GREMLIN Database
EPMA - Elongation factor P--(R)-beta-lysine ligase
UniProt: P0A8N7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11211
Length: 325 (306)
Sequences: 9668 (4834)
Seq/√Len: 276.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R133_D4.4941.00
24_A31_A3.9091.00
31_A93_F3.5001.00
24_A28_R3.4371.00
28_R32_D3.2241.00
29_F133_D3.1601.00
25_E137_Q2.9161.00
122_Y126_R2.8701.00
25_E141_C2.7741.00
250_H295_S2.6301.00
42_C99_F2.6041.00
81_M92_V2.4471.00
18_K309_L2.4431.00
27_R37_E2.4401.00
214_H226_S2.4001.00
22_I305_V2.3881.00
85_L294_C2.3001.00
28_R31_A2.1541.00
26_I115_L2.1511.00
26_I134_L2.1501.00
259_Q263_E2.1471.00
124_M234_E2.1381.00
23_M301_V2.1341.00
226_S234_E2.0891.00
15_N311_A2.0771.00
148_S151_Q2.0611.00
119_R122_Y2.0221.00
174_A178_L2.0131.00
57_E70_N1.9851.00
240_Y245_L1.9811.00
20_A31_A1.9691.00
13_I17_L1.9671.00
29_F134_L1.9641.00
29_F137_Q1.9541.00
28_R141_C1.9151.00
227_T234_E1.8941.00
259_Q281_Q1.8821.00
42_C96_C1.8821.00
117_W297_V1.8641.00
29_F33_R1.8571.00
137_Q141_C1.8571.00
211_F238_V1.8421.00
155_R168_Q1.8221.00
127_L295_S1.8151.00
123_D126_R1.8051.00
32_D137_Q1.7891.00
260_Q264_Q1.7511.00
255_A259_Q1.7361.00
129_N133_D1.7361.00
259_Q284_I1.7191.00
39_E97_R1.7011.00
174_A177_D1.6951.00
135_L238_V1.6851.00
25_E138_V1.6801.00
163_S208_K1.6341.00
119_R130_E1.6201.00
17_L36_L1.6101.00
21_A24_A1.5961.00
255_A288_K1.5601.00
59_R70_N1.5541.00
59_R68_G1.5501.00
151_Q155_R1.5371.00
35_V119_R1.5301.00
263_E269_R1.5131.00
139_L308_A1.5061.00
193_Q197_T1.4741.00
25_E28_R1.4741.00
16_L319_A1.4641.00
260_Q263_E1.4601.00
147_L152_A1.4451.00
145_E208_K1.4331.00
259_Q269_R1.4031.00
98_S114_M1.4021.00
264_Q267_R1.3871.00
171_E174_A1.3841.00
14_P18_K1.3821.00
14_P17_L1.3761.00
10_S14_P1.3731.00
225_I257_E1.3721.00
115_L301_V1.3651.00
257_E260_Q1.3621.00
30_F115_L1.3461.00
11_A311_A1.3431.00
169_L173_A1.3401.00
168_Q171_E1.3221.00
191_L195_L1.3171.00
26_I301_V1.3161.00
128_M211_F1.3081.00
217_A225_I1.3061.00
21_A141_C1.3051.00
150_Q154_L1.3041.00
2_S285_E1.2971.00
217_A261_R1.2941.00
28_R137_Q1.2931.00
30_F117_W1.2821.00
22_I138_V1.2581.00
17_L21_A1.2551.00
238_V246_A1.2441.00
25_E142_P1.2381.00
155_R158_E1.2281.00
254_D257_E1.2161.00
153_F158_E1.2141.00
226_S232_V1.2041.00
225_I254_D1.2031.00
259_Q288_K1.1961.00
189_D193_Q1.1961.00
209_P240_Y1.1941.00
250_H253_T1.1921.00
91_P119_R1.1921.00
91_P120_P1.1911.00
34_G91_P1.1891.00
285_E288_K1.1671.00
149_Y153_F1.1591.00
