_R0.9211.00
134_S138_Y0.9131.00
176_H244_H0.9091.00
154_A157_I0.9081.00
222_H244_H0.9021.00
37_E41_E0.9001.00
140_A234_P0.9001.00
33_S78_A0.8971.00
85_V93_A0.8961.00
148_I152_A0.8931.00
220_Q224_A0.8931.00
225_I241_L0.8901.00
140_A229_I0.8801.00
132_E176_H0.8791.00
41_E45_R0.8781.00
235_D239_R0.8771.00
142_H184_G0.8741.00
62_M72_V0.8681.00
224_A227_D0.8671.00
32_L35_M0.8631.00
235_D238_D0.8591.00
127_L187_I0.8571.00
54_Q92_R0.8541.00
183_P189_M0.8531.00
224_A228_A0.8521.00
76_L85_V0.8511.00
156_E160_Q0.8411.00
157_I160_Q0.8411.00
219_Y223_I0.8381.00
139_A182_I0.8351.00
145_D232_H0.8291.00
41_E84_L0.8281.00
140_A232_H0.8201.00
91_E94_R0.8201.00
88_N92_R0.8181.00
77_A80_K0.8151.00
151_L178_V0.8091.00
225_I240_A0.8091.00
31_K34_E0.8081.00
147_Q150_L0.8061.00
172_D222_H0.7981.00
145_D149_D0.7961.00
161_S167_A0.7941.00
34_E78_A0.7931.00
54_Q57_S0.7901.00
240_A243_S0.7871.00
128_R245_L0.7861.00
99_S102_T0.7861.00
152_A227_D0.7791.00
138_Y185_N0.7771.00
60_E63_A0.7741.00
138_Y141_E0.7711.00
32_L71_S0.7711.00
77_A87_I0.7681.00
156_E223_I0.7661.00
187_I191_I0.7641.00
173_V200_I0.7631.00
140_A237_A0.7631.00
177_R196_L0.7611.00
126_Q142_H0.7571.00
143_A229_I0.7571.00
68_G71_S0.7571.00
30_K34_E0.7521.00
158_N168_F0.7511.00
137_R141_E0.7471.00
126_Q249_S0.7431.00
125_E248_V0.7421.00
228_A240_A0.7371.00
187_I190_A0.7321.00
151_L226_V0.7301.00
61_L76_L0.7241.00
127_L188_F0.7181.00
150_L174_D0.7161.00
246_N249_S0.7141.00
225_I237_A0.7131.00
149_D230_R0.7071.00
127_L135_L0.7051.00
78_A82_K0.7021.00
246_N250_A0.6941.00
161_S171_S0.6901.00
216_N220_Q0.6901.00
239_R242_Q0.6871.00
102_T187_I0.6861.00
167_A171_S0.6851.00
243_S247_S0.6841.00
149_D152_A0.6841.00
67_V72_V0.6811.00
221_Q224_A0.6791.00
157_I167_A0.6781.00
153_K156_E0.6731.00
147_Q178_V0.6701.00
49_F53_E0.6691.00
147_Q181_E0.6691.00
173_V196_L0.6671.00
33_S37_E0.6661.00
247_S251_T0.6641.00
160_Q164_N0.6601.00
174_D177_R0.6601.00
177_R189_M0.6601.00
130_F188_F0.6581.00
155_L219_Y0.6531.00
126_Q134_S0.6401.00
159_S163_D0.6391.00
33_S74_E0.6381.00
164_N167_A0.6371.00
139_A183_P0.6341.00
225_I244_H0.6311.00
139_A143_A0.6311.00
43_M47_R0.6301.00
71_S75_A0.6291.00
148_I229_I0.6271.00
101_D184_G0.6271.00
48_E64_F0.6211.00
157_I161_S0.6161.00
51_E97_R0.6151.00
127_L131_F0.6051.00
135_L183_P0.6031.00
90_G93_A0.5941.00
55_L85_V0.5921.00
28_A35_M0.5881.00
135_L188_F0.5861.00
250_A253_H0.5841.00
52_G97_R0.5831.00
130_F133_S0.5801.00
29_R35_M0.5791.00
133_S241_L0.5781.00
173_V177_R0.5771.00
151_L182_I0.5771.00
136_V234_P0.5771.00
137_R242_Q0.5751.00
158_N219_Y0.5751.00
43_M46_R0.5741.00
94_R97_R0.5711.00
65_F72_V0.5701.00
132_E222_H0.5621.00
40_L61_L0.5621.00
190_A198_W0.5571.00
133_S234_P0.5531.00
214_H217_V0.5501.00
250_A254_A0.5501.00
220_Q223_I0.5491.00
168_F218_S0.5481.00
45_R84_L0.5461.00
101_D123_H0.5461.00
139_A179_L0.5461.00
132_E245_L0.5461.00
129_L245_L0.5431.00
146_E150_L0.5391.00
151_L154_A0.5381.00
77_A81_R0.5371.00
186_P189_M0.5361.00
136_V179_L0.5341.00
34_E38_E0.5271.00
133_S136_V0.5261.00
127_L130_F0.5251.00
221_Q243_S0.5251.00
145_D230_R0.5251.00
126_Q130_F0.5241.00
247_S250_A0.5231.00
144_T184_G0.5151.00
135_L179_L0.5151.00
151_L155_L0.5151.00
138_Y183_P0.5131.00
243_S246_N0.5131.00
160_Q163_D0.5121.00
180_A196_L0.5111.00
225_I228_A0.5111.00
134_S188_F0.5091.00
217_V247_S0.5081.00
49_F55_L0.5081.00
229_I237_A0.5061.00
89_N92_R0.5031.00
213_E216_N0.5021.00
126_Q129_L0.5021.00
131_F192_H0.5011.00
63_A66_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c7jA 4 0.8973 100 0.257 Contact Map
3sxyA 2 0.7605 100 0.273 Contact Map
4p96A 2 0.8973 100 0.28 Contact Map
4p9fA 1 0.7947 100 0.287 Contact Map
3ihuA 1 0.7681 100 0.29 Contact Map
2hs5A 1 0.7795 100 0.3 Contact Map
2di3A 2 0.8555 100 0.301 Contact Map
1hw1A 2 0.8555 100 0.313 Contact Map
3ic7A 2 0.4221 99.9 0.589 Contact Map
3by6A 2 0.4715 99.9 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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