GREMLIN Database
SYN - Asparagine--tRNA ligase
UniProt: P0A8M0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10094
Length: 466 (421)
Sequences: 9467 (4798)
Seq/√Len: 233.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_Q268_A4.5681.00
77_T96_K3.9981.00
15_A18_S3.8451.00
52_A94_A3.8361.00
153_N227_Y3.6761.00
19_E77_T3.6341.00
21_T77_T3.6321.00
146_Q150_R3.5241.00
151_F268_A3.5181.00
19_E95_S3.3051.00
150_R154_E3.2421.00
146_Q153_N3.2271.00
75_I98_E2.9191.00
216_G226_I2.9101.00
147_A276_A2.8951.00
147_A272_Y2.8101.00
257_A261_D2.7551.00
395_Q432_S2.7511.00
105_D425_R2.4541.00
140_V446_T2.4431.00
164_L233_F2.3951.00
302_R312_D2.3901.00
318_T322_N2.3881.00
148_L250_L2.3291.00
13_R89_Q2.3111.00
52_A76_V2.3101.00
23_R75_I2.2761.00
144_L442_I2.2241.00
178_R205_E2.1851.00
50_V92_I2.1491.00
145_A438_F2.1321.00
164_L230_G2.1031.00
19_E79_K2.0871.00
295_D298_S2.0841.00
408_L414_K2.0801.00
149_H159_W2.0641.00
404_D408_L2.0221.00
384_A390_I2.0151.00
254_V257_A2.0071.00
79_K95_S2.0051.00
150_R153_N1.9961.00
142_H153_N1.9801.00
318_T321_E1.9781.00
20_V92_I1.9741.00
358_N370_L1.9731.00
271_K289_A1.9481.00
272_Y276_A1.9471.00
137_V448_V1.9391.00
151_F272_Y1.9351.00
259_L378_A1.9131.00
151_F155_Q1.9091.00
17_D79_K1.9091.00
150_R276_A1.9031.00
219_Y431_H1.8971.00
262_I432_S1.8571.00
264_G268_A1.8451.00
151_F269_M1.8391.00
148_L269_M1.8271.00
22_V50_V1.8121.00
355_V382_V1.8111.00
147_A273_V1.8101.00
405_E409_E1.8071.00
81_V93_Q1.7821.00
400_L404_D1.7741.00
252_P434_F1.7701.00
295_D358_N1.7611.00
298_S302_R1.7561.00
154_E272_Y1.7551.00
135_G139_R1.7491.00
12_G15_A1.7171.00
270_L382_V1.6921.00
139_R158_F1.6621.00
404_D421_R1.6461.00
371_N378_A1.6381.00
180_S203_G1.6311.00
21_T75_I1.6051.00
294_K299_R1.5851.00
405_E408_L1.5681.00
136_A140_V1.5611.00
370_L378_A1.5591.00
400_L425_R1.5561.00
157_F254_V1.5531.00
258_N261_D1.5391.00
26_V74_V1.5321.00
404_D414_K1.5301.00
297_V301_E1.5111.00
79_K93_Q1.4931.00
26_V39_L1.4891.00
156_G225_K1.4851.00
121_L128_R1.4731.00
26_V68_L1.4721.00
254_V265_L1.4631.00
292_V352_A1.4561.00
16_V82_A1.4531.00
143_T146_Q1.4501.00
369_R398_E1.4401.00
369_R399_R1.4291.00
274_F445_V1.4261.00
132_N136_A1.4251.00
138_A223_L1.4091.00
239_N242_R1.3991.00
260_N293_D1.3931.00
68_L74_V1.3911.00
347_E350_F1.3901.00
144_L273_V1.3871.00
312_D315_D1.3871.00
395_Q398_E1.3811.00
232_T249_M1.3751.00
313_Y317_V1.3731.00
413_N416_D1.3701.00
133_L448_V1.3661.00
294_K356_V1.3641.00
297_V376_T1.3581.00
180_S205_E1.3541.00
260_N264_G1.3541.00
94_A97_V1.3481.00
147_A150_R1.3481.00
143_T276_A1.3321.00
332_Y335_V1.3251.00
250_L438_F1.3241.00
298_S301_E1.3221.00
404_D418_W1.3211.00
