GREMLIN Database
SYK2 - Lysine--tRNA ligase, heat inducible
UniProt: P0A8N5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10553
Length: 505 (433)
Sequences: 9675 (4841)
Seq/√Len: 232.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_R296_S4.6191.00
125_R142_E4.0261.00
97_L140_C3.8401.00
63_S66_I3.7051.00
199_V256_F3.6661.00
69_S125_R3.6651.00
67_E125_R3.6221.00
192_A196_Q3.5091.00
197_F296_S3.5031.00
67_E141_T3.3681.00
196_Q200_A3.3021.00
192_A199_V3.2331.00
244_L255_V2.9731.00
123_G144_R2.9721.00
193_A304_E2.9021.00
193_A300_T2.8021.00
285_A289_D2.7731.00
428_S473_A2.6951.00
335_K347_N2.5471.00
186_V487_T2.5211.00
210_M262_F2.3941.00
61_L135_E2.3561.00
97_L124_A2.3531.00
194_I278_M2.3121.00
150_L466_E2.2611.00
248_V472_T2.2281.00
374_E378_E2.2231.00
190_I483_I2.2141.00
71_A123_G2.2101.00
95_I138_I2.1341.00
191_L479_I2.1081.00
343_A386_Q2.0931.00
299_R322_K2.0741.00
195_R205_E2.0711.00
210_M259_N2.0701.00
67_E127_T2.0521.00
224_I233_D2.0461.00
418_I423_I2.0201.00
127_T141_T2.0041.00
68_V138_I1.9761.00
196_Q199_V1.9571.00
65_N127_T1.9551.00
282_M285_A1.9501.00
300_T304_E1.9461.00
196_Q304_E1.9441.00
197_F201_R1.9421.00
437_A441_Q1.9371.00
197_F300_T1.9361.00
328_T331_E1.9361.00
188_S199_V1.9141.00
392_E404_N1.9081.00
292_E296_S1.8821.00
183_T489_S1.8791.00
287_Y412_D1.8631.00
290_L473_A1.8511.00
194_I297_L1.8471.00
389_F416_F1.8311.00
197_F297_L1.8151.00
280_L475_L1.8101.00
328_T392_E1.7871.00
433_A437_A1.7811.00
193_A301_L1.7761.00
438_E442_E1.7731.00
129_F139_H1.7601.00
200_A300_T1.7271.00
70_V95_I1.7181.00
331_E335_K1.7171.00
181_R185_V1.6741.00
327_L332_A1.6701.00
185_V204_M1.6601.00
89_Q94_R1.6521.00
286_D289_D1.6371.00
298_F416_F1.6321.00
437_A462_V1.6321.00
405_D412_D1.6221.00
203_F282_M1.5891.00
69_S123_G1.5851.00
74_M122_I1.5781.00
182_Q186_V1.5691.00
438_E441_Q1.5671.00
404_N412_D1.5341.00
433_A466_E1.5311.00
74_M116_W1.5191.00
212_Q217_G1.5131.00
330_R334_K1.5111.00
127_T139_H1.5111.00
74_M86_V1.5091.00
455_M463_T1.5031.00
87_T94_R1.5001.00
189_K192_A1.4971.00
202_G254_R1.4971.00
403_R431_N1.4931.00
310_K319_D1.4881.00
381_E384_L1.4871.00
166_R173_D1.4811.00
140_C143_L1.4571.00
282_M293_L1.4421.00
331_E334_K1.4321.00
60_E63_S1.4251.00
403_R432_D1.4221.00
178_D182_Q1.4211.00
325_E386_Q1.4191.00
302_A486_F1.4171.00
190_I301_L1.4161.00
189_K304_E1.4151.00
428_S431_N1.4111.00
193_A196_Q1.4101.00
353_A356_E1.4041.00
288_H292_E1.4021.00
212_Q216_G1.3871.00
184_F252_F1.3871.00
373_T377_D1.3851.00
261_N277_M1.3841.00
116_W122_I1.3651.00
327_L390_I1.3581.00
347_N350_A1.3571.00
179_K489_S1.3521.00
303_Q307_G1.3511.00
212_Q215_P1.3501.00
285_A473_A1.3441.00
288_H326_K1.3431.00
247_L498_F1.3331.00
278_M479_I1.3331.00
193_A305_V1.3321.00
368_L372_V1.3231.00
