GREMLIN Database
LFTR - Leucyl/phenylalanyl-tRNA--protein transferase
UniProt: P0A8P1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11112
Length: 234 (203)
Sequences: 2004 (1404)
Seq/√Len: 98.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_A97_Q4.7571.00
71_S200_C4.7211.00
81_F164_N3.5741.00
100_E117_V3.5231.00
136_R162_M3.5151.00
90_T93_Y3.2021.00
96_G121_H2.9691.00
39_L128_H2.7801.00
16_P208_L2.7331.00
35_P126_L2.3891.00
190_L195_A2.3851.00
72_L174_C2.3481.00
177_F182_G2.2791.00
90_T135_W2.2661.00
32_D37_R2.2481.00
40_M44_R2.1901.00
101_G161_R2.1681.00
78_M171_L2.1461.00
176_E180_H2.1281.00
139_E162_M2.1241.00
92_N130_H2.0971.00
77_S80_R2.0691.00
89_V168_T2.0431.00
190_L201_E2.0181.00
88_R138_D2.0161.00
72_L171_L1.9761.00
94_A135_W1.9551.00
74_I171_L1.8671.00
75_S196_S1.8551.00
122_R125_E1.7631.00
89_V134_V1.6371.00
68_W210_Y1.6201.00
120_Y147_V1.5821.00
60_S204_R1.5791.00
65_A190_L1.5521.00
99_I117_V1.5441.00
38_L147_V1.5411.00
148_A182_G1.5071.00
170_L197_L1.4971.00
70_E178_I1.4941.00
96_G100_E1.4871.00
65_A195_A1.4761.00
174_C178_I1.4541.00
75_S197_L1.4521.00
122_R126_L1.4401.00
79_K83_K1.4371.00
97_Q101_G1.4191.00
100_E114_R1.4101.00
51_S54_D1.4071.00
105_D161_R1.3991.00
89_V172_V1.3980.99
91_M132_I1.3690.99
99_I121_H1.3500.99
206_D210_Y1.3490.99
152_L214_M1.3420.99
117_V121_H1.3260.99
95_F129_A1.3190.99
134_V169_A1.3070.99
87_Y168_T1.3010.99
124_H131_S1.2990.99
104_S161_R1.2860.99
38_L119_A1.2840.99
151_T217_G1.2840.99
98_V159_F1.2700.99
34_S37_R1.2700.99
91_M176_E1.2630.99
66_V202_I1.2610.99
87_Y162_M1.2540.99
173_F177_F1.2270.99
151_T183_K1.2240.99
96_G125_E1.2010.98
60_S208_L1.1790.98
183_K214_M1.1740.98
82_H171_L1.1660.98
65_A191_N1.1570.98
72_L197_L1.1560.98
67_L187_C1.1450.98
98_V140_L1.1360.98
175_E178_I1.1290.98
146_G153_F1.1240.98
121_H125_E1.1210.98
202_I210_Y1.1110.97
149_Q154_C1.0930.97
132_I173_F1.0910.97
43_Q149_Q1.0770.97
51_S113_T1.0750.97
88_R93_Y1.0720.97
69_P174_C1.0650.97
206_D209_N1.0540.96
41_A58_W1.0510.96
132_I144_M1.0450.96
116_V145_Y1.0420.96
17_E205_R1.0400.96
87_Y141_V1.0330.96
68_W200_C1.0160.96
187_C191_N1.0150.96
87_Y136_R1.0140.96
68_W71_S1.0140.96
192_D195_A1.0030.95
86_P136_R1.0030.95
101_G159_F0.9950.95
66_V184_L0.9910.95
144_M173_F0.9860.95
50_F115_G0.9850.95
172_V175_E0.9830.95
213_Q217_G0.9780.95
174_C185_I0.9750.95
149_Q215_R0.9600.94
67_L191_N0.9590.94
101_G105_D0.9580.94
65_A199_A0.9530.94
90_T134_V0.9500.94
155_G158_M0.9390.93
103_A117_V0.9330.93
203_P206_D0.9230.93
144_M185_I0.9220.93
136_R139_E0.9170.93
171_L197_L0.9170.93
114_R118_E0.9000.92
51_S55_P0.8980.92
31_G56_I0.8970.92
92_N180_H0.8880.91
65_A201_E0.8860.91
19_A27_L0.8820.91
43_Q216_L0.8700.90
80_R83_K0.8700.90
73_H197_L0.8610.90
116_V119_A0.8600.90
78_M164_N0.8560.90
190_L199_A0.8550.90
100_E121_H0.8530.90
124_H129_A0.8470.89
90_T131_S0.8430.89
139_E161_R0.8430.89
33_L119_A0.8410.89
166_S193_H0.8320.88
50_F56_I0.8320.88
142_G165_A0.8240.88
63_P203_P0.8230.88
170_L174_C0.8210.88
136_R141_V0.8210.88
138_D141_V0.8200.88
100_E104_S0.8200.88
123_L129_A0.8190.88
96_G117_V0.8170.87
141_V162_M0.8160.87
81_F86_P0.8110.87
184_L210_Y0.8080.87
114_R117_V0.8030.87
69_P185_I0.8010.86
70_E174_C0.8000.86
82_H168_T0.7940.86
81_F163_E0.7910.86
72_L170_L0.7900.86
202_I206_D0.7870.85
98_V101_G0.7820.85
81_F168_T0.7750.85