37_S62_N1.3151.00
147_A277_V1.3091.00
45_S50_V1.3071.00
143_T281_R1.3051.00
361_K406_R1.3051.00
152_F250_L1.2951.00
422_D425_R1.2921.00
35_G56_N1.2921.00
225_K254_V1.2841.00
333_W337_L1.2801.00
257_A432_S1.2801.00
334_G337_L1.2781.00
399_R402_V1.2761.00
152_F252_P1.2731.00
409_E412_L1.2671.00
22_V41_V1.2651.00
292_V302_R1.2611.00
373_D376_T1.2581.00
138_A456_P1.2551.00
76_V94_A1.2541.00
139_R143_T1.2461.00
382_V391_I1.2341.00
275_K279_E1.2331.00
140_V277_V1.2331.00
402_V405_E1.2321.00
150_R272_Y1.2301.00
75_I100_A1.2291.00
315_D318_T1.2281.00
13_R16_V1.2201.00
136_A139_R1.2181.00
303_F349_H1.2101.00
264_G310_Q1.2081.00
124_V422_D1.2071.00
59_P63_E1.1911.00
212_G232_T1.1861.00
80_V90_F1.1791.00
36_I53_V1.1771.00
369_R402_V1.1711.00
370_L376_T1.1681.00
28_T40_A1.1451.00
55_N58_L1.1401.00
338_S342_E1.1401.00
144_L445_V1.1241.00
406_R409_E1.1231.00
80_V92_I1.1201.00
40_A47_F1.1181.00
367_Y394_S1.1151.00
214_L419_W1.1111.00
54_I94_A1.1091.00
266_A436_L1.1091.00
42_Y47_F1.1081.00
152_F269_M1.1011.00
148_L438_F1.0981.00
68_L97_V1.0951.00
135_G223_L1.0811.00
160_V223_L1.0801.00
159_W227_Y1.0791.00
13_R82_A1.0761.00
268_A271_K1.0751.00
176_M200_D1.0751.00
263_A293_D1.0741.00
155_Q265_L1.0711.00
143_T153_N1.0691.00
353_P384_A1.0691.00
41_V74_V1.0691.00
22_V92_I1.0661.00
270_L441_L1.0631.00
267_E271_K1.0601.00
212_G249_M1.0591.00
39_L52_A1.0591.00
69_T72_C1.0581.00
176_M463_N1.0581.00
148_L273_V1.0531.00
339_S343_R1.0491.00
43_D46_C1.0481.00
237_N461_P1.0451.00
27_R42_Y1.0391.00
406_R410_M1.0311.00
67_R102_W1.0311.00
338_S363_I1.0281.00
45_S224_S1.0251.00
273_V277_V1.0251.00
140_V144_L1.0211.00
144_L438_F1.0161.00
161_S231_P1.0131.00
63_E66_L1.0111.00
331_V335_V1.0071.00
55_N93_Q1.0061.00
299_R356_V0.9981.00
271_K288_F0.9961.00
448_V454_V0.9951.00
42_Y71_G0.9921.00
320_L323_C0.9901.00
149_H227_Y0.9891.00
311_V316_A0.9891.00
358_N376_T0.9741.00
319_I323_C0.9711.00
448_V453_D0.9701.00
275_K281_R0.9681.00
165_I206_S0.9631.00
261_D264_G0.9591.00
335_V338_S0.9581.00
275_K286_K0.9571.00
129_P138_A0.9571.00
428_T431_H0.9531.00
68_L99_V0.9521.00
269_M273_V0.9511.00
281_R288_F0.9481.00
22_V76_V0.9421.00
266_A434_F0.9421.00
212_G230_G0.9381.00
20_V80_V0.9321.00
73_S101_G0.9301.00
257_A262_I0.9301.00
145_A159_W0.9291.00
220_A428_T0.9281.00
58_L93_Q0.9271.00
166_T215_N0.9251.00
276_A280_E0.9241.00
212_G215_N0.9231.00
54_I65_V0.9221.00
268_A272_Y0.9211.00
140_V143_T0.9211.00
338_S341_H0.9201.00
39_L74_V0.9141.00
319_I322_N0.9141.00
50_V80_V0.9131.00
316_A320_L0.9101.00
259_L263_A0.9081.00
400_L421_R0.9061.00
117_S120_Y0.9051.00
267_E310_Q0.9041.00
361_K369_R0.9021.00
142_H146_Q0.9001.00