57_D60_E1.3211.00
463_T466_E1.3201.00
82_K101_R1.3191.00
432_D435_D1.3141.00
223_F229_A1.3081.00
254_R282_M1.3061.00
336_Y383_H1.3011.00
189_K309_T1.2961.00
437_A459_E1.2881.00
407_N410_I1.2781.00
369_G372_V1.2781.00
198_M278_M1.2781.00
352_K356_E1.2721.00
325_E335_K1.2641.00
214_I217_G1.2541.00
330_R410_I1.2521.00
70_V88_L1.2521.00
395_A439_R1.2451.00
198_M280_L1.2401.00
184_F497_L1.2341.00
128_L136_L1.2331.00
416_F424_G1.2311.00
185_V189_K1.2281.00
226_H231_D1.2261.00
196_Q300_T1.2251.00
435_D438_E1.2181.00
124_A140_C1.2181.00
451_D455_M1.2161.00
240_P261_N1.2151.00
123_G146_L1.2051.00
83_A98_Y1.1971.00
186_V305_V1.1951.00
226_H233_D1.1941.00
182_Q185_V1.1911.00
450_G453_E1.1861.00
169_Q463_T1.1861.00
439_R442_E1.1831.00
181_R252_F1.1801.00
401_A427_F1.1661.00
353_A357_S1.1611.00
292_E344_D1.1581.00
86_V97_L1.1511.00
441_Q453_E1.1471.00
128_L138_I1.1461.00
61_L64_L1.1411.00
380_A384_L1.1401.00
76_T87_T1.1391.00
194_I301_L1.1351.00
198_M297_L1.1311.00
403_R435_D1.1281.00
213_V217_G1.1251.00
194_I479_I1.1181.00
213_V216_G1.1151.00
84_S109_Y1.1141.00
360_I363_E1.1141.00
404_N410_I1.1131.00
206_V252_F1.1031.00
156_K159_G1.0981.00
190_I486_F1.0961.00
294_T477_I1.0871.00
451_D454_A1.0861.00
70_V138_I1.0841.00
99_V140_C1.0821.00
116_W143_L1.0821.00
240_P277_M1.0771.00
189_K199_V1.0771.00
59_Q63_S1.0711.00
117_D120_D1.0591.00
205_E256_F1.0591.00
190_I479_I1.0581.00
303_Q319_D1.0501.00
367_G370_R1.0491.00
92_G95_I1.0481.00
242_L460_D1.0471.00
296_S299_R1.0451.00
298_F482_M1.0431.00
201_R293_L1.0431.00
387_P418_I1.0371.00
100_A103_S1.0341.00
295_E299_R1.0291.00
211_M225_T1.0281.00
348_F368_L1.0271.00
115_K148_K1.0271.00
174_L184_F1.0261.00
88_L122_I1.0261.00
90_D93_G1.0251.00
100_A139_H1.0251.00
75_M89_Q1.0201.00
299_R321_G1.0121.00
291_I326_K1.0121.00
355_A358_I1.0111.00
99_V104_L1.0111.00
207_E260_R1.0071.00
215_P219_S1.0061.00
195_R256_F1.0051.00
295_E344_D1.0041.00
86_V122_I0.9991.00
285_A290_L0.9991.00
489_S495_V0.9971.00
155_D159_G0.9961.00
55_A92_G0.9961.00
439_R443_Q0.9961.00
211_M234_M0.9881.00
186_V190_I0.9861.00
155_D158_H0.9841.00
348_F352_K0.9831.00
301_L305_V0.9761.00
147_T469_L0.9741.00
240_P243_Y0.9711.00
89_Q119_G0.9701.00
266_G502_R0.9681.00
489_S494_D0.9661.00
52_E66_I0.9641.00
116_W145_L0.9611.00
332_A390_I0.9571.00
297_L301_L0.9561.00
240_P259_N0.9561.00
186_V189_K0.9551.00
343_A388_T0.9481.00
70_V124_A0.9481.00
333_I372_V0.9471.00
270_R421_R0.9451.00
215_P456_F0.9451.00
92_G253_E0.9451.00
188_S192_A0.9421.00
373_T397_V0.9411.00
437_A466_E0.9401.00
303_Q309_T0.9381.00
294_T475_L0.9361.00
121_I147_T0.9341.00
341_D344_D0.9331.00
103_S139_H0.9321.00
395_A403_R0.9291.00
309_T321_G0.9281.00
68_V128_L0.9261.00
469_L472_T0.9231.00
289_D292_E0.9211.00
296_S300_T0.9211.00
