GREMLIN Database
RBN - Ribonuclease BN
UniProt: P0A8V0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14260
Length: 305 (293)
Sequences: 2389 (1677)
Seq/√Len: 97.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_T119_V4.5871.00
177_E182_K3.9591.00
208_A226_V3.5311.00
98_R102_E3.4901.00
135_T151_E3.3311.00
99_E106_R3.1741.00
128_D153_H3.0921.00
33_G58_D2.6961.00
227_D264_G2.6891.00
225_G262_G2.6431.00
140_E214_G2.5371.00
88_P115_P2.4581.00
183_T194_G2.4461.00
252_R289_S2.3941.00
90_T117_E2.3891.00
149_R206_A2.3801.00
152_E205_K2.3651.00
237_I252_R2.3651.00
265_K295_E2.3391.00
206_A226_V2.3341.00
235_L246_R2.2011.00
100_F104_A2.1771.00
167_A197_Y2.1571.00
37_F150_I2.1521.00
133_K151_E2.0981.00
42_G45_H2.0581.00
176_Q180_A2.0311.00
46_Q49_H2.0171.00
256_T260_E2.0171.00
77_L89_L2.0101.00
255_A290_I1.9941.00
267_I303_F1.9721.00
221_D224_K1.9721.00
96_G120_E1.9291.00
21_A36_L1.9221.00
186_L190_R1.8951.00
267_I297_A1.8951.00
163_A166_A1.8911.00
3_L230_V1.8801.00
298_N301_T1.8781.00
61_F134_V1.8731.00
23_L36_L1.8641.00
192_I197_Y1.8541.00
92_Y119_V1.8531.00
151_E206_A1.8421.00
284_L288_R1.8371.00
74_P104_A1.8051.00
295_E301_T1.7901.00
22_I269_T1.7701.00
2_E25_N1.7401.00
231_H249_S1.7291.00
9_S14_T1.7221.00
23_L34_L1.7151.00
193_N196_D1.7011.00
81_S113_D1.7011.00
88_P117_E1.6741.00
183_T193_N1.6721.00
59_K92_Y1.6701.00
50_T300_F1.6691.00
160_N163_A1.6331.00
297_A301_T1.6091.00
214_G253_Q1.6041.00
2_E302_V1.6041.00
240_E253_Q1.5871.00
128_D133_K1.5761.00
21_A43_T1.5731.00
220_L260_E1.5581.00
237_I240_E1.5571.00
284_L296_L1.5541.00
285_R288_R1.5531.00
252_R290_I1.5531.00
3_L24_L1.5311.00
5_F8_T1.5061.00
208_A223_A1.5001.00
224_K262_G1.4861.00
233_A268_I1.4751.00
185_T191_Q1.4721.00
137_Y222_L1.4361.00
218_A221_D1.4221.00
23_L52_F1.4131.00
220_L257_L1.4010.99
185_T189_G1.3590.99
237_I286_E1.3590.99
18_N45_H1.3570.99
217_D260_E1.3520.99
67_G71_F1.3500.99
159_L164_L1.3500.99
57_L76_L1.3450.99
46_Q300_F1.3370.99
147_G210_F1.3320.99
181_G194_G1.3290.99
24_L150_I1.3030.99
161_A165_K1.3030.99
236_D283_L1.3000.99
139_L147_G1.2950.99
59_K90_T1.2920.99
223_A261_A1.2900.99
238_T286_E1.2740.99
35_W132_R1.2590.99
126_I148_Y1.2500.99
281_Q284_L1.2400.99
229_M263_V1.2310.99
98_R118_I1.2110.99
149_R226_V1.2070.98
4_I302_V1.2040.98
288_R294_T1.2010.98
63_S148_Y1.1960.98
78_C110_S1.1910.98
295_E303_F1.1910.98
268_I287_C1.1910.98
220_L261_A1.1830.98
20_T269_T1.1770.98
139_L145_C1.1760.98
140_E247_G1.1680.98
95_Q122_G1.1650.98
256_T259_R1.1640.98
251_T286_E1.1630.98
251_T255_A1.1590.98
91_I101_V1.1490.98
178_L197_Y1.1330.98
194_G197_Y1.1310.98
282_H285_R1.1310.98
223_A226_V1.1290.98
142_P247_G1.1250.98
194_G198_L1.1240.98
139_L210_F1.1170.97
37_F61_F1.1120.97
169_V175_F1.1080.97
281_Q285_R1.1070.97
160_N199_A1.0930.97
60_I73_L1.0870.97
241_A245_S1.0860.97
250_S254_A1.0860.97
133_K153_H1.0860.97
252_R256_T1.0840.97
258_A266_L1.0730.97
149_R208_A1.0700.97
5_F297_A1.0690.97
3_L228_V1.0650.97
98_R120_E1.0590.97
252_R286_E1.0310.96
60_I76_L1.0280.96
284_L294_T1.0250.96
173_P177_E1.0160.96
8_T17_R1.0070.95
277_D281_Q1.0050.95
93_G97_I1.0020.95
35_W150_I0.9950.95