151_F265_L0.8990.99
404_D425_R0.8960.99
218_T457_F0.8940.99
101_G428_T0.8940.99
309_A352_A0.8910.99
78_G92_I0.8880.99
314_T318_T0.8870.99
412_L417_Y0.8750.99
109_Y112_A0.8750.99
252_P266_A0.8750.99
418_W422_D0.8750.99
178_R207_F0.8680.99
44_G139_R0.8680.99
321_E332_Y0.8640.99
334_G338_S0.8640.99
266_A391_I0.8610.99
407_M417_Y0.8570.99
262_I434_F0.8560.99
294_K354_V0.8550.99
145_A250_L0.8530.99
332_Y362_D0.8520.99
140_V278_L0.8520.99
343_R347_E0.8520.99
72_C102_W0.8510.99
29_R37_S0.8490.99
126_H422_D0.8480.99
291_R382_V0.8470.99
62_N66_L0.8470.99
267_E293_D0.8470.99
60_N63_E0.8460.99
204_K462_R0.8430.99
334_G342_E0.8400.99
334_G341_H0.8390.99
333_W336_D0.8380.99
321_E327_F0.8370.99
61_Y65_V0.8350.99
39_L54_I0.8340.99
271_K281_R0.8290.99
397_E402_V0.8270.99
155_Q225_K0.8260.99
160_V219_Y0.8250.99
304_I308_F0.8250.99
157_F225_K0.8240.99
133_L137_V0.8180.99
331_V334_G0.8180.99
370_L402_V0.8130.99
58_L95_S0.8130.99
69_T102_W0.8050.99
443_A451_V0.8050.99
390_I441_L0.8050.99
142_H227_Y0.8040.99
328_E331_V0.8020.99
31_D37_S0.8020.99
327_F331_V0.8010.99
290_E293_D0.8000.99
276_A279_E0.7980.99
27_R47_F0.7970.99
331_V339_S0.7970.99
109_Y116_H0.7970.99
22_V52_A0.7950.99
76_V92_I0.7940.99
32_S36_I0.7920.99
273_V276_A0.7910.99
25_W256_F0.7910.99
137_V446_T0.7890.99
168_S207_F0.7870.99
300_L337_L0.7860.99
31_D35_G0.7850.99
267_E290_E0.7830.99
277_V445_V0.7790.99
317_V321_E0.7760.99
312_D357_K0.7760.99
358_N378_A0.7730.98
218_T423_L0.7730.98
257_A265_L0.7720.98
339_S342_E0.7720.98
28_T70_T0.7710.98
325_R344_Y0.7700.98
401_D404_D0.7700.98
220_A424_R0.7700.98
336_D340_E0.7650.98
61_Y64_D0.7640.98
73_S429_V0.7630.98
164_L212_G0.7630.98
147_A151_F0.7620.98
314_T317_V0.7600.98
436_L441_L0.7570.98
64_D67_R0.7560.98
418_W421_R0.7560.98
252_P262_I0.7550.98
259_L358_N0.7440.98
82_A89_Q0.7430.98
364_K379_A0.7420.98
199_K206_S0.7420.98
62_N65_V0.7410.98
164_L231_P0.7400.98
285_M385_P0.7380.98
144_L277_V0.7360.98
33_K36_I0.7350.98
83_S89_Q0.7340.98
39_L94_A0.7320.98
335_V341_H0.7300.98
301_E315_D0.7290.98
42_Y132_N0.7270.98
110_P113_A0.7270.98
368_M378_A0.7260.98
362_D375_K0.7230.98
257_A395_Q0.7230.98
368_M398_E0.7190.98
361_K377_V0.7170.98
37_S65_V0.7160.97
337_L341_H0.7130.97
340_E344_Y0.7120.97
252_P265_L0.7120.97
358_N371_N0.7110.97
379_A392_G0.7100.97
397_E406_R0.7100.97
412_L416_D0.7070.97
272_Y275_K0.7070.97
142_H158_F0.7050.97
167_A215_N0.7050.97
368_M371_N0.7050.97
73_S256_F0.7020.97
263_A355_V0.7020.97
165_I179_V0.7000.97
380_M393_G0.7000.97
131_T134_I0.6980.97
16_V90_F0.6970.97
356_V383_L0.6970.97
83_S88_Q0.6960.97
64_D97_V0.6950.97
258_N378_A0.6950.97
72_C99_V0.6940.97
229_F438_F0.6940.97
