GREMLIN Database
ICIA - Chromosome initiation inhibitor
UniProt: P0A8S1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10490
Length: 297 (281)
Sequences: 79777 (57835)
Seq/√Len: 3450.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_Q76_L3.6411.00
18_E27_K3.4021.00
157_D287_L2.6981.00
96_A140_V2.4751.00
69_L83_D2.4651.00
14_A27_K2.3571.00
231_A238_C2.2691.00
161_A264_R2.2311.00
158_K161_A2.2231.00
92_L122_N2.2111.00
172_F189_A2.2031.00
163_D242_H2.1771.00
158_K264_R2.1661.00
48_Q62_Q2.1281.00
92_L120_R2.1131.00
11_A38_R2.0741.00
23_R26_Q2.0731.00
182_T185_A2.0271.00
112_P285_A2.0181.00
13_D71_R2.0171.00
69_L76_L1.9981.00
17_R71_R1.9961.00
228_V248_E1.9721.00
94_S122_N1.9691.00
13_D17_R1.9631.00
13_D67_L1.9611.00
14_A18_E1.9341.00
14_A17_R1.9231.00
165_L242_H1.9211.00
16_I59_P1.8861.00
11_A35_V1.8841.00
192_V236_T1.8821.00
73_V77_E1.8621.00
67_L71_R1.8241.00
232_R248_E1.7901.00
52_V58_R1.7361.00
190_P218_C1.7351.00
21_F39_I1.7341.00
134_R139_E1.7201.00
66_L80_W1.7001.00
131_T143_A1.6951.00
161_A262_F1.6861.00
65_K83_D1.6831.00
177_F185_A1.6811.00
156_V266_M1.6631.00
16_I67_L1.6501.00
18_E23_R1.5941.00
113_V282_V1.5921.00
155_L271_R1.5831.00
13_D70_L1.5681.00
17_R27_K1.5591.00
8_T38_R1.5281.00
12_L67_L1.5161.00
11_A30_I1.5141.00
69_L72_Q1.5051.00
133_E137_R1.4961.00
8_T45_M1.4881.00
31_T34_A1.4781.00
20_G23_R1.4771.00
157_D269_W1.4771.00
201_H205_L1.4711.00
88_S118_P1.4681.00
113_V119_I1.4671.00
22_E32_Q1.4661.00
8_T41_Q1.4491.00
49_P52_V1.4431.00
5_D8_T1.4381.00
283_T287_L1.4291.00
61_E64_Q1.4261.00
14_A28_L1.4221.00
145_S268_Y1.3921.00
69_L79_E1.3921.00
155_L269_W1.3911.00
275_E279_M1.3901.00
13_D74_E1.3881.00
103_A225_E1.3861.00
73_V80_W1.3761.00
54_T58_R1.3751.00
147_Q266_M1.3671.00
94_S124_Q1.3501.00
90_P118_P1.3431.00
281_K284_D1.3371.00
269_W283_T1.3351.00
116_D285_A1.3271.00
134_R140_V1.3221.00
162_L243_L1.3181.00
66_L81_L1.3051.00
232_R253_E1.3051.00
6_Y77_E1.3041.00
165_L256_D1.3031.00
76_L79_E1.3031.00
267_L283_T1.2981.00
112_P116_D1.2931.00
142_G279_M1.2871.00
136_R153_S1.2811.00
168_S237_C1.2811.00
227_F238_C1.2711.00
142_G267_L1.2641.00
68_A72_Q1.2631.00
189_A237_C1.2581.00
114_L218_C1.2561.00
45_M81_L1.2411.00
69_L80_W1.2411.00
229_Q232_R1.2361.00
114_L190_P1.2121.00
111_A115_A1.2031.00
65_K68_A1.2031.00
249_L252_G1.1981.00
158_K266_M1.1971.00
30_I34_A1.1891.00
12_L51_L1.1851.00
179_N255_I1.1761.00
37_Q41_Q1.1621.00
242_H246_E1.1611.00
40_K44_N1.1561.00
242_H256_D1.1551.00
64_Q68_A1.1511.00
111_A233_Q1.1471.00
12_L16_I1.1431.00
173_A189_A1.1321.00
170_K253_E1.1291.00
156_V268_Y1.1271.00
37_Q40_K1.1261.00
122_N220_I1.1231.00
65_K69_L1.1051.00
190_P216_V1.0971.00
284_D287_L1.0931.00
9_L70_L1.0931.00
12_L50_L1.0901.00
208_N213_P1.0891.00
102_L125_V1.0881.00
72_Q79_E1.0851.00
112_P115_A1.0801.00
21_F57_P1.0771.00
228_V232_R1.0771.00
192_V227_F1.0741.00
108_P233_Q1.0711.00
177_F180_G1.0711.00
36_S40_K1.0691.00
113_V285_A1.0661.00
38_R41_Q1.0651.00
14_A24_A1.0581.00
