GREMLIN Database
FETP - Probable Fe(2+)-trafficking protein
UniProt: P0A8P3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12984
Length: 91 (88)
Sequences: 611 (285)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D36_K4.2401.00
6_F11_Q4.1341.00
15_E36_K3.2571.00
28_K32_N3.1551.00
12_R37_E2.9361.00
3_R16_G2.9241.00
69_E72_N2.5390.99
65_L80_V2.4300.99
16_G31_Y2.2990.99
85_Y88_E1.9230.96
10_L14_A1.8950.96
26_L29_R1.6890.93
3_R31_Y1.6510.92
22_Y70_M1.5740.90
10_L37_E1.5260.88
65_L69_E1.5100.88
29_R75_F1.4690.86
22_Y67_E1.4560.86
59_N62_H1.4340.85
48_M82_I1.3960.83
8_T34_I1.3750.82
53_K65_L1.3220.80
8_T33_E1.2940.78
22_Y30_I1.2570.76
5_I34_I1.2230.74
20_Q31_Y1.2160.74
41_Q73_F1.2130.73
64_K68_Q1.2130.73
48_M84_G1.2060.73
29_R33_E1.2060.73
48_M58_M1.1990.73
14_A37_E1.1960.72
9_F21_L1.1880.72
10_L35_S1.1690.71
52_E85_Y1.1470.69
76_E79_E1.0500.62
34_I81_H1.0480.62
25_E28_K1.0440.62
23_P47_T1.0310.61
61_E68_Q1.0280.61
29_R71_V1.0150.60
74_L77_G1.0040.59
53_K84_G1.0020.59
45_K81_H0.9890.58
2_S18_D0.9840.57
45_K79_E0.9730.56
37_E41_Q0.9320.53
57_M67_E0.9230.52
9_F41_Q0.9170.52
48_M85_Y0.9140.52
34_I74_L0.9080.51
6_F13_E0.9000.50
81_H84_G0.8960.50
47_T63_R0.8870.49
63_R70_M0.8860.49
26_L75_F0.8680.48
45_K49_L0.8430.46
4_T13_E0.8430.46
22_Y57_M0.8350.45
53_K83_E0.8290.45
23_P63_R0.8160.44
3_R32_N0.7930.42
18_D40_A0.7740.41
57_M70_M0.7610.40
46_Q52_E0.7580.39
4_T15_E0.7420.38
49_L65_L0.7340.37
69_E81_H0.7330.37
53_K69_E0.7320.37
24_G56_N0.7250.37
61_E65_L0.7120.36
43_Q57_M0.7120.36
21_L45_K0.6970.35
26_L71_V0.6880.34
61_E64_K0.6820.34
23_P59_N0.6800.34
54_K59_N0.6780.33
35_S62_H0.6770.33
19_F22_Y0.6750.33
53_K79_E0.6750.33
17_Q21_L0.6740.33
57_M63_R0.6730.33
57_M65_L0.6690.33
65_L82_I0.6680.33
67_E70_M0.6630.32
45_K48_M0.6550.32
4_T14_A0.6510.31
50_I58_M0.6500.31
64_K86_T0.6480.31
78_K83_E0.6450.31
56_N60_A0.6450.31
46_Q63_R0.6380.31
11_Q40_A0.6290.30
49_L70_M0.6280.30
26_L53_K0.6270.30
17_Q33_E0.6260.30
10_L75_F0.6210.29
34_I76_E0.6090.29
25_E76_E0.6080.29
50_I73_F0.6040.28
49_L63_R0.5940.28
45_K78_K0.5850.27
58_M70_M0.5800.27
19_F58_M0.5790.27
3_R24_G0.5760.27
19_F25_E0.5740.26
8_T74_L0.5720.26
62_H82_I0.5700.26
60_A83_E0.5660.26
49_L54_K0.5630.26
25_E68_Q0.5620.26
49_L74_L0.5610.26
6_F37_E0.5600.26
23_P46_Q0.5600.26
4_T50_I0.5450.25
11_Q41_Q0.5450.25
5_I17_Q0.5350.24
49_L52_E0.5340.24
72_N77_G0.5290.24
45_K72_N0.5280.24
20_Q72_N0.5200.23
2_S30_I0.5180.23
43_Q68_Q0.5140.23
46_Q49_L0.5120.23
8_T75_F0.5110.23
43_Q67_E0.5100.23
56_N59_N0.5040.22
29_R76_E0.5040.22
26_L30_I0.5040.22
9_F62_H0.5010.22
40_A43_Q0.5010.22
43_Q54_K0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xs8A 1 1 100 0.02 Contact Map
1t07A 1 0.8681 100 0.029 Contact Map
2mzyA 1 1 100 0.029 Contact Map
2m5wA 1 0.3736 13.5 0.94 Contact Map
3ljbA 2 0.7582 13.2 0.94 Contact Map
2owlA 2 0.5275 9.9 0.943 Contact Map
2qm4A 2 0.3846 8.5 0.945 Contact Map
2vooA 1 0.3736 6.8 0.947 Contact Map
2owyA 2 0.5165 6.7 0.947 Contact Map
4pzuA 4 0.3626 6.1 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0052 seconds.