RBN - ECOLI - GREMLIN Contacts

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RBN - Ribonuclease BN

UniProt:	P0A8V0	Sequences: MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSRSMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITMEAKANSRGHSSTRQAATLAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14260
Length:	305 (293)
Sequences:	2389 (1677)
Seq/√Len:	97.9

ECOLI - RBN
BACSU - RNZ YHFI
HALSA - RNZ Q9HPR7
SULSO - RNZ Q981E1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_T	119_V	4.587	1.00
177_E	182_K	3.959	1.00
208_A	226_V	3.531	1.00
98_R	102_E	3.490	1.00
135_T	151_E	3.331	1.00
99_E	106_R	3.174	1.00
128_D	153_H	3.092	1.00
33_G	58_D	2.696	1.00
227_D	264_G	2.689	1.00
225_G	262_G	2.643	1.00
140_E	214_G	2.537	1.00
88_P	115_P	2.458	1.00
183_T	194_G	2.446	1.00
252_R	289_S	2.394	1.00
90_T	117_E	2.389	1.00
149_R	206_A	2.380	1.00
152_E	205_K	2.365	1.00
237_I	252_R	2.365	1.00
265_K	295_E	2.339	1.00
206_A	226_V	2.334	1.00
235_L	246_R	2.201	1.00
100_F	104_A	2.177	1.00
167_A	197_Y	2.157	1.00
37_F	150_I	2.152	1.00
133_K	151_E	2.098	1.00
42_G	45_H	2.058	1.00
176_Q	180_A	2.031	1.00
46_Q	49_H	2.017	1.00
256_T	260_E	2.017	1.00
77_L	89_L	2.010	1.00
255_A	290_I	1.994	1.00
267_I	303_F	1.972	1.00
221_D	224_K	1.972	1.00
96_G	120_E	1.929	1.00
21_A	36_L	1.922	1.00
186_L	190_R	1.895	1.00
267_I	297_A	1.895	1.00
163_A	166_A	1.891	1.00
3_L	230_V	1.880	1.00
298_N	301_T	1.878	1.00
61_F	134_V	1.873	1.00
23_L	36_L	1.864	1.00
192_I	197_Y	1.854	1.00
92_Y	119_V	1.853	1.00
151_E	206_A	1.842	1.00
284_L	288_R	1.837	1.00
74_P	104_A	1.805	1.00
295_E	301_T	1.790	1.00
22_I	269_T	1.770	1.00
2_E	25_N	1.740	1.00
231_H	249_S	1.729	1.00
9_S	14_T	1.722	1.00
23_L	34_L	1.715	1.00
193_N	196_D	1.701	1.00
81_S	113_D	1.701	1.00
88_P	117_E	1.674	1.00
183_T	193_N	1.672	1.00
59_K	92_Y	1.670	1.00
50_T	300_F	1.669	1.00
160_N	163_A	1.633	1.00
297_A	301_T	1.609	1.00
214_G	253_Q	1.604	1.00
2_E	302_V	1.604	1.00
240_E	253_Q	1.587	1.00
128_D	133_K	1.576	1.00
21_A	43_T	1.573	1.00
220_L	260_E	1.558	1.00
237_I	240_E	1.557	1.00
284_L	296_L	1.554	1.00
285_R	288_R	1.553	1.00
252_R	290_I	1.553	1.00
3_L	24_L	1.531	1.00
5_F	8_T	1.506	1.00
208_A	223_A	1.500	1.00
224_K	262_G	1.486	1.00
233_A	268_I	1.475	1.00
185_T	191_Q	1.472	1.00
137_Y	222_L	1.436	1.00
218_A	221_D	1.422	1.00
23_L	52_F	1.413	1.00
220_L	257_L	1.401	0.99
185_T	189_G	1.359	0.99
237_I	286_E	1.359	0.99
18_N	45_H	1.357	0.99
217_D	260_E	1.352	0.99
67_G	71_F	1.350	0.99
159_L	164_L	1.350	0.99
57_L	76_L	1.345	0.99
46_Q	300_F	1.337	0.99
147_G	210_F	1.332	0.99
181_G	194_G	1.329	0.99
24_L	150_I	1.303	0.99
161_A	165_K	1.303	0.99
236_D	283_L	1.300	0.99
139_L	147_G	1.295	0.99
59_K	90_T	1.292	0.99
223_A	261_A	1.290	0.99
238_T	286_E	1.274	0.99
35_W	132_R	1.259	0.99
