GREMLIN Database
SYS - Serine--tRNA ligase
UniProt: P0A8L1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10947
Length: 430 (417)
Sequences: 4331 (2319)
Seq/√Len: 113.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
408_Q414_E4.4561.00
246_V260_M3.9841.00
183_L315_V3.7781.00
122_E125_R3.7401.00
320_G417_E3.3061.00
297_R300_D3.2461.00
36_R88_E3.1721.00
50_E74_E3.1401.00
302_M363_W3.0781.00
414_E420_R2.9471.00
43_K81_E2.9371.00
300_D303_A2.7681.00
137_R145_M2.7611.00
179_F318_L2.7191.00
164_V245_L2.6841.00
338_C363_W2.5861.00
142_L413_I2.5691.00
147_S166_K2.5501.00
376_S383_R2.5281.00
101_L205_Y2.5161.00
314_K318_L2.4231.00
133_D409_A2.4221.00
113_V330_T2.4211.00
124_S313_E2.3801.00
183_L318_L2.3771.00
20_R113_V2.3621.00
15_A28_D2.3481.00
29_K95_E2.3461.00
259_K307_E2.3321.00
124_S325_K2.2801.00
62_K72_R2.2591.00
417_E420_R2.1871.00
403_M413_I2.1811.00
182_D422_Y2.1101.00
313_E317_Q2.0601.00
304_A307_E2.0541.00
408_Q412_R2.0521.00
153_A249_E2.0441.00
108_A302_M2.0161.00
91_A95_E2.0151.00
10_E13_A2.0111.00
188_H314_K1.9731.00
375_R382_T1.9441.00
157_L164_V1.9311.00
16_E20_R1.8961.00
294_Q304_A1.8861.00
321_L345_V1.8811.00
61_A66_E1.8771.00
187_Q318_L1.8591.00
201_Q233_A1.8551.00
198_L220_T1.8491.00
126_W317_Q1.8421.00
203_T247_R1.8421.00
236_P240_V1.8281.00
322_P405_N1.8121.00
193_N245_L1.7921.00
110_E339_K1.7921.00
148_G169_I1.7911.00
328_L340_T1.7851.00
57_S60_Q1.7531.00
108_A363_W1.7181.00
327_I339_K1.7061.00
32_A36_R1.7051.00
16_E19_A1.7001.00
128_T131_E1.6971.00
197_Y267_F1.6931.00
49_A53_S1.6891.00
8_R34_E1.6851.00
94_A98_D1.6701.00
69_E73_L1.6501.00
143_G149_L1.6501.00
107_P333_M1.6491.00
17_K109_D1.6451.00
376_S379_D1.6361.00
195_V241_P1.6261.00
252_D255_D1.6211.00
337_A340_T1.6191.00
29_K32_A1.6161.00
221_R229_T1.6031.00
77_K81_E1.5891.00
93_Q97_R1.5821.00
314_K317_Q1.5751.00
6_L10_E1.5721.00
156_K249_E1.5711.00
301_S386_H1.5681.00
253_E297_R1.5571.00
335_F365_F1.5481.00
47_L78_L1.5461.00
107_P330_T1.5361.00
53_S57_S1.5261.00
259_K294_Q1.5151.00
41_Q45_E1.5131.00
202_D247_R1.4971.00
198_L232_Y1.4811.00
17_K20_R1.4771.00
39_V43_K1.4771.00
81_E84_A1.4731.00
393_L398_T1.4691.00
115_K119_D1.4631.00
173_H288_D1.4551.00
163_V284_M1.4501.00
35_E39_V1.4441.00
138_D141_T1.4321.00
48_Q86_K1.4311.00
230_S269_S1.4291.00
69_E72_R1.4261.00
40_L89_L1.4231.00
297_R374_C1.4161.00
201_Q231_N1.4141.00
43_K46_N1.4091.00
144_E152_A1.4061.00
153_A245_L1.4011.00
154_A163_V1.3981.00
50_E53_S1.3911.00
259_K304_A1.3831.00
201_Q214_A1.3771.00
242_L262_A1.3691.00
87_A91_A1.3631.00
11_P31_G1.3531.00
119_D329_C1.3401.00
54_R75_V1.3351.00