197_F293_L0.9201.00
356_E362_V0.9181.00
162_D165_V0.9171.00
191_L205_E0.9091.00
336_Y347_N0.9071.00
433_A462_V0.9061.00
249_V469_L0.9041.00
367_G396_E0.9020.99
112_Q115_K0.8970.99
304_E308_T0.8950.99
56_K59_Q0.8900.99
392_E410_I0.8880.99
191_L278_M0.8840.99
171_Y463_T0.8820.99
60_E132_Q0.8800.99
299_R309_T0.8800.99
111_D114_K0.8790.99
103_S141_T0.8750.99
120_D148_K0.8730.99
290_L475_L0.8720.99
294_T424_G0.8680.99
75_M94_R0.8670.99
437_A453_E0.8640.99
95_I128_L0.8620.99
323_P326_K0.8600.99
459_E463_T0.8590.99
351_A355_A0.8560.99
404_N435_D0.8540.99
287_Y291_I0.8530.99
280_L294_T0.8520.99
249_V465_L0.8500.99
186_V306_L0.8500.99
304_E307_G0.8490.99
117_D148_K0.8490.99
179_K183_T0.8430.99
99_V113_F0.8410.99
430_L435_D0.8410.99
91_V185_V0.8400.99
295_E326_K0.8390.99
363_E366_W0.8370.99
354_L358_I0.8350.99
213_V243_Y0.8350.99
452_D457_Y0.8340.99
126_G138_I0.8340.99
224_I235_Y0.8340.99
80_M83_A0.8310.99
477_I482_M0.8270.99
360_I383_H0.8270.99
188_S256_F0.8240.99
332_A335_K0.8230.99
484_M492_I0.8220.99
70_V97_L0.8200.99
206_V248_V0.8150.99
79_I84_S0.8150.99
440_F458_D0.8150.99
110_N113_F0.8120.99
73_R284_Y0.8120.99
232_L503_P0.8090.99
210_M240_P0.8080.99
324_F416_F0.8080.99
437_A451_D0.8060.99
86_V99_V0.8060.99
324_F387_P0.8040.99
216_G219_S0.8030.99
153_L157_F0.8000.99
369_G373_T0.8000.99
441_Q451_D0.7960.99
287_Y392_E0.7960.99
121_I470_P0.7960.99
111_D115_K0.7960.99
301_L304_E0.7920.99
53_F66_I0.7900.99
358_I375_I0.7890.99
203_F254_R0.7890.99
334_K338_P0.7870.99
366_W370_R0.7860.99
421_R485_L0.7860.99
124_A138_I0.7850.99
434_E438_E0.7840.99
372_V375_I0.7840.99
206_V247_L0.7830.99
434_E437_A0.7820.99
395_A411_T0.7800.99
193_A197_F0.7770.98
451_D458_D0.7750.98
423_I482_M0.7750.98
183_T487_T0.7730.98
285_A293_L0.7700.98
327_L388_T0.7690.98
79_I82_K0.7660.98
392_E412_D0.7650.98
227_H234_M0.7650.98
190_I305_V0.7630.98
349_D352_K0.7620.98
430_L439_R0.7590.98
327_L331_E0.7580.98
110_N114_K0.7580.98
248_V469_L0.7570.98
327_L335_K0.7570.98
334_K350_A0.7560.98
396_E409_E0.7550.98
86_V140_C0.7550.98
380_A383_H0.7510.98
201_R254_R0.7460.98
280_L290_L0.7450.98
55_A95_I0.7430.98
77_R84_S0.7370.98
300_T303_Q0.7370.98
402_R431_N0.7360.98
295_E323_P0.7340.98
373_T376_F0.7330.98
390_I417_F0.7330.98
55_A58_N0.7310.98
285_A428_S0.7300.98
334_K337_R0.7290.98
305_V486_F0.7280.98
299_R323_P0.7250.98
459_E462_V0.7240.98
59_Q136_L0.7220.98
398_S413_R0.7220.98
97_L122_I0.7220.98
89_Q178_D0.7220.98
210_M260_R0.7210.98
154_P157_F0.7190.98
370_R373_T0.7170.97
392_E405_D0.7160.97
125_R141_T0.7140.97
291_I389_F0.7130.97
76_T118_L0.7130.97
413_R425_N0.7120.97
280_L293_L0.7110.97
212_Q219_S0.7090.97
302_A320_F0.7070.97
113_F143_L0.7070.97
338_P369_G0.7050.97
402_R412_D0.7050.97
56_K60_E0.7040.97