157_D283_T1.0561.00
221_V227_F1.0531.00
73_V76_L1.0511.00
7_R10_Q1.0501.00
93_L282_V1.0471.00
280_R284_D1.0461.00
15_V24_A1.0351.00
229_Q233_Q1.0341.00
126_E134_R1.0341.00
109_A286_L1.0251.00
246_E250_A1.0221.00
169_S234_G1.0201.00
10_Q78_E1.0181.00
181_V185_A1.0131.00
81_L85_Q1.0131.00
252_G256_D1.0021.00
59_P63_G0.9921.00
285_A288_D0.9871.00
136_R151_L0.9841.00
66_L70_L0.9781.00
30_I35_V0.9711.00
247_K251_S0.9701.00
124_Q134_R0.9671.00
75_L79_E0.9671.00
172_F175_K0.9621.00
202_Q205_L0.9611.00
11_A28_L0.9601.00
78_E82_G0.9581.00
135_L143_A0.9571.00
16_I51_L0.9561.00
166_F237_C0.9561.00
78_E81_L0.9531.00
167_V245_I0.9491.00
168_S172_F0.9481.00
163_D262_F0.9461.00
12_L59_P0.9451.00
15_V21_F0.9441.00
193_A217_P0.9441.00
170_K251_S0.9381.00
253_E256_D0.9341.00
24_A35_V0.9291.00
221_V230_L0.9271.00
41_Q44_N0.9261.00
248_E253_E0.9221.00
12_L42_L0.9151.00
48_Q84_E0.9151.00
276_S279_M0.9141.00
116_D288_D0.9071.00
180_G258_T0.9061.00
23_R27_K0.9051.00
96_A145_S0.9031.00
168_S255_I0.9021.00
109_A285_A0.9001.00
191_V215_S0.8911.00
51_L57_P0.8841.00
172_F176_Y0.8771.00
19_R58_R0.8751.00
68_A71_R0.8711.00
99_A223_S0.8681.00
204_F208_N0.8661.00
72_Q75_L0.8661.00
120_R216_V0.8641.00
16_I63_G0.8561.00
7_R38_R0.8541.00
134_R137_R0.8531.00
22_E26_Q0.8521.00
140_V143_A0.8521.00
119_I278_M0.8511.00
248_E251_S0.8511.00
147_Q264_R0.8481.00
270_H273_A0.8461.00
174_E189_A0.8431.00
91_L278_M0.8421.00
62_Q84_E0.8371.00
173_A179_N0.8371.00
168_S173_A0.8351.00
28_L35_V0.8341.00
111_A235_T0.8301.00
185_A188_K0.8301.00
190_P217_P0.8301.00
91_L119_I0.8251.00
167_V238_C0.8231.00
155_L158_K0.8231.00
6_Y74_E0.8201.00
163_D256_D0.8181.00
95_L142_G0.8171.00
77_E81_L0.8161.00
172_F190_P0.8151.00
96_A143_A0.8141.00
132_Q136_R0.8061.00
124_Q140_V0.8061.00
176_Y190_P0.8031.00
12_L66_L0.8031.00
284_D288_D0.8031.00
19_R64_Q0.8021.00
77_E80_W0.7961.00
275_E280_R0.7961.00
19_R56_P0.7951.00
154_C268_Y0.7941.00
202_Q206_Q0.7911.00
232_R251_S0.7891.00
153_S271_R0.7891.00
114_L235_T0.7891.00
169_S235_T0.7871.00
16_I19_R0.7861.00
79_E83_D0.7821.00
76_L80_W0.7801.00
62_Q65_K0.7801.00
32_Q36_S0.7781.00
17_R67_L0.7781.00
245_I248_E0.7771.00
207_Q211_L0.7761.00
18_E24_A0.7731.00
277_R281_K0.7731.00
15_V51_L0.7671.00
142_G282_V0.7671.00
40_K49_P0.7661.00
184_S187_L0.7631.00
8_T11_A0.7631.00
168_S257_L0.7611.00
15_V39_I0.7551.00
96_A131_T0.7541.00
116_D281_K0.7421.00
230_L235_T0.7421.00
10_Q14_A0.7391.00
71_R75_L0.7321.00
70_L73_V0.7311.00
80_W84_E0.7311.00
113_V281_K0.7271.00
52_V60_T0.7261.00
21_F35_V0.7261.00
15_V35_V0.7261.00
171_P175_K0.7221.00
97_V102_L0.7201.00
223_S226_A0.7171.00
168_S174_E0.7141.00
187_L213_P0.7131.00
136_R154_C0.7111.00
138_G270_H0.7111.00
169_S172_F0.7081.00
167_V240_I0.7051.00
249_L256_D0.7051.00
64_Q67_L0.7031.00
126_E131_T0.6951.00
43_E53_R0.6941.00
58_R64_Q0.6941.00
94_S140_V0.6921.00
281_K285_A0.6881.00
34_A38_R0.6881.00
43_E48_Q0.6881.00
195_D220_I0.6861.00
184_S211_L0.6851.00
59_P64_Q0.6841.00
