GREMLIN Database
XERC - Tyrosine recombinase XerC
UniProt: P0A8P6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11069
Length: 298 (271)
Sequences: 37991 (30394)
Seq/√Len: 1846.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_A264_L5.1041.00
52_D55_M3.2581.00
157_I193_L3.2541.00
177_R265_G3.2481.00
238_H241_K2.8161.00
149_L240_H2.8021.00
146_G246_F2.7941.00
142_M239_P2.7421.00
246_F263_L2.6281.00
63_S76_R2.5301.00
156_D214_R2.3131.00
46_Q55_M2.2731.00
266_H272_T2.2411.00
156_D205_A2.2301.00
142_M152_L2.2261.00
244_H277_H2.2121.00
32_Q75_L2.0821.00
165_G186_V2.0761.00
168_W178_R2.0641.00
151_E177_R2.0541.00
137_A192_W2.0361.00
115_D118_D2.0261.00
256_D259_G1.9901.00
156_D204_D1.9541.00
251_L260_V1.9511.00
144_G182_G1.9411.00
60_A77_L1.8671.00
186_V190_E1.8281.00
258_R261_Q1.8171.00
30_Q34_E1.7931.00
161_D164_S1.7821.00
180_P263_L1.7701.00
175_K267_A1.7491.00
35_A76_R1.7391.00
86_W90_Q1.7241.00
264_L272_T1.7041.00
32_Q79_A1.7011.00
135_D223_R1.6431.00
12_L30_Q1.6311.00
56_V98_A1.6131.00
250_M255_G1.6111.00
147_L152_L1.5931.00
252_E282_H1.5821.00
116_V249_H1.5591.00
8_V33_L1.5521.00
47_S50_Q1.5351.00
270_S273_Q1.5221.00
143_Y249_H1.4991.00
246_F250_M1.4991.00
251_L276_T1.4971.00
181_I186_V1.4911.00
8_V83_F1.4861.00
157_I206_L1.4801.00
161_D166_E1.4781.00
138_M220_V1.4771.00
136_R140_E1.4651.00
83_F87_L1.4561.00
250_M260_V1.4541.00
71_A75_L1.4541.00
51_C84_F1.4531.00
248_T277_H1.4401.00
166_E178_R1.4171.00
162_L190_E1.4151.00
140_E188_W1.4031.00
24_I27_L1.3931.00
156_D159_H1.3921.00
114_I245_S1.3851.00
25_T29_Y1.3701.00
149_L217_A1.3641.00
261_Q269_L1.3581.00
149_L153_V1.3481.00
159_H170_M1.3451.00
59_F76_R1.3401.00
144_G185_A1.3311.00
118_D121_R1.3201.00
205_A214_R1.3081.00
271_T274_I1.3051.00
137_A191_H1.3031.00
74_A104_P1.2991.00
23_P27_L1.2921.00
158_K204_D1.2891.00
119_M143_Y1.2881.00
258_R262_E1.2871.00
11_Y82_S1.2671.00
148_R240_H1.2481.00
59_F63_S1.2371.00
150_S154_G1.2361.00
261_Q272_T1.2311.00
114_I237_V1.2311.00
138_M152_L1.2281.00
120_N124_D1.2281.00
217_A221_Q1.2251.00
123_L140_E1.2191.00
7_D87_L1.2171.00
137_A188_W1.2161.00
85_D99_K1.2101.00
72_S76_R1.2001.00
245_S249_H1.1941.00
16_S26_L1.1941.00
64_R73_L1.1911.00
149_L221_Q1.1861.00
60_A64_R1.1761.00
143_Y242_L1.1731.00
119_M249_H1.1651.00
77_L81_R1.1631.00
218_R221_Q1.1551.00
27_L31_R1.1511.00
247_A260_V1.1381.00
69_G72_S1.1371.00
268_N271_T1.1331.00
12_L26_L1.1301.00
125_I231_Q1.1211.00
216_S219_N1.1201.00
165_G183_R1.1191.00
116_V253_S1.1141.00
252_E279_D1.1121.00
228_G237_V1.1121.00
143_Y245_S1.1081.00
158_K203_D1.1031.00
183_R187_A1.0951.00
138_M207_F1.0951.00
7_D86_W1.0861.00
224_F228_G1.0861.00
223_R226_E1.0831.00
246_F264_L1.0791.00
88_V93_L1.0771.00
57_R61_V1.0731.00
147_L169_V1.0701.00
113_N245_S1.0641.00
91_N95_A1.0601.00
221_Q225_A1.0591.00
68_L76_R1.0591.00
155_L167_V1.0571.00
114_I122_L1.0571.00
268_N273_Q1.0521.00
