FADR - ECOLI - GREMLIN Contacts

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FADR - Fatty acid metabolism regulator protein

UniProt:	P0A8V6	Sequences: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10281
Length:	239 (199)
Sequences:	23365 (17266)
Seq/√Len:	1223.9

ECOLI - FADR LLDR NANR GLCC PDHR DGOR UXUR YDFH EXUR YIEP YJJM MCBR CSIR FRLR YIDP YEGW MNGR YIHL
BACSU - YCBG GNTR YDHC LUTR YVOA YMFC YURK TRER YYDK
SULSO - Q97YR4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_A	201_S	3.563	1.00
114_R	209_Y	3.408	1.00
204_A	207_Q	3.004	1.00
19_S	24_R	2.820	1.00
26_P	29_T	2.758	1.00
19_S	40_L	2.489	1.00
107_N	111_I	2.415	1.00
34_E	45_R	2.302	1.00
127_V	151_G	2.271	1.00
100_N	159_P	2.217	1.00
106_T	217_H	2.161	1.00
13_E	54_R	2.157	1.00
62_T	72_N	2.112	1.00
17_I	58_D	2.043	1.00
118_R	205_H	2.026	1.00
12_A	43_V	1.995	1.00
103_S	115_T	1.987	1.00
154_F	162_G	1.866	1.00
12_A	41_I	1.858	1.00
63_I	69_T	1.852	1.00
125_Q	201_S	1.848	1.00
124_A	157_G	1.847	1.00
199_L	207_Q	1.842	1.00
121_P	124_A	1.779	1.00
151_G	154_F	1.773	1.00
15_Y	19_S	1.771	1.00
110_T	213_R	1.753	1.00
114_R	205_H	1.702	1.00
192_F	218_E	1.691	1.00
209_Y	213_R	1.662	1.00
137_H	140_A	1.660	1.00
110_T	209_Y	1.652	1.00
207_Q	211_T	1.634	1.00
104_V	164_I	1.633	1.00
18_E	22_N	1.624	1.00
111_I	114_R	1.606	1.00
195_K	211_T	1.548	1.00
6_Q	14_E	1.503	1.00
113_I	208_V	1.496	1.00
64_Q	67_K	1.484	1.00
149_F	193_Y	1.475	1.00
106_T	213_R	1.468	1.00
163_L	167_G	1.457	1.00
129_A	197_S	1.449	1.00
153_A	165_L	1.446	1.00
160_I	171_L	1.443	1.00
13_E	58_D	1.438	1.00
124_A	155_A	1.436	1.00
150_R	166_N	1.416	1.00
198_A	202_E	1.398	1.00
131_A	144_L	1.382	1.00
35_R	39_E	1.376	1.00
202_E	207_Q	1.370	1.00
120_H	125_Q	1.361	1.00
106_T	220_G	1.352	1.00
100_N	160_I	1.341	1.00
205_H	209_Y	1.320	1.00
33_A	36_E	1.291	1.00
30_I	70_K	1.274	1.00
36_E	40_L	1.269	1.00
99_D	224_H	1.258	1.00
11_F	15_Y	1.246	1.00
37_L	48_L	1.243	1.00
192_F	215_Y	1.230	1.00
194_H	198_A	1.224	1.00
64_Q	70_K	1.222	1.00
106_T	110_T	1.221	1.00
131_A	151_G	1.201	1.00
210_E	214_R	1.200	1.00
213_R	217_H	1.196	1.00
150_R	154_F	1.195	1.00
147_N	151_G	1.191	1.00
105_R	109_S	1.185	1.00
15_Y	41_I	1.168	1.00
120_H	124_A	1.164	1.00
120_H	203_G	1.163	1.00
15_Y	18_E	1.163	1.00
56_A	63_I	1.160	1.00
110_T	114_R	1.159	1.00
145_D	149_F	1.158	1.00
99_D	220_G	1.155	1.00
152_L	200_C	1.153	1.00
19_S	41_I	1.150	1.00
113_I	212_V	1.149	1.00
114_R	206_D	1.148	1.00
207_Q	210_E	1.148	1.00
113_I	117_F	1.138	1.00
197_S	201_S	1.130	1.00
120_H	155_A	1.121	1.00
125_Q	203_G	1.114	1.00
112_F	153_A	1.111	1.00
100_N	158_N	1.094	1.00