133_D136_Q1.1561.00
148_S152_A1.1501.00
33_R130_E1.1481.00
146_S153_F1.1451.00
95_L301_V1.1441.00
125_Y129_N1.1431.00
145_E155_R1.1411.00
152_A158_E1.1401.00
140_D144_A1.1391.00
131_V299_L1.1271.00
311_A317_V1.1241.00
229_D232_V1.1001.00
26_I138_V1.0951.00
214_H232_V1.0791.00
135_L304_L1.0771.00
30_F134_L1.0761.00
148_S214_H1.0721.00
132_D136_Q1.0721.00
146_S149_Y1.0621.00
176_L181_V1.0601.00
261_R264_Q1.0581.00
18_K22_I1.0571.00
21_A31_A1.0531.00
107_Y243_I1.0531.00
18_K21_A1.0521.00
125_Y146_S1.0501.00
37_E93_F1.0471.00
16_L89_C1.0431.00
173_A177_D1.0411.00
311_A316_E1.0401.00
40_T94_Q1.0361.00
122_Y295_S1.0341.00
176_L179_S1.0331.00
161_P164_A1.0281.00
79_Y282_N1.0251.00
77_P98_S1.0161.00
27_R93_F1.0111.00
13_I89_C1.0111.00
149_Y152_A1.0011.00
223_A249_F0.9991.00
129_N166_K0.9971.00
124_M128_M0.9941.00
234_E250_H0.9891.00
194_L198_F0.9861.00
291_M294_C0.9861.00
155_R161_P0.9841.00
175_K178_L0.9731.00
198_F202_P0.9721.00
77_P114_M0.9691.00
160_D163_S0.9671.00
200_V203_N0.9671.00
172_V176_L0.9631.00
131_V246_A0.9611.00
152_A156_Y0.9591.00
128_M213_Y0.9591.00
261_R265_D0.9591.00
131_V297_V0.9581.00
150_Q232_V0.9561.00
128_M146_S0.9551.00
35_V91_P0.9521.00
255_A284_I0.9491.00
134_L138_V0.9441.00
86_V291_M0.9441.00
22_I308_A0.9431.00
151_Q154_L0.9391.00
176_L180_N0.9391.00
187_D190_T0.9381.00
54_V60_F0.9361.00
252_L257_E0.9341.00
200_V204_I0.9291.00
195_L199_G0.9281.00
196_F212_V0.9221.00
18_K142_P0.9211.00
154_L160_D0.9181.00
77_P80_H0.9131.00
157_L160_D0.9111.00
226_S229_D0.9051.00
146_S152_A0.9031.00
152_A157_L0.9011.00
190_T193_Q0.8941.00
268_K278_P0.8941.00
122_Y127_L0.8871.00
81_M94_Q0.8851.00
23_M37_E0.8821.00
156_Y203_N0.8781.00
214_H234_E0.8731.00
193_Q219_Q0.8711.00
281_Q285_E0.8711.00
38_V84_L0.8711.00
170_R173_A0.8701.00
4_T285_E0.8681.00
158_E162_L0.8661.00
132_D166_K0.8651.00
195_L198_F0.8641.00
22_I301_V0.8611.00
269_R278_P0.8601.00
152_A155_R0.8551.00
53_L56_F0.8541.00
124_M214_H0.8541.00
258_Q287_L0.8491.00
160_D164_A0.8471.00
153_F162_L0.8441.00
11_A15_N0.8441.00
165_D208_K0.8391.00
167_T171_E0.8391.00
15_N309_L0.8391.00
141_C144_A0.8341.00
156_Y161_P0.8331.00
150_Q153_F0.8291.00
138_V142_P0.8271.00
7_W16_L0.8250.99
153_F157_L0.8250.99
175_K179_S0.8240.99
20_A24_A0.8220.99
77_P96_C0.8200.99
262_F280_D0.8180.99
157_L164_A0.8180.99
43_M71_L0.8170.99
157_L163_S0.8160.99
248_G297_V0.8120.99
44_S80_H0.8110.99
109_N318_I0.8100.99
252_L261_R0.8080.99
29_F130_E0.8070.99