247_A276_T1.0511.00
170_M176_E1.0501.00
248_T276_T1.0501.00
26_L30_Q1.0471.00
125_I230_K1.0401.00
168_W176_E1.0381.00
182_G185_A1.0361.00
121_R125_I1.0141.00
7_D48_W1.0071.00
32_Q76_R1.0021.00
153_V217_A1.0001.00
28_N32_Q0.9921.00
219_N222_K0.9891.00
141_V207_F0.9851.00
157_I196_R0.9801.00
140_E184_N0.9781.00
87_L92_E0.9761.00
28_N31_R0.9721.00
40_A43_N0.9691.00
136_R188_W0.9611.00
57_R90_Q0.9591.00
114_I118_D0.9591.00
21_L26_L0.9541.00
22_S25_T0.9531.00
116_V120_N0.9481.00
24_I28_N0.9471.00
225_A236_H0.9461.00
84_F97_P0.9421.00
10_R14_Y0.9411.00
249_H252_E0.9361.00
144_G184_N0.9351.00
116_V252_E0.9341.00
282_H285_S0.9331.00
192_W196_R0.9331.00
64_R70_A0.9281.00
284_A288_D0.9251.00
63_S68_L0.9221.00
15_L21_L0.9211.00
31_R35_A0.9191.00
29_Y79_A0.9131.00
205_A208_L0.9131.00
85_D96_N0.9071.00
68_L72_S0.8991.00
133_V191_H0.8971.00
84_F93_L0.8911.00
262_E283_L0.8901.00
113_N277_H0.8901.00
53_V57_R0.8881.00
53_V89_S0.8871.00
42_E62_R0.8871.00
259_G286_V0.8841.00
184_N187_A0.8811.00
10_R92_E0.8781.00
9_E13_R0.8781.00
141_V167_V0.8771.00
221_Q239_P0.8751.00
244_H274_I0.8751.00
247_A251_L0.8691.00
37_I41_S0.8651.00
226_E230_K0.8651.00
281_Q285_S0.8631.00
21_L29_Y0.8591.00
89_S100_G0.8571.00
133_V195_L0.8551.00
209_S213_K0.8521.00
155_L160_L0.8511.00
261_Q273_Q0.8471.00
255_G259_G0.8471.00
141_V185_A0.8431.00
149_L220_V0.8431.00
137_A207_F0.8411.00
225_A229_I0.8401.00
269_L272_T0.8351.00
9_E30_Q0.8321.00
28_N75_L0.8311.00
23_P26_L0.8301.00
257_L273_Q0.8291.00
75_L78_S0.8291.00
12_L16_S0.8251.00
81_R85_D0.8191.00
89_S102_S0.8181.00
68_L73_L0.8171.00
46_Q50_Q0.8141.00
141_V152_L0.8141.00
112_K241_K0.8131.00
162_L186_V0.8091.00
146_G264_L0.8091.00
59_F62_R0.8071.00
153_V220_V0.8021.00
268_N272_T0.8001.00
58_N62_R0.8001.00
63_S73_L0.7971.00
55_M58_N0.7961.00
88_V96_N0.7951.00
36_I84_F0.7931.00
84_F98_A0.7931.00
9_E40_A0.7921.00
145_A179_L0.7891.00
170_M174_S0.7861.00
252_E281_Q0.7851.00
43_N59_F0.7841.00
157_I197_D0.7821.00
96_N99_K0.7781.00
227_W230_K0.7731.00
125_I227_W0.7691.00
133_V137_A0.7671.00
185_A188_W0.7641.00
191_H195_L0.7591.00
31_R34_E0.7571.00
135_D227_W0.7521.00
149_L239_P0.7481.00
77_L98_A0.7471.00
122_L139_L0.7441.00
247_A272_T0.7411.00
251_L279_D0.7391.00
247_A266_H0.7351.00
181_I185_A0.7331.00
133_V136_R0.7321.00
222_K226_E0.7291.00
218_R225_A0.7261.00
122_L228_G0.7211.00
71_A74_A0.7171.00
141_V147_L0.7161.00
91_N100_G0.7121.00
83_F86_W0.7071.00
114_I241_K0.7071.00
155_L206_L0.7061.00
190_E194_D0.7061.00
196_R208_L0.7051.00
11_Y15_L0.7041.00
223_R227_W0.7011.00
269_L273_Q0.7001.00
224_F242_L0.7001.00
257_L269_L0.6981.00
220_V239_P0.6971.00
88_V95_A0.6951.00
57_R60_A0.6931.00
190_E193_L0.6921.00
33_L83_F0.6881.00
193_L197_D0.6871.00
36_I80_L0.6841.00
142_M149_L0.6831.00
240_H244_H0.6821.00
285_S288_D0.6821.00
16_S30_Q0.6811.00
87_L93_L0.6791.00
224_F239_P0.6751.00
263_L283_L0.6741.00
219_N223_R0.6721.00