295_I385_V1.3271.00
20_R330_T1.3251.00
166_K191_S1.3231.00
6_L13_A1.3231.00
253_E377_K1.3201.00
214_A233_A1.3201.00
40_L92_L1.3181.00
158_T232_Y1.3131.00
73_L77_K1.3111.00
68_I72_R1.3000.99
36_R39_V1.2960.99
296_V304_A1.2810.99
306_E341_Y1.2780.99
246_V295_I1.2780.99
60_Q64_R1.2770.99
34_E38_K1.2680.99
124_S309_T1.2590.99
301_S361_N1.2590.99
37_R41_Q1.2580.99
84_A88_E1.2420.99
183_L187_Q1.2400.99
80_E84_A1.2350.99
116_D119_D1.2340.99
12_D16_E1.2280.99
320_G406_Y1.2190.99
350_Q354_R1.2190.99
406_Y415_V1.2170.99
302_M338_C1.2140.99
183_L314_K1.2040.99
129_P322_P1.2020.99
310_G317_Q1.1960.99
79_G83_D1.1940.99
17_K107_P1.1910.99
168_Q426_L1.1910.99
74_E77_K1.1840.99
46_N50_E1.1780.99
125_R129_P1.1770.99
57_S61_A1.1770.99
282_I400_V1.1740.99
87_A90_D1.1710.99
200_N203_T1.1640.99
298_P374_C1.1630.99
325_K343_L1.1620.99
6_L14_V1.1590.99
177_S263_H1.1540.99
242_L362_V1.1510.99
76_N79_G1.1440.99
88_E91_A1.1440.99
308_M359_C1.1380.99
317_Q323_Y1.1380.99
359_C390_G1.1350.99
138_D349_A1.1340.99
110_E302_M1.1340.99
317_Q325_K1.1320.99
124_S317_Q1.1320.99
372_A385_V1.1290.99
40_L85_A1.1220.99
415_V420_R1.1190.98
308_M362_V1.1190.98
15_A27_V1.1110.98
294_Q307_E1.1090.98
183_L188_H1.1050.98
98_D102_T1.0990.98
70_P74_E1.0900.98
337_A362_V1.0800.98
7_L10_E1.0730.98
61_A71_L1.0730.98
206_G370_M1.0630.98
141_T144_E1.0610.98
83_D86_K1.0560.98
180_M315_V1.0540.98
8_R38_K1.0540.98
250_I373_R1.0530.98
60_Q63_A1.0520.98
219_H233_A1.0510.98
193_N242_L1.0480.98
67_D70_P1.0480.98
90_D94_A1.0450.98
33_L92_L1.0410.98
302_M306_E1.0400.98
309_T325_K1.0400.98
327_I333_M1.0350.97
367_A387_T1.0310.97
255_D258_I1.0260.97
402_V406_Y1.0250.97
29_K99_I1.0230.97
371_Q384_L1.0160.97
132_F136_V1.0160.97
347_I354_R1.0090.97
347_I400_V1.0080.97
108_A111_V1.0080.97
171_R182_D1.0060.97
5_N9_N1.0030.97
294_Q311_H1.0020.97
2_L7_L1.0010.97
179_F418_V1.0000.97
83_D87_A0.9990.97
30_L99_I0.9950.97
306_E309_T0.9880.97
42_V46_N0.9860.97
376_S380_K0.9840.97
204_L217_L0.9840.97
134_F409_A0.9820.97
44_T82_L0.9810.96
32_A35_E0.9790.96
309_T343_L0.9780.96
70_P73_L0.9770.96
55_S75_V0.9750.96
374_C383_R0.9740.96
77_K80_E0.9720.96
194_Y288_D0.9710.96
137_R141_T0.9710.96
318_L418_V0.9700.96
210_L217_L0.9690.96
56_K59_G0.9680.96
13_A17_K0.9680.96
243_T293_V0.9650.96
92_L96_I0.9650.96
13_A16_E0.9590.96
17_K106_L0.9540.96
36_R95_E0.9540.96
248_G371_Q0.9490.96
116_D331_G0.9480.96
7_L30_L0.9420.96
47_L81_E0.9410.96
181_L185_T0.9380.95
154_A158_T0.9360.95
253_E376_S0.9290.95
30_L103_I0.9270.95
219_H231_N0.9260.95
320_G414_E0.9260.95
303_A307_E0.9250.95
51_R79_G0.9250.95
250_I382_T0.9240.95
