XERC - ECOLI - GREMLIN Contacts

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XERC - Tyrosine recombinase XerC

UniProt:	P0A8P6	Sequences: MTDLHTDVERYLRYLSVERQLSPITLLNYQRQLEAIINFASENGLQSWQQCDVTMVRNFAVRSRRKGLGAASLALRLSALRSFFDWLVSQNELKANPAKGVSAPKAPRHLPKNIDVDDMNRLLDIDINDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLESGEVWVMGKGSKERRLPIGRNAVAWIEHWLDLRDLFGSEDDALFLSKLGKRISARNVQKRFAEWGIKQGLNNHVHPHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11069
Length:	298 (271)
Sequences:	37991 (30394)
Seq/√Len:	1846.3

ECOLI - XERC XERD INTR INTQ INTF INTZ INTD INTB INTA INTS INTE FIMB FIME
BACSU - XERC XERD INT YOPP YOMM YOEC
HALSA - Q9HR66 Q9HQV5 O54590 O52010 Q9HSI7
SULSO - Q980D9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
247_A	264_L	5.104	1.00
52_D	55_M	3.258	1.00
157_I	193_L	3.254	1.00
177_R	265_G	3.248	1.00
238_H	241_K	2.816	1.00
149_L	240_H	2.802	1.00
146_G	246_F	2.794	1.00
142_M	239_P	2.742	1.00
246_F	263_L	2.628	1.00
63_S	76_R	2.530	1.00
156_D	214_R	2.313	1.00
46_Q	55_M	2.273	1.00
266_H	272_T	2.241	1.00
156_D	205_A	2.230	1.00
142_M	152_L	2.226	1.00
244_H	277_H	2.212	1.00
32_Q	75_L	2.082	1.00
165_G	186_V	2.076	1.00
168_W	178_R	2.064	1.00
151_E	177_R	2.054	1.00
137_A	192_W	2.036	1.00
115_D	118_D	2.026	1.00
256_D	259_G	1.990	1.00
156_D	204_D	1.954	1.00
251_L	260_V	1.951	1.00
144_G	182_G	1.941	1.00
60_A	77_L	1.867	1.00
186_V	190_E	1.828	1.00
258_R	261_Q	1.817	1.00
30_Q	34_E	1.793	1.00
161_D	164_S	1.782	1.00
180_P	263_L	1.770	1.00
175_K	267_A	1.749	1.00
35_A	76_R	1.739	1.00
86_W	90_Q	1.724	1.00
264_L	272_T	1.704	1.00
32_Q	79_A	1.701	1.00
135_D	223_R	1.643	1.00
12_L	30_Q	1.631	1.00
56_V	98_A	1.613	1.00
250_M	255_G	1.611	1.00
147_L	152_L	1.593	1.00
252_E	282_H	1.582	1.00
116_V	249_H	1.559	1.00
8_V	33_L	1.552	1.00
47_S	50_Q	1.535	1.00
270_S	273_Q	1.522	1.00
143_Y	249_H	1.499	1.00
246_F	250_M	1.499	1.00
251_L	276_T	1.497	1.00
181_I	186_V	1.491	1.00
8_V	83_F	1.486	1.00
157_I	206_L	1.480	1.00
161_D	166_E	1.478	1.00
138_M	220_V	1.477	1.00
136_R	140_E	1.465	1.00
83_F	87_L	1.456	1.00
250_M	260_V	1.454	1.00
71_A	75_L	1.454	1.00
51_C	84_F	1.453	1.00
248_T	277_H	1.440	1.00
166_E	178_R	1.417	1.00
162_L	190_E	1.415	1.00
140_E	188_W	1.403	1.00
24_I	27_L	1.393	1.00
156_D	159_H	1.392	1.00
114_I	245_S	1.385	1.00
25_T	29_Y	1.370	1.00
149_L	217_A	1.364	1.00
261_Q	269_L	1.358	1.00
149_L	153_V	1.348	1.00
159_H	170_M	1.345	1.00
59_F	76_R	1.340	1.00
144_G	185_A	1.331	1.00
118_D	121_R	1.320	1.00
205_A	214_R	1.308	1.00
271_T	274_I	1.305	1.00
137_A	191_H	1.303	1.00
74_A	104_P	1.299	1.00
23_P	27_L	1.292	1.00
158_K	204_D	1.289	1.00
