GREMLIN Database
FADR - Fatty acid metabolism regulator protein
UniProt: P0A8V6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10281
Length: 239 (199)
Sequences: 23365 (17266)
Seq/√Len: 1223.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A201_S3.5631.00
114_R209_Y3.4081.00
204_A207_Q3.0041.00
19_S24_R2.8201.00
26_P29_T2.7581.00
19_S40_L2.4891.00
107_N111_I2.4151.00
34_E45_R2.3021.00
127_V151_G2.2711.00
100_N159_P2.2171.00
106_T217_H2.1611.00
13_E54_R2.1571.00
62_T72_N2.1121.00
17_I58_D2.0431.00
118_R205_H2.0261.00
12_A43_V1.9951.00
103_S115_T1.9871.00
154_F162_G1.8661.00
12_A41_I1.8581.00
63_I69_T1.8521.00
125_Q201_S1.8481.00
124_A157_G1.8471.00
199_L207_Q1.8421.00
121_P124_A1.7791.00
151_G154_F1.7731.00
15_Y19_S1.7711.00
110_T213_R1.7531.00
114_R205_H1.7021.00
192_F218_E1.6911.00
209_Y213_R1.6621.00
137_H140_A1.6601.00
110_T209_Y1.6521.00
207_Q211_T1.6341.00
104_V164_I1.6331.00
18_E22_N1.6241.00
111_I114_R1.6061.00
195_K211_T1.5481.00
6_Q14_E1.5031.00
113_I208_V1.4961.00
64_Q67_K1.4841.00
149_F193_Y1.4751.00
106_T213_R1.4681.00
163_L167_G1.4571.00
129_A197_S1.4491.00
153_A165_L1.4461.00
160_I171_L1.4431.00
13_E58_D1.4381.00
124_A155_A1.4361.00
150_R166_N1.4161.00
198_A202_E1.3981.00
131_A144_L1.3821.00
35_R39_E1.3761.00
202_E207_Q1.3701.00
120_H125_Q1.3611.00
106_T220_G1.3521.00
100_N160_I1.3411.00
205_H209_Y1.3201.00
33_A36_E1.2911.00
30_I70_K1.2741.00
36_E40_L1.2691.00
99_D224_H1.2581.00
11_F15_Y1.2461.00
37_L48_L1.2431.00
192_F215_Y1.2301.00
194_H198_A1.2241.00
64_Q70_K1.2221.00
106_T110_T1.2211.00
131_A151_G1.2011.00
210_E214_R1.2001.00
213_R217_H1.1961.00
150_R154_F1.1951.00
147_N151_G1.1911.00
105_R109_S1.1851.00
15_Y41_I1.1681.00
120_H124_A1.1641.00
120_H203_G1.1631.00
15_Y18_E1.1631.00
56_A63_I1.1601.00
110_T114_R1.1591.00
145_D149_F1.1581.00
99_D220_G1.1551.00
152_L200_C1.1531.00
19_S41_I1.1501.00
113_I212_V1.1491.00
114_R206_D1.1481.00
207_Q210_E1.1481.00
113_I117_F1.1381.00
197_S201_S1.1301.00
120_H155_A1.1211.00
125_Q203_G1.1141.00
112_F153_A1.1111.00
100_N158_N1.0941.00
151_G155_A1.0821.00
198_A201_S1.0751.00
25_F71_V1.0731.00
62_T70_K1.0631.00
220_G224_H1.0541.00
103_S158_N1.0501.00
50_E53_Q1.0461.00
56_A61_L1.0461.00
127_V154_F1.0441.00
164_I167_G1.0431.00
140_A143_E1.0301.00
144_L147_N1.0271.00
125_Q197_S1.0231.00
131_A147_N1.0151.00
115_T119_Q1.0091.00
199_L204_A1.0091.00
6_Q11_F0.9951.00
149_F215_Y0.9931.00
111_I209_Y0.9921.00
117_F205_H0.9911.00
19_S25_F0.9901.00
148_I197_S0.9841.00
109_S149_F0.9801.00
52_L69_T0.9761.00
34_E49_R0.9761.00
127_V130_T0.9711.00
54_R57_R0.9651.00
195_K214_R0.9581.00
195_K207_Q0.9571.00
191_G195_K0.9561.00
193_Y215_Y0.9531.00
30_I68_P0.9461.00
9_A54_R0.9451.00
195_K198_A0.9431.00
119_Q157_G0.9301.00
127_V131_A0.9291.00
64_Q68_P0.9291.00
20_I71_V0.9251.00
117_F200_C0.9241.00
156_S162_G0.9171.00
97_L160_I0.9171.00
126_E130_T0.9141.00
206_D210_E0.9131.00
13_E17_I0.9081.00
196_L212_V0.9061.00
190_L194_H0.9041.00
105_R216_G0.9001.00
104_V160_I0.8871.00
162_G166_N0.8861.00
38_S48_L0.8841.00
17_I21_W0.8811.00
96_Q100_N0.8781.00
61_L69_T0.8771.00
111_I115_T0.8771.00
67_K70_K0.8721.00
206_D209_Y0.8701.00
96_Q157_G0.8631.00
129_A194_H0.8601.00
122_D126_E0.8591.00
145_D193_Y0.8551.00
116_A155_A0.8511.00
143_E147_N0.8491.00
52_L61_L0.8401.00
30_I33_A0.8371.00
