GREMLIN Database
SYK1 - Lysine--tRNA ligase
UniProt: P0A8N3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10552
Length: 505 (432)
Sequences: 9665 (4818)
Seq/√Len: 231.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_R296_S4.5501.00
125_K142_E4.0051.00
97_L140_C3.8461.00
63_A66_I3.7291.00
199_V256_F3.6691.00
69_A125_K3.6391.00
67_E125_K3.6341.00
197_F296_S3.5121.00
192_S196_Q3.4731.00
67_E141_T3.3371.00
196_Q200_N3.2821.00
192_S199_V3.2481.00
123_G144_R2.9621.00
244_L255_V2.9351.00
193_G304_D2.8561.00
193_G300_T2.7781.00
285_A289_D2.7761.00
428_S473_A2.6551.00
186_V487_T2.4861.00
210_M262_F2.4281.00
97_L124_A2.3811.00
61_L135_E2.3671.00
194_I278_M2.3291.00
71_A123_G2.2611.00
190_I483_V2.2601.00
248_V472_T2.2261.00
392_E404_N2.2231.00
335_K350_S2.2041.00
150_L466_E2.1971.00
95_I138_I2.1621.00
191_L479_I2.0991.00
343_A386_Q2.0901.00
195_R205_E2.0631.00
224_I233_D2.0601.00
210_M259_N2.0451.00
418_I423_I2.0261.00
67_E127_K2.0251.00
127_K141_T2.0171.00
68_V138_I2.0121.00
299_R322_K1.9971.00
196_Q199_V1.9921.00
65_N127_K1.9791.00
300_T304_D1.9701.00
374_E378_E1.9651.00
188_S199_V1.9641.00
196_Q304_D1.9561.00
282_M285_A1.9391.00
197_F201_R1.9201.00
183_T489_S1.9121.00
328_T331_E1.9091.00
197_F300_T1.9041.00
437_A441_L1.8941.00
292_E296_S1.8701.00
287_Y412_D1.8681.00
290_L473_A1.8601.00
194_I297_L1.8251.00
438_Q442_D1.8251.00
197_F297_L1.8171.00
129_F139_H1.8101.00
389_F416_F1.8051.00
433_A437_A1.8051.00
193_G301_L1.8011.00
280_L475_L1.7971.00
405_D412_D1.7941.00
328_T392_E1.7871.00
331_E335_K1.7791.00
200_N300_T1.7181.00
70_V95_I1.7061.00
369_G372_V1.6921.00
298_F416_F1.6741.00
404_N412_D1.6691.00
185_K204_M1.6681.00
181_R185_K1.6611.00
327_L332_A1.6471.00
89_Q94_R1.6441.00
438_Q441_L1.6261.00
346_D350_S1.6181.00
286_D289_D1.6181.00
437_A462_V1.6071.00
206_V247_L1.5921.00
182_N186_V1.5801.00
203_F282_M1.5741.00
69_A123_G1.5721.00
433_A466_E1.5561.00
202_G254_R1.5471.00
74_M122_L1.5421.00
87_T94_R1.5281.00
74_M116_W1.5191.00
127_K139_H1.5021.00
330_R334_K1.5001.00
403_R431_N1.4831.00
166_R173_D1.4661.00
60_E63_A1.4661.00
189_Q192_S1.4561.00
74_M86_V1.4531.00
331_E334_K1.4511.00
442_D445_A1.4501.00
403_R432_D1.4491.00
282_M293_L1.4431.00
310_E319_D1.4311.00
325_E386_Q1.4311.00
178_D182_N1.4251.00
288_K292_E1.4151.00
190_I301_L1.4131.00
428_S431_N1.4121.00
189_Q304_D1.4111.00
302_A486_F1.4071.00
373_T377_E1.4061.00
184_F252_F1.3971.00
381_E384_L1.3951.00
116_W122_L1.3931.00
193_G196_Q1.3871.00
179_E489_S1.3821.00
261_N277_M1.3741.00
140_C143_L1.3721.00
303_Q307_G1.3671.00
463_T466_E1.3521.00
285_A473_A1.3421.00
223_F229_A1.3421.00
366_W369_G1.3361.00
278_M479_I1.3291.00
193_G305_I1.3221.00
288_K326_K1.3201.00
254_R282_M1.3151.00
57_E60_E1.3071.00
369_G373_T1.2971.00