143_T280_E0.6930.97
333_W340_E0.6920.97
263_A357_K0.6890.97
442_I446_T0.6870.97
120_Y124_V0.6860.97
274_F287_F0.6860.97
77_T95_S0.6860.97
275_K278_L0.6850.97
150_R280_E0.6850.97
315_D319_I0.6840.97
41_V52_A0.6830.97
63_E67_R0.6820.97
305_E308_F0.6810.97
382_V436_L0.6790.97
26_V29_R0.6790.97
311_V350_F0.6780.97
460_T463_N0.6770.96
319_I349_H0.6750.96
301_E305_E0.6740.96
99_V102_W0.6740.96
291_R353_P0.6720.96
271_K290_E0.6700.96
337_L340_E0.6690.96
140_V442_I0.6680.96
320_L336_D0.6680.96
266_A380_M0.6670.96
274_F351_K0.6670.96
12_G16_V0.6630.96
336_D339_S0.6610.96
52_A74_V0.6610.96
55_N81_V0.6590.96
401_D405_E0.6590.96
82_A85_G0.6580.96
126_H426_Y0.6560.96
378_A395_Q0.6550.96
44_G224_S0.6530.96
446_T454_V0.6510.96
340_E343_R0.6500.96
180_S200_D0.6490.96
162_T228_T0.6470.95
61_Y97_V0.6460.95
402_V406_R0.6460.95
334_G340_E0.6440.95
359_Y383_L0.6420.95
122_R453_D0.6410.95
170_T211_S0.6410.95
134_I453_D0.6410.95
258_N395_Q0.6370.95
54_I97_V0.6360.95
65_V97_V0.6360.95
221_C429_V0.6350.95
312_D358_N0.6340.95
45_S139_R0.6330.95
347_E352_A0.6330.95
299_R303_F0.6330.95
303_F312_D0.6310.95
18_S80_V0.6290.95
270_L436_L0.6290.95
271_K275_K0.6270.95
327_F336_D0.6270.95
260_N263_A0.6270.95
314_T333_W0.6260.95
412_L415_E0.6250.95
330_P335_V0.6240.95
335_V340_E0.6230.94
299_R345_L0.6210.94
336_D341_H0.6200.94
12_G50_V0.6190.94
152_F265_L0.6180.94
346_A350_F0.6180.94
331_V336_D0.6170.94
299_R302_R0.6160.94
134_I137_V0.6160.94
294_K303_F0.6150.94
109_Y120_Y0.6150.94
398_E428_T0.6140.94
330_P334_G0.6140.94
102_W399_R0.6140.94
254_V261_D0.6140.94
220_A420_Y0.6130.94
141_R161_S0.6130.94
294_K302_R0.6130.94
278_L445_V0.6110.94
145_A161_S0.6110.94
240_T450_N0.6110.94
364_K394_S0.6110.94
57_S93_Q0.6090.94
271_K291_R0.6080.94
128_R131_T0.6070.94
17_D82_A0.6070.94
200_D463_N0.6070.94
332_Y342_E0.6060.94
259_L357_K0.6060.94
145_A229_F0.6060.94
58_L79_K0.6050.94
238_S460_T0.6050.94
332_Y336_D0.6020.93
132_N135_G0.6000.93
36_I81_V0.5980.93
152_F434_F0.5980.93
381_D392_G0.5970.93
259_L370_L0.5960.93
111_M116_H0.5950.93
262_I266_A0.5930.93
391_I436_L0.5920.93
109_Y113_A0.5900.93
368_M402_V0.5890.93
270_L291_R0.5890.93
265_L268_A0.5890.93
125_A129_P0.5890.93
289_A293_D0.5860.92
56_N62_N0.5850.92
286_K289_A0.5850.92
316_A319_I0.5850.92
167_A204_K0.5850.92
161_S248_W0.5840.92
304_I307_D0.5770.92
262_I265_L0.5750.92
162_T212_G0.5750.92
158_F223_L0.5750.92
113_A116_H0.5730.92
133_L453_D0.5730.92
127_L422_D0.5730.92
293_D299_R0.5720.92
152_F227_Y0.5710.91
371_N376_T0.5700.91
155_Q272_Y0.5670.91
326_K329_N0.5660.91
285_M351_K0.5660.91
133_L136_A0.5660.91
355_V380_M0.5650.91
30_R40_A0.5630.91