38_V85_L0.8020.99
188_R192_L0.7980.99
236_F248_G0.7950.99
6_S9_P0.7940.99
132_D146_S0.7930.99
193_Q198_F0.7860.99
243_I307_L0.7840.99
42_C97_R0.7830.99
133_D137_Q0.7820.99
126_R129_N0.7800.99
237_E247_N0.7800.99
18_K143_A0.7770.99
127_L297_V0.7770.99
170_R174_A0.7770.99
183_D186_E0.7760.99
124_M250_H0.7750.99
9_P12_S0.7740.99
19_R39_E0.7740.99
23_M95_L0.7680.99
48_V278_P0.7640.99
38_V89_C0.7620.99
23_M39_E0.7610.99
146_S151_Q0.7610.99
147_L210_T0.7590.99
90_G120_P0.7580.99
154_L157_L0.7530.99
196_F200_V0.7480.99
299_L304_L0.7460.99
225_I253_T0.7430.99
151_Q157_L0.7430.99
154_L162_L0.7340.99
125_Y128_M0.7330.99
163_S210_T0.7300.99
306_M314_L0.7270.99
256_R260_Q0.7270.99
147_L212_V0.7230.99
268_K279_I0.7230.99
158_E161_P0.7230.99
167_T172_V0.7220.99
263_E279_I0.7210.99
171_E175_K0.7210.99
266_N279_I0.7200.99
226_S231_R0.7200.99
10_S13_I0.7190.99
45_Q69_M0.7190.99
123_D234_E0.7180.99
117_W131_V0.7170.99
149_Y161_P0.7110.98
128_M132_D0.7110.98
217_A233_A0.7100.98
257_E261_R0.7090.98
12_S15_N0.7090.98
193_Q196_F0.7050.98
74_M94_Q0.7040.98
193_Q200_V0.7030.98
117_W127_L0.7010.98
4_T289_V0.6990.98
165_D171_E0.6990.98
305_V309_L0.6980.98
149_Y157_L0.6930.98
117_W130_E0.6930.98
56_F101_N0.6920.98
137_Q140_D0.6910.98
220_A235_R0.6880.98
189_D192_L0.6880.98
142_P308_A0.6870.98
159_I164_A0.6860.98
57_E72_W0.6840.98
149_Y155_R0.6840.98
122_Y130_E0.6820.98
150_Q155_R0.6810.98
281_Q284_I0.6810.98
285_E289_V0.6810.98
256_R259_Q0.6800.98
86_V287_L0.6790.98
131_V236_F0.6790.98
194_L199_G0.6780.98
25_E29_F0.6770.98
71_L322_V0.6730.98
19_R302_D0.6700.98
267_R279_I0.6640.98
170_R188_R0.6630.98
42_C77_P0.6620.98
155_R160_D0.6610.98
138_V141_C0.6610.98
189_D197_T0.6600.98
224_Q253_T0.6590.98
191_L194_L0.6580.98
258_Q262_F0.6570.97
235_R247_N0.6560.97
224_Q234_E0.6540.97
159_I163_S0.6540.97
154_L161_P0.6520.97
119_R126_R0.6510.97
227_T230_H0.6510.97
123_D250_H0.6480.97
48_V76_S0.6470.97
20_A93_F0.6470.97
165_D168_Q0.6460.97
147_L156_Y0.6450.97
159_I162_L0.6430.97
104_M323_D0.6430.97
169_L172_V0.6410.97
148_S153_F0.6410.97
23_M115_L0.6390.97
197_T201_E0.6370.97
85_L291_M0.6360.97
146_S158_E0.6350.97
212_V239_Y0.6350.97
259_Q279_I0.6350.97
150_Q156_Y0.6310.97
136_Q140_D0.6270.97
176_L191_L0.6270.97
245_L304_L0.6250.97
33_R91_P0.6240.97
187_D218_S0.6230.97
56_F60_F0.6220.97
190_T194_L0.6220.97
151_Q158_E0.6190.96
106_R194_L0.6170.96
5_A285_E0.6160.96
20_A36_L0.6160.96
173_A188_R0.6120.96
21_A25_E0.6110.96