197_Y265_P0.9220.95
259_K311_H0.9180.95
188_H311_H0.9160.95
36_R92_L0.9160.95
54_R57_S0.9160.95
212_K216_D0.9070.95
423_M426_L0.9030.94
95_E98_D0.9030.94
2_L14_V0.8960.94
310_G313_E0.8920.94
415_V423_M0.8900.94
184_H392_G0.8900.94
158_T200_N0.8870.94
130_R414_E0.8830.94
45_E48_Q0.8790.94
246_V258_I0.8730.93
2_L6_L0.8640.93
201_Q205_Y0.8620.93
313_E323_Y0.8610.93
111_V327_I0.8540.93
253_E256_L0.8530.93
11_P27_V0.8520.93
40_L88_E0.8500.92
182_D421_P0.8470.92
220_T232_Y0.8470.92
44_T86_K0.8410.92
168_Q423_M0.8380.92
310_G314_K0.8360.92
168_Q425_G0.8290.92
190_Y294_Q0.8280.91
99_I102_T0.8280.91
86_K90_D0.8260.91
122_E324_R0.8250.91
75_V78_L0.8240.91
320_G418_V0.8240.91
197_Y288_D0.8200.91
305_L341_Y0.8180.91
61_A64_R0.8180.91
361_N386_H0.8170.91
297_R376_S0.8150.91
242_L260_M0.8130.91
187_Q314_K0.8120.91
377_K380_K0.8110.91
349_A400_V0.8100.91
22_G115_K0.8100.91
21_R334_G0.8100.91
420_R426_L0.8030.90
173_H194_Y0.8010.90
250_I375_R0.7950.90
218_F269_S0.7930.90
130_R322_P0.7930.90
158_T203_T0.7930.90
246_V251_I0.7920.90
208_G336_G0.7910.89
197_Y286_Q0.7880.89
45_E89_L0.7870.89
406_Y418_V0.7850.89
44_T48_Q0.7850.89
33_L95_E0.7840.89
315_V393_L0.7820.89
177_S395_V0.7810.89
265_P288_D0.7790.89
123_V327_I0.7780.89
97_R101_L0.7680.88
62_K68_I0.7670.88
56_K60_Q0.7660.88
153_A164_V0.7640.88
203_T244_N0.7620.88
75_V79_G0.7620.88
55_S59_G0.7610.88
349_A352_T0.7580.87
252_D375_R0.7570.87
123_V341_Y0.7570.87
115_K329_C0.7560.87
221_R230_S0.7550.87
35_E38_K0.7540.87
127_G130_R0.7520.87
282_I354_R0.7520.87
44_T89_L0.7480.87
245_L260_M0.7470.87
121_V327_I0.7460.87
190_Y311_H0.7420.86
120_N329_C0.7420.86
59_G72_R0.7380.86
40_L43_K0.7380.86
165_M399_L0.7350.86
4_P100_A0.7340.86
175_A423_M0.7340.86
30_L96_I0.7330.86
43_K85_A0.7330.86
45_E49_A0.7320.86
138_D400_V0.7310.85
159_G232_Y0.7280.85
149_L163_V0.7280.85
166_K193_N0.7280.85
54_R71_L0.7270.85
92_L95_E0.7270.85
161_R356_I0.7240.85
171_R424_N0.7230.85
148_G166_K0.7210.85
48_Q82_L0.7170.84
197_Y235_I0.7160.84
148_G403_M0.7160.84
147_S167_G0.7150.84
214_A219_H0.7150.84
94_A97_R0.7140.84
28_D32_A0.7120.84
302_M361_N0.7110.84
72_R76_N0.7110.84
29_K33_L0.7110.84
292_M308_M0.7090.84
298_P383_R0.7090.84
184_H261_T0.7090.84
59_G76_N0.7080.84
117_E326_I0.7080.84
54_R74_E0.7070.84
143_G403_M0.7060.83
65_G68_I0.7060.83
154_A164_V0.7040.83
148_G168_Q0.7030.83
328_L337_A0.7010.83
41_Q93_Q0.7000.83
210_L214_A0.6980.83
7_L14_V0.6940.82
158_T220_T0.6920.82
379_D383_R0.6920.82
146_H413_I0.6920.82
143_G146_H0.6920.82
309_T359_C0.6910.82
111_V333_M0.6890.82
209_Q244_N0.6870.82
76_N80_E0.6840.81
330_T333_M0.6820.81