151_G	155_A	1.082	1.00
198_A	201_S	1.075	1.00
25_F	71_V	1.073	1.00
62_T	70_K	1.063	1.00
220_G	224_H	1.054	1.00
103_S	158_N	1.050	1.00
50_E	53_Q	1.046	1.00
56_A	61_L	1.046	1.00
127_V	154_F	1.044	1.00
164_I	167_G	1.043	1.00
140_A	143_E	1.030	1.00
144_L	147_N	1.027	1.00
125_Q	197_S	1.023	1.00
131_A	147_N	1.015	1.00
115_T	119_Q	1.009	1.00
199_L	204_A	1.009	1.00
6_Q	11_F	0.995	1.00
149_F	215_Y	0.993	1.00
111_I	209_Y	0.992	1.00
117_F	205_H	0.991	1.00
19_S	25_F	0.990	1.00
148_I	197_S	0.984	1.00
109_S	149_F	0.980	1.00
52_L	69_T	0.976	1.00
34_E	49_R	0.976	1.00
127_V	130_T	0.971	1.00
54_R	57_R	0.965	1.00
195_K	214_R	0.958	1.00
195_K	207_Q	0.957	1.00
191_G	195_K	0.956	1.00
193_Y	215_Y	0.953	1.00
30_I	68_P	0.946	1.00
9_A	54_R	0.945	1.00
195_K	198_A	0.943	1.00
119_Q	157_G	0.930	1.00
127_V	131_A	0.929	1.00
64_Q	68_P	0.929	1.00
20_I	71_V	0.925	1.00
117_F	200_C	0.924	1.00
156_S	162_G	0.917	1.00
97_L	160_I	0.917	1.00
126_E	130_T	0.914	1.00
206_D	210_E	0.913	1.00
13_E	17_I	0.908	1.00
196_L	212_V	0.906	1.00
190_L	194_H	0.904	1.00
105_R	216_G	0.900	1.00
104_V	160_I	0.887	1.00
162_G	166_N	0.886	1.00
38_S	48_L	0.884	1.00
17_I	21_W	0.881	1.00
96_Q	100_N	0.878	1.00
61_L	69_T	0.877	1.00
111_I	115_T	0.877	1.00
67_K	70_K	0.872	1.00
206_D	209_Y	0.870	1.00
96_Q	157_G	0.863	1.00
129_A	194_H	0.860	1.00
122_D	126_E	0.859	1.00
145_D	193_Y	0.855	1.00
116_A	155_A	0.851	1.00
143_E	147_N	0.849	1.00
52_L	61_L	0.840	1.00
30_I	33_A	0.837	1.00
53_Q	56_A	0.837	1.00
44_T	47_T	0.835	1.00
8_P	11_F	0.824	1.00
117_F	208_V	0.824	1.00
132_N	194_H	0.819	1.00
120_H	200_C	0.818	1.00
196_L	211_T	0.817	1.00
10_G	54_R	0.816	1.00
117_F	203_G	0.814	1.00
195_K	199_L	0.813	1.00
36_E	39_E	0.813	1.00
17_I	60_W	0.805	1.00
122_D	203_G	0.803	1.00
114_R	118_R	0.794	1.00
160_I	163_L	0.794	1.00
199_L	211_T	0.794	1.00
53_Q	63_I	0.793	1.00
125_Q	129_A	0.793	1.00
115_T	118_R	0.791	1.00
128_L	151_G	0.787	1.00
124_A	127_V	0.786	1.00
8_P	47_T	0.781	1.00
115_T	158_N	0.780	1.00
103_S	220_G	0.779	1.00
37_L	52_L	0.776	1.00
160_I	164_I	0.776	1.00
7_S	10_G	0.775	1.00
129_A	198_A	0.774	1.00
211_T	214_R	0.773	1.00
150_R	169_K	0.770	1.00
116_A	120_H	0.765	1.00
43_V	48_L	0.762	1.00
103_S	119_Q	0.755	1.00
217_H	221_E	0.748	1.00
187_S	191_G	0.737	1.00
126_E	201_S	0.736	1.00
210_E	213_R	0.733	1.00
104_V	161_Y	0.728	1.00
140_A	144_L	0.727	1.00
9_A	13_E	0.725	1.00
217_H	220_G	0.721	1.00
124_A	151_G	0.712	1.00
102_L	219_S	0.708	1.00
24_R	40_L	0.706	1.00
196_L	208_V	0.700	1.00
104_V	112_F	0.699	1.00
146_Y	169_K	0.697	1.00
214_R	218_E	0.693	1.00
103_S	111_I	0.688	1.00
97_L	159_P	0.687	1.00
