GREMLIN Database
RRAA - Regulator of ribonuclease activity A
UniProt: P0A8R0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11879
Length: 161 (153)
Sequences: 3617 (2217)
Seq/√Len: 179.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_A101_D3.4091.00
100_D148_N3.0861.00
37_I128_D3.0211.00
65_G73_L2.6641.00
55_N87_W2.6511.00
144_L153_L2.6011.00
74_V79_A2.5601.00
128_D140_S2.5211.00
126_E129_V2.4421.00
56_G59_R2.4091.00
36_I144_L2.3821.00
90_L107_I2.1791.00
40_K126_E2.1111.00
37_I59_R2.1001.00
8_L145_Y2.0831.00
95_A113_A1.9961.00
103_E148_N1.9711.00
36_I138_F1.9481.00
40_K64_D1.9321.00
130_R139_F1.8991.00
79_A102_L1.8631.00
32_F89_G1.8581.00
29_R106_D1.7971.00
19_V133_F1.7791.00
110_Q146_A1.7401.00
74_V90_L1.7391.00
29_R148_N1.7371.00
57_R86_E1.7081.00
102_L109_I1.6711.00
35_Q59_R1.6551.00
139_F157_P1.6381.00
25_N110_Q1.6231.00
32_F60_V1.5931.00
83_V105_L1.5871.00
26_F111_A1.5831.00
99_V114_A1.5511.00
146_A151_I1.5351.00
22_L112_M1.5031.00
80_R84_Q1.5011.00
96_V102_L1.4981.00
32_F146_A1.4701.00
54_Q127_S1.4471.00
99_V149_T1.3951.00
91_V144_L1.3801.00
45_N121_G1.2991.00
60_V88_E1.2771.00
129_V140_S1.2691.00
32_F110_Q1.2531.00
74_V82_A1.2491.00
36_I142_D1.2491.00
6_S149_T1.2471.00
83_V106_D1.2141.00
35_Q58_G1.2001.00
132_N137_T1.1641.00
19_V138_F1.1611.00
28_G103_E1.1501.00
7_E10_D1.1251.00
30_A106_D1.1251.00
71_R119_A1.1201.00
69_V95_A1.1061.00
145_Y154_S1.1031.00
99_V103_E1.0971.00
93_Y112_M1.0781.00
47_L50_D1.0681.00
91_V151_I1.0651.00
53_E81_L1.0591.00
62_V144_L1.0471.00
80_R105_L1.0361.00
74_V78_L1.0351.00
55_N61_L1.0321.00
77_E81_L1.0280.99
101_D104_E1.0110.99
83_V107_I0.9990.99
40_K66_G0.9980.99
35_Q143_H0.9980.99
52_L78_L0.9970.99
22_L134_G0.9860.99
19_V134_G0.9800.99
73_L92_I0.9640.99
23_F133_F0.9630.99
20_E134_G0.9580.99
37_I127_S0.9580.99
27_G106_D0.9550.99
91_V146_A0.9530.99
44_D123_G0.9520.99
64_D93_Y0.9510.99
36_I153_L0.9510.99
96_V111_A0.9510.99
27_G30_A0.9470.99
4_D7_E0.9450.99
25_N28_G0.9340.99
24_S114_A0.9260.99
33_G145_Y0.9240.99
142_D155_E0.9160.99
133_F138_F0.9160.99
82_A87_W0.9130.99
17_N142_D0.9110.99
9_C13_Q0.9020.99
61_L87_W0.8980.99
93_Y133_F0.8870.98
52_L81_L0.8860.98
77_E80_R0.8830.98
31_S100_D0.8780.98
138_F153_L0.8690.98
96_V109_I0.8680.98
69_V112_M0.8670.98
38_T128_D0.8650.98
37_I51_L0.8620.98
61_L82_A0.8610.98
51_L61_L0.8480.98
130_R137_T0.8440.98
41_C73_L0.8420.98
76_A80_R0.8340.98
35_Q156_D0.8340.98
31_S148_N0.8330.98
56_G85_N0.8310.98
22_L69_V0.8140.97
71_R115_I0.8110.97
50_D54_Q0.8080.97
50_D127_S0.8010.97
20_E133_F0.8000.97