126_I	148_Y	1.250	0.99
281_Q	284_L	1.240	0.99
229_M	263_V	1.231	0.99
98_R	118_I	1.211	0.99
149_R	226_V	1.207	0.98
4_I	302_V	1.204	0.98
288_R	294_T	1.201	0.98
63_S	148_Y	1.196	0.98
78_C	110_S	1.191	0.98
295_E	303_F	1.191	0.98
268_I	287_C	1.191	0.98
220_L	261_A	1.183	0.98
20_T	269_T	1.177	0.98
139_L	145_C	1.176	0.98
140_E	247_G	1.168	0.98
95_Q	122_G	1.165	0.98
256_T	259_R	1.164	0.98
251_T	286_E	1.163	0.98
251_T	255_A	1.159	0.98
91_I	101_V	1.149	0.98
178_L	197_Y	1.133	0.98
194_G	197_Y	1.131	0.98
282_H	285_R	1.131	0.98
223_A	226_V	1.129	0.98
142_P	247_G	1.125	0.98
194_G	198_L	1.124	0.98
139_L	210_F	1.117	0.97
37_F	61_F	1.112	0.97
169_V	175_F	1.108	0.97
281_Q	285_R	1.107	0.97
160_N	199_A	1.093	0.97
60_I	73_L	1.087	0.97
241_A	245_S	1.086	0.97
250_S	254_A	1.086	0.97
133_K	153_H	1.086	0.97
252_R	256_T	1.084	0.97
258_A	266_L	1.073	0.97
149_R	208_A	1.070	0.97
5_F	297_A	1.069	0.97
3_L	228_V	1.065	0.97
98_R	120_E	1.059	0.97
252_R	286_E	1.031	0.96
60_I	76_L	1.028	0.96
284_L	294_T	1.025	0.96
173_P	177_E	1.016	0.96
8_T	17_R	1.007	0.95
277_D	281_Q	1.005	0.95
93_G	97_I	1.002	0.95
35_W	150_I	0.995	0.95
138_P	146_Y	0.992	0.95
54_P	57_L	0.984	0.95
228_V	267_I	0.983	0.95
93_G	120_E	0.982	0.95
67_G	234_T	0.977	0.95
18_N	43_T	0.969	0.94
154_D	204_G	0.969	0.94
244_N	253_Q	0.965	0.94
44_Q	75_G	0.963	0.94
265_K	293_A	0.960	0.94
164_L	197_Y	0.958	0.94
20_T	209_I	0.958	0.94
174_L	177_E	0.955	0.94
91_I	97_I	0.954	0.94
138_P	144_E	0.945	0.93
101_V	118_I	0.940	0.93
101_V	105_L	0.936	0.93
102_E	106_R	0.932	0.93
214_G	247_G	0.919	0.93
62_I	97_I	0.919	0.93
218_A	222_L	0.915	0.92
215_P	253_Q	0.910	0.92
259_R	290_I	0.904	0.92
167_A	192_I	0.893	0.91
210_F	219_A	0.892	0.91
5_F	22_I	0.890	0.91
61_F	92_Y	0.889	0.91
219_A	257_L	0.889	0.91
64_H	69_H	0.885	0.91
271_V	296_L	0.882	0.91
215_P	257_L	0.881	0.91
109_G	144_E	0.871	0.90
34_L	57_L	0.871	0.90
85_I	114_Y	0.861	0.90
163_A	167_A	0.861	0.90
182_K	194_G	0.854	0.89
71_F	108_S	0.850	0.89
63_S	211_G	0.849	0.89
183_T	191_Q	0.847	0.89
36_L	57_L	0.846	0.89
253_Q	256_T	0.845	0.89
9_S	17_R	0.842	0.89
243_A	250_S	0.840	0.89
47_L	57_L	0.834	0.88
154_D	203_P	0.831	0.88
226_V	263_V	0.829	0.88
193_N	197_Y	0.828	0.88
228_V	265_K	0.825	0.88
18_N	46_Q	0.824	0.88
16_T	276_D	0.819	0.87
267_I	295_E	0.815	0.87
288_R	293_A	0.815	0.87
178_L	184_I	0.813	0.87
177_E	181_G	0.811	0.87
174_L	184_I	0.811	0.87
104_A	108_S	0.806	0.87
15_R	49_H	0.806	0.87
58_D	87_Q	0.802	0.86
225_G	264_G	0.802	0.86
271_V	297_A	0.800	0.86
206_A	227_D	0.798	0.86
4_I	50_T	0.797	0.86
170_P	174_L	0.795	0.86
71_F	78_C	0.792	0.86
66_H	69_H	0.788	0.85
54_P	76_L	0.788	0.85
278_K	296_L	0.786	0.85
237_I	251_T	0.782	0.85
162_Q	166_A	0.777	0.85
255_A	291_F	0.774	0.84
219_A	223_A	0.772	0.84
209_I	230_V	0.772	0.84