138_P146_Y0.9920.95
54_P57_L0.9840.95
228_V267_I0.9830.95
93_G120_E0.9820.95
67_G234_T0.9770.95
18_N43_T0.9690.94
154_D204_G0.9690.94
244_N253_Q0.9650.94
44_Q75_G0.9630.94
265_K293_A0.9600.94
164_L197_Y0.9580.94
20_T209_I0.9580.94
174_L177_E0.9550.94
91_I97_I0.9540.94
138_P144_E0.9450.93
101_V118_I0.9400.93
101_V105_L0.9360.93
102_E106_R0.9320.93
214_G247_G0.9190.93
62_I97_I0.9190.93
218_A222_L0.9150.92
215_P253_Q0.9100.92
259_R290_I0.9040.92
167_A192_I0.8930.91
210_F219_A0.8920.91
5_F22_I0.8900.91
61_F92_Y0.8890.91
219_A257_L0.8890.91
64_H69_H0.8850.91
271_V296_L0.8820.91
215_P257_L0.8810.91
109_G144_E0.8710.90
34_L57_L0.8710.90
85_I114_Y0.8610.90
163_A167_A0.8610.90
182_K194_G0.8540.89
71_F108_S0.8500.89
63_S211_G0.8490.89
183_T191_Q0.8470.89
36_L57_L0.8460.89
253_Q256_T0.8450.89
9_S17_R0.8420.89
243_A250_S0.8400.89
47_L57_L0.8340.88
154_D203_P0.8310.88
226_V263_V0.8290.88
193_N197_Y0.8280.88
228_V265_K0.8250.88
18_N46_Q0.8240.88
16_T276_D0.8190.87
267_I295_E0.8150.87
288_R293_A0.8150.87
178_L184_I0.8130.87
177_E181_G0.8110.87
174_L184_I0.8110.87
104_A108_S0.8060.87
15_R49_H0.8060.87
58_D87_Q0.8020.86
225_G264_G0.8020.86
271_V297_A0.8000.86
206_A227_D0.7980.86
4_I50_T0.7970.86
170_P174_L0.7950.86
71_F78_C0.7920.86
66_H69_H0.7880.85
54_P76_L0.7880.85
278_K296_L0.7860.85
237_I251_T0.7820.85
162_Q166_A0.7770.85
255_A291_F0.7740.84
219_A223_A0.7720.84
209_I230_V0.7720.84
24_L37_F0.7660.84
73_L77_L0.7630.83
254_A263_V0.7630.83
33_G129_D0.7610.83
70_L74_P0.7610.83
178_L194_G0.7610.83
8_T297_A0.7580.83
3_L267_I0.7560.83
230_V269_T0.7550.83
137_Y147_G0.7540.83
298_N303_F0.7510.83
25_N34_L0.7490.82
236_D251_T0.7460.82
242_K246_R0.7460.82
93_G96_G0.7420.82
70_L108_S0.7420.82
63_S210_F0.7410.82
281_Q298_N0.7390.81
251_T287_C0.7390.81
224_K260_E0.7380.81
233_A283_L0.7360.81
95_Q120_E0.7310.81
9_S273_S0.7300.81
169_V178_L0.7280.81
121_I148_Y0.7240.80
183_T195_A0.7220.80
291_F294_T0.7210.80
121_I146_Y0.7190.80
233_A251_T0.7180.80
145_C211_G0.7170.80
36_L47_L0.7170.80
211_G249_S0.7150.79
163_A196_D0.7140.79
131_L153_H0.7130.79
41_E44_Q0.7090.79
69_H212_D0.7050.78
137_Y221_D0.7030.78
76_L79_S0.6920.77
80_R114_Y0.6910.77
147_G219_A0.6890.77
129_D153_H0.6850.76
71_F110_S0.6840.76
217_D221_D0.6830.76
220_L224_K0.6830.76
250_S258_A0.6820.76
285_R289_S0.6800.76
186_L192_I0.6780.76
225_G263_V0.6770.76
216_C222_L0.6760.75
211_G231_H0.6740.75
126_I135_T0.6720.75
161_A175_F0.6700.75
24_L207_L0.6670.74
64_H68_D0.6660.74
103_T107_I0.6650.74
11_G19_V0.6630.74
172_G176_Q0.6620.74
85_I89_L0.6620.74
255_A258_A0.6600.74
181_G184_I0.6580.73
242_K245_S0.6580.73
163_A197_Y0.6580.73
137_Y149_R0.6560.73
105_L110_S0.6550.73
199_A202_V0.6530.73
286_E289_S0.6520.73
212_D232_E0.6510.73
260_E290_I0.6490.72
10_A20_T0.6490.72
217_D220_L0.6480.72
240_E251_T0.6470.72
139_L232_E0.6460.72
236_D239_M0.6440.72
100_F108_S0.6440.72
176_Q184_I0.6430.72
62_I91_I0.6410.71
288_R295_E0.6400.71
60_I91_I0.6390.71
139_L219_A0.6390.71
4_I52_F0.6340.71
186_L189_G0.6310.70
65_L100_F0.6310.70
178_L193_N0.6290.70
65_L97_I0.6290.70
77_L114_Y0.6250.70
229_M257_L0.6210.69
69_H232_E0.6210.69
