GREMLIN Database
FRDC - Fumarate reductase subunit C
UniProt: P0A8Q0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10332
Length: 131 (126)
Sequences: 183 (106)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T79_A4.3770.99
87_W94_A3.1130.93
39_F73_N3.0670.92
55_E58_A3.0180.92
28_L82_L2.9460.91
90_L94_A2.8130.89
85_K89_E2.5150.82
87_W93_K2.2700.75
63_F69_I2.1690.71
38_W60_F2.1430.70
69_I73_N2.1320.70
26_Y50_L2.1100.69
91_A94_A2.0460.67
43_L74_L1.8950.60
87_W90_L1.8920.60
31_G34_V1.8740.59
34_V97_I1.8480.58
46_G50_L1.8170.57
38_W72_I1.6840.51
20_L60_F1.6600.50
3_T128_A1.6380.49
15_T18_K1.5920.47
49_A52_N1.5890.47
49_A63_F1.5550.45
72_I109_I1.5490.45
35_P79_A1.5170.44
75_I116_V1.5160.44
42_E64_L1.4500.41
21_P126_F1.4360.40
48_F118_V1.4180.39
40_S91_A1.3980.39
94_A113_L1.3960.38
17_W90_L1.3690.37
123_V128_A1.3570.37
70_V118_V1.3210.35
114_W117_T1.3090.35
43_L72_I1.3040.35
33_A64_L1.2960.34
39_F69_I1.2690.33
41_I59_G1.2420.32
84_T98_I1.2100.31
89_E110_I1.1960.30
75_I81_L1.1820.30
46_G125_L1.1750.30
15_T118_V1.1560.29
40_S94_A1.1480.29
44_I61_V1.1350.28
90_L93_K1.1340.28
41_I68_V1.1030.27
23_Y29_R1.0720.26
63_F73_N1.0590.26
36_A87_W1.0290.24
7_P57_W1.0250.24
39_F49_A1.0200.24
71_I75_I1.0180.24
63_F115_A1.0080.24
21_P96_N0.9970.23
84_T116_V0.9900.23
11_P78_A0.9890.23
4_K91_A0.9860.23
71_I120_A0.9860.23
95_A127_V0.9810.23
76_T80_A0.9800.23
104_M123_V0.9730.23
54_P58_A0.9730.23
47_L85_K0.9710.23
113_L117_T0.9680.23
33_A75_I0.9600.22
71_I78_A0.9570.22
123_V127_V0.9410.22
54_P124_I0.9280.21
87_W91_A0.9260.21
26_Y46_G0.9180.21
36_A114_W0.9140.21
13_T95_A0.9020.21
9_V66_N0.9020.21
61_V70_V0.9010.21
106_P112_S0.9010.21
81_L119_V0.8990.20
4_K19_K0.8970.20
93_K96_N0.8920.20
28_L84_T0.8910.20
76_T112_S0.8880.20
13_T113_L0.8780.20
91_A96_N0.8750.20
100_K105_G0.8640.19
31_G104_M0.8610.19
31_G79_A0.8560.19
53_G101_D0.8550.19
32_T114_W0.8520.19
34_V100_K0.8390.19
17_W64_L0.8330.19
55_E110_I0.8300.19
72_I128_A0.8270.18
11_P107_E0.8180.18
118_V125_L0.8070.18
17_W83_H0.8030.18
49_A72_I0.7880.17
29_R81_L0.7860.17
68_V81_L0.7860.17
35_P104_M0.7840.17
71_I125_L0.7800.17
15_T94_A0.7800.17
63_F72_I0.7780.17
77_L125_L0.7770.17
41_I104_M0.7740.17
46_G86_T0.7710.17
41_I95_A0.7540.17
78_A118_V0.7510.17
78_A122_I0.7460.16
77_L109_I0.7420.16
75_I119_V0.7410.16
97_I101_D0.7380.16
24_R79_A0.7350.16
112_S120_A0.7340.16
41_I116_V0.7270.16
64_L87_W0.7240.16
32_T91_A0.7240.16
17_W86_T0.7190.16
60_F64_L0.7170.16
15_T21_P0.7120.16
87_W113_L0.7100.16
31_G100_K0.6980.15
63_F66_N0.6970.15
31_G58_A0.6930.15
21_P101_D0.6920.15
32_T122_I0.6900.15
38_W42_E0.6860.15
98_I106_P0.6850.15
82_L96_N0.6840.15
33_A117_T0.6770.15
111_K115_A0.6730.15
29_R90_L0.6690.15
20_L117_T0.6680.15
54_P100_K0.6650.14
34_V61_V0.6620.14
5_R22_F0.6540.14
52_N63_F0.6510.14
70_V107_E0.6440.14
39_F63_F0.6420.14
55_E109_I0.6360.14
24_R82_L0.6360.14
18_K128_A0.6340.14
38_W73_N0.6340.14
19_K62_D0.6290.14
93_K106_P0.6200.14
104_M118_V0.6200.14
97_I111_K0.6130.13
21_P25_F0.6110.13
35_P114_W0.6030.13
25_F29_R0.5970.13
25_F52_N0.5960.13
67_P92_P0.5960.13
110_I126_F0.5890.13
25_F82_L0.5890.13
14_S102_E0.5870.13
85_K110_I0.5840.13
71_I118_V0.5820.13
95_A122_I0.5740.13
52_N109_I0.5700.13
79_A114_W0.5680.12
76_T96_N0.5540.12
40_S87_W0.5530.12
12_M51_K0.5520.12
27_M37_V0.5490.12
68_V126_F0.5440.12
40_S98_I0.5330.12
83_H101_D0.5330.12
3_T111_K0.5320.12
100_K104_M0.5320.12
101_D111_K0.5300.12
40_S93_K0.5260.12
82_L111_K0.5230.12
33_A87_W0.5220.12
77_L83_H0.5220.12
32_T128_A0.5210.12
78_A119_V0.5180.12
82_L91_A0.5150.11
62_D123_V0.5120.11
59_G75_I0.5120.11
23_Y100_K0.5110.11
51_K107_E0.5110.11
79_A117_T0.5090.11
64_L98_I0.5070.11
45_F123_V0.5070.11
26_Y125_L0.5060.11
74_L127_V0.5030.11
13_T89_E0.5010.11
81_L122_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kf6C 1 0.9924 100 0.018 Contact Map
2wdqC 1 0.8855 93.3 0.896 Contact Map
2wdqD 2 0.771 90.8 0.904 Contact Map
1zoyC 1 0.9008 90.5 0.904 Contact Map
4ytpC 1 0.8855 88.6 0.908 Contact Map
2h88C 2 0.9008 84.6 0.913 Contact Map
4ysxC 1 0.9313 84.1 0.914 Contact Map
2bs2C 2 0.8931 80.4 0.917 Contact Map
1kf6D 2 0.8779 29 0.941 Contact Map
1m56C 2 0.7328 8.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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