119_M	143_Y	1.288	1.00
258_R	262_E	1.287	1.00
11_Y	82_S	1.267	1.00
148_R	240_H	1.248	1.00
59_F	63_S	1.237	1.00
150_S	154_G	1.236	1.00
261_Q	272_T	1.231	1.00
114_I	237_V	1.231	1.00
138_M	152_L	1.228	1.00
120_N	124_D	1.228	1.00
217_A	221_Q	1.225	1.00
123_L	140_E	1.219	1.00
7_D	87_L	1.217	1.00
137_A	188_W	1.216	1.00
85_D	99_K	1.210	1.00
72_S	76_R	1.200	1.00
245_S	249_H	1.194	1.00
16_S	26_L	1.194	1.00
64_R	73_L	1.191	1.00
149_L	221_Q	1.186	1.00
60_A	64_R	1.176	1.00
143_Y	242_L	1.173	1.00
119_M	249_H	1.165	1.00
77_L	81_R	1.163	1.00
218_R	221_Q	1.155	1.00
27_L	31_R	1.151	1.00
247_A	260_V	1.138	1.00
69_G	72_S	1.137	1.00
268_N	271_T	1.133	1.00
12_L	26_L	1.130	1.00
125_I	231_Q	1.121	1.00
216_S	219_N	1.120	1.00
165_G	183_R	1.119	1.00
116_V	253_S	1.114	1.00
252_E	279_D	1.112	1.00
228_G	237_V	1.112	1.00
143_Y	245_S	1.108	1.00
158_K	203_D	1.103	1.00
183_R	187_A	1.095	1.00
138_M	207_F	1.095	1.00
7_D	86_W	1.086	1.00
224_F	228_G	1.086	1.00
223_R	226_E	1.083	1.00
246_F	264_L	1.079	1.00
88_V	93_L	1.077	1.00
57_R	61_V	1.073	1.00
147_L	169_V	1.070	1.00
113_N	245_S	1.064	1.00
91_N	95_A	1.060	1.00
221_Q	225_A	1.059	1.00
68_L	76_R	1.059	1.00
155_L	167_V	1.057	1.00
114_I	122_L	1.057	1.00
268_N	273_Q	1.052	1.00
247_A	276_T	1.051	1.00
170_M	176_E	1.050	1.00
248_T	276_T	1.050	1.00
26_L	30_Q	1.047	1.00
125_I	230_K	1.040	1.00
168_W	176_E	1.038	1.00
182_G	185_A	1.036	1.00
121_R	125_I	1.014	1.00
7_D	48_W	1.007	1.00
32_Q	76_R	1.002	1.00
153_V	217_A	1.000	1.00
28_N	32_Q	0.992	1.00
219_N	222_K	0.989	1.00
141_V	207_F	0.985	1.00
157_I	196_R	0.980	1.00
140_E	184_N	0.978	1.00
87_L	92_E	0.976	1.00
28_N	31_R	0.972	1.00
40_A	43_N	0.969	1.00
136_R	188_W	0.961	1.00
57_R	90_Q	0.959	1.00
114_I	118_D	0.959	1.00
21_L	26_L	0.954	1.00
22_S	25_T	0.953	1.00
116_V	120_N	0.948	1.00
24_I	28_N	0.947	1.00
225_A	236_H	0.946	1.00
84_F	97_P	0.942	1.00
10_R	14_Y	0.941	1.00
249_H	252_E	0.936	1.00
144_G	184_N	0.935	1.00
116_V	252_E	0.934	1.00
282_H	285_S	0.933	1.00
192_W	196_R	0.933	1.00
64_R	70_A	0.928	1.00
284_A	288_D	0.925	1.00
63_S	68_L	0.922	1.00
15_L	21_L	0.921	1.00
31_R	35_A	0.919	1.00
29_Y	79_A	0.913	1.00
205_A	208_L	0.913	1.00
85_D	96_N	0.907	1.00
68_L	72_S	0.899	1.00
133_V	191_H	0.897	1.00
84_F	93_L	0.891	1.00
262_E	283_L	0.890	1.00
113_N	277_H	0.890	1.00
53_V	57_R	0.888	1.00
53_V	89_S	0.887	1.00
42_E	62_R	0.887	1.00
259_G	286_V	0.884	1.00
184_N	187_A	0.881	1.00
10_R	92_E	0.878	1.00
9_E	13_R	0.878	1.00
141_V	167_V	0.877	1.00
221_Q	239_P	0.875	1.00
244_H	274_I	0.875	1.00
247_A	251_L	0.869	1.00
37_I	41_S	0.865	1.00
226_E	230_K	0.865	1.00
281_Q	285_S	0.863	1.00
21_L	29_Y	0.859	1.00