24_L	37_F	0.766	0.84
73_L	77_L	0.763	0.83
254_A	263_V	0.763	0.83
33_G	129_D	0.761	0.83
70_L	74_P	0.761	0.83
178_L	194_G	0.761	0.83
8_T	297_A	0.758	0.83
3_L	267_I	0.756	0.83
230_V	269_T	0.755	0.83
137_Y	147_G	0.754	0.83
298_N	303_F	0.751	0.83
25_N	34_L	0.749	0.82
236_D	251_T	0.746	0.82
242_K	246_R	0.746	0.82
93_G	96_G	0.742	0.82
70_L	108_S	0.742	0.82
63_S	210_F	0.741	0.82
281_Q	298_N	0.739	0.81
251_T	287_C	0.739	0.81
224_K	260_E	0.738	0.81
233_A	283_L	0.736	0.81
95_Q	120_E	0.731	0.81
9_S	273_S	0.730	0.81
169_V	178_L	0.728	0.81
121_I	148_Y	0.724	0.80
183_T	195_A	0.722	0.80
291_F	294_T	0.721	0.80
121_I	146_Y	0.719	0.80
233_A	251_T	0.718	0.80
145_C	211_G	0.717	0.80
36_L	47_L	0.717	0.80
211_G	249_S	0.715	0.79
163_A	196_D	0.714	0.79
131_L	153_H	0.713	0.79
41_E	44_Q	0.709	0.79
69_H	212_D	0.705	0.78
137_Y	221_D	0.703	0.78
76_L	79_S	0.692	0.77
80_R	114_Y	0.691	0.77
147_G	219_A	0.689	0.77
129_D	153_H	0.685	0.76
71_F	110_S	0.684	0.76
217_D	221_D	0.683	0.76
220_L	224_K	0.683	0.76
250_S	258_A	0.682	0.76
285_R	289_S	0.680	0.76
186_L	192_I	0.678	0.76
225_G	263_V	0.677	0.76
216_C	222_L	0.676	0.75
211_G	231_H	0.674	0.75
126_I	135_T	0.672	0.75
161_A	175_F	0.670	0.75
24_L	207_L	0.667	0.74
64_H	68_D	0.666	0.74
103_T	107_I	0.665	0.74
11_G	19_V	0.663	0.74
172_G	176_Q	0.662	0.74
85_I	89_L	0.662	0.74
255_A	258_A	0.660	0.74
181_G	184_I	0.658	0.73
242_K	245_S	0.658	0.73
163_A	197_Y	0.658	0.73
137_Y	149_R	0.656	0.73
105_L	110_S	0.655	0.73
199_A	202_V	0.653	0.73
286_E	289_S	0.652	0.73
212_D	232_E	0.651	0.73
260_E	290_I	0.649	0.72
10_A	20_T	0.649	0.72
217_D	220_L	0.648	0.72
240_E	251_T	0.647	0.72
139_L	232_E	0.646	0.72
236_D	239_M	0.644	0.72
100_F	108_S	0.644	0.72
176_Q	184_I	0.643	0.72
62_I	91_I	0.641	0.71
288_R	295_E	0.640	0.71
60_I	91_I	0.639	0.71
139_L	219_A	0.639	0.71
4_I	52_F	0.634	0.71
186_L	189_G	0.631	0.70
65_L	100_F	0.631	0.70
178_L	193_N	0.629	0.70
65_L	97_I	0.629	0.70
77_L	114_Y	0.625	0.70
229_M	257_L	0.621	0.69
69_H	232_E	0.621	0.69
136_A	146_Y	0.621	0.69
24_L	35_W	0.620	0.69
238_T	282_H	0.619	0.69
288_R	292_P	0.618	0.69
145_C	148_Y	0.617	0.69
154_D	201_P	0.615	0.68
36_L	43_T	0.614	0.68
33_G	132_R	0.613	0.68
62_I	73_L	0.613	0.68
159_L	179_K	0.612	0.68
216_C	223_A	0.610	0.68
77_L	110_S	0.609	0.68
39_C	43_T	0.604	0.67
212_D	248_H	0.602	0.67
27_Q	32_S	0.601	0.67
287_C	294_T	0.601	0.67
89_L	113_D	0.598	0.66
233_A	271_V	0.598	0.66
47_L	52_F	0.596	0.66
121_I	241_A	0.596	0.66
178_L	181_G	0.596	0.66
266_L	287_C	0.596	0.66
10_A	271_V	0.595	0.66
137_Y	219_A	0.595	0.66
165_K	170_P	0.595	0.66
177_E	180_A	0.594	0.66
140_E	216_C	0.594	0.66
168_G	172_G	0.592	0.65
167_A	196_D	0.592	0.65
287_C	291_F	0.591	0.65
121_I	125_E	0.589	0.65
186_L	191_Q	0.588	0.65
11_G	234_T	0.588	0.65
64_H	248_H	0.587	0.65