13_A109_D0.6820.81
142_L407_Q0.6810.81
33_L96_I0.6780.81
165_M288_D0.6750.81
50_E54_R0.6750.81
243_T362_V0.6740.81
19_A24_K0.6740.81
250_I371_Q0.6730.80
251_I255_D0.6730.80
184_H292_M0.6720.80
161_R277_D0.6720.80
158_T199_V0.6700.80
36_R40_L0.6690.80
12_D15_A0.6690.80
89_L92_L0.6670.80
246_V372_A0.6660.80
406_Y417_E0.6650.80
133_D136_V0.6650.80
136_V349_A0.6650.80
44_T85_A0.6640.80
414_E417_E0.6630.79
61_A67_D0.6630.79
26_D29_K0.6630.79
333_M340_T0.6620.79
85_A88_E0.6610.79
59_G68_I0.6590.79
217_L236_P0.6570.79
51_R82_L0.6570.79
258_I261_T0.6570.79
146_H169_I0.6550.79
167_G191_S0.6540.78
51_R78_L0.6530.78
95_E99_I0.6530.78
73_L76_N0.6510.78
57_S71_L0.6490.78
238_A261_T0.6470.78
37_R96_I0.6460.78
199_V241_P0.6460.78
88_E92_L0.6450.78
263_H288_D0.6450.78
149_L165_M0.6400.77
193_N260_M0.6400.77
220_T230_S0.6390.77
376_S381_K0.6380.77
251_I385_V0.6370.77
345_V401_A0.6360.77
299_E376_S0.6350.76
174_R192_E0.6340.76
57_S67_D0.6340.76
190_Y292_M0.6330.76
217_L240_V0.6330.76
7_L31_G0.6320.76
249_E255_D0.6310.76
207_T293_V0.6310.76
179_F183_L0.6300.76
238_A241_P0.6300.76
157_L203_T0.6300.76
238_A262_A0.6300.76
27_V30_L0.6280.76
214_A221_R0.6260.75
207_T243_T0.6260.75
181_L261_T0.6260.75
80_E83_D0.6250.75
295_I372_A0.6230.75
37_R92_L0.6230.75
178_Q263_H0.6230.75
74_E81_E0.6230.75
123_V309_T0.6220.75
81_E85_A0.6220.75
254_D377_K0.6210.75
415_V425_G0.6190.75
47_L82_L0.6190.75
37_R93_Q0.6180.75
415_V426_L0.6170.74
198_L234_L0.6170.74
168_Q171_R0.6160.74
293_V362_V0.6150.74
15_A19_A0.6150.74
305_L309_T0.6150.74
151_F281_L0.6140.74
308_M388_L0.6140.74
302_M305_L0.6130.74
114_G331_G0.6120.74
53_S56_K0.6120.74
269_S273_S0.6110.74
306_E339_K0.6090.73
305_L359_C0.6090.73
281_L400_V0.6080.73
115_K118_N0.6080.73
90_D93_Q0.6060.73
194_Y197_Y0.6060.73
140_V279_R0.6050.73
194_Y265_P0.6050.73
219_H229_T0.6050.73
82_L86_K0.6040.73
284_M399_L0.6030.73
71_L74_E0.6030.73
41_Q44_T0.6020.73
356_I398_T0.5990.72
163_V281_L0.5980.72
126_W323_Y0.5970.72
199_V235_I0.5960.72
132_F135_E0.5950.72
135_E141_T0.5940.72
97_R205_Y0.5930.71
6_L11_P0.5930.71
137_R142_L0.5930.71
402_V415_V0.5930.71
364_D386_H0.5930.71
277_D354_R0.5910.71
339_K361_N0.5900.71
68_I71_L0.5900.71
130_R320_G0.5900.71
158_T198_L0.5880.71
62_K67_D0.5880.71
374_C385_V0.5860.71
244_N247_R0.5860.71
34_E100_A0.5860.71
157_L245_L0.5860.71
130_R408_Q0.5850.70
200_N232_Y0.5850.70
14_V106_L0.5840.70
315_V318_L0.5830.70
214_A217_L0.5830.70
220_T269_S0.5820.70
218_F232_Y0.5800.70
173_H395_V0.5790.70
20_R107_P0.5780.70
143_G148_G0.5780.70
294_Q308_M0.5770.69
84_A87_A0.5770.69
43_K47_L0.5760.69