455_M463_T1.2951.00
327_L390_I1.2941.00
189_Q309_T1.2941.00
437_A459_E1.2851.00
198_M278_M1.2811.00
336_Y383_H1.2801.00
432_D435_D1.2771.00
407_N410_I1.2731.00
82_K101_R1.2721.00
70_V88_L1.2711.00
372_V375_I1.2701.00
352_K356_E1.2701.00
184_F497_L1.2651.00
123_G146_L1.2551.00
325_E335_K1.2441.00
124_A140_C1.2441.00
373_T376_F1.2431.00
416_F424_G1.2361.00
435_D438_Q1.2361.00
185_K189_Q1.2361.00
128_L136_L1.2331.00
330_R410_I1.2321.00
240_P261_N1.2141.00
186_V305_I1.2101.00
369_G376_F1.2061.00
198_M280_L1.2031.00
182_N185_K1.2001.00
368_L372_V1.1961.00
196_Q300_T1.1941.00
169_Q463_T1.1891.00
128_L138_I1.1771.00
439_R442_D1.1751.00
156_K159_G1.1691.00
86_V97_L1.1691.00
83_A98_Y1.1661.00
395_A439_R1.1541.00
403_R435_D1.1521.00
181_R252_F1.1511.00
194_I479_I1.1501.00
206_V252_F1.1451.00
198_M297_L1.1451.00
84_S109_Y1.1381.00
404_N410_I1.1381.00
437_A455_M1.1371.00
367_G370_R1.1371.00
61_L64_L1.1351.00
292_E344_D1.1331.00
194_I301_L1.1301.00
401_A427_F1.1221.00
116_W143_L1.1101.00
353_A356_E1.1101.00
366_W370_R1.1101.00
205_E256_F1.1041.00
99_V140_C1.1021.00
76_T87_T1.1021.00
190_I486_F1.0911.00
70_V138_I1.0891.00
92_G95_I1.0851.00
371_I375_I1.0831.00
303_Q319_D1.0761.00
294_T477_I1.0731.00
117_D120_D1.0711.00
240_P277_M1.0691.00
298_F482_M1.0651.00
226_H231_D1.0611.00
189_Q199_V1.0601.00
201_R293_L1.0601.00
242_L460_D1.0591.00
296_S299_R1.0571.00
249_V469_L1.0571.00
88_L122_L1.0531.00
295_E299_R1.0501.00
353_A357_S1.0471.00
90_D93_G1.0461.00
211_M225_T1.0341.00
75_M89_Q1.0341.00
226_H233_D1.0311.00
59_E63_A1.0291.00
174_L184_F1.0281.00
115_K148_K1.0251.00
55_G92_G1.0231.00
291_I326_K1.0221.00
155_D159_G1.0221.00
190_I479_I1.0181.00
445_A454_A1.0171.00
454_A457_Y1.0161.00
52_E66_I1.0151.00
116_W145_L1.0151.00
100_A139_H1.0141.00
195_R256_F1.0131.00
228_N231_D1.0121.00
301_L305_I1.0101.00
266_G502_R1.0101.00
349_D353_A1.0081.00
439_R443_Q1.0061.00
207_E260_R1.0051.00
86_V122_L1.0001.00
387_P418_I0.9931.00
489_S495_V0.9931.00
352_K355_A0.9921.00
89_Q119_G0.9921.00
372_V376_F0.9911.00
370_R373_T0.9881.00
380_A384_L0.9881.00
211_M234_M0.9821.00
295_E344_D0.9811.00
297_L301_L0.9801.00
299_R321_G0.9751.00
100_A103_D0.9721.00
349_D352_K0.9691.00
99_V104_L0.9651.00
92_G253_E0.9641.00
285_A290_L0.9641.00
489_S494_D0.9631.00
147_T469_L0.9621.00
240_P259_N0.9601.00
240_P243_Y0.9551.00
332_A390_I0.9531.00
186_V190_I0.9511.00
296_S300_T0.9491.00
186_V189_Q0.9481.00
294_T475_L0.9461.00
121_I147_T0.9441.00
363_E366_W0.9401.00
437_A466_E0.9391.00
366_W372_V0.9371.00
70_V124_A0.9331.00
341_D344_D0.9291.00
191_L205_E0.9291.00
392_E410_I0.9271.00
395_A403_R0.9271.00
433_A462_V0.9261.00
188_S192_S0.9261.00
197_F293_L0.9221.00
68_V128_L0.9201.00
112_Q115_K0.9171.00
469_L472_T0.9141.00
