GREMLIN Database
CLPS - ATP-dependent Clp protease adapter protein ClpS
UniProt: P0A8Q6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14241
Length: 106 (94)
Sequences: 1061 (603)
Seq/√Len: 62.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_Y61_L4.2491.00
85_V103_L4.0671.00
64_A68_Q3.7681.00
53_Y57_R3.6291.00
48_Q55_V3.2831.00
33_V102_T3.1251.00
61_L71_A3.1171.00
50_F91_Y2.9161.00
39_P97_H2.6391.00
31_I70_K2.5021.00
79_E82_E2.3071.00
54_D57_R2.0911.00
64_A71_A2.0371.00
89_N100_L2.0171.00
31_I72_I1.8991.00
88_V101_C1.7230.99
29_K72_I1.5840.99
79_E83_T1.5670.99
29_K75_V1.5400.99
32_L99_L1.4980.98
39_P100_L1.3520.97
73_C101_C1.3230.96
83_T87_M1.2720.95
91_Y95_N1.2690.95
45_D91_Y1.2530.95
33_V100_L1.2500.95
50_F87_M1.2390.95
86_A90_K1.2060.94
33_V39_P1.1980.94
37_Y82_E1.1890.93
44_I62_M1.1780.93
20_D24_P1.1640.93
59_T63_L1.1460.92
85_V102_T1.1350.92
22_L94_E1.0970.90
40_M62_M1.0580.89
86_A94_E1.0420.88
82_E103_L1.0380.88
32_L101_C1.0210.87
29_K104_E1.0210.87
23_K26_S1.0150.86
32_L65_V0.9620.83
77_T80_V0.9540.83
32_L71_A0.9230.81
55_V59_T0.8920.78
91_Y96_E0.8800.77
11_D80_V0.8750.77
15_E20_D0.8740.77
45_D49_K0.8660.76
13_L16_E0.8630.76
45_D48_Q0.8590.76
48_Q75_V0.8520.75
70_K104_E0.8400.74
50_F95_N0.8150.72
90_K102_T0.8090.71
11_D52_S0.8080.71
23_K65_V0.7970.70
32_L46_V0.7800.68
50_F88_V0.7770.68
89_N93_R0.7750.68
90_K94_E0.7740.68
32_L78_A0.7670.67
30_V63_L0.7500.65
79_E103_L0.7450.65
50_F97_H0.7190.62
32_L103_L0.7140.62
41_E55_V0.7100.61
71_A74_G0.7100.61
46_V49_K0.7080.61
53_Y96_E0.7010.60
14_A17_K0.7000.60
88_V99_L0.6990.60
31_I71_A0.6940.59
60_Q64_A0.6850.58
82_E100_L0.6800.58
91_Y94_E0.6640.56
24_P52_S0.6610.56
53_Y76_F0.6590.55
46_V76_F0.6560.55
11_D15_E0.6520.55
28_Y40_M0.6520.55
58_A74_G0.6480.54
40_M63_L0.6450.54
68_Q77_T0.6400.53
50_F96_E0.6390.53
63_L67_Y0.6380.53
13_L17_K0.6380.53
36_D39_P0.6360.53
26_S101_C0.6350.53
80_V94_E0.6330.52
54_D60_Q0.6320.52
73_C88_V0.6290.52
65_V71_A0.6260.52
12_Q15_E0.6230.51
40_M66_H0.6230.51
30_V92_A0.6130.50
57_R60_Q0.6110.50
45_D50_F0.6060.49
11_D14_A0.5950.48
23_K70_K0.5840.47
16_E79_E0.5830.47
26_S84_K0.5810.47
26_S60_Q0.5800.46
22_L90_K0.5760.46
22_L100_L0.5720.46
29_K70_K0.5690.45
73_C97_H0.5680.45
77_T94_E0.5680.45
47_L52_S0.5670.45
17_K60_Q0.5650.45
24_P78_A0.5640.45
58_A93_R0.5630.44
75_V99_L0.5610.44
48_Q94_E0.5540.43
39_P50_F0.5530.43
13_L22_L0.5510.43
19_R48_Q0.5500.43
32_L40_M0.5490.43
84_K87_M0.5450.42
33_V78_A0.5430.42
72_I102_T0.5420.42
25_P74_G0.5410.42
44_I54_D0.5400.42
71_A104_E0.5360.41
21_A100_L0.5360.41
22_L56_E0.5330.41
33_V73_C0.5310.41
62_M66_H0.5310.41
63_L95_N0.5300.41
24_P68_Q0.5250.40
26_S103_L0.5230.40
31_I69_G0.5160.39
45_D95_N0.5080.38
46_V69_G0.5080.38
65_V74_G0.5060.38
49_K91_Y0.5060.38
24_P37_Y0.5030.38
49_K86_A0.5030.38
65_V73_C0.5020.38
17_K95_N0.5010.38
39_P89_N0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w9rA 1 0.8962 100 0.269 Contact Map
3dnjA 1 0.7642 100 0.316 Contact Map
3o1fA 1 0.7547 100 0.343 Contact Map
4xczA 2 0.5755 22.2 0.934 Contact Map
2blnA 1 0.5094 17.4 0.937 Contact Map
3tqqA 1 0.5283 12.9 0.941 Contact Map
1fmtA 1 0.5755 12.2 0.941 Contact Map
2bw0A 1 0.5755 11.8 0.941 Contact Map
3ewtE 1 0.1226 11.2 0.942 Contact Map
4wkgA 5 0.5283 10.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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