89_S	100_G	0.857	1.00
133_V	195_L	0.855	1.00
209_S	213_K	0.852	1.00
155_L	160_L	0.851	1.00
261_Q	273_Q	0.847	1.00
255_G	259_G	0.847	1.00
141_V	185_A	0.843	1.00
149_L	220_V	0.843	1.00
137_A	207_F	0.841	1.00
225_A	229_I	0.840	1.00
269_L	272_T	0.835	1.00
9_E	30_Q	0.832	1.00
28_N	75_L	0.831	1.00
23_P	26_L	0.830	1.00
257_L	273_Q	0.829	1.00
75_L	78_S	0.829	1.00
12_L	16_S	0.825	1.00
81_R	85_D	0.819	1.00
89_S	102_S	0.818	1.00
68_L	73_L	0.817	1.00
46_Q	50_Q	0.814	1.00
141_V	152_L	0.814	1.00
112_K	241_K	0.813	1.00
162_L	186_V	0.809	1.00
146_G	264_L	0.809	1.00
59_F	62_R	0.807	1.00
153_V	220_V	0.802	1.00
268_N	272_T	0.800	1.00
58_N	62_R	0.800	1.00
63_S	73_L	0.797	1.00
55_M	58_N	0.796	1.00
88_V	96_N	0.795	1.00
36_I	84_F	0.793	1.00
84_F	98_A	0.793	1.00
9_E	40_A	0.792	1.00
145_A	179_L	0.789	1.00
170_M	174_S	0.786	1.00
252_E	281_Q	0.785	1.00
43_N	59_F	0.784	1.00
157_I	197_D	0.782	1.00
96_N	99_K	0.778	1.00
227_W	230_K	0.773	1.00
125_I	227_W	0.769	1.00
133_V	137_A	0.767	1.00
185_A	188_W	0.764	1.00
191_H	195_L	0.759	1.00
31_R	34_E	0.757	1.00
135_D	227_W	0.752	1.00
149_L	239_P	0.748	1.00
77_L	98_A	0.747	1.00
122_L	139_L	0.744	1.00
247_A	272_T	0.741	1.00
251_L	279_D	0.739	1.00
247_A	266_H	0.735	1.00
181_I	185_A	0.733	1.00
133_V	136_R	0.732	1.00
222_K	226_E	0.729	1.00
218_R	225_A	0.726	1.00
122_L	228_G	0.721	1.00
71_A	74_A	0.717	1.00
141_V	147_L	0.716	1.00
91_N	100_G	0.712	1.00
83_F	86_W	0.707	1.00
114_I	241_K	0.707	1.00
155_L	206_L	0.706	1.00
190_E	194_D	0.706	1.00
196_R	208_L	0.705	1.00
11_Y	15_L	0.704	1.00
223_R	227_W	0.701	1.00
269_L	273_Q	0.700	1.00
224_F	242_L	0.700	1.00
257_L	269_L	0.698	1.00
220_V	239_P	0.697	1.00
88_V	95_A	0.695	1.00
57_R	60_A	0.693	1.00
190_E	193_L	0.692	1.00
33_L	83_F	0.688	1.00
193_L	197_D	0.687	1.00
36_I	80_L	0.684	1.00
142_M	149_L	0.683	1.00
240_H	244_H	0.682	1.00
285_S	288_D	0.682	1.00
16_S	30_Q	0.681	1.00
87_L	93_L	0.679	1.00
224_F	239_P	0.675	1.00
263_L	283_L	0.674	1.00
219_N	223_R	0.672	1.00
147_L	151_E	0.672	1.00
54_T	90_Q	0.672	1.00
35_A	59_F	0.671	1.00
53_V	91_N	0.669	1.00
140_E	185_A	0.665	1.00
193_L	196_R	0.664	1.00
7_D	83_F	0.662	1.00
123_L	136_R	0.661	1.00
259_G	263_L	0.659	1.00
237_V	241_K	0.658	1.00
74_A	78_S	0.655	1.00
61_V	64_R	0.655	1.00
139_L	242_L	0.654	1.00
187_A	191_H	0.653	1.00
15_L	19_R	0.653	1.00
54_T	58_N	0.653	1.00
241_K	244_H	0.650	1.00
161_D	165_G	0.648	1.00
171_G	177_R	0.645	1.00
187_A	190_E	0.645	1.00
60_A	73_L	0.641	1.00
137_A	185_A	0.640	1.00
117_D	121_R	0.640	1.00
13_R	16_S	0.638	1.00
137_A	141_V	0.634	1.00
84_F	88_V	0.632	1.00
15_L	82_S	0.632	1.00
113_N	248_T	0.631	1.00
8_V	12_L	0.630	1.00