322_K326_K0.7040.97
332_A336_Y0.7020.97
414_F426_G0.6970.97
145_L148_K0.6960.97
121_I284_Y0.6940.97
100_A129_F0.6890.97
58_N132_Q0.6860.97
483_I487_T0.6850.97
487_T495_V0.6850.97
186_V483_I0.6840.97
369_G377_D0.6830.97
362_V366_W0.6820.97
345_L373_T0.6810.97
188_S204_M0.6810.97
303_Q306_L0.6800.97
54_D63_S0.6790.97
189_K308_T0.6790.97
375_I379_V0.6770.96
349_D353_A0.6760.96
112_Q143_L0.6760.96
88_L97_L0.6750.96
258_I479_I0.6730.96
66_I128_L0.6730.96
74_M77_R0.6720.96
402_R405_D0.6710.96
198_M293_L0.6700.96
247_L497_L0.6690.96
294_T414_F0.6680.96
180_S183_T0.6670.96
393_Y417_F0.6650.96
196_Q308_T0.6630.96
84_S113_F0.6630.96
247_L464_A0.6620.96
158_H179_K0.6620.96
179_K494_D0.6610.96
208_T257_E0.6590.96
171_Y467_Y0.6580.96
291_I391_T0.6560.96
321_G325_E0.6560.96
398_S401_A0.6550.96
148_K434_E0.6520.96
216_G239_A0.6520.96
435_D439_R0.6500.96
170_R174_L0.6490.95
329_M333_I0.6470.95
416_F477_I0.6460.95
346_D391_T0.6460.95
250_G470_P0.6460.95
412_D428_S0.6460.95
290_L294_T0.6420.95
302_A385_I0.6420.95
378_E382_A0.6420.95
180_S494_D0.6420.95
178_D181_R0.6420.95
267_I501_M0.6400.95
120_D145_L0.6400.95
167_Y494_D0.6380.95
346_D392_E0.6360.95
191_L207_E0.6350.95
52_E56_K0.6350.95
383_H488_N0.6330.95
64_L136_L0.6310.95
77_R86_V0.6300.95
348_F351_A0.6290.95
77_R118_L0.6280.95
165_V169_Q0.6270.95
187_R207_E0.6260.95
355_A359_G0.6240.94
362_V365_S0.6240.94
375_I378_E0.6230.94
424_G477_I0.6210.94
371_I375_I0.6210.94
288_H291_I0.6210.94
91_V253_E0.6210.94
431_N469_L0.6190.94
148_K432_D0.6190.94
172_L463_T0.6190.94
299_R303_Q0.6180.94
287_Y391_T0.6160.94
369_G376_F0.6160.94
92_G185_V0.6140.94
232_L235_Y0.6140.94
198_M475_L0.6130.94
286_D428_S0.6110.94
293_L296_S0.6110.94
398_S427_F0.6090.94
131_T135_E0.6080.94
249_V461_Y0.6080.94
299_R324_F0.6070.94
450_G454_A0.6060.94
366_W369_G0.6060.94
381_E386_Q0.6050.93
298_F324_F0.6050.93
54_D58_N0.6050.93
421_R491_T0.6040.93
343_A346_D0.6030.93
204_M252_F0.6020.93
246_R460_D0.6000.93
282_M289_D0.5990.93
99_V143_L0.5980.93
327_L336_Y0.5950.93
174_L250_G0.5940.93
184_F248_V0.5920.93
290_L414_F0.5910.93
347_N351_A0.5910.93
374_E377_D0.5900.93
214_I235_Y0.5870.92
208_T244_L0.5870.92
103_S127_T0.5850.92
457_Y462_V0.5850.92
108_V111_D0.5850.92
108_V142_E0.5850.92
84_S110_N0.5840.92
290_L293_L0.5840.92
207_E276_T0.5840.92
415_E425_N0.5820.92
132_Q135_E0.5820.92
337_R379_V0.5800.92
213_V232_L0.5790.92
78_R87_T0.5780.92
298_F477_I0.5780.92
333_I336_Y0.5780.92
163_Q167_Y0.5770.92
208_T240_P0.5760.92
454_A462_V0.5760.92
213_V219_S0.5760.92
406_V409_E0.5750.92
72_G97_L0.5750.92
179_K182_Q0.5740.92
120_D149_A0.5720.91
352_K355_A0.5720.91
287_Y404_N0.5700.91
261_N278_M0.5690.91
104_L109_Y0.5680.91
201_R300_T0.5670.91
443_Q450_G0.5670.91
131_T134_G0.5650.91