126_E	129_A	0.685	1.00
218_E	222_I	0.680	1.00
150_R	162_G	0.678	1.00
192_F	195_K	0.678	1.00
125_Q	200_C	0.677	1.00
54_R	58_D	0.674	1.00
196_L	215_Y	0.669	1.00
147_N	150_R	0.665	1.00
128_L	197_S	0.658	1.00
75_W	97_L	0.657	1.00
146_Y	173_T	0.654	1.00
66_G	69_T	0.654	1.00
25_F	29_T	0.639	1.00
124_A	154_F	0.637	1.00
6_Q	10_G	0.635	1.00
47_T	51_V	0.633	1.00
107_N	161_Y	0.624	1.00
110_T	212_V	0.622	1.00
104_V	108_I	0.620	1.00
113_I	205_H	0.619	1.00
9_A	50_E	0.619	1.00
112_F	156_S	0.615	1.00
116_A	156_S	0.610	1.00
141_F	189_A	0.610	1.00
107_N	110_T	0.607	1.00
127_V	147_N	0.604	1.00
19_S	23_N	0.601	1.00
28_G	73_N	0.601	1.00
53_Q	57_R	0.595	1.00
112_F	161_Y	0.594	1.00
116_A	152_L	0.593	1.00
27_P	73_N	0.590	1.00
163_L	171_L	0.588	1.00
128_L	155_A	0.587	1.00
41_I	48_L	0.586	1.00
106_T	216_G	0.583	1.00
175_I	179_Y	0.581	1.00
109_S	193_Y	0.581	1.00
110_T	205_H	0.580	1.00
96_Q	159_P	0.579	1.00
31_L	61_L	0.577	1.00
114_R	213_R	0.575	1.00
35_R	38_S	0.573	1.00
70_K	73_N	0.570	1.00
16_I	37_L	0.570	1.00
185_A	188_L	0.569	1.00
128_L	131_A	0.569	1.00
221_E	224_H	0.568	1.00
113_I	152_L	0.562	1.00
188_L	191_G	0.557	1.00
122_D	201_S	0.554	1.00
19_S	22_N	0.553	1.00
115_T	156_S	0.553	1.00
123_K	127_V	0.549	1.00
103_S	106_T	0.549	1.00
135_A	138_A	0.547	1.00
25_F	31_L	0.545	1.00
200_C	208_V	0.544	1.00
214_R	217_H	0.543	1.00
196_L	199_L	0.539	1.00
146_Y	150_R	0.537	1.00
218_E	221_E	0.537	1.00
176_G	180_F	0.536	1.00
108_I	165_L	0.534	1.00
21_W	60_W	0.533	1.00
159_P	162_G	0.532	1.00
99_D	103_S	0.532	1.00
163_L	166_N	0.532	1.00
96_Q	99_D	0.531	1.00
104_V	107_N	0.528	1.00
109_S	216_G	0.528	1.00
212_V	216_G	0.524	1.00
141_F	186_R	0.523	1.00
39_E	42_G	0.522	1.00
192_F	214_R	0.518	1.00
10_G	14_E	0.518	1.00
122_D	125_Q	0.517	1.00
145_D	189_A	0.515	1.00
153_A	169_K	0.514	1.00
65_H	68_P	0.511	1.00
139_D	177_R	0.508	1.00
9_A	53_Q	0.508	1.00
103_S	107_N	0.508	1.00
188_L	218_E	0.507	1.00
56_A	62_T	0.504	1.00
123_K	126_E	0.504	1.00
143_E	173_T	0.502	1.00
185_A	189_A	0.501	1.00
111_I	161_Y	0.501	1.00
25_F	40_L	0.501	1.00
149_F	212_V	0.500	1.00
53_Q	69_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hw1A	2	0.9456	100	0.139	Contact Map
4p96A	2	0.9958	100	0.157	Contact Map
3sxyA	2	0.8201	100	0.221	Contact Map
3c7jA	4	0.887	100	0.221	Contact Map
2hs5A	1	0.841	100	0.223	Contact Map
3ihuA	1	0.8285	100	0.231	Contact Map
2di3A	2	0.9163	100	0.236	Contact Map
4p9fA	1	0.8494	100	0.238	Contact Map
3ic7A	2	0.4644	99.8	0.552	Contact Map
3by6A	2	0.5021	99.8	0.552	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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