GREMLIN Database
FRDD - Fumarate reductase subunit D
UniProt: P0A8Q3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10333
Length: 119 (112)
Sequences: 166 (94)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_I100_V2.5510.81
39_L44_L2.5090.80
62_F68_L2.4190.77
56_L60_Q2.1230.67
14_F23_M2.1010.66
14_F25_S2.0980.66
74_L105_A2.0390.64
58_F77_W1.9430.60
80_L105_A1.8820.57
59_A68_L1.8630.56
95_P101_F1.8480.56
87_M115_G1.8300.55
25_S32_M1.8130.54
38_I70_L1.7940.53
49_A90_L1.7270.50
19_G84_H1.7260.50
37_G41_P1.7100.50
38_I106_A1.7000.49
88_H93_H1.7000.49
11_E85_H1.6540.47
11_E19_G1.6490.47
39_L45_F1.6060.45
38_I111_V1.5780.44
36_V116_V1.5690.44
6_P84_H1.5530.43
28_I40_L1.5130.41
31_V117_V1.5000.41
39_L43_G1.4660.39
40_L90_L1.4640.39
20_A42_L1.4430.38
23_M103_G1.3820.36
23_M77_W1.3720.36
8_R19_G1.3670.35
33_I51_S1.3270.34
64_G75_P1.3050.33
34_L111_V1.3000.33
44_L49_A1.2790.32
110_V113_L1.2760.32
43_G49_A1.2600.31
59_A77_W1.2600.31
19_G85_H1.2600.31
76_L108_L1.2470.31
77_W109_T1.2400.30
31_V107_I1.2360.30
16_G67_F1.2350.30
8_R88_H1.2140.30
59_A62_F1.1560.28
9_S13_V1.1470.27
28_I38_I1.1330.27
24_W67_F1.1220.26
22_G78_C1.1210.26
11_E109_T1.1150.26
10_D65_R1.1080.26
90_L100_V1.0970.26
11_E23_M1.0890.25
31_V34_L1.0890.25
65_R116_V1.0750.25
34_L58_F1.0750.25
11_E75_P1.0580.24
5_N32_M1.0500.24
23_M27_I1.0310.23
13_V78_C1.0280.23
17_L117_V1.0140.23
76_L90_L1.0100.23
34_L69_F1.0050.23
72_I109_T0.9860.22
84_H97_G0.9790.22
80_L86_A0.9560.21
69_F113_L0.9520.21
69_F109_T0.9430.21
27_I61_S0.9340.21
13_V92_I0.9290.20
57_A111_V0.9280.20
44_L115_G0.9260.20
35_L92_I0.8990.20
46_P57_A0.8990.20
81_H85_H0.8980.20
52_Y55_V0.8880.19
76_L80_L0.8690.19
62_F67_F0.8650.19
46_P69_F0.8590.19
104_L108_L0.8510.18
55_V70_L0.8420.18
41_P44_L0.8410.18
33_I56_L0.8370.18
111_V115_G0.8310.18
61_S83_M0.8240.18
84_H95_P0.8230.18
62_F117_V0.8130.17
28_I117_V0.8130.17
55_V114_I0.7940.17
81_H90_L0.7880.17
78_C101_F0.7840.17
27_I32_M0.7820.17
24_W29_A0.7790.17
85_H89_D0.7760.16
75_P86_A0.7740.16
59_A104_L0.7690.16
69_F106_A0.7680.16
5_N31_V0.7670.16
84_H91_K0.7660.16
32_M79_G0.7640.16
14_F32_M0.7600.16
78_C105_A0.7570.16
45_F51_S0.7570.16
41_P75_P0.7510.16
25_S29_A0.7470.16
72_I100_V0.7410.16
25_S69_F0.7320.15
61_S68_L0.7190.15
103_G115_G0.7140.15
19_G24_W0.7120.15
8_R12_P0.7110.15
5_N116_V0.7110.15
72_I112_T0.7060.15
17_L67_F0.7010.15
106_A114_I0.6990.15
73_V104_L0.6970.15
63_I113_L0.6860.14
48_D68_L0.6770.14
70_L106_A0.6760.14
56_L117_V0.6720.14
14_F98_K0.6710.14
10_D63_I0.6710.14
33_I92_I0.6700.14
60_Q72_I0.6660.14
63_I83_M0.6610.14
75_P84_H0.6530.14
73_V89_D0.6520.14
45_F55_V0.6440.14
25_S79_G0.6370.13
17_L26_A0.6320.13
8_R85_H0.6250.13
90_L101_F0.6050.13
31_V96_A0.6030.13
40_L50_L0.5990.13
27_I78_C0.5950.13
61_S117_V0.5950.13
43_G88_H0.5920.13
19_G77_W0.5910.13
13_V39_L0.5890.12
42_L50_L0.5880.12
95_P98_K0.5870.12
10_D107_I0.5840.12
20_A64_G0.5830.12
18_F21_G0.5690.12
15_W21_G0.5690.12
15_W18_F0.5690.12
52_Y72_I0.5640.12
42_L81_H0.5620.12
35_L58_F0.5610.12
29_A78_C0.5600.12
53_E86_A0.5590.12
14_F29_A0.5580.12
29_A32_M0.5510.12
23_M92_I0.5500.12
31_V91_K0.5460.12
19_G65_R0.5430.12
30_P42_L0.5410.12
31_V108_L0.5360.12
50_L99_W0.5280.11
64_G77_W0.5230.11
25_S65_R0.5230.11
22_G105_A0.5100.11
19_G29_A0.5030.11
67_F117_V0.5030.11
69_F73_V0.5020.11
68_L96_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kf6D 2 1 100 0.022 Contact Map
2wdqC 1 0.8739 96.3 0.863 Contact Map
2wdqD 2 0.8403 95.6 0.872 Contact Map
4ytpC 1 0.8908 86.5 0.901 Contact Map
1zoyC 1 0.8908 84.8 0.903 Contact Map
2h88C 2 0.8908 81.6 0.907 Contact Map
4ysxC 1 0.916 74.9 0.912 Contact Map
2bs2C 2 0.9412 53.2 0.924 Contact Map
1kf6C 1 0.9664 45.3 0.927 Contact Map
3wxyA 2 0.2689 14.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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