GREMLIN Database
XERD - Tyrosine recombinase XerD
UniProt: P0A8P8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11071
Length: 298 (269)
Sequences: 37778 (30311)
Seq/√Len: 1848.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_A268_L5.0571.00
157_M193_L3.2231.00
51_Q54_D3.1841.00
177_R269_G3.0801.00
146_G250_F2.7851.00
242_S245_V2.7461.00
142_L243_P2.7291.00
149_V244_H2.6991.00
250_F267_L2.5911.00
45_L54_D2.5731.00
62_R75_L2.4961.00
156_T217_Q2.2261.00
156_T208_V2.2021.00
142_L152_L2.1901.00
168_R178_L2.1781.00
270_H276_T2.1551.00
165_G186_V2.0671.00
248_H281_H2.0501.00
32_D74_R2.0481.00
137_A192_Y2.0281.00
156_T207_D2.0011.00
114_S117_Q1.9691.00
144_A182_G1.9331.00
260_D263_V1.9071.00
166_V178_L1.8921.00
255_L264_V1.8791.00
59_L76_L1.8601.00
186_V190_E1.8491.00
262_R265_Q1.8201.00
151_E177_R1.7941.00
161_S164_Q1.7811.00
32_D78_A1.7581.00
35_M75_L1.7471.00
30_R34_S1.7391.00
180_P267_L1.7271.00
85_Y89_E1.7231.00
268_L276_T1.6811.00
12_L30_R1.6731.00
175_K271_S1.6501.00
135_D226_R1.6451.00
254_L259_A1.6221.00
274_S277_Q1.5981.00
55_L97_S1.5781.00
147_L152_L1.5751.00
256_N286_R1.5301.00
115_E253_H1.5261.00
250_F254_L1.5121.00
255_L280_T1.5001.00
82_L86_L1.4951.00
25_T29_Y1.4941.00
143_Y253_H1.4871.00
8_I33_L1.4811.00
181_L186_V1.4711.00
138_M223_F1.4661.00
162_L190_E1.4371.00
8_I82_L1.4351.00
136_K140_E1.4331.00
50_A83_F1.4301.00
156_T159_D1.4191.00
46_T49_T1.4141.00
140_E188_W1.4121.00
157_M209_L1.4021.00
149_V220_R1.4011.00
70_T74_R1.4001.00
149_V153_V1.3951.00
265_Q273_L1.3821.00
113_L249_A1.3711.00
254_L264_V1.3671.00
125_P230_Y1.3631.00
252_T281_H1.3611.00
275_T278_I1.3571.00
144_A185_A1.3451.00
161_S166_V1.3371.00
24_N27_N1.3271.00
262_R266_M1.3191.00
118_V143_Y1.3111.00
23_E27_N1.3041.00
117_Q120_R1.2821.00
137_A191_T1.2811.00
122_L140_E1.2631.00
150_S154_G1.2551.00
58_L75_L1.2521.00
63_L72_S1.2441.00
73_A103_P1.2401.00
113_L241_L1.2381.00
208_V217_Q1.2381.00
138_M152_L1.2161.00
137_A188_W1.2121.00
118_V253_H1.2111.00
265_Q276_T1.2101.00
36_M39_W1.2071.00
58_L62_R1.2021.00
220_R224_W1.2001.00
27_N31_R1.1991.00
148_R244_H1.1881.00
147_L169_V1.1871.00
158_S207_D1.1861.00
143_Y246_L1.1801.00
249_A253_H1.1771.00
149_V224_W1.1751.00
11_F81_R1.1741.00
84_Q98_A1.1701.00
59_L63_L1.1661.00
16_W26_L1.1661.00
39_W61_E1.1651.00
71_S75_L1.1641.00
256_N283_A1.1541.00
119_E123_Q1.1471.00
251_A264_V1.1471.00
221_Q224_W1.1371.00
76_L80_R1.1251.00
87_Y92_R1.1251.00
170_I176_E1.1201.00
231_A241_L1.1151.00
165_G183_E1.1151.00
124_A233_L1.1121.00
226_R229_H1.1081.00
112_D249_A1.1041.00
227_I231_A1.1021.00
12_L26_L1.0991.00
155_L167_V1.0981.00
272_D277_Q1.0961.00
115_E257_H1.0951.00
124_A234_A1.0951.00
168_R176_E1.0931.00
67_Y75_L1.0871.00
68_K71_S1.0801.00
138_M210_F1.0721.00
143_Y249_A1.0711.00
219_T222_T1.0701.00
272_D275_T1.0691.00
56_Q60_A1.0671.00
250_F268_L1.0611.00
113_L121_L1.0601.00