53_Q56_A0.8371.00
44_T47_T0.8351.00
8_P11_F0.8241.00
117_F208_V0.8241.00
132_N194_H0.8191.00
120_H200_C0.8181.00
196_L211_T0.8171.00
10_G54_R0.8161.00
117_F203_G0.8141.00
195_K199_L0.8131.00
36_E39_E0.8131.00
17_I60_W0.8051.00
122_D203_G0.8031.00
114_R118_R0.7941.00
160_I163_L0.7941.00
199_L211_T0.7941.00
53_Q63_I0.7931.00
125_Q129_A0.7931.00
115_T118_R0.7911.00
128_L151_G0.7871.00
124_A127_V0.7861.00
8_P47_T0.7811.00
115_T158_N0.7801.00
103_S220_G0.7791.00
37_L52_L0.7761.00
160_I164_I0.7761.00
7_S10_G0.7751.00
129_A198_A0.7741.00
211_T214_R0.7731.00
150_R169_K0.7701.00
116_A120_H0.7651.00
43_V48_L0.7621.00
103_S119_Q0.7551.00
217_H221_E0.7481.00
187_S191_G0.7371.00
126_E201_S0.7361.00
210_E213_R0.7331.00
104_V161_Y0.7281.00
140_A144_L0.7271.00
9_A13_E0.7251.00
217_H220_G0.7211.00
124_A151_G0.7121.00
102_L219_S0.7081.00
24_R40_L0.7061.00
196_L208_V0.7001.00
104_V112_F0.6991.00
146_Y169_K0.6971.00
214_R218_E0.6931.00
103_S111_I0.6881.00
97_L159_P0.6871.00
126_E129_A0.6851.00
218_E222_I0.6801.00
150_R162_G0.6781.00
192_F195_K0.6781.00
125_Q200_C0.6771.00
54_R58_D0.6741.00
196_L215_Y0.6691.00
147_N150_R0.6651.00
128_L197_S0.6581.00
75_W97_L0.6571.00
146_Y173_T0.6541.00
66_G69_T0.6541.00
25_F29_T0.6391.00
124_A154_F0.6371.00
6_Q10_G0.6351.00
47_T51_V0.6331.00
107_N161_Y0.6241.00
110_T212_V0.6221.00
104_V108_I0.6201.00
113_I205_H0.6191.00
9_A50_E0.6191.00
112_F156_S0.6151.00
116_A156_S0.6101.00
141_F189_A0.6101.00
107_N110_T0.6071.00
127_V147_N0.6041.00
19_S23_N0.6011.00
28_G73_N0.6011.00
53_Q57_R0.5951.00
112_F161_Y0.5941.00
116_A152_L0.5931.00
27_P73_N0.5901.00
163_L171_L0.5881.00
128_L155_A0.5871.00
41_I48_L0.5861.00
106_T216_G0.5831.00
175_I179_Y0.5811.00
109_S193_Y0.5811.00
110_T205_H0.5801.00
96_Q159_P0.5791.00
31_L61_L0.5771.00
114_R213_R0.5751.00
35_R38_S0.5731.00
70_K73_N0.5701.00
16_I37_L0.5701.00
185_A188_L0.5691.00
128_L131_A0.5691.00
221_E224_H0.5681.00
113_I152_L0.5621.00
188_L191_G0.5571.00
122_D201_S0.5541.00
19_S22_N0.5531.00
115_T156_S0.5531.00
123_K127_V0.5491.00
103_S106_T0.5491.00
135_A138_A0.5471.00
25_F31_L0.5451.00
200_C208_V0.5441.00
214_R217_H0.5431.00
196_L199_L0.5391.00
146_Y150_R0.5371.00
218_E221_E0.5371.00
176_G180_F0.5361.00
108_I165_L0.5341.00
21_W60_W0.5331.00
159_P162_G0.5321.00
99_D103_S0.5321.00
163_L166_N0.5321.00
96_Q99_D0.5311.00
104_V107_N0.5281.00
109_S216_G0.5281.00
212_V216_G0.5241.00
141_F186_R0.5231.00
39_E42_G0.5221.00
192_F214_R0.5181.00
10_G14_E0.5181.00
122_D125_Q0.5171.00
145_D189_A0.5151.00
153_A169_K0.5141.00
65_H68_P0.5111.00
139_D177_R0.5081.00
9_A53_Q0.5081.00
103_S107_N0.5081.00
188_L218_E0.5071.00
56_A62_T0.5041.00
123_K126_E0.5041.00
143_E173_T0.5021.00
185_A189_A0.5011.00
111_I161_Y0.5011.00
25_F40_L0.5011.00
149_F212_V0.5001.00
53_Q69_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hw1A 2 0.9456 100 0.139 Contact Map
4p96A 2 0.9958 100 0.157 Contact Map
3sxyA 2 0.8201 100 0.221 Contact Map
3c7jA 4 0.887 100 0.221 Contact Map
2hs5A 1 0.841 100 0.223 Contact Map
3ihuA 1 0.8285 100 0.231 Contact Map
2di3A 2 0.9163 100 0.236 Contact Map
4p9fA 1 0.8494 100 0.238 Contact Map
3ic7A 2 0.4644 99.8 0.552 Contact Map
3by6A 2 0.5021 99.8 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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