136_A146_Y0.6210.69
24_L35_W0.6200.69
238_T282_H0.6190.69
288_R292_P0.6180.69
145_C148_Y0.6170.69
154_D201_P0.6150.68
36_L43_T0.6140.68
33_G132_R0.6130.68
62_I73_L0.6130.68
159_L179_K0.6120.68
216_C223_A0.6100.68
77_L110_S0.6090.68
39_C43_T0.6040.67
212_D248_H0.6020.67
27_Q32_S0.6010.67
287_C294_T0.6010.67
89_L113_D0.5980.66
233_A271_V0.5980.66
47_L52_F0.5960.66
121_I241_A0.5960.66
178_L181_G0.5960.66
266_L287_C0.5960.66
10_A271_V0.5950.66
137_Y219_A0.5950.66
165_K170_P0.5950.66
177_E180_A0.5940.66
140_E216_C0.5940.66
168_G172_G0.5920.65
167_A196_D0.5920.65
287_C291_F0.5910.65
121_I125_E0.5890.65
186_L191_Q0.5880.65
11_G234_T0.5880.65
64_H248_H0.5870.65
139_L211_G0.5870.65
219_A222_L0.5860.65
21_A39_C0.5840.64
170_P175_F0.5840.64
135_T222_L0.5820.64
255_A261_A0.5810.64
213_T254_A0.5810.64
213_T216_C0.5790.64
141_H148_Y0.5790.64
93_G104_A0.5790.64
162_Q165_K0.5780.64
39_C62_I0.5780.64
295_E298_N0.5770.63
99_E102_E0.5770.63
69_H248_H0.5770.63
5_F267_I0.5750.63
212_D270_H0.5700.63
165_K168_G0.5700.63
251_T283_L0.5700.63
97_I104_A0.5660.62
17_R299_D0.5660.62
173_P176_Q0.5630.62
210_F231_H0.5630.62
9_S15_R0.5610.61
6_L18_N0.5600.61
185_T262_G0.5590.61
214_G244_N0.5590.61
151_E154_D0.5580.61
64_H212_D0.5580.61
241_A244_N0.5560.61
159_L169_V0.5560.61
224_K261_A0.5560.61
101_V108_S0.5540.60
97_I120_E0.5540.60
216_C219_A0.5530.60
224_K285_R0.5520.60
18_N49_H0.5520.60
16_T21_A0.5480.60
11_G273_S0.5470.59
216_C220_L0.5470.59
151_E226_V0.5460.59
278_K282_H0.5450.59
237_I282_H0.5450.59
177_E184_I0.5440.59
25_N32_S0.5430.59
145_C209_I0.5430.59
269_T297_A0.5430.59
259_R292_P0.5430.59
158_A202_V0.5420.59
69_H270_H0.5410.59
38_D69_H0.5410.59
169_V174_L0.5410.59
205_K287_C0.5400.58
255_A287_C0.5400.58
256_T290_I0.5380.58
167_A190_R0.5380.58
126_I136_A0.5370.58
131_L155_K0.5370.58
233_A297_A0.5360.58
66_H232_E0.5350.58
231_H257_L0.5340.58
258_A291_F0.5330.57
215_P261_A0.5330.57
271_V299_D0.5320.57
207_L230_V0.5310.57
10_A19_V0.5290.57
290_I294_T0.5280.57
57_L60_I0.5280.57
251_T275_Y0.5280.57
77_L91_I0.5270.57
135_T206_A0.5260.56
66_H248_H0.5240.56
284_L291_F0.5230.56
38_D64_H0.5230.56
67_G78_C0.5220.56
239_M275_Y0.5220.56
127_L132_R0.5210.56
45_H48_L0.5200.56
145_C210_F0.5200.56
43_T90_T0.5200.56
174_L186_L0.5200.56
22_I209_I0.5180.55
25_N207_L0.5170.55
91_I182_K0.5130.55
15_R50_T0.5130.55
149_R222_L0.5120.54
66_H212_D0.5110.54
231_H234_T0.5110.54
216_C221_D0.5100.54
81_S100_F0.5080.54
38_D68_D0.5060.54
180_A203_P0.5060.54
50_T54_P0.5060.54
92_Y126_I0.5040.53
73_L91_I0.5040.53
35_W61_F0.5040.53
219_A229_M0.5010.53
102_E118_I0.5010.53
211_G234_T0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.7705 100 0.303 Contact Map
2cbnA 2 0.9869 100 0.352 Contact Map
1y44A 2 0.9869 100 0.359 Contact Map
2e7yA 2 0.8557 100 0.529 Contact Map
1zkpA 2 0.7836 100 0.59 Contact Map
3jxpA 2 0.8361 100 0.597 Contact Map
4ojvA 2 0.8295 100 0.609 Contact Map
3g1pA 2 0.7475 100 0.613 Contact Map
3md7A 2 0.7607 100 0.632 Contact Map
3bk2A 2 0.7705 100 0.695 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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