315_V392_G0.5760.69
336_G340_T0.5750.69
64_R68_I0.5750.69
353_Y398_T0.5740.69
312_A357_S0.5720.69
91_A94_A0.5710.69
312_A343_L0.5710.69
58_I75_V0.5700.68
161_R354_R0.5690.68
136_V407_Q0.5680.68
6_L9_N0.5670.68
307_E311_H0.5650.68
273_S276_R0.5650.68
407_Q411_G0.5650.68
402_V418_V0.5640.68
51_R55_S0.5630.68
217_L233_A0.5620.67
150_D153_A0.5620.67
108_A338_C0.5610.67
21_R107_P0.5610.67
39_V42_V0.5600.67
357_S390_G0.5600.67
246_V249_E0.5590.67
349_A354_R0.5580.67
142_L145_M0.5570.67
111_V330_T0.5570.67
61_A70_P0.5570.67
156_K248_G0.5560.67
347_I352_T0.5560.67
134_F407_Q0.5560.67
37_R89_L0.5560.67
253_E380_K0.5550.66
246_V385_V0.5540.66
3_D368_R0.5530.66
251_I258_I0.5520.66
242_L261_T0.5520.66
140_V151_F0.5520.66
220_T231_N0.5500.66
173_H396_G0.5480.65
421_P424_N0.5470.65
354_R396_G0.5460.65
42_V45_E0.5460.65
336_G362_V0.5460.65
184_H188_H0.5440.65
89_L93_Q0.5440.65
395_V398_T0.5420.65
43_K88_E0.5400.64
7_L11_P0.5400.64
379_D382_T0.5400.64
276_R326_I0.5380.64
327_I343_L0.5370.64
229_T269_S0.5360.64
164_V195_V0.5350.64
258_I295_I0.5350.64
178_Q182_D0.5340.63
165_M194_Y0.5340.63
243_T387_T0.5340.63
110_E306_E0.5340.63
184_H315_V0.5330.63
21_R330_T0.5330.63
199_V204_L0.5330.63
46_N49_A0.5310.63
154_A162_F0.5310.63
398_T402_V0.5310.63
376_S382_T0.5300.63
15_A25_L0.5300.63
40_L44_T0.5290.63
28_D31_G0.5290.63
235_I241_P0.5290.63
274_Y278_T0.5280.63
322_P353_Y0.5260.62
64_R67_D0.5240.62
181_L192_E0.5240.62
309_T341_Y0.5240.62
284_M400_V0.5220.62
297_R303_A0.5210.62
175_A425_G0.5200.61
207_T240_V0.5190.61
155_V159_G0.5180.61
217_L264_T0.5180.61
364_D368_R0.5170.61
116_D329_C0.5170.61
59_G63_A0.5170.61
292_M311_H0.5160.61
364_D384_L0.5150.61
180_M391_S0.5150.61
67_D72_R0.5140.61
215_G269_S0.5140.61
19_A25_L0.5140.61
108_A361_N0.5120.60
11_P15_A0.5120.60
110_E327_I0.5110.60
237_T389_N0.5110.60
305_L361_N0.5110.60
420_R423_M0.5100.60
236_P391_S0.5100.60
173_H263_H0.5090.60
130_R133_D0.5080.60
347_I356_I0.5070.60
161_R276_R0.5050.59
125_R353_Y0.5050.59
97_R371_Q0.5040.59
177_S288_D0.5030.59
120_N331_G0.5020.59
206_G247_R0.5020.59
374_C377_K0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dq0A 2 0.9814 100 0.239 Contact Map
1sesA 2 0.9674 100 0.241 Contact Map
2dq3A 2 0.9791 100 0.25 Contact Map
1wleA 2 0.9791 100 0.253 Contact Map
3lssA 2 0.9791 100 0.257 Contact Map
3vbbA 2 0.9791 100 0.272 Contact Map
3qneA 2 0.9628 100 0.279 Contact Map
3errA 2 0.9674 100 0.37 Contact Map
2cjaA 2 0.9302 100 0.537 Contact Map
3w3sA 2 0.9047 100 0.601 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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