103_D139_H0.9131.00
343_A388_T0.9111.00
155_D158_H0.9111.00
303_Q309_T0.9091.00
365_S369_G0.9091.00
289_D292_E0.9071.00
373_T397_V0.9051.00
270_R421_R0.9010.99
247_L497_L0.8980.99
162_D165_A0.8970.99
304_D308_K0.8900.99
334_K338_P0.8880.99
333_I372_V0.8860.99
360_I383_H0.8840.99
246_R498_F0.8820.99
287_Y291_I0.8770.99
191_L278_M0.8730.99
294_T424_G0.8720.99
358_I375_I0.8720.99
171_Y463_T0.8710.99
369_G375_I0.8710.99
179_E183_T0.8630.99
80_M83_A0.8620.99
280_L294_T0.8610.99
299_R309_T0.8580.99
95_I128_L0.8580.99
111_E114_K0.8570.99
290_L475_L0.8520.99
120_D148_K0.8500.99
371_I376_F0.8500.99
117_D148_K0.8490.99
75_M94_R0.8490.99
186_V306_L0.8470.99
346_D349_D0.8470.99
99_V113_F0.8470.99
484_M492_I0.8450.99
430_L435_D0.8440.99
309_T321_G0.8430.99
441_L455_M0.8410.99
212_Q217_G0.8390.99
459_E463_T0.8380.99
295_E326_K0.8370.99
215_P456_F0.8370.99
79_I84_S0.8360.99
73_R284_Y0.8340.99
367_G396_E0.8340.99
53_F66_I0.8330.99
248_V469_L0.8320.99
103_D141_T0.8320.99
249_V465_L0.8320.99
440_F458_D0.8300.99
477_I482_M0.8280.99
126_G138_I0.8240.99
246_R464_A0.8240.99
91_V185_K0.8220.99
124_A138_I0.8190.99
334_K337_R0.8180.99
323_P326_K0.8150.99
111_E115_K0.8140.99
332_A335_K0.8140.99
70_V97_L0.8130.99
327_L335_K0.8120.99
336_Y350_S0.8100.99
60_E132_K0.8100.99
201_R254_R0.8090.99
232_L503_P0.8080.99
224_I235_Y0.8050.99
188_S256_F0.8030.99
79_I82_K0.8010.99
121_I470_P0.8000.99
304_D307_G0.7960.99
203_F254_R0.7950.99
369_G377_E0.7930.99
86_V99_V0.7920.99
445_A458_D0.7920.99
56_K59_E0.7910.99
227_H234_M0.7890.99
360_I363_E0.7890.99
324_F387_P0.7890.99
210_M240_P0.7840.99
193_G197_F0.7840.99
285_A293_L0.7820.99
395_A411_T0.7810.99
301_L304_D0.7790.99
421_R485_L0.7770.98
302_A320_F0.7740.98
327_L388_T0.7720.98
190_I305_I0.7670.98
423_I482_M0.7660.98
183_T487_T0.7620.98
434_E437_A0.7620.98
110_N113_F0.7620.98
396_E409_E0.7620.98
86_V140_C0.7610.98
213_V243_Y0.7610.98
390_I417_F0.7590.98
324_F416_F0.7580.98
280_L290_L0.7550.98
55_G58_N0.7510.98
77_R84_S0.7500.98
287_Y392_E0.7480.98
355_A367_G0.7430.98
97_L122_L0.7400.98
359_G363_E0.7380.98
430_L439_R0.7360.98
402_R431_N0.7350.98
305_I486_F0.7350.98
445_A457_Y0.7330.98
402_R405_D0.7320.98
76_T118_L0.7280.98
392_E412_D0.7270.98
357_S360_I0.7270.98
356_E362_V0.7230.98
285_A428_S0.7200.98
158_H179_E0.7170.97
56_K60_E0.7170.97
398_S413_R0.7140.97
89_Q178_D0.7140.97
300_T303_Q0.7120.97
280_L293_L0.7120.97
434_E438_Q0.7110.97
459_E462_V0.7110.97
375_I378_E0.7090.97
365_S370_R0.7080.97
55_G95_I0.7080.97
210_M260_R0.7080.97
291_I389_F0.7080.97
378_E382_A0.7070.97
402_R412_D0.7070.97
59_E136_L0.7050.97
414_F426_G0.7040.97
188_S204_M0.7040.97
112_Q143_L0.7030.97
327_L331_E0.7020.97
295_E323_P0.7010.97
212_Q215_P0.6990.97
318_L419_G0.6970.97