15_L	29_Y	0.626	1.00
255_G	286_V	0.624	1.00
51_C	56_V	0.624	1.00
157_I	189_I	0.622	1.00
119_M	123_L	0.622	1.00
189_I	206_L	0.621	1.00
121_R	124_D	0.620	1.00
81_R	98_A	0.619	1.00
225_A	228_G	0.614	1.00
10_R	13_R	0.613	1.00
255_G	260_V	0.613	1.00
81_R	103_A	0.613	1.00
145_A	182_G	0.612	1.00
163_E	166_E	0.611	1.00
62_R	66_K	0.611	1.00
251_L	256_D	0.607	1.00
36_I	59_F	0.606	1.00
258_R	273_Q	0.605	1.00
111_P	238_H	0.603	1.00
56_V	80_L	0.602	1.00
188_W	191_H	0.602	1.00
251_L	258_R	0.601	1.00
88_V	99_K	0.598	1.00
140_E	144_G	0.597	1.00
160_L	189_I	0.597	1.00
260_V	276_T	0.595	1.00
183_R	288_D	0.592	1.00
119_M	245_S	0.588	1.00
281_Q	284_A	0.588	1.00
134_R	192_W	0.587	1.00
43_N	58_N	0.587	1.00
48_W	87_L	0.586	1.00
257_L	272_T	0.583	1.00
116_V	245_S	0.583	1.00
117_D	120_N	0.583	1.00
126_D	227_W	0.583	1.00
86_W	92_E	0.581	1.00
261_Q	271_T	0.578	1.00
85_D	88_V	0.576	1.00
280_F	283_L	0.576	1.00
147_L	155_L	0.575	1.00
70_A	74_A	0.574	1.00
10_R	86_W	0.571	1.00
261_Q	268_N	0.569	1.00
251_L	257_L	0.568	1.00
33_L	79_A	0.568	1.00
36_I	41_S	0.568	1.00
161_D	168_W	0.567	1.00
279_D	282_H	0.566	1.00
137_A	189_I	0.566	1.00
98_A	101_V	0.565	1.00
134_R	137_A	0.564	1.00
129_D	132_A	0.564	1.00
218_R	222_K	0.564	1.00
59_F	80_L	0.561	1.00
227_W	231_Q	0.560	1.00
154_G	214_R	0.559	1.00
33_L	40_A	0.556	1.00
191_H	194_D	0.550	1.00
80_L	98_A	0.549	1.00
88_V	91_N	0.548	1.00
151_E	265_G	0.540	1.00
139_L	224_F	0.539	1.00
134_R	223_R	0.539	1.00
267_A	271_T	0.538	1.00
74_A	103_A	0.535	1.00
21_L	25_T	0.534	1.00
126_D	136_R	0.534	1.00
74_A	106_A	0.533	1.00
53_V	100_G	0.529	1.00
192_W	195_L	0.529	1.00
111_P	244_H	0.528	1.00
108_R	274_I	0.528	1.00
82_S	85_D	0.527	1.00
261_Q	264_L	0.523	1.00
251_L	278_L	0.521	1.00
114_I	119_M	0.520	1.00
84_F	96_N	0.520	1.00
121_R	231_Q	0.520	1.00
132_A	136_R	0.519	1.00
142_M	242_L	0.519	1.00
126_D	139_L	0.518	1.00
156_D	203_D	0.518	1.00
77_L	101_V	0.517	1.00
147_L	167_V	0.516	1.00
35_A	66_K	0.515	1.00
160_L	206_L	0.514	1.00
162_L	165_G	0.512	1.00
257_L	261_Q	0.506	1.00
43_N	55_M	0.503	1.00
152_L	239_P	0.501	1.00
29_Y	32_Q	0.501	1.00
248_T	252_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a0pA	1	0.8926	100	0.171	Contact Map
2a3vA	3	0.9329	100	0.211	Contact Map
1z19A	3	0.9295	100	0.214	Contact Map
1z1bA	3	0.9295	100	0.22	Contact Map
1xo0A	3	0.9597	100	0.225	Contact Map
4a8eA	2	0.8792	100	0.25	Contact Map
3nkhA	2	0.6342	100	0.401	Contact Map
1ae9A	4	0.5537	100	0.471	Contact Map
1aihA	2	0.5638	100	0.513	Contact Map
4e0gA	2	0.8826	99.9	0.554	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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