389_F414_F0.5640.91
330_R333_I0.5640.91
358_I379_V0.5640.91
109_Y112_Q0.5640.91
80_M84_S0.5630.91
212_Q243_Y0.5630.91
109_Y143_L0.5620.91
345_L350_A0.5620.91
151_R466_E0.5620.91
244_L257_E0.5610.91
187_R480_D0.5610.91
436_Q465_L0.5580.90
350_A353_A0.5580.90
443_Q451_D0.5570.90
228_N231_D0.5560.90
291_I425_N0.5550.90
128_L137_S0.5550.90
198_M201_R0.5540.90
440_F451_D0.5540.90
291_I294_T0.5540.90
83_A129_F0.5530.90
174_L252_F0.5530.90
377_D380_A0.5520.90
405_D410_I0.5510.90
388_T416_F0.5510.90
108_V112_Q0.5500.90
372_V376_F0.5500.90
437_A457_Y0.5490.90
333_I337_R0.5490.90
240_P258_I0.5470.90
203_F240_P0.5470.90
489_S492_I0.5470.90
354_L357_S0.5460.89
408_P435_D0.5460.89
121_I146_L0.5450.89
424_G475_L0.5450.89
242_L461_Y0.5440.89
355_A371_I0.5430.89
465_L469_L0.5430.89
102_D139_H0.5430.89
198_M256_F0.5420.89
199_V202_G0.5410.89
183_T494_D0.5400.89
194_I258_I0.5390.89
216_G237_R0.5370.89
453_E457_Y0.5370.89
191_L258_I0.5360.89
306_L486_F0.5360.89
98_Y137_S0.5360.89
323_P327_L0.5350.89
66_I127_T0.5350.89
396_E399_P0.5340.88
463_T467_Y0.5330.88
345_L348_F0.5330.88
322_K328_T0.5330.88
214_I219_S0.5330.88
54_D59_Q0.5320.88
287_Y428_S0.5320.88
232_L500_A0.5320.88
153_L175_I0.5310.88
288_H391_T0.5310.88
161_Q165_V0.5300.88
60_E135_E0.5280.88
272_N496_I0.5280.88
116_W120_D0.5260.88
58_N63_S0.5250.88
95_I136_L0.5240.88
244_L249_V0.5240.88
337_R340_T0.5240.88
282_M290_L0.5220.87
77_R117_D0.5210.87
402_R435_D0.5200.87
337_R342_M0.5190.87
301_L482_M0.5190.87
461_Y465_L0.5180.87
79_I83_A0.5180.87
189_K193_A0.5180.87
71_A146_L0.5170.87
227_H230_L0.5170.87
395_A409_E0.5160.87
253_E283_A0.5150.87
153_L159_G0.5150.87
76_T80_M0.5140.87
185_V252_F0.5130.86
55_A59_Q0.5120.86
361_T365_S0.5110.86
291_I295_E0.5110.86
54_D66_I0.5100.86
332_A380_A0.5090.86
153_L165_V0.5090.86
426_G475_L0.5090.86
80_M502_R0.5080.86
291_I414_F0.5080.86
99_V103_S0.5080.86
190_I482_M0.5080.86
396_E439_R0.5070.86
346_D350_A0.5070.86
197_F301_L0.5050.86
363_E367_G0.5050.86
174_L251_G0.5050.86
213_V500_A0.5050.86
53_F69_S0.5040.85
166_R180_S0.5040.85
377_D382_A0.5040.85
60_E64_L0.5040.85
149_A467_Y0.5030.85
455_M466_E0.5030.85
79_I114_K0.5020.85
159_G179_K0.5020.85
299_R319_D0.5010.85
153_L156_K0.5010.85
112_Q116_W0.5010.85
366_W374_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ex5A 2 0.9545 100 0.103 Contact Map
4pg3A 2 0.9307 100 0.116 Contact Map
4ycuA 3 0.9683 100 0.12 Contact Map
4up7A 2 0.9762 100 0.121 Contact Map
1e1oA 2 0.9584 100 0.123 Contact Map
3a74A 4 0.9545 100 0.143 Contact Map
3i7fA 2 0.8792 100 0.222 Contact Map
1eovA 2 0.899 100 0.23 Contact Map
4j15A 2 0.8257 100 0.235 Contact Map
1l0wA 2 0.8594 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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