139_L	211_G	0.587	0.65
219_A	222_L	0.586	0.65
21_A	39_C	0.584	0.64
170_P	175_F	0.584	0.64
135_T	222_L	0.582	0.64
255_A	261_A	0.581	0.64
213_T	254_A	0.581	0.64
213_T	216_C	0.579	0.64
141_H	148_Y	0.579	0.64
93_G	104_A	0.579	0.64
162_Q	165_K	0.578	0.64
39_C	62_I	0.578	0.64
295_E	298_N	0.577	0.63
99_E	102_E	0.577	0.63
69_H	248_H	0.577	0.63
5_F	267_I	0.575	0.63
212_D	270_H	0.570	0.63
165_K	168_G	0.570	0.63
251_T	283_L	0.570	0.63
97_I	104_A	0.566	0.62
17_R	299_D	0.566	0.62
173_P	176_Q	0.563	0.62
210_F	231_H	0.563	0.62
9_S	15_R	0.561	0.61
6_L	18_N	0.560	0.61
185_T	262_G	0.559	0.61
214_G	244_N	0.559	0.61
151_E	154_D	0.558	0.61
64_H	212_D	0.558	0.61
241_A	244_N	0.556	0.61
159_L	169_V	0.556	0.61
224_K	261_A	0.556	0.61
101_V	108_S	0.554	0.60
97_I	120_E	0.554	0.60
216_C	219_A	0.553	0.60
224_K	285_R	0.552	0.60
18_N	49_H	0.552	0.60
16_T	21_A	0.548	0.60
11_G	273_S	0.547	0.59
216_C	220_L	0.547	0.59
151_E	226_V	0.546	0.59
278_K	282_H	0.545	0.59
237_I	282_H	0.545	0.59
177_E	184_I	0.544	0.59
25_N	32_S	0.543	0.59
145_C	209_I	0.543	0.59
269_T	297_A	0.543	0.59
259_R	292_P	0.543	0.59
158_A	202_V	0.542	0.59
69_H	270_H	0.541	0.59
38_D	69_H	0.541	0.59
169_V	174_L	0.541	0.59
205_K	287_C	0.540	0.58
255_A	287_C	0.540	0.58
256_T	290_I	0.538	0.58
167_A	190_R	0.538	0.58
126_I	136_A	0.537	0.58
131_L	155_K	0.537	0.58
233_A	297_A	0.536	0.58
66_H	232_E	0.535	0.58
231_H	257_L	0.534	0.58
258_A	291_F	0.533	0.57
215_P	261_A	0.533	0.57
271_V	299_D	0.532	0.57
207_L	230_V	0.531	0.57
10_A	19_V	0.529	0.57
290_I	294_T	0.528	0.57
57_L	60_I	0.528	0.57
251_T	275_Y	0.528	0.57
77_L	91_I	0.527	0.57
135_T	206_A	0.526	0.56
66_H	248_H	0.524	0.56
284_L	291_F	0.523	0.56
38_D	64_H	0.523	0.56
67_G	78_C	0.522	0.56
239_M	275_Y	0.522	0.56
127_L	132_R	0.521	0.56
45_H	48_L	0.520	0.56
145_C	210_F	0.520	0.56
43_T	90_T	0.520	0.56
174_L	186_L	0.520	0.56
22_I	209_I	0.518	0.55
25_N	207_L	0.517	0.55
91_I	182_K	0.513	0.55
15_R	50_T	0.513	0.55
149_R	222_L	0.512	0.54
66_H	212_D	0.511	0.54
231_H	234_T	0.511	0.54
216_C	221_D	0.510	0.54
81_S	100_F	0.508	0.54
38_D	68_D	0.506	0.54
180_A	203_P	0.506	0.54
50_T	54_P	0.506	0.54
92_Y	126_I	0.504	0.53
73_L	91_I	0.504	0.53
35_W	61_F	0.504	0.53
219_A	229_M	0.501	0.53
102_E	118_I	0.501	0.53
211_G	234_T	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zwfA	2	0.7705	100	0.303	Contact Map
2cbnA	2	0.9869	100	0.352	Contact Map
1y44A	2	0.9869	100	0.359	Contact Map
2e7yA	2	0.8557	100	0.529	Contact Map
1zkpA	2	0.7836	100	0.59	Contact Map
3jxpA	2	0.8361	100	0.597	Contact Map
4ojvA	2	0.8295	100	0.609	Contact Map
3g1pA	2	0.7475	100	0.613	Contact Map
3md7A	2	0.7607	100	0.632	Contact Map
3bk2A	2	0.7705	100	0.695	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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