167_A459_R0.5630.91
422_D463_N0.5630.91
80_V91_E0.5630.91
112_A117_S0.5630.91
129_P221_C0.5630.91
72_C103_V0.5630.91
37_S61_Y0.5630.91
143_T147_A0.5620.91
162_T216_G0.5600.91
278_L285_M0.5590.91
151_F273_V0.5580.91
118_I122_R0.5570.90
323_C340_E0.5570.90
29_R70_T0.5550.90
341_H356_V0.5550.90
31_D66_L0.5550.90
303_F308_F0.5540.90
420_Y424_R0.5530.90
219_Y428_T0.5530.90
29_R39_L0.5520.90
311_V315_D0.5520.90
137_V453_D0.5510.90
361_K375_K0.5500.90
141_R439_E0.5490.90
263_A392_G0.5480.90
50_V90_F0.5470.90
448_V451_V0.5470.90
32_S37_S0.5470.90
18_S79_K0.5470.90
138_A219_Y0.5470.90
391_I434_F0.5450.90
263_A266_A0.5450.90
254_V262_I0.5450.90
325_R328_E0.5440.89
301_E307_D0.5440.89
24_G52_A0.5440.89
332_Y341_H0.5430.89
68_L72_C0.5430.89
102_W401_D0.5420.89
27_R112_A0.5420.89
232_T250_L0.5420.89
103_V426_Y0.5420.89
424_R428_T0.5410.89
264_G293_D0.5400.89
262_I380_M0.5400.89
263_A267_E0.5380.89
364_K367_Y0.5360.89
23_R100_A0.5360.89
58_L61_Y0.5350.89
214_L420_Y0.5350.89
12_G89_Q0.5350.89
127_L130_R0.5350.89
259_L395_Q0.5350.89
372_E375_K0.5350.89
267_E291_R0.5350.89
212_G229_F0.5350.89
266_A382_V0.5330.88
175_E209_T0.5330.88
415_E418_W0.5320.88
341_H344_Y0.5320.88
218_T419_W0.5310.88
422_D426_Y0.5300.88
110_P117_S0.5290.88
108_T426_Y0.5290.88
310_Q313_Y0.5290.88
349_H447_G0.5280.88
329_N338_S0.5280.88
313_Y333_W0.5270.88
403_L424_R0.5270.88
169_D207_F0.5270.88
270_L287_F0.5270.88
362_D365_A0.5270.88
215_N232_T0.5260.88
332_Y338_S0.5250.88
53_V91_E0.5250.88
206_S459_R0.5240.88
323_C344_Y0.5230.88
54_I58_L0.5220.87
152_F155_Q0.5220.87
107_D110_P0.5220.87
335_V339_S0.5210.87
45_S156_G0.5210.87
291_R354_V0.5210.87
144_L441_L0.5190.87
271_K286_K0.5180.87
216_G220_A0.5170.87
333_W338_S0.5160.87
111_M124_V0.5160.87
327_F330_P0.5160.87
59_P62_N0.5140.87
166_T214_L0.5140.87
331_V342_E0.5130.87
263_A310_Q0.5100.86
331_V337_L0.5080.86
157_F212_G0.5080.86
273_V441_L0.5070.86
335_V343_R0.5070.86
279_E284_D0.5070.86
201_F204_K0.5070.86
216_G228_T0.5070.86
129_P223_L0.5050.86
309_A315_D0.5040.86
316_A356_V0.5040.86
29_R69_T0.5020.85
73_S100_A0.5020.85
335_V342_E0.5010.85
331_V340_E0.5010.85
294_K298_S0.5010.85
39_L65_V0.5000.85
146_Q154_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i7fA 2 0.8948 100 0.197 Contact Map
1eovA 2 0.9442 100 0.202 Contact Map
4pg3A 2 0.9163 100 0.208 Contact Map
4up7A 2 0.9056 100 0.215 Contact Map
4j15A 2 0.8519 100 0.216 Contact Map
4ycuA 3 0.9378 100 0.216 Contact Map
4ex5A 2 0.9206 100 0.217 Contact Map
4wj4A 2 0.9249 100 0.221 Contact Map
1c0aA 1 0.927 100 0.221 Contact Map
3a74A 4 0.9227 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0131 seconds.