GREMLIN Database
YCJF - UPF0283 membrane protein YcjF
UniProt: P0A8R7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12870
Length: 353 (307)
Sequences: 534 (351)
Seq/√Len: 20.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_I313_M5.1561.00
74_G114_A4.3291.00
139_A319_L4.2321.00
321_W327_P3.6451.00
149_G184_D3.6021.00
206_E238_L3.5071.00
242_I316_C3.2431.00
283_M291_L3.1280.99
142_L154_F3.0260.99
218_I301_A2.8010.99
122_E251_G2.7550.99
325_D328_R2.6730.98
87_V91_M2.5600.98
138_E157_K2.5090.97
265_N269_A2.4910.97
178_I187_V2.4550.97
235_N305_T2.4200.97
155_C191_Y2.4140.97
215_T223_L2.4120.97
173_R194_L2.2870.95
70_M207_I2.2280.95
303_L336_L2.1770.94
200_D227_D2.0790.92
283_M330_G2.0610.92
180_E326_K2.0050.91
106_A109_A1.9900.91
207_I242_I1.9840.91
54_A61_R1.9670.90
206_E245_L1.9480.90
200_D317_R1.9420.90
99_W242_I1.9380.89
135_E158_L1.9160.89
93_A192_A1.8990.88
155_C159_A1.8910.88
147_G150_K1.8860.88
43_D131_Q1.8550.87
249_E284_S1.8450.87
242_I245_L1.8420.87
124_R127_W1.8380.87
164_I308_L1.8140.86
76_A79_G1.8110.86
65_S69_K1.8060.86
138_E150_K1.7570.84
219_A298_G1.7540.84
55_V58_A1.7410.84
156_E178_I1.7240.83
41_T44_E1.7210.83
202_Q205_R1.7080.82
126_L252_Y1.6840.81
224_A302_G1.6660.81
222_P270_G1.6480.80
50_G63_K1.6470.80
125_R249_E1.6190.79
64_R110_L1.6030.78
141_D145_S1.5960.78
227_D317_R1.5930.78
99_W207_I1.5780.77
41_T137_D1.5770.77
211_A214_S1.5670.76
102_L106_A1.5590.76
112_I196_Q1.5550.76
273_E297_Q1.5290.75
73_G118_S1.5290.75
166_Q308_L1.5150.74
155_C174_W1.4950.73
267_A288_A1.4810.72
100_V192_A1.4460.70
122_E190_L1.4300.69
68_R207_I1.4270.69
199_L245_L1.4220.69
40_A43_D1.4210.69
302_G306_A1.4080.68
270_G292_S1.4010.68
45_A113_G1.3930.67
235_N304_L1.3600.65
270_G294_R1.3600.65
223_L250_L1.3540.65
278_V282_W1.3410.64
213_E300_G1.3290.64
314_E326_K1.3270.63
46_Q49_E1.3220.63
280_M330_G1.3220.63
284_S301_A1.3220.63
332_F337_I1.3140.63
237_R320_P1.3080.62
120_V123_W1.3060.62
269_A297_Q1.3060.62
41_T56_M1.3030.62
37_F40_A1.2960.62
226_V262_V1.2880.61
191_Y214_S1.2800.61
279_G283_M1.2760.60
155_C281_D1.2520.59
272_S297_Q1.2480.59
183_N327_P1.2450.58
220_V279_G1.2440.58
162_A191_Y1.2380.58
87_V180_E1.2320.58
200_D298_G1.2240.57
151_G224_A1.2160.57
78_F115_G1.2110.56
203_A238_L1.2110.56
80_A84_G1.2040.56
241_R257_R1.1950.55
69_K157_K1.1890.55
36_N39_P1.1820.54
61_R72_M1.1800.54
141_D150_K1.1790.54
133_A136_R1.1770.54
163_G257_R1.1770.54
251_G260_K1.1690.54
49_E54_A1.1610.53
279_G330_G1.1560.53