147_L151_E0.6721.00
54_T90_Q0.6721.00
35_A59_F0.6711.00
53_V91_N0.6691.00
140_E185_A0.6651.00
193_L196_R0.6641.00
7_D83_F0.6621.00
123_L136_R0.6611.00
259_G263_L0.6591.00
237_V241_K0.6581.00
74_A78_S0.6551.00
61_V64_R0.6551.00
139_L242_L0.6541.00
187_A191_H0.6531.00
15_L19_R0.6531.00
54_T58_N0.6531.00
241_K244_H0.6501.00
161_D165_G0.6481.00
171_G177_R0.6451.00
187_A190_E0.6451.00
60_A73_L0.6411.00
137_A185_A0.6401.00
117_D121_R0.6401.00
13_R16_S0.6381.00
137_A141_V0.6341.00
84_F88_V0.6321.00
15_L82_S0.6321.00
113_N248_T0.6311.00
8_V12_L0.6301.00
15_L29_Y0.6261.00
255_G286_V0.6241.00
51_C56_V0.6241.00
157_I189_I0.6221.00
119_M123_L0.6221.00
189_I206_L0.6211.00
121_R124_D0.6201.00
81_R98_A0.6191.00
225_A228_G0.6141.00
10_R13_R0.6131.00
255_G260_V0.6131.00
81_R103_A0.6131.00
145_A182_G0.6121.00
163_E166_E0.6111.00
62_R66_K0.6111.00
251_L256_D0.6071.00
36_I59_F0.6061.00
258_R273_Q0.6051.00
111_P238_H0.6031.00
56_V80_L0.6021.00
188_W191_H0.6021.00
251_L258_R0.6011.00
88_V99_K0.5981.00
140_E144_G0.5971.00
160_L189_I0.5971.00
260_V276_T0.5951.00
183_R288_D0.5921.00
119_M245_S0.5881.00
281_Q284_A0.5881.00
134_R192_W0.5871.00
43_N58_N0.5871.00
48_W87_L0.5861.00
257_L272_T0.5831.00
116_V245_S0.5831.00
117_D120_N0.5831.00
126_D227_W0.5831.00
86_W92_E0.5811.00
261_Q271_T0.5781.00
85_D88_V0.5761.00
280_F283_L0.5761.00
147_L155_L0.5751.00
70_A74_A0.5741.00
10_R86_W0.5711.00
261_Q268_N0.5691.00
251_L257_L0.5681.00
33_L79_A0.5681.00
36_I41_S0.5681.00
161_D168_W0.5671.00
279_D282_H0.5661.00
137_A189_I0.5661.00
98_A101_V0.5651.00
134_R137_A0.5641.00
129_D132_A0.5641.00
218_R222_K0.5641.00
59_F80_L0.5611.00
227_W231_Q0.5601.00
154_G214_R0.5591.00
33_L40_A0.5561.00
191_H194_D0.5501.00
80_L98_A0.5491.00
88_V91_N0.5481.00
151_E265_G0.5401.00
139_L224_F0.5391.00
134_R223_R0.5391.00
267_A271_T0.5381.00
74_A103_A0.5351.00
21_L25_T0.5341.00
126_D136_R0.5341.00
74_A106_A0.5331.00
53_V100_G0.5291.00
192_W195_L0.5291.00
111_P244_H0.5281.00
108_R274_I0.5281.00
82_S85_D0.5271.00
261_Q264_L0.5231.00
251_L278_L0.5211.00
114_I119_M0.5201.00
84_F96_N0.5201.00
121_R231_Q0.5201.00
132_A136_R0.5191.00
142_M242_L0.5191.00
126_D139_L0.5181.00
156_D203_D0.5181.00
77_L101_V0.5171.00
147_L167_V0.5161.00
35_A66_K0.5151.00
160_L206_L0.5141.00
162_L165_G0.5121.00
257_L261_Q0.5061.00
43_N55_M0.5031.00
152_L239_P0.5011.00
29_Y32_Q0.5011.00
248_T252_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.8926 100 0.171 Contact Map
2a3vA 3 0.9329 100 0.211 Contact Map
1z19A 3 0.9295 100 0.214 Contact Map
1z1bA 3 0.9295 100 0.22 Contact Map
1xo0A 3 0.9597 100 0.225 Contact Map
4a8eA 2 0.8792 100 0.25 Contact Map
3nkhA 2 0.6342 100 0.401 Contact Map
1ae9A 4 0.5537 100 0.471 Contact Map
1aihA 2 0.5638 100 0.513 Contact Map
4e0gA 2 0.8826 99.9 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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