291_I391_T0.6930.97
88_L97_L0.6920.97
322_K326_K0.6900.97
212_Q216_G0.6890.97
393_Y417_F0.6880.97
186_V483_V0.6880.97
84_S113_F0.6870.97
54_D58_N0.6860.97
487_T495_V0.6850.97
215_P219_A0.6840.97
405_D408_P0.6820.97
125_K141_T0.6800.96
413_R425_N0.6800.96
362_V366_W0.6790.96
121_I284_Y0.6780.96
343_A346_D0.6780.96
196_Q308_K0.6770.96
299_R323_P0.6760.96
404_N409_E0.6750.96
180_S183_T0.6720.96
189_Q308_K0.6710.96
370_R376_F0.6660.96
198_M293_L0.6650.96
302_A385_I0.6640.96
74_M77_R0.6640.96
145_L148_K0.6620.96
483_V487_T0.6610.96
332_A336_Y0.6610.96
100_A129_F0.6610.96
321_G325_E0.6610.96
294_T414_F0.6600.96
170_R174_L0.6600.96
329_M333_I0.6600.96
366_W373_T0.6600.96
258_I479_I0.6570.96
216_G239_A0.6530.96
435_D439_R0.6520.96
416_F477_I0.6520.96
208_T257_E0.6520.96
171_Y467_H0.6500.95
269_V491_T0.6500.95
91_V253_E0.6480.95
66_I128_L0.6480.95
228_N233_D0.6480.95
108_V142_E0.6460.95
180_S494_D0.6450.95
404_N408_P0.6430.95
178_D181_R0.6410.95
153_L157_F0.6410.95
380_A383_H0.6400.95
58_N132_K0.6400.95
167_Y494_D0.6390.95
444_V457_Y0.6390.95
366_W371_I0.6370.95
357_S361_H0.6350.95
148_K432_D0.6340.95
64_L136_L0.6340.95
165_A169_Q0.6330.95
187_R207_E0.6320.95
54_D63_A0.6320.95
154_P157_F0.6310.95
303_Q306_L0.6310.95
453_E457_Y0.6300.95
267_I501_M0.6300.95
412_D428_S0.6300.95
120_D145_L0.6280.95
148_K434_E0.6270.95
333_I337_R0.6270.95
77_R86_V0.6270.95
287_Y404_N0.6260.94
299_R303_Q0.6260.94
113_F143_L0.6260.94
346_D392_E0.6240.94
198_M475_L0.6220.94
214_I235_Y0.6220.94
77_R118_L0.6220.94
191_L207_E0.6210.94
366_W376_F0.6200.94
398_S427_F0.6190.94
361_H369_G0.6170.94
131_T135_E0.6160.94
299_R324_F0.6150.94
431_N469_L0.6140.94
248_V283_A0.6140.94
172_L463_T0.6130.94
334_K353_A0.6130.94
216_G237_R0.6120.94
290_L294_T0.6120.94
318_L385_I0.6100.94
286_D428_S0.6090.94
361_H372_V0.6090.94
213_V232_L0.6070.94
375_I379_V0.6070.94
179_E494_D0.6070.94
424_G477_I0.6060.93
350_S353_A0.6050.93
204_M252_F0.6050.93
365_S371_I0.6040.93
361_H365_S0.6040.93
282_M289_D0.6040.93
288_K291_I0.6010.93
372_V377_E0.5980.93
358_I362_V0.5970.93
337_R379_V0.5920.93
330_R333_I0.5920.93
365_S372_V0.5910.93
290_L414_F0.5900.93
151_R466_E0.5890.92
207_E276_T0.5880.92
120_D149_A0.5870.92
72_G97_L0.5850.92
99_V143_L0.5850.92
92_G185_K0.5850.92
191_L258_I0.5840.92
78_R87_T0.5840.92
261_N278_M0.5820.92
327_L336_Y0.5810.92
293_L296_S0.5800.92
102_D139_H0.5790.92
421_R491_T0.5780.92
287_Y391_T0.5770.92
110_N114_K0.5770.92
346_D391_T0.5760.92
58_N63_A0.5750.92
454_A462_V0.5750.92
208_T240_P0.5740.92
366_W374_E0.5740.92
298_F477_I0.5740.92
415_E425_N0.5720.91
187_R480_D0.5720.91
208_T244_L0.5700.91
332_A380_A0.5690.91
198_M256_F0.5690.91
83_A129_F0.5690.91
290_L293_L0.5680.91
383_H488_N0.5680.91