199_L210_S1.1560.53
126_L129_L1.1550.53
206_E241_R1.1500.52
62_P195_V1.1420.52
134_H207_I1.1340.51
147_G315_L1.1300.51
88_Q106_A1.1240.51
43_D77_L1.1210.50
259_F263_L1.1170.50
307_R318_P1.1160.50
292_S318_P1.1070.49
238_L268_F1.1040.49
260_K326_K1.1030.49
107_A235_N1.1000.49
131_Q202_Q1.0990.49
88_Q96_T1.0960.49
306_A316_C1.0940.49
228_M300_G1.0930.49
81_S84_G1.0830.48
76_A80_A1.0770.48
130_R242_I1.0680.47
234_R273_E1.0680.47
221_S336_L1.0650.47
262_V271_A1.0650.47
223_L226_V1.0600.46
337_I341_K1.0600.46
112_I229_A1.0580.46
298_G317_R1.0560.46
190_L251_G1.0540.46
265_N276_R1.0530.46
73_G110_L1.0450.45
235_N316_C1.0450.45
235_N265_N1.0450.45
202_Q207_I1.0330.45
44_E75_L1.0310.45
181_T217_M1.0310.45
234_R332_F1.0290.44
188_V278_V1.0290.44
277_E294_R1.0250.44
154_F319_L1.0110.43
221_S250_L1.0110.43
251_G302_G1.0080.43
188_V216_L1.0030.43
98_D102_L1.0030.43
265_N297_Q0.9980.42
86_G215_T0.9930.42
75_L260_K0.9930.42
224_A305_T0.9920.42
254_S304_L0.9890.42
99_W335_Q0.9860.42
106_A201_A0.9860.42
240_N300_G0.9860.42
138_E151_G0.9810.41
130_R144_H0.9790.41
266_I311_K0.9790.41
79_G260_K0.9760.41
234_R269_A0.9730.41
210_S241_R0.9730.41
75_L172_Q0.9710.41
74_G104_G0.9630.40
216_L303_L0.9630.40
208_S308_L0.9620.40
39_P44_E0.9480.39
256_L259_F0.9430.39
127_W136_R0.9420.39
208_S335_Q0.9410.39
221_S231_I0.9390.39
116_V216_L0.9350.39
201_A264_L0.9340.38
68_R114_A0.9340.38
42_L324_D0.9250.38
213_E281_D0.9240.38
139_A187_V0.9180.37
235_N294_R0.9130.37
237_R241_R0.9060.37
212_A215_T0.9040.37
214_S218_I0.8960.36
88_Q100_V0.8930.36
316_C327_P0.8890.36
86_G261_L0.8860.36
281_D295_A0.8850.36
294_R305_T0.8840.35
213_E234_R0.8830.35
120_V138_E0.8800.35
50_G54_A0.8800.35
235_N277_E0.8780.35
80_A207_I0.8760.35
76_A323_D0.8680.34
279_G300_G0.8680.34
107_A310_I0.8650.34
234_R297_Q0.8600.34
152_R245_L0.8510.34
180_E316_C0.8460.33
227_D298_G0.8460.33
147_G216_L0.8450.33
68_R98_D0.8390.33
235_N280_M0.8360.33
126_L136_R0.8300.32
132_R296_A0.8300.32
223_L271_A0.8300.32
215_T226_V0.8270.32
98_D101_A0.8260.32
64_R69_K0.8240.32
65_S314_E0.8230.32
272_S293_T0.8230.32
328_R335_Q0.8210.32
76_A260_K0.8210.32
250_L255_R0.8210.32
174_W195_V0.8200.32
167_S171_L0.8190.32
191_Y195_V0.8160.32
228_M255_R0.8140.31
173_R328_R0.8130.31
289_A299_I0.8130.31
164_I316_C0.8110.31
262_V294_R0.8090.31
40_A54_A0.8050.31
66_L69_K0.8040.31
103_G163_G0.8040.31
206_E319_L0.8020.31
158_L183_N0.8020.31
293_T303_L0.8010.31
53_E56_M0.7980.31
