GREMLIN Database
SYDP - Protein Syd
UniProt: P0A8U0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12959
Length: 181 (175)
Sequences: 288 (198)
Seq/√Len: 14.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_T128_L5.5621.00
116_L132_L5.3011.00
169_N172_E4.5061.00
123_Q128_L4.3131.00
12_F91_A3.9481.00
120_L130_P3.8091.00
109_F126_L2.9380.98
98_L135_A2.8280.97
137_L157_T2.5570.94
143_V158_L2.3990.92
134_I146_V2.1460.87
14_A22_E2.1130.86
10_K83_T2.1090.86
58_G62_V2.0280.84
146_V153_V1.9240.80
62_V78_H1.8660.78
76_T169_N1.8430.77
69_F117_I1.8110.76
81_Y134_I1.7930.75
19_A23_E1.7330.72
152_E168_S1.7270.72
74_Q148_N1.6800.70
75_P146_V1.6540.69
85_F106_E1.6210.67
88_D111_R1.6090.67
73_I80_F1.6010.66
146_V170_L1.5920.66
122_T158_L1.5820.65
30_S87_G1.5620.64
56_F134_I1.5150.62
78_H124_K1.5140.62
64_A112_V1.5100.61
127_K143_V1.4970.61
93_F144_I1.4750.60
135_A166_L1.4740.59
91_A98_L1.4640.59
101_L131_T1.4600.59
123_Q141_L1.4420.58
121_V147_C1.4310.57
68_A117_I1.4280.57
56_F82_T1.4010.55
65_V120_L1.3720.54
66_E78_H1.3460.52
9_L15_R1.3230.51
65_V73_I1.3220.51
109_F113_Q1.3110.50
84_Q89_M1.3060.50
76_T112_V1.2820.49
38_S105_S1.2770.49
107_D172_E1.2650.48
17_C112_V1.2550.47
155_K174_L1.2490.47
13_T89_M1.2400.46
90_H107_D1.2180.45
33_L89_M1.2170.45
128_L141_L1.2030.44
122_T139_E1.1880.44
122_T126_L1.1860.43
73_I103_T1.1700.43
128_L159_G1.1580.42
125_R145_S1.1520.42
81_Y86_A1.1440.41
73_I117_I1.1240.40
68_A170_L1.0930.38
172_E176_Q1.0900.38
59_E63_N1.0830.38
135_A145_S1.0730.37
42_I52_Q1.0730.37
147_C163_R1.0710.37
89_M149_L1.0700.37
153_V164_T1.0630.37
93_F96_I1.0530.36
85_F167_A1.0520.36
140_E163_R1.0460.36
64_A113_Q1.0420.36
150_S165_H1.0410.36
91_A177_L1.0270.35
104_W135_A1.0250.35
38_S104_W1.0210.35
15_R140_E0.9960.33
113_Q159_G0.9940.33
15_R179_P0.9920.33
16_Y144_I0.9920.33
73_I148_N0.9850.33
70_D135_A0.9830.33
124_K170_L0.9770.33
7_Q175_N0.9750.32
64_A103_T0.9730.32
64_A67_R0.9520.31
22_E58_G0.9510.31
19_A52_Q0.9510.31
64_A73_I0.9490.31
116_L129_P0.9470.31
53_P111_R0.9450.31
45_T48_A0.9340.30
154_C165_H0.9290.30
5_T58_G0.9240.30
18_D79_T0.9180.30
141_L158_L0.9110.29
80_F102_Q0.9070.29
76_T118_G0.9010.29
72_V92_Q0.8910.28
117_I170_L0.8860.28
30_S89_M0.8830.28
9_L86_A0.8830.28
168_S172_E0.8780.28
13_T36_V0.8770.28
19_A24_H0.8740.28
64_A74_Q0.8700.27
46_E63_N0.8600.27
6_A14_A0.8580.27
40_C105_S0.8580.27
44_T150_S0.8580.27
78_H164_T0.8560.27
104_W109_F0.8560.27
74_Q129_P0.8500.27
26_S29_L0.8440.26
68_A159_G0.8430.26
63_N78_H0.8420.26
81_Y85_F0.8320.26
12_F73_I0.8270.26
105_S169_N0.8200.25
20_W30_S0.8170.25
74_Q77_I0.8110.25
84_Q88_D0.8100.25
5_T16_Y0.8050.25
30_S36_V0.7930.24
36_V68_A0.7920.24
27_W42_I0.7910.24
54_Q116_L0.7820.24
91_A137_L0.7770.24
12_F89_M0.7750.23
123_Q158_L0.7700.23
11_D169_N0.7650.23
78_H114_E0.7570.23
128_L158_L0.7570.23
69_F159_G0.7560.23
146_V176_Q0.7530.23
155_K166_L0.7510.22
