GREMLIN Database
MATP - Macrodomain Ter protein
UniProt: P0A8N0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12855
Length: 150 (148)
Sequences: 107 (30)
Seq/√Len: 2.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Y105_A3.5380.53
108_A126_A2.8590.38
131_K138_S2.7640.36
30_R135_K2.4240.29
69_R125_D2.3410.28
19_V54_V2.2550.26
45_L118_T2.1990.25
49_N77_R2.1310.24
66_L100_V1.9780.22
87_Q103_R1.9770.22
103_R127_E1.9520.21
9_L12_G1.9410.21
5_Q9_L1.9250.21
107_L127_E1.9140.21
129_K132_Y1.9000.21
69_R102_Q1.8530.20
69_R146_L1.8480.20
134_N144_Q1.8370.20
70_M73_T1.7420.18
34_A53_L1.7360.18
73_T121_Q1.7120.18
2_K8_N1.7090.18
62_M84_A1.6790.17
32_I54_V1.6510.17
33_E132_Y1.6420.17
62_M97_E1.6330.17
123_I140_K1.6320.17
110_R130_E1.5990.16
43_V53_L1.5880.16
81_H142_D1.5820.16
38_Q42_D1.5730.16
129_K144_Q1.5390.16
111_R121_Q1.5380.16
7_E62_M1.5120.15
47_L105_A1.5100.15
73_T125_D1.4980.15
11_S112_G1.4930.15
86_H117_E1.4850.15
5_Q71_K1.4800.15
121_Q125_D1.4760.15
109_Q128_N1.4450.15
64_P119_I1.4240.14
8_N100_V1.4180.14
49_N60_K1.3780.14
54_V77_R1.3710.14
38_Q137_S1.3620.14
107_L125_D1.3500.14
8_N66_L1.3140.13
126_A139_L1.3120.13
98_F124_E1.2520.13
5_Q12_G1.2370.12
60_K123_I1.2360.12
126_A138_S1.2280.12
65_E118_T1.2250.12
99_I105_A1.2190.12
98_F125_D1.1960.12
109_Q113_K1.1900.12
90_R107_L1.1710.12
103_R111_R1.1610.12
38_Q45_L1.1550.12
87_Q127_E1.1490.12
117_E136_M1.1480.12
48_E81_H1.1440.11
71_K122_L1.1390.11
20_K24_E1.1300.11
53_L108_A1.1210.11
103_R107_L1.1190.11
47_L54_V1.1080.11
27_L141_Q1.1030.11
33_E129_K1.0990.11
127_E132_Y1.0720.11
40_A142_D1.0540.11
70_M141_Q1.0520.11
69_R121_Q1.0510.11
90_R145_A1.0500.11
32_I141_Q1.0480.11
33_E36_A1.0410.11
61_H100_V1.0300.10
47_L98_F1.0210.10
2_K100_V1.0190.10
32_I48_E1.0100.10
125_D146_L1.0050.10
48_E140_K1.0050.10
110_R121_Q0.9780.10
49_N97_E0.9770.10
87_Q129_K0.9760.10
68_N88_H0.9760.10
49_N135_K0.9730.10
70_M120_V0.9710.10
129_K133_A0.9670.10
97_E108_A0.9190.10
103_R129_K0.9180.10
69_R124_E0.9140.10
61_H66_L0.9080.09
43_V128_N0.9060.09
105_A130_E0.9050.09
2_K66_L0.9040.09
33_E70_M0.9030.09
37_A118_T0.8970.09
90_R118_T0.8960.09
107_L124_E0.8920.09
2_K9_L0.8910.09
32_I65_E0.8880.09
52_V113_K0.8830.09
69_R73_T0.8830.09
27_L59_D0.8760.09
16_K118_T0.8700.09
34_A112_G0.8670.09
103_R144_Q0.8660.09
9_L81_H0.8660.09
110_R133_A0.8640.09
111_R125_D0.8640.09
22_H128_N0.8560.09
30_R56_G0.8560.09
26_E46_S0.8520.09
87_Q132_Y0.8520.09
41_V90_R0.8350.09
7_E74_I0.8270.09