186_E272_S0.7970.30
235_N340_V0.7960.30
71_V143_L0.7930.30
161_Q235_N0.7850.30
276_R296_A0.7840.30
307_R317_R0.7810.30
41_T49_E0.7790.29
140_R144_H0.7780.29
103_G106_A0.7770.29
185_R242_I0.7740.29
308_L328_R0.7700.29
159_A171_L0.7690.29
213_E285_Q0.7680.29
208_S230_F0.7680.29
302_G307_R0.7660.29
93_A273_E0.7650.29
125_R257_R0.7640.29
189_S322_I0.7640.29
200_D219_A0.7630.29
52_V57_D0.7620.29
61_R73_G0.7560.28
122_E195_V0.7540.28
139_A256_L0.7510.28
167_S170_A0.7510.28
214_S248_I0.7500.28
183_N276_R0.7470.28
53_E61_R0.7430.28
68_R72_M0.7430.28
166_Q202_Q0.7420.28
216_L293_T0.7380.27
38_A42_L0.7360.27
232_A286_D0.7330.27
204_R286_D0.7300.27
265_N304_L0.7300.27
108_G193_H0.7290.27
139_A224_A0.7250.27
56_M83_V0.7220.26
51_Q55_V0.7190.26
224_A227_D0.7140.26
230_F285_Q0.7120.26
219_A227_D0.7100.26
108_G136_R0.7040.26
90_T334_R0.7040.26
133_A329_L0.7010.25
269_A273_E0.7000.25
87_V90_T0.6950.25
330_G336_L0.6940.25
223_L254_S0.6940.25
175_Y205_R0.6940.25
196_Q324_D0.6930.25
183_N301_A0.6920.25
272_S296_A0.6910.25
134_H176_A0.6880.25
77_L123_W0.6840.25
114_A289_A0.6810.24
122_E222_P0.6790.24
277_E285_Q0.6780.24
51_Q156_E0.6770.24
156_E159_A0.6760.24
214_S297_Q0.6760.24
116_V144_H0.6760.24
156_E332_F0.6750.24
61_R66_L0.6740.24
70_M74_G0.6730.24
107_A333_R0.6710.24
90_T244_T0.6670.24
51_Q61_R0.6660.24
45_A51_Q0.6660.24
217_M296_A0.6650.24
288_A331_D0.6650.24
124_R136_R0.6620.24
83_V127_W0.6600.23
121_T342_E0.6590.23
243_A342_E0.6580.23
159_A242_I0.6530.23
159_A321_W0.6530.23
275_V296_A0.6520.23
231_I288_A0.6500.23
122_E126_L0.6470.23
86_G207_I0.6470.23
265_N273_E0.6440.23
286_D290_R0.6440.23
150_K163_G0.6420.23
45_A330_G0.6410.23
39_P42_L0.6370.22
276_R301_A0.6370.22
64_R76_A0.6360.22
144_H197_P0.6350.22
274_L291_L0.6350.22
166_Q293_T0.6350.22
303_L327_P0.6330.22
308_L329_L0.6330.22
47_E175_Y0.6320.22
201_A332_F0.6310.22
68_R153_A0.6280.22
99_W115_G0.6270.22
126_L217_M0.6270.22
264_L299_I0.6260.22
145_S150_K0.6240.22
36_N40_A0.6230.22
57_D256_L0.6200.22
213_E231_I0.6140.21
118_S274_L0.6140.21
231_I301_A0.6140.21
259_F279_G0.6120.21
220_V262_V0.6120.21
206_E221_S0.6110.21
175_Y324_D0.6100.21
49_E105_C0.6100.21
104_G230_F0.6080.21
47_E64_R0.6080.21
268_F303_L0.6070.21
68_R323_D0.6060.21
162_A308_L0.6050.21
217_M269_A0.6020.21
271_A277_E0.6010.21
291_L324_D0.6000.21
134_H334_R0.6000.21
282_W285_Q0.5960.21
39_P88_Q0.5910.20
125_R313_M0.5900.20
161_Q228_M0.5890.20
72_M117_G0.5890.20
313_M327_P0.5870.20
143_L314_E0.5860.20