27_W45_T0.7490.22
80_F172_E0.7460.22
70_D124_K0.7400.22
102_Q134_I0.7370.22
6_A175_N0.7360.22
32_E160_T0.7340.22
94_G155_K0.7310.22
67_R71_I0.7280.22
97_K168_S0.7240.21
11_D15_R0.7210.21
40_C173_F0.7170.21
113_Q126_L0.7150.21
33_L121_V0.7150.21
103_T112_V0.7130.21
56_F139_E0.7130.21
143_V157_T0.7090.21
27_W46_E0.7070.21
139_E144_I0.7070.21
101_L111_R0.7050.21
56_F60_Q0.7040.21
37_P42_I0.7040.21
154_C162_K0.7030.21
9_L102_Q0.7030.21
72_V169_N0.7030.21
7_Q80_F0.7000.21
16_Y20_W0.7000.21
116_L146_V0.6990.21
81_Y116_L0.6920.20
77_I148_N0.6910.20
121_V149_L0.6880.20
36_V117_I0.6850.20
47_D179_P0.6810.20
129_P143_V0.6780.20
40_C104_W0.6760.20
112_V160_T0.6760.20
26_S140_E0.6750.20
62_V74_Q0.6750.20
45_T150_S0.6720.20
21_H155_K0.6680.19
105_S162_K0.6630.19
66_E143_V0.6560.19
10_K144_I0.6550.19
16_Y150_S0.6520.19
35_G80_F0.6520.19
139_E162_K0.6470.19
74_Q136_T0.6420.19
33_L135_A0.6420.19
29_L75_P0.6380.18
82_T109_F0.6350.18
21_H107_D0.6310.18
32_E41_I0.6300.18
79_T83_T0.6290.18
18_D168_S0.6280.18
30_S111_R0.6260.18
88_D147_C0.6250.18
13_T84_Q0.6250.18
124_K155_K0.6230.18
43_S167_A0.6200.18
101_L141_L0.6150.18
77_I146_V0.6140.18
71_I117_I0.6130.18
47_D167_A0.6090.17
40_C113_Q0.6030.17
54_Q146_V0.6030.17
98_L150_S0.6010.17
113_Q128_L0.6010.17
92_Q172_E0.5970.17
85_F142_E0.5960.17
91_A135_A0.5940.17
84_Q130_P0.5910.17
74_Q112_V0.5910.17
56_F86_A0.5870.17
33_L84_Q0.5870.17
74_Q81_Y0.5850.17
15_R89_M0.5850.17
75_P172_E0.5840.17
113_Q122_T0.5840.17
63_N178_K0.5810.17
54_Q132_L0.5770.16
103_T154_C0.5770.16
89_M105_S0.5770.16
43_S46_E0.5770.16
18_D59_E0.5700.16
96_I123_Q0.5670.16
37_P45_T0.5660.16
5_T10_K0.5630.16
42_I103_T0.5630.16
120_L132_L0.5610.16
62_V148_N0.5600.16
35_G169_N0.5510.16
95_D158_L0.5500.16
138_E145_S0.5490.16
24_H172_E0.5450.15
96_I144_I0.5440.15
30_S88_D0.5420.15
65_V117_I0.5410.15
94_G176_Q0.5390.15
102_Q120_L0.5380.15
33_L120_L0.5360.15
91_A125_R0.5350.15
111_R125_R0.5340.15
45_T92_Q0.5320.15
99_T154_C0.5300.15
48_A63_N0.5290.15
62_V96_I0.5290.15
37_P105_S0.5280.15
49_V84_Q0.5280.15
153_V157_T0.5250.15
26_S46_E0.5230.15
47_D175_N0.5210.15
18_D22_E0.5210.15
97_K124_K0.5190.15
112_V155_K0.5190.15
77_I112_V0.5150.15
99_T135_A0.5130.15
57_T85_F0.5110.14
19_A128_L0.5100.14
136_T140_E0.5080.14
74_Q149_L0.5080.14
76_T91_A0.5070.14
120_L163_R0.5050.14
5_T21_H0.5030.14
41_I61_N0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ffvA 1 1 100 0.074 Contact Map
3d5pA 2 0.6961 93.8 0.927 Contact Map
2pagA 1 0.7017 92.3 0.931 Contact Map
2icgA 1 0.768 90.2 0.934 Contact Map
2prvA 2 0.7348 86.4 0.938 Contact Map
3uipD 1 0.2818 30.1 0.959 Contact Map
4qtqA 1 0.2983 15.4 0.964 Contact Map
1z5sD 1 0.3039 15.4 0.964 Contact Map
1mvfD 1 0.1823 14.3 0.965 Contact Map
4lt5A 1 0.7845 12.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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