102_Q124_E0.8160.09
54_V61_H0.8050.09
23_R39_E0.8040.09
90_R139_L0.8010.09
103_R110_R0.8010.09
89_T146_L0.7990.09
65_E97_E0.7980.09
109_Q118_T0.7970.09
32_I97_E0.7930.09
102_Q107_L0.7870.09
129_K134_N0.7760.08
67_V109_Q0.7750.08
7_E15_W0.7590.08
108_A138_S0.7580.08
73_T110_R0.7510.08
32_I146_L0.7470.08
77_R127_E0.7400.08
33_E120_V0.7380.08
21_K39_E0.7320.08
5_Q19_V0.7320.08
33_E127_E0.7320.08
23_R127_E0.7250.08
34_A43_V0.7200.08
108_A118_T0.7180.08
110_R125_D0.7140.08
30_R61_H0.7020.08
108_A142_D0.7010.08
111_R127_E0.7000.08
55_N106_G0.6980.08
77_R97_E0.6970.08
102_Q125_D0.6970.08
16_K98_F0.6940.08
62_M120_V0.6930.08
97_E129_K0.6910.08
136_M148_G0.6910.08
23_R77_R0.6840.08
55_N88_H0.6830.08
120_V129_K0.6790.08
16_K145_A0.6730.08
45_L48_E0.6660.08
112_G130_E0.6550.08
52_V136_M0.6530.08
34_A108_A0.6510.08
12_G90_R0.6440.08
20_K41_V0.6380.08
106_G109_Q0.6330.08
41_V123_I0.6250.07
50_E71_K0.6250.07
22_H59_D0.6180.07
30_R68_N0.6170.07
9_L40_A0.6110.07
35_S58_I0.6100.07
12_G122_L0.6100.07
37_A73_T0.6100.07
52_V134_N0.6100.07
70_M121_Q0.6090.07
9_L139_L0.6010.07
7_E49_N0.5970.07
102_Q132_Y0.5950.07
9_L71_K0.5950.07
15_W119_I0.5880.07
127_E133_A0.5830.07
32_I50_E0.5800.07
103_R132_Y0.5760.07
24_E31_Y0.5710.07
54_V62_M0.5630.07
88_H139_L0.5600.07
124_E132_Y0.5530.07
21_K113_K0.5510.07
60_K117_E0.5510.07
36_A124_E0.5490.07
27_L63_N0.5410.07
77_R129_K0.5380.07
36_A146_L0.5360.07
28_I127_E0.5330.07
1_M17_Y0.5310.07
1_M10_E0.5310.07
1_M13_W0.5310.07
6_L18_L0.5310.07
6_L17_Y0.5310.07
6_L13_W0.5310.07
1_M18_L0.5310.07
6_L10_E0.5310.07
3_Y18_L0.5310.07
3_Y6_L0.5310.07
3_Y10_E0.5310.07
3_Y13_W0.5310.07
3_Y17_Y0.5310.07
13_W17_Y0.5310.07
1_M6_L0.5310.07
10_E13_W0.5310.07
13_W18_L0.5310.07
10_E17_Y0.5310.07
10_E18_L0.5310.07
71_K100_V0.5300.07
73_T99_I0.5290.07
58_I88_H0.5290.07
42_D46_S0.5280.07
21_K31_Y0.5180.07
37_A65_E0.5160.07
87_Q118_T0.5110.07
63_N121_Q0.5090.07
35_S147_L0.5080.07
7_E61_H0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3veaB 3 0.9933 100 0.025 Contact Map
1p94A 2 0.5067 65.6 0.948 Contact Map
4hv0A 1 0.3867 47.9 0.953 Contact Map
2mdvA 2 0.2533 46 0.954 Contact Map
2k9iA 2 0.3667 32.2 0.958 Contact Map
2kelA 2 0.28 24.9 0.96 Contact Map
2cpgA 2 0.2933 23.9 0.96 Contact Map
2dq0A 2 0.5933 15.3 0.964 Contact Map
2gpeA 2 0.2933 14.5 0.964 Contact Map
2ba3A 2 0.34 12.7 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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