62_Q66_L0.6831.00
171_P234_G0.6821.00
203_A207_Q0.6811.00
141_V279_M0.6741.00
103_A229_Q0.6741.00
10_Q13_D0.6731.00
61_E65_K0.6721.00
94_S141_V0.6721.00
207_Q210_D0.6671.00
52_V56_P0.6641.00
112_P288_D0.6621.00
241_P244_Q0.6581.00
194_F227_F0.6571.00
163_D260_G0.6531.00
201_H220_I0.6531.00
202_Q207_Q0.6511.00
66_L84_E0.6501.00
79_E82_G0.6471.00
75_L78_E0.6471.00
205_L209_F0.6471.00
206_Q209_F0.6451.00
167_V249_L0.6451.00
39_I43_E0.6441.00
191_V237_C0.6431.00
7_R41_Q0.6421.00
219_H230_L0.6421.00
171_P174_E0.6401.00
69_L73_V0.6391.00
273_A276_S0.6371.00
188_K216_V0.6371.00
133_E136_R0.6341.00
120_R220_I0.6321.00
173_A176_Y0.6301.00
206_Q210_D0.6281.00
26_Q29_C0.6261.00
97_V106_L0.6261.00
166_F239_M0.6221.00
93_L278_M0.6181.00
166_F186_L0.6151.00
167_V254_L0.6151.00
277_R280_R0.6131.00
70_L74_E0.6071.00
24_A28_L0.6071.00
195_D222_N0.6051.00
174_E177_F0.6051.00
21_F56_P0.6041.00
125_V222_N0.6041.00
15_V20_G0.6021.00
108_P111_A0.6021.00
144_V286_L0.6011.00
203_A206_Q0.6001.00
245_I249_L0.5961.00
142_G283_T0.5961.00
205_L208_N0.5941.00
173_A177_F0.5931.00
182_T258_T0.5911.00
201_H204_F0.5891.00
82_G86_T0.5891.00
10_Q74_E0.5891.00
125_V223_S0.5871.00
48_Q52_V0.5861.00
90_P120_R0.5861.00
204_F207_Q0.5851.00
99_A127_D0.5851.00
282_V286_L0.5821.00
201_H207_Q0.5821.00
106_L109_A0.5811.00
259_P262_F0.5791.00
65_K84_E0.5781.00
166_F191_V0.5771.00
269_W280_R0.5771.00
176_Y179_N0.5751.00
7_R11_A0.5731.00
200_M203_A0.5721.00
93_L142_G0.5721.00
51_L59_P0.5711.00
247_K250_A0.5701.00
46_F66_L0.5701.00
108_P112_P0.5681.00
227_F231_A0.5671.00
12_L63_G0.5651.00
74_E78_E0.5631.00
59_P67_L0.5611.00
31_T37_Q0.5591.00
164_Y239_M0.5591.00
46_F84_E0.5581.00
221_V226_A0.5571.00
101_S105_W0.5551.00
208_N215_S0.5521.00
147_Q156_V0.5511.00
34_A37_Q0.5491.00
196_H220_I0.5481.00
33_S37_Q0.5471.00
230_L236_T0.5461.00
21_F53_R0.5461.00
172_F237_C0.5451.00
155_L272_F0.5451.00
96_A124_Q0.5451.00
5_D45_M0.5411.00
174_E181_V0.5411.00
21_F32_Q0.5401.00
86_T89_T0.5361.00
11_A39_I0.5341.00
159_L267_L0.5341.00
240_I245_I0.5331.00
68_A83_D0.5311.00
108_P229_Q0.5311.00
160_G265_R0.5311.00
110_L121_L0.5291.00
16_I64_Q0.5291.00
105_W109_A0.5281.00
46_F49_P0.5261.00
49_P62_Q0.5241.00
91_L118_P0.5231.00
168_S175_K0.5181.00
224_S241_P0.5181.00
74_E77_E0.5151.00
30_I38_R0.5141.00
11_A24_A0.5121.00
107_L111_A0.5111.00
69_L84_E0.5081.00
73_V81_L0.5081.00
83_D86_T0.5071.00
19_R57_P0.5061.00
96_A126_E0.5061.00
170_K255_I0.5011.00
103_A223_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7441 100 0.131 Contact Map
2esnA 3 0.9731 100 0.134 Contact Map
3fzvA 4 0.9529 100 0.134 Contact Map
1ixcA 4 0.9663 100 0.135 Contact Map
2h9bA 2 0.6936 100 0.148 Contact Map
2h98A 2 0.6936 100 0.149 Contact Map
3ispA 3 0.9731 100 0.15 Contact Map
1al3A 1 0.7003 100 0.155 Contact Map
4x6gA 4 0.9899 100 0.156 Contact Map
3fxqA 3 0.963 100 0.163 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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