224_W228_K1.0591.00
26_L30_R1.0511.00
158_S206_I1.0481.00
251_A280_T1.0441.00
120_R124_A1.0431.00
222_T225_H1.0351.00
28_A31_R1.0321.00
32_D75_L1.0281.00
90_K94_D1.0251.00
182_G185_A1.0171.00
183_E187_Y1.0151.00
39_W57_A1.0051.00
29_Y78_A1.0041.00
252_T280_T1.0041.00
28_A32_D1.0031.00
45_L49_T0.9961.00
21_L26_L0.9811.00
144_A184_E0.9791.00
192_Y196_G0.9741.00
141_V210_F0.9651.00
286_R289_Q0.9641.00
83_F92_R0.9621.00
136_K188_W0.9601.00
141_V167_V0.9591.00
212_S216_Q0.9561.00
115_E119_E0.9541.00
52_S56_Q0.9481.00
228_K240_K0.9471.00
125_P139_L0.9471.00
253_H256_N0.9461.00
140_E184_E0.9451.00
113_L117_Q0.9401.00
153_V220_R0.9371.00
84_Q95_D0.9361.00
86_L91_F0.9361.00
10_Q14_A0.9341.00
170_I174_N0.9291.00
56_Q89_E0.9281.00
15_L21_L0.9241.00
63_L69_A0.9211.00
31_R35_M0.9201.00
208_V211_P0.9181.00
157_M196_G0.9141.00
115_E256_N0.9111.00
39_W58_L0.9051.00
161_S168_R0.8921.00
22_A25_T0.8921.00
24_N28_A0.8911.00
133_L191_T0.8861.00
28_A74_R0.8811.00
88_R101_A0.8791.00
259_A263_V0.8751.00
67_Y71_S0.8741.00
62_R67_Y0.8731.00
133_L195_H0.8711.00
251_A255_L0.8681.00
184_E187_Y0.8641.00
10_Q91_F0.8581.00
83_F96_P0.8581.00
162_L186_V0.8571.00
74_R77_S0.8571.00
248_H278_I0.8571.00
9_E13_D0.8571.00
112_D281_H0.8561.00
12_L16_W0.8551.00
263_V290_L0.8541.00
141_V185_A0.8461.00
80_R84_Q0.8461.00
137_A210_F0.8441.00
36_M41_H0.8441.00
266_M287_L0.8421.00
21_L29_Y0.8401.00
67_Y72_S0.8381.00
34_S38_E0.8351.00
111_K245_V0.8351.00
52_S88_R0.8341.00
261_L277_Q0.8341.00
159_D170_I0.8301.00
224_W243_P0.8271.00
88_R99_H0.8201.00
23_E26_L0.8191.00
36_M83_F0.8181.00
285_E289_Q0.8171.00
133_L137_A0.8141.00
155_L160_I0.8131.00
229_H233_L0.8081.00
129_Q132_E0.8051.00
230_Y233_L0.8051.00
62_R72_S0.8021.00
265_Q277_Q0.8021.00
149_V223_F0.7981.00
54_D57_A0.7971.00
33_L38_E0.7951.00
153_V223_F0.7941.00
145_T179_V0.7891.00
11_F15_L0.7861.00
228_K232_V0.7821.00
87_Y95_D0.7821.00
57_A61_E0.7781.00
251_A276_T0.7711.00
256_N285_E0.7671.00
146_G268_L0.7661.00
191_T195_H0.7661.00
95_D98_A0.7661.00
181_L185_A0.7641.00
61_E65_G0.7631.00
185_A188_W0.7611.00
125_P136_K0.7601.00
149_V243_P0.7491.00
124_A230_Y0.7481.00
133_L136_K0.7431.00
135_D230_Y0.7401.00
225_H229_H0.7391.00
141_V152_L0.7351.00
261_L273_L0.7341.00
31_R34_S0.7341.00
86_L92_R0.7321.00
227_I246_L0.7311.00
83_F97_S0.7301.00
9_E30_R0.7291.00
148_R170_I0.7221.00
82_L85_Y0.7211.00
8_I12_L0.7201.00
37_V41_H0.7171.00
121_L231_A0.7161.00
221_Q228_K0.7151.00
255_L283_A0.7111.00
222_T226_R0.7091.00
52_S90_K0.7091.00
226_R230_Y0.7041.00
190_E194_E0.7041.00
121_L139_L0.7031.00
58_L61_E0.6991.00
196_G211_P0.6981.00
15_L19_K0.6961.00
113_L245_V0.6951.00
190_E193_L0.6941.00
267_L287_L0.6921.00
87_Y94_D0.6901.00
56_Q59_L0.6901.00
141_V147_L0.6871.00
35_M65_G0.6871.00
155_L209_L0.6851.00
263_V267_L0.6851.00
87_Y98_A0.6841.00
273_L277_Q0.6831.00
60_A63_L0.6821.00
228_K231_A0.6801.00
