GREMLIN Database
SLYX - Protein SlyX
UniProt: P0A8R4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11664
Length: 72 (69)
Sequences: 215 (110)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A65_E2.8350.96
61_A67_T2.5500.92
22_I26_E2.3580.89
34_H41_L2.3160.88
9_R14_E2.2110.85
30_T34_H2.1450.83
43_D47_L2.1180.82
60_I63_Q2.1090.82
29_V32_T2.0580.81
30_T35_E2.0000.79
6_L9_R1.8280.72
31_V35_E1.8280.72
52_L55_S1.6700.65
7_E11_A1.6560.64
23_T50_E1.6440.63
31_V34_H1.5900.61
16_R42_R1.5760.60
5_S53_K1.4040.51
42_R56_Q1.3410.48
54_A59_N1.3260.47
21_E65_E1.3030.46
42_R51_K1.2850.45
47_L54_A1.2370.42
35_E56_Q1.2260.42
54_A57_P1.2140.41
6_L38_M1.1980.40
57_P63_Q1.1940.40
35_E42_R1.1930.40
26_E44_H1.1840.39
28_N40_K1.1810.39
5_S12_E1.1540.38
23_T54_A1.1350.37
25_E49_T1.1060.36
19_F63_Q1.0860.35
7_E15_S1.0830.34
7_E43_D1.0720.34
35_E41_L1.0550.33
4_L8_A1.0400.32
34_H39_A0.9720.29
12_E17_L0.9720.29
11_A25_E0.9650.29
50_E57_P0.9460.28
42_R46_R0.9270.27
25_E28_N0.9170.27
29_V62_S0.8910.26
45_L56_Q0.8700.25
18_A23_T0.8630.25
6_L32_T0.8460.24
32_T56_Q0.8370.24
37_E42_R0.8360.24
30_T47_L0.8130.23
15_S43_D0.8050.23
36_M46_R0.7950.22
55_S59_N0.7930.22
30_T38_M0.7790.22
21_E61_A0.7570.21
4_L45_L0.7540.21
18_A33_A0.7490.21
12_E39_A0.7330.20
31_V44_H0.7250.20
51_K62_S0.7190.20
48_L52_L0.7110.19
12_E51_K0.6880.19
40_K44_H0.6780.18
28_N49_T0.6660.18
33_A45_L0.6620.18
4_L25_E0.6510.17
14_E56_Q0.6490.17
38_M45_L0.6480.17
9_R53_K0.6470.17
26_E37_E0.6440.17
32_T40_K0.6370.17
22_I47_L0.6330.17
12_E29_V0.6270.17
59_N65_E0.6200.17
12_E21_E0.6080.16
25_E45_L0.6000.16
15_S42_R0.5960.16
34_H51_K0.5930.16
16_R25_E0.5930.16
15_S50_E0.5860.16
37_E59_N0.5830.15
12_E16_R0.5800.15
42_R58_S0.5780.15
30_T33_A0.5740.15
38_M52_L0.5690.15
12_E37_E0.5660.15
20_Q24_I0.5630.15
33_A58_S0.5620.15
15_S59_N0.5610.15
33_A37_E0.5520.15
19_F59_N0.5490.15
34_H38_M0.5470.15
61_A64_A0.5390.14
21_E25_E0.5380.14
9_R48_L0.5330.14
29_V41_L0.5270.14
7_E17_L0.5200.14
41_L62_S0.5180.14
40_K52_L0.5110.14
18_A24_I0.5090.14
48_L57_P0.5060.13
29_V49_T0.5050.13
6_L16_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3efgA 3 0.7083 99.9 0.274 Contact Map
1fzcC 2 0.8194 66.2 0.868 Contact Map
1lwuC 1 1 61.8 0.872 Contact Map
1m1jC 2 1 48.2 0.882 Contact Map
2ykoA 3 0.8889 48.1 0.882 Contact Map
3a7oA 2 0.6528 46.7 0.883 Contact Map
4rgwB 1 0 40.7 0.887 Contact Map
3ghgC 2 1 38.5 0.889 Contact Map
4rsjA 2 0.8194 38.4 0.889 Contact Map
4cr2M 1 0.6528 37.9 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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