GREMLIN Database
FLHD - Flagellar transcriptional regulator FlhD
UniProt: P0A8S9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10320
Length: 116 (101)
Sequences: 213 (118)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_G68_R4.2091.00
66_H70_D3.2100.97
22_Q26_V2.4920.88
22_Q34_F2.4630.88
25_I32_A2.4440.87
29_K44_T2.2070.81
33_M43_A2.1880.80
19_L59_E2.0380.75
24_L57_L2.0070.74
75_I99_R1.9500.72
90_I93_G1.9250.71
46_L76_T1.9200.71
31_S90_I1.9100.70
23_R62_Q1.8230.67
9_H16_S1.6940.61
34_F91_H1.5420.53
20_L35_R1.5150.52
37_G94_I1.5010.51
32_A70_D1.4860.50
33_M69_F1.4850.50
52_P94_I1.4770.50
9_H66_H1.4440.48
77_Q81_D1.4380.48
61_N86_D1.4320.48
71_S78_L1.4280.48
69_F77_Q1.3970.46
59_E89_Q1.3690.45
43_A98_T1.3620.44
9_H38_I1.3600.44
28_D98_T1.3440.43
42_M74_T1.3430.43
53_Q95_M1.3140.42
31_S84_V1.3010.41
49_L79_T1.2840.40
57_L96_L1.2540.39
19_L27_Q1.2480.39
37_G74_T1.2390.38
64_V95_M1.2250.38
44_T95_M1.1910.36
37_G55_V1.1890.36
50_T70_D1.1850.36
7_L61_N1.1750.35
4_S19_L1.1720.35
16_S78_L1.1620.35
7_L58_A1.1600.35
49_L54_M1.1490.34
59_E74_T1.1370.34
25_I63_L1.1300.33
11_Y52_P1.1100.32
26_V66_H1.1070.32
38_I46_L1.1070.32
8_K11_Y1.0910.32
15_L70_D1.0720.31
66_H102_N1.0550.30
25_I47_A1.0530.30
53_Q65_C1.0510.30
95_M102_N1.0260.29
18_L101_L1.0020.28
78_L93_G0.9770.27
92_T96_L0.9700.27
8_K69_F0.9270.25
43_A69_F0.9190.25
11_Y59_E0.9110.24
19_L52_P0.8990.24
25_I78_L0.8950.24
3_T46_L0.8880.24
16_S63_L0.8820.23
57_L73_Q0.8810.23
23_R77_Q0.8740.23
33_M48_A0.8710.23
86_D96_L0.8420.22
7_L65_C0.8420.22
53_Q80_Q0.8380.22
26_V60_T0.8310.22
68_R94_I0.8300.22
51_L56_K0.8230.21
55_V80_Q0.8120.21
22_Q92_T0.8090.21
61_N64_V0.8020.21
55_V81_D0.7970.21
55_V68_R0.7880.20
4_S73_Q0.7790.20
88_Q94_I0.7680.20
51_L74_T0.7620.19
15_L32_A0.7590.19
32_A40_E0.7560.19
38_I41_E0.7460.19
39_N103_D0.7320.18
35_R91_H0.7220.18
84_V90_I0.7190.18
29_K82_S0.7160.18
3_T87_L0.7070.18
28_D63_L0.7020.18
29_K43_A0.6900.17
42_M72_H0.6880.17
23_R27_Q0.6870.17
57_L75_I0.6830.17
61_N65_C0.6830.17
56_K95_M0.6780.17
40_E62_Q0.6780.17
46_L71_S0.6700.17
50_T87_L0.6670.17
19_L96_L0.6590.16
62_Q90_I0.6580.16
92_T101_L0.6450.16
33_M51_L0.6410.16
66_H74_T0.6400.16
21_A56_K0.6390.16
21_A68_R0.6390.16
63_L97_S0.6330.16
38_I59_E0.6230.15
13_I58_A0.6180.15
64_V75_I0.6150.15
32_A36_L0.6060.15
37_G59_E0.6060.15
55_V88_Q0.6030.15
82_S98_T0.6020.15
55_V94_I0.6020.15
21_A37_G0.6000.15
28_D31_S0.5980.15
32_A94_I0.5970.15
41_E60_T0.5860.14
38_I84_V0.5820.14
45_T67_F0.5820.14
23_R75_I0.5700.14
52_P67_F0.5700.14
48_A54_M0.5580.14
37_G50_T0.5580.14
43_A95_M0.5570.14
28_D44_T0.5560.14
19_L89_Q0.5560.14
13_I85_D0.5550.14
42_M100_L0.5510.14
94_I99_R0.5510.14
3_T98_T0.5460.14
7_L16_S0.5420.13
4_S103_D0.5330.13
70_D94_I0.5320.13
52_P102_N0.5300.13
61_N89_Q0.5290.13
8_K50_T0.5260.13
51_L62_Q0.5250.13
6_L30_A0.5240.13
28_D85_D0.5180.13
64_V100_L0.5160.13
7_L25_I0.5110.13
61_N96_L0.5100.13
83_R90_I0.5060.13
8_K101_L0.5050.13
44_T56_K0.5030.13
9_H74_T0.5000.12
40_E99_R0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8eA 2 0.8448 100 0.089 Contact Map
1so9A 1 0.2241 8.9 0.944 Contact Map
4eivA 2 0.4741 3.8 0.953 Contact Map
1i7fA 2 0.319 3.5 0.954 Contact Map
4ag6A 2 0.6552 3.4 0.954 Contact Map
1vkeA 6 0.8879 3 0.956 Contact Map
1vzyA 3 0.6724 2.4 0.958 Contact Map
2llwA 1 0.4741 2.3 0.958 Contact Map
4lunU 1 0.6983 2.1 0.959 Contact Map
2qq8A 1 0.2672 2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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