52_L82_A0.7970.97
77_E118_G0.7910.97
43_E70_R0.7850.97
20_E135_G0.7830.97
61_L90_L0.7800.97
7_E13_Q0.7800.97
138_F144_L0.7790.97
21_P95_A0.7690.96
19_V23_F0.7670.96
132_N135_G0.7640.96
50_D53_E0.7480.96
48_L63_V0.7440.96
37_I56_G0.7420.95
9_C12_Y0.7350.95
26_F99_V0.7310.95
139_F142_D0.7290.95
46_G124_I0.7280.95
35_Q88_E0.7210.95
19_V153_L0.7170.95
18_V117_V0.7130.94
76_A105_L0.6940.94
33_G143_H0.6890.93
23_F134_G0.6780.93
74_V92_I0.6760.93
13_Q122_E0.6730.93
44_D125_G0.6690.92
37_I54_Q0.6570.92
12_Y155_E0.6570.92
27_G103_E0.6560.92
37_I55_N0.6540.91
110_Q151_I0.6530.91
100_D104_E0.6520.91
39_V63_V0.6520.91
24_S99_V0.6500.91
64_D132_N0.6500.91
139_F155_E0.6480.91
53_E78_L0.6480.91
59_R128_D0.6470.91
56_G87_W0.6440.91
49_Y121_G0.6430.91
100_D149_T0.6410.91
79_A105_L0.6350.90
41_C48_L0.6340.90
136_V153_L0.6340.90
122_E126_E0.6310.90
41_C63_V0.6290.90
59_R88_E0.6240.89
38_T131_V0.6210.89
9_C116_P0.6210.89
42_F125_G0.6170.89
35_Q56_G0.6170.89
23_F151_I0.6160.89
19_V144_L0.6130.89
92_I96_V0.6060.88
55_N59_R0.6030.88
55_N85_N0.6030.88
51_L127_S0.6010.88
97_R118_G0.6010.88
71_R117_V0.5940.87
46_G119_A0.5930.87
63_V92_I0.5890.87
49_Y78_L0.5860.86
60_V91_V0.5840.86
100_D103_E0.5830.86
64_D67_G0.5810.86
72_A119_A0.5770.85
53_E77_E0.5760.85
72_A149_T0.5730.85
13_Q16_V0.5710.85
45_N125_G0.5700.85
67_G93_Y0.5690.85
12_Y154_S0.5690.85
5_T8_L0.5650.84
55_N82_A0.5600.84
79_A107_I0.5540.83
8_L154_S0.5510.83
49_Y53_E0.5500.83
46_G50_D0.5490.83
25_N30_A0.5490.83
99_V148_N0.5450.82
17_N155_E0.5440.82
73_L94_G0.5390.81
52_L61_L0.5360.81
81_L84_Q0.5350.81
116_P150_G0.5340.81
72_A78_L0.5340.81
40_K131_V0.5310.80
4_D143_H0.5250.80
52_L83_V0.5250.80
21_P69_V0.5240.80
57_R88_E0.5240.80
4_D101_D0.5210.79
45_N118_G0.5200.79
138_F142_D0.5190.79
53_E85_N0.5190.79
23_F26_F0.5190.79
83_V86_E0.5190.79
93_Y138_F0.5180.79
9_C18_V0.5170.79
130_R142_D0.5150.78
9_C117_V0.5110.78
134_G138_F0.5110.78
43_E71_R0.5080.77
64_D131_V0.5070.77
96_V99_V0.5070.77
73_L119_A0.5070.77
65_G92_I0.5040.77
5_T9_C0.5010.76
40_K129_V0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vi4A 1 0.9938 100 0.078 Contact Map
3c8oA 4 1 100 0.081 Contact Map
1q5xA 3 0.9938 100 0.085 Contact Map
1j3lA 3 0.9938 100 0.103 Contact Map
3nojA 5 0.9938 100 0.106 Contact Map
2pcnA 3 0.9876 100 0.114 Contact Map
3k4iA 3 0.9814 100 0.12 Contact Map
2c5qA 3 1 100 0.131 Contact Map
1nxjA 3 0.9441 100 0.133 Contact Map
1kblA 2 0.8509 47 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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