70_T73_A0.6801.00
36_M79_V0.6801.00
193_L196_G0.6801.00
76_L97_S0.6781.00
251_A270_H0.6781.00
39_W42_H0.6741.00
142_L149_V0.6741.00
161_S165_G0.6731.00
53_D57_A0.6721.00
16_W30_R0.6711.00
33_L82_L0.6691.00
227_I243_P0.6691.00
244_H248_H0.6691.00
273_L276_T0.6661.00
53_D89_E0.6651.00
187_Y191_T0.6591.00
55_L79_V0.6571.00
241_L245_V0.6551.00
223_F243_P0.6541.00
97_S100_L0.6541.00
73_A77_S0.6521.00
38_E42_H0.6511.00
35_M58_L0.6501.00
90_K99_H0.6491.00
139_L246_L0.6491.00
15_L29_Y0.6481.00
272_D276_T0.6461.00
187_Y190_E0.6441.00
137_A141_V0.6441.00
118_V122_L0.6431.00
59_L72_S0.6421.00
13_D16_W0.6401.00
83_F87_Y0.6391.00
137_A185_A0.6391.00
40_L61_E0.6361.00
112_D252_T0.6331.00
9_E38_E0.6311.00
140_E185_A0.6311.00
284_T287_L0.6301.00
120_R123_Q0.6291.00
147_L151_E0.6291.00
61_E64_E0.6281.00
116_A120_R0.6221.00
134_R192_Y0.6221.00
84_Q87_Y0.6191.00
255_L260_D0.6181.00
36_M58_L0.6171.00
145_T182_G0.6161.00
259_A290_L0.6161.00
262_R277_Q0.6151.00
50_A55_L0.6151.00
69_A73_A0.6101.00
122_L136_K0.6091.00
283_A286_R0.6071.00
189_L209_L0.6061.00
140_E144_A0.6051.00
171_G177_R0.6021.00
110_P242_S0.6001.00
259_A264_V0.6001.00
154_G217_Q0.5991.00
36_M40_L0.5961.00
80_R102_S0.5951.00
264_V280_T0.5951.00
147_L167_V0.5921.00
38_E41_H0.5901.00
41_H58_L0.5891.00
188_W191_T0.5881.00
245_V248_H0.5881.00
115_E249_A0.5871.00
118_V249_A0.5861.00
265_Q275_T0.5841.00
285_E288_R0.5831.00
47_L86_L0.5831.00
255_L262_R0.5821.00
192_Y195_H0.5811.00
10_Q85_Y0.5791.00
255_L261_L0.5781.00
80_R97_S0.5781.00
14_A85_Y0.5771.00
10_Q13_D0.5771.00
58_L79_V0.5751.00
116_A119_E0.5731.00
85_Y91_F0.5711.00
15_L81_R0.5691.00
79_V97_S0.5641.00
33_L78_A0.5641.00
261_L276_T0.5621.00
139_L227_I0.5581.00
147_L155_L0.5541.00
137_A189_L0.5541.00
160_I189_L0.5531.00
87_Y90_K0.5421.00
265_Q268_L0.5421.00
271_S275_T0.5411.00
81_R84_Q0.5371.00
253_H257_H0.5371.00
151_E269_G0.5361.00
141_V189_L0.5351.00
10_Q89_E0.5341.00
142_L246_L0.5341.00
33_L37_V0.5261.00
162_L209_L0.5251.00
113_L118_V0.5251.00
110_P248_H0.5241.00
73_A105_L0.5231.00
157_M189_L0.5221.00
255_L282_V0.5211.00
134_R137_A0.5191.00
76_L100_L0.5181.00
73_A102_S0.5181.00
107_Q278_I0.5161.00
230_Y234_A0.5161.00
134_R226_R0.5131.00
47_L83_F0.5131.00
160_I209_L0.5081.00
12_L15_L0.5071.00
261_L265_Q0.5061.00
87_Y99_H0.5051.00
151_E169_V0.5031.00
80_R98_A0.5021.00
162_L181_L0.5011.00
156_T206_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.9094 100 0.127 Contact Map
1z1bA 3 0.9329 100 0.198 Contact Map
2a3vA 3 0.943 100 0.202 Contact Map
1z19A 3 0.9396 100 0.203 Contact Map
1xo0A 3 0.9631 100 0.218 Contact Map
4a8eA 2 0.8792 100 0.231 Contact Map
3nkhA 2 0.6409 100 0.397 Contact Map
1ae9A 4 0.5671 100 0.462 Contact Map
1aihA 2 0.5537 99.9 0.514 Contact Map
4e0gA 2 0.896 99.9 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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