200_D246_Y0.5860.20
81_S231_I0.5860.20
136_R331_D0.5850.20
255_R300_G0.5830.20
134_H220_V0.5830.20
205_R303_L0.5830.20
51_Q54_A0.5820.20
186_E336_L0.5810.20
183_N249_E0.5810.20
172_Q207_I0.5810.20
153_A156_E0.5790.20
103_G198_V0.5790.20
116_V120_V0.5780.20
225_L228_M0.5780.20
145_S205_R0.5780.20
278_V294_R0.5780.20
309_G318_P0.5780.20
256_L296_A0.5760.20
112_I119_V0.5750.20
129_L294_R0.5730.20
139_A149_G0.5720.20
85_Q181_T0.5700.20
93_A199_L0.5700.20
55_V140_R0.5670.19
252_Y255_R0.5670.19
196_Q232_A0.5640.19
104_G278_V0.5630.19
54_A119_V0.5620.19
238_L261_L0.5610.19
107_A176_A0.5610.19
143_L184_D0.5610.19
52_V68_R0.5590.19
105_C323_D0.5590.19
111_I294_R0.5580.19
289_A305_T0.5580.19
48_E63_K0.5570.19
141_D236_L0.5570.19
248_I275_V0.5560.19
199_L249_E0.5550.19
186_E221_S0.5550.19
159_A281_D0.5550.19
132_R161_Q0.5550.19
233_W297_Q0.5550.19
169_P176_A0.5550.19
239_I262_V0.5520.19
42_L116_V0.5520.19
219_A302_G0.5500.19
158_L257_R0.5500.19
250_L279_G0.5500.19
47_E160_Q0.5490.19
207_I259_F0.5480.19
54_A110_L0.5470.19
297_Q311_K0.5470.19
304_L308_L0.5430.18
67_W300_G0.5430.18
246_Y318_P0.5420.18
206_E335_Q0.5410.18
58_A137_D0.5390.18
183_N213_E0.5390.18
274_L277_E0.5390.18
77_L150_K0.5370.18
268_F277_E0.5360.18
251_G292_S0.5350.18
93_A297_Q0.5350.18
112_I116_V0.5330.18
49_E109_A0.5330.18
64_R68_R0.5330.18
44_E242_I0.5310.18
308_L336_L0.5310.18
235_N262_V0.5310.18
64_R156_E0.5310.18
105_C137_D0.5300.18
117_G120_V0.5270.18
88_Q130_R0.5270.18
103_G135_E0.5240.18
122_E290_R0.5220.18
206_E239_I0.5220.18
48_E53_E0.5210.18
79_G175_Y0.5210.18
89_W220_V0.5210.18
164_I259_F0.5200.18
274_L315_L0.5190.18
176_A316_C0.5170.17
265_N315_L0.5150.17
213_E265_N0.5150.17
139_A299_I0.5130.17
97_Q102_L0.5130.17
194_L314_E0.5130.17
188_V330_G0.5120.17
103_G108_G0.5110.17
173_R188_V0.5090.17
133_A337_I0.5040.17
164_I340_V0.5030.17
45_A160_Q0.5020.17
128_R210_S0.5020.17
84_G115_G0.5010.17
191_Y199_L0.5010.17
77_L108_G0.5010.17
206_E231_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.1926 24.5 0.97 Contact Map
1pi7A 1 0.0538 9.3 0.975 Contact Map
3j00Z 1 0.272 7.2 0.976 Contact Map
3effK 4 0.3059 7.2 0.976 Contact Map
2f95B 2 0.1161 6.6 0.977 Contact Map
2kncB 1 0.2238 6.5 0.977 Contact Map
2m20A 2 0.17 5.4 0.978 Contact Map
3ph0A 1 0.1501 4.6 0.978 Contact Map
3fymA 1 0.1388 3.8 0.979 Contact Map
3wdoA 1 0.17 3.4 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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