108_V112_Q0.5660.91
103_D127_K0.5650.91
365_S376_F0.5650.91
128_L137_S0.5650.91
389_F414_F0.5650.91
163_Q167_Y0.5650.91
174_L250_G0.5630.91
424_G475_L0.5630.91
333_I336_Y0.5630.91
465_L469_L0.5620.91
489_S492_I0.5620.91
367_G372_V0.5610.91
322_K328_T0.5600.91
298_F324_F0.5570.90
60_E135_E0.5570.90
244_L257_E0.5560.90
80_M84_S0.5560.90
179_E182_N0.5550.90
306_L318_L0.5550.90
371_I374_E0.5540.90
201_R300_T0.5530.90
354_I358_I0.5530.90
365_S373_T0.5520.90
391_T404_N0.5500.90
457_Y462_V0.5490.90
52_E56_K0.5490.90
249_V470_P0.5470.89
203_F240_P0.5470.89
367_G373_T0.5460.89
84_S110_N0.5460.89
291_I294_T0.5450.89
463_T467_H0.5450.89
240_P258_I0.5450.89
153_L175_I0.5430.89
287_Y428_S0.5430.89
198_M201_R0.5430.89
396_E411_T0.5420.89
54_D59_E0.5400.89
71_A146_L0.5380.89
306_L486_F0.5370.89
345_L350_S0.5370.89
404_N435_D0.5370.89
77_R117_D0.5360.89
190_I482_M0.5340.88
184_F247_L0.5330.88
436_Q465_L0.5330.88
75_M156_K0.5330.88
319_D322_K0.5330.88
242_L461_Y0.5330.88
272_N496_I0.5320.88
116_W120_D0.5320.88
131_T134_G0.5320.88
194_I258_I0.5310.88
174_L252_F0.5310.88
342_M345_L0.5310.88
402_R435_D0.5290.88
98_Y137_S0.5290.88
121_I146_L0.5280.88
132_K135_E0.5260.88
396_E399_P0.5250.88
155_D172_L0.5250.88
461_Y465_L0.5240.87
353_A384_L0.5230.87
337_R342_M0.5230.87
246_R460_D0.5220.87
56_K64_L0.5220.87
95_I136_L0.5210.87
79_I83_A0.5200.87
291_I425_N0.5200.87
288_K391_T0.5180.87
155_D161_Q0.5180.87
66_I127_K0.5180.87
112_Q116_W0.5170.87
398_S401_A0.5170.87
301_L482_M0.5170.87
232_L500_A0.5160.87
406_V409_E0.5160.87
388_T416_F0.5160.87
99_V103_D0.5160.87
291_I414_F0.5150.87
288_K344_D0.5140.86
282_M290_L0.5140.86
154_P159_G0.5140.86
359_G362_V0.5120.86
104_L109_Y0.5120.86
189_Q193_G0.5120.86
426_G475_L0.5120.86
354_I357_S0.5120.86
227_H230_L0.5120.86
291_I295_E0.5120.86
253_E283_A0.5110.86
404_N407_N0.5110.86
298_F320_F0.5100.86
172_L467_H0.5090.86
355_A371_I0.5080.86
351_A355_A0.5080.86
215_P235_Y0.5070.86
120_D147_T0.5070.86
53_F69_A0.5070.86
455_M459_E0.5060.86
174_L251_G0.5060.86
437_A457_Y0.5050.85
441_L445_A0.5050.85
183_T494_D0.5050.85
292_E326_K0.5040.85
350_S354_I0.5040.85
381_E386_Q0.5040.85
292_E322_K0.5030.85
197_F200_N0.5020.85
156_K160_L0.5020.85
123_G142_E0.5010.85
359_G369_G0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ex5A 2 0.9545 100 0.107 Contact Map
4pg3A 2 0.9307 100 0.12 Contact Map
4ycuA 3 0.9683 100 0.123 Contact Map
4up7A 2 0.9762 100 0.124 Contact Map
1e1oA 2 0.9584 100 0.129 Contact Map
3a74A 4 0.9545 100 0.148 Contact Map
3i7fA 2 0.8792 100 0.225 Contact Map
1l0wA 2 0.8594 100 0.235 Contact Map
1eovA 2 0.895 100 0.236 Contact Map
4j15A 2 0.8257 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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