67_L174_C0.7720.84
142_G160_S0.7710.84
124_H130_H0.7680.84
193_H197_L0.7680.84
50_F54_D0.7660.84
87_Y163_E0.7600.83
130_H148_A0.7570.83
154_C215_R0.7550.83
77_S84_R0.7510.83
113_T116_V0.7500.83
68_W202_I0.7460.82
123_L147_V0.7440.82
33_L58_W0.7430.82
66_V200_C0.7400.82
209_N212_N0.7320.81
77_S81_F0.7320.81
24_N63_P0.7310.81
204_R208_L0.7270.81
164_N167_K0.7220.80
160_S170_L0.7180.80
69_P187_C0.7140.79
210_Y214_M0.7140.79
31_G37_R0.7130.79
154_C207_Y0.7130.79
144_M155_G0.7120.79
33_L41_A0.7040.78
69_P178_I0.7020.78
128_H147_V0.7020.78
61_P204_R0.6950.78
30_G119_A0.6940.78
73_H80_R0.6850.77
36_A126_L0.6850.77
116_V120_Y0.6830.76
77_S196_S0.6800.76
162_M165_A0.6770.76
154_C189_V0.6740.75
184_L214_M0.6660.75
153_F177_F0.6650.74
112_I156_E0.6640.74
134_V138_D0.6620.74
160_S174_C0.6610.74
50_F59_W0.6540.73
52_P113_T0.6500.73
47_F156_E0.6500.73
144_M187_C0.6470.72
69_P184_L0.6460.72
35_P122_R0.6460.72
39_L126_L0.6430.72
99_I112_I0.6430.72
55_P113_T0.6420.72
19_A23_P0.6390.72
26_L57_L0.6370.71
141_V165_A0.6360.71
65_A189_V0.6350.71
66_V210_Y0.6300.70
65_A187_C0.6260.70
77_S193_H0.6260.70
155_G194_T0.6250.70
50_F113_T0.6250.70
56_I116_V0.6180.69
19_A25_G0.6140.68
152_L215_R0.6100.68
199_A204_R0.6070.68
22_E26_L0.6040.67
99_I145_Y0.6030.67
49_W156_E0.6000.67
70_E200_C0.5990.67
160_S163_E0.5990.67
62_D203_P0.5990.67
80_R144_M0.5980.66
92_N173_F0.5970.66
145_Y156_E0.5940.66
92_N124_H0.5910.66
89_V132_I0.5900.65
84_R168_T0.5900.65
175_E179_G0.5900.65
151_T214_M0.5890.65
40_M43_Q0.5880.65
61_P154_C0.5870.65
80_R84_R0.5840.65
184_L202_I0.5820.64
112_I116_V0.5810.64
205_R213_Q0.5790.64
86_P168_T0.5760.64
49_W189_V0.5750.63
164_N171_L0.5730.63
134_V139_E0.5690.63
53_G57_L0.5690.63
73_H163_E0.5670.62
77_S167_K0.5650.62
87_Y165_A0.5640.62
33_L115_G0.5640.62
183_K217_G0.5610.62
103_A110_T0.5610.62
19_A26_L0.5600.61
94_A131_S0.5590.61
142_G169_A0.5570.61
61_P189_V0.5570.61
36_A40_M0.5560.61
72_L178_I0.5560.61
115_G118_E0.5550.61
22_E25_G0.5550.61
59_W204_R0.5530.60
78_M167_K0.5530.60
155_G188_Q0.5520.60
171_L175_E0.5520.60
167_K193_H0.5510.60
213_Q216_L0.5500.60
24_N189_V0.5500.60
191_N199_A0.5500.60
95_F124_H0.5440.59
112_I120_Y0.5430.59
78_M81_F0.5410.59
86_P141_V0.5390.59
78_M168_T0.5390.59
158_M188_Q0.5390.59
15_S18_G0.5380.58
132_I176_E0.5360.58
81_F84_R0.5320.58
37_R55_P0.5290.57
194_T197_L0.5280.57
152_L184_L0.5280.57
90_T94_A0.5270.57
161_R165_A0.5270.57
24_N27_L0.5270.57
67_L199_A0.5270.57
160_S192_D0.5250.57
67_L197_L0.5240.56
118_E209_N0.5220.56
42_Y156_E0.5200.56
63_P201_E0.5180.56
122_R205_R0.5180.56
160_S194_T0.5170.55
27_L46_I0.5160.55
147_V170_L0.5140.55
34_S119_A0.5140.55
62_D205_R0.5110.55
122_R209_N0.5100.54
152_L211_L0.5100.54
39_L43_Q0.5090.54
86_P134_V0.5080.54
101_G165_A0.5060.54
203_P209_N0.5060.54
151_T181_G0.5050.54
50_F57_L0.5030.53
32_D56_I0.5030.53
156_E188_Q0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cxaA 1 0.9701 100 0.018 Contact Map
3gkrA 1 0.9231 87.8 0.944 Contact Map
2o28A 2 0.6966 61.9 0.956 Contact Map
2dxqA 2 0.5427 41.6 0.96 Contact Map
4jxqA 2 0.6368 39.7 0.961 Contact Map
3i3gA 2 0.5385 29.8 0.963 Contact Map
4zbgA 1 0.5855 27.2 0.964 Contact Map
4evyA 2 0.5427 27.2 0.964 Contact Map
4ehiA 2 0.3504 27.1 0.964 Contact Map
1s3zA 2 0.5299 26.2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.