157_L161_P0.6090.96
106_R313_T0.6040.96
26_I95_L0.6010.96
18_K305_V0.5990.96
140_D143_A0.5990.96
39_E113_T0.5990.96
150_Q157_L0.5980.96
267_R280_D0.5970.96
246_A297_V0.5970.96
150_Q161_P0.5970.96
177_D187_D0.5950.96
189_D198_F0.5940.95
157_L162_L0.5940.95
130_E133_D0.5930.95
156_Y160_D0.5890.95
226_S230_H0.5880.95
125_Y213_Y0.5880.95
309_L317_V0.5880.95
33_R137_Q0.5870.95
183_D187_D0.5870.95
147_L151_Q0.5860.95
124_M226_S0.5860.95
189_D196_F0.5840.95
122_Y250_H0.5790.95
119_R127_L0.5770.95
158_E164_A0.5770.95
131_V238_V0.5760.95
150_Q158_E0.5730.95
3_E7_W0.5720.94
153_F160_D0.5720.94
177_D180_N0.5690.94
189_D200_V0.5690.94
12_S316_E0.5680.94
186_E194_L0.5670.94
45_Q322_V0.5660.94
186_E190_T0.5650.94
211_F236_F0.5640.94
127_L131_V0.5630.94
79_Y283_L0.5630.94
193_Q202_P0.5610.94
84_L320_F0.5550.94
152_A162_L0.5540.93
127_L236_F0.5540.93
228_E231_R0.5530.93
189_D218_S0.5510.93
154_L171_E0.5510.93
279_I284_I0.5490.93
127_L130_E0.5470.93
147_L153_F0.5440.93
148_S162_L0.5430.93
153_F156_Y0.5410.93
29_F138_V0.5410.93
172_V179_S0.5410.93
16_L85_L0.5400.93
30_F130_E0.5370.92
153_F164_A0.5360.92
35_V127_L0.5350.92
97_R113_T0.5340.92
177_D181_V0.5340.92
155_R162_L0.5310.92
117_W299_L0.5310.92
263_E267_R0.5310.92
224_Q227_T0.5300.92
196_F204_I0.5300.92
30_F297_V0.5300.92
36_L89_C0.5290.92
78_E251_E0.5280.92
60_F66_S0.5280.92
5_A8_Q0.5280.92
5_A289_V0.5270.92
55_P58_T0.5240.92
40_T81_M0.5240.92
220_A249_F0.5220.91
3_E6_S0.5210.91
45_Q80_H0.5200.91
287_L291_M0.5190.91
168_Q172_V0.5190.91
197_T200_V0.5170.91
129_N146_S0.5150.91
156_Y212_V0.5150.91
156_Y164_A0.5140.91
143_A308_A0.5130.91
266_N278_P0.5120.91
11_A14_P0.5100.90
84_L319_A0.5100.90
69_M322_V0.5090.90
190_T268_K0.5090.90
199_G203_N0.5070.90
151_Q156_Y0.5060.90
149_Y158_E0.5060.90
156_Y159_I0.5060.90
168_Q213_Y0.5050.90
58_T101_N0.5050.90
132_D211_F0.5050.90
252_L258_Q0.5050.90
152_A212_V0.5020.90
304_L307_L0.5000.90
15_N316_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4up7A 2 0.9508 100 0.094 Contact Map
4pg3A 2 0.9262 100 0.094 Contact Map
4ex5A 2 0.9662 100 0.095 Contact Map
4ycuA 3 0.9785 100 0.095 Contact Map
3i7fA 2 0.8923 100 0.115 Contact Map
1e1oA 2 0.9631 100 0.123 Contact Map
1eovA 2 0.9569 100 0.124 Contact Map
3a74A 4 0.9723 100 0.126 Contact Map
4wj4A 2 0.9723 100 0.136 Contact Map
1c0aA 1 0.9662 100 0.137 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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