GREMLIN Database
FLIE - Flagellar hook-basal body complex protein FliE
UniProt: P0A8T5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11346
Length: 104 (93)
Sequences: 1058 (799)
Seq/√Len: 82.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_T81_S3.7291.00
58_K63_E3.7221.00
39_H43_D3.0811.00
45_I85_G3.0431.00
59_F71_V2.9971.00
67_A70_D2.9851.00
42_L85_G2.8451.00
46_S50_T2.6221.00
94_A97_Q2.5391.00
81_S85_G2.4831.00
44_R47_D2.2991.00
97_Q101_S2.2291.00
83_Q87_Q2.2281.00
57_E61_L1.9421.00
14_L17_T1.7831.00
56_A75_M1.7161.00
98_E101_S1.5210.99
55_Q74_D1.5050.99
54_T57_E1.3950.99
51_A55_Q1.3850.99
54_T58_K1.3480.99
44_R48_T1.2960.98
50_T54_T1.2830.98
70_D77_K1.2800.98
17_T21_A1.2570.98
46_S49_Q1.2320.98
60_T103_Q1.2160.97
33_S36_G1.2100.97
14_L18_A1.1910.97
52_A56_A1.1640.97
83_Q86_I1.1350.96
27_L31_T1.1300.96
51_A54_T1.0860.95
36_G39_H1.0820.95
40_A94_A1.0480.94
47_D51_A1.0460.94
52_A78_A1.0350.94
55_Q66_V1.0010.92
77_K100_M0.9840.92
27_L30_P0.9800.92
69_N86_I0.9750.91
36_G40_A0.9720.91
55_Q58_K0.9560.91
94_A103_Q0.9490.90
37_Q85_G0.9490.90
78_A81_S0.9360.90
51_A74_D0.9350.90
71_V97_Q0.9200.89
53_R78_A0.9050.88
66_V70_D0.8920.87
68_L79_S0.8910.87
82_M87_Q0.8650.86
91_K94_A0.8620.86
12_S22_R0.8580.85
30_P51_A0.8510.85
42_L87_Q0.8500.85
94_A98_E0.8420.84
82_M85_G0.8360.84
54_T63_E0.8270.83
95_A99_V0.8240.83
38_L41_A0.8200.83
34_F38_L0.8070.82
40_A43_D0.8000.81
46_S71_V0.7840.80
45_I82_M0.7700.78
49_Q82_M0.7650.78
74_D78_A0.7620.78
52_A84_M0.7590.77
87_Q94_A0.7580.77
22_R54_T0.7570.77
33_S45_I0.7560.77
19_M86_I0.7540.77
14_L21_A0.7500.77
26_S29_Q0.7500.77
37_Q84_M0.7460.76
53_R80_V0.7370.75
45_I48_T0.7200.74
13_Q39_H0.7050.72
35_A39_H0.7030.72
65_G71_V0.7010.72
71_V75_M0.6950.71
16_A20_S0.6950.71
17_T104_V0.6860.70
64_P87_Q0.6780.69
22_R25_E0.6770.69
17_T20_S0.6680.68
56_A80_V0.6630.67
70_D91_K0.6610.67
52_A81_S0.6600.67
13_Q70_D0.6590.67
52_A71_V0.6560.67
35_A76_Q0.6510.66
25_E28_P0.6500.66
20_S25_E0.6500.66
19_M22_R0.6440.65
60_T69_N0.6430.65
39_H95_A0.6420.65
37_Q41_A0.6410.65
35_A71_V0.6300.63
40_A73_T0.6200.62
20_S99_V0.6190.62
89_R97_Q0.6190.62
13_Q16_A0.6130.61
69_N84_M0.6130.61
81_S87_Q0.6110.61
76_Q95_A0.6100.61
69_N74_D0.6060.60
82_M86_I0.6050.60
74_D84_M0.6000.60
90_N97_Q0.5980.59
52_A75_M0.5970.59
17_T22_R0.5960.59
100_M104_V0.5940.59
79_S100_M0.5910.59
85_G92_L0.5880.58
14_L70_D0.5850.58
56_A71_V0.5840.58
76_Q88_V0.5830.58
83_Q99_V0.5820.57
67_A71_V0.5760.57
59_F68_L0.5760.57
49_Q80_V0.5650.55
53_R57_E0.5630.55
44_R53_R0.5550.54
18_A21_A0.5500.53
52_A74_D0.5470.53
29_Q57_E0.5460.53
69_N73_T0.5420.52
68_L80_V0.5400.52
12_S15_Q0.5400.52
97_Q103_Q0.5390.52
15_Q82_M0.5380.52
69_N75_M0.5380.52
55_Q70_D0.5380.52
41_A86_I0.5350.51
39_H49_Q0.5280.50
21_A24_Q0.5280.50
19_M31_T0.5220.50
79_S93_V0.5200.49
38_L96_Y0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ut1A 1 0.5769 13 0.922 Contact Map
2ca5A 1 0.6154 8.1 0.928 Contact Map
3a69A 3 0.8558 6.4 0.932 Contact Map
3v47C 1 0.9808 6.2 0.932 Contact Map
1io1A 1 0.8269 5 0.935 Contact Map
3zqeA 1 0.6731 4.2 0.937 Contact Map
4cfiA 1 0.9135 4.2 0.937 Contact Map
4um2A 1 0.5192 3.8 0.939 Contact Map
1zzpA 1 0.4712 3.7 0.939 Contact Map
1y4cA 1 0.4423 3.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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