GREMLIN Database
YIHY - UPF0761 membrane protein YihY
UniProt: P0A8K8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11851
Length: 290 (262)
Sequences: 5409 (3921)
Seq/√Len: 242.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_D267_E5.7991.00
31_N126_T3.9001.00
221_F258_T3.2501.00
33_T260_C3.1521.00
224_G257_W3.1191.00
213_G269_T2.9561.00
37_G42_V2.8991.00
216_V268_I2.8341.00
141_A145_M2.7861.00
124_L266_A2.7671.00
34_T38_N2.6541.00
118_Y140_F2.5991.00
23_L264_L2.4731.00
194_W214_A2.4051.00
27_I32_M2.4011.00
82_A85_D2.3321.00
194_W207_N2.3171.00
216_V220_L2.2751.00
27_I260_C2.2361.00
17_W21_K2.2141.00
19_W23_L2.1671.00
31_N122_S2.0311.00
124_L200_V2.0031.00
125_N201_P1.9841.00
190_W215_F1.9641.00
22_L275_Y1.9521.00
135_P138_Y1.9401.00
197_Y217_A1.9231.00
23_L268_I1.8631.00
30_D129_R1.8531.00
39_L259_W1.8451.00
210_A214_A1.8341.00
190_W211_I1.8241.00
197_Y265_G1.8201.00
212_V269_T1.8141.00
228_F232_I1.7861.00
123_A263_L1.7781.00
128_W269_T1.7741.00
125_N202_T1.7531.00
230_L234_M1.7291.00
175_T179_N1.7131.00
92_E96_A1.7051.00
217_A265_G1.6881.00
227_G230_L1.6501.00
137_I141_A1.6451.00
22_L271_T1.6321.00
114_L140_F1.6251.00
140_F143_Y1.6241.00
190_W218_A1.6201.00
198_S207_N1.6121.00
232_I250_I1.6091.00
75_I79_F1.5771.00
26_R30_D1.5671.00
121_D143_Y1.5551.00
26_R129_R1.5511.00
83_T86_V1.5151.00
222_E225_K1.4771.00
31_N34_T1.4671.00
88_Q92_E1.4501.00
21_K25_Q1.4471.00
26_R271_T1.4341.00
24_W28_D1.4271.00
26_R267_E1.4221.00
36_A263_L1.4151.00
85_D88_Q1.4101.00
206_P209_D1.4041.00
103_A107_C1.3991.00
121_D200_V1.3971.00
107_C111_V1.3901.00
36_A260_C1.3761.00
18_A21_K1.3731.00
89_R92_E1.3721.00
133_A202_T1.3681.00
194_W210_A1.3641.00
193_F262_V1.3641.00
125_N130_S1.3581.00
20_L23_L1.3461.00
25_Q29_E1.3281.00
144_W148_T1.3241.00
46_S116_L1.3241.00
186_L218_A1.3211.00
23_L271_T1.3181.00
211_I215_F1.3061.00
193_F218_A1.3041.00
127_I263_L1.2951.00
136_K140_F1.2721.00
23_L32_M1.2701.00
220_L261_I1.2681.00
70_Q73_H1.2611.00
205_V210_A1.2541.00
26_R270_V1.2441.00
209_D273_G1.2361.00
219_L223_A1.2361.00
42_V46_S1.2211.00
39_L263_L1.2111.00
134_R142_V1.1981.00
169_W172_D1.1951.00
85_D89_R1.1911.00
104_V108_G1.1761.00
34_T122_S1.1721.00
225_K254_W1.1681.00
190_W194_W1.1551.00
193_F221_F1.1521.00
212_V216_V1.1461.00
90_Y93_Q1.1361.00
209_D272_L1.1291.00
65_S69_I1.1151.00
19_W272_L1.1081.00
87_I90_Y1.0991.00
76_F84_G1.0941.00
198_S210_A1.0901.00
195_L199_I1.0881.00
246_A250_I1.0871.00
190_W214_A1.0851.00
212_V215_F1.0821.00
40_A259_W1.0811.00
39_L123_A1.0731.00
231_Y235_F1.0731.00
73_H76_F1.0681.00
43_S255_V1.0631.00
138_Y142_V1.0571.00
196_L200_V1.0561.00
32_M260_C1.0501.00
244_V247_V1.0461.00
68_S72_R1.0441.00
17_W20_L1.0441.00
268_I272_L1.0261.00
26_R274_E1.0211.00
35_L38_N1.0191.00
27_I264_L1.0181.00
42_V112_T1.0131.00
69_I73_H1.0061.00
205_V209_D1.0011.00
271_T274_E0.9911.00
130_S202_T0.9891.00
19_W268_I0.9881.00
18_A275_Y0.9871.00
58_F62_P0.9791.00
211_I214_A0.9631.00
53_V105_G0.9611.00
48_V80_L0.9551.00
20_L24_W0.9541.00
39_L120_I0.9491.00
216_V265_G0.9411.00
40_A255_V0.9381.00
254_W258_T0.9361.00
127_I267_E0.9341.00
218_A222_E0.9321.00
35_L123_A0.9291.00
37_G256_Y0.9291.00
56_A105_G0.9271.00
56_A102_T0.9221.00
35_L126_T0.9201.00
170_A173_L0.9181.00
186_L190_W0.9151.00
81_P85_D0.9131.00
255_V259_W0.9081.00
32_M264_L0.9061.00
40_A256_Y0.9061.00
194_W198_S0.9041.00
25_Q28_D0.9041.00
117_M121_D0.9031.00
95_V98_S0.9011.00
119_S122_S0.8971.00
32_M267_E0.8951.00
128_W225_K0.8931.00
31_N35_L0.8911.00
193_F217_A0.8891.00
93_Q96_A0.8810.99
41_Y252_F0.8810.99
237_S240_L0.8710.99
52_A56_A0.8690.99
113_A147_L0.8690.99
72_R88_Q0.8680.99
34_T119_S0.8680.99
197_Y266_A0.8640.99
45_L249_P0.8620.99
35_L41_Y0.8580.99
27_I33_T0.8560.99
74_F77_A0.8520.99
198_S204_R0.8510.99
90_Y94_F0.8490.99
194_W211_I0.8420.99
138_Y141_A0.8390.99
42_V119_S0.8360.99
41_Y253_V0.8330.99
179_N183_I0.8300.99
214_A218_A0.8290.99
114_L147_L0.8270.99
187_L190_W0.8170.99
116_L259_W0.8110.99
227_G257_W0.8100.99
45_L253_V0.8100.99
96_A99_N0.8080.99
168_R171_S0.8030.99
115_L140_F0.7990.99
28_D33_T0.7980.99
48_V249_P0.7970.99
63_M69_I0.7960.99
79_F87_I0.7880.99
251_L254_W0.7880.99
158_L162_S0.7870.99
37_G41_Y0.7860.99
226_K230_L0.7860.99
228_F238_Y0.7850.99
90_Y95_V0.7850.99
208_R211_I0.7830.99
224_G258_T0.7810.99
212_V272_L0.7750.99
121_D139_S0.7740.99
228_F251_L0.7710.99
223_A227_G0.7680.99
228_F250_I0.7670.99
161_S222_E0.7660.99
105_G108_G0.7650.99
264_L268_I0.7610.98
187_L191_I0.7550.98
32_M263_L0.7510.98
176_V179_N0.7500.98
48_V248_I0.7470.98
155_G158_L0.7470.98
72_R84_G0.7400.98
50_L147_L0.7390.98
163_Y166_S0.7380.98
52_A105_G0.7350.98
241_I244_V0.7300.98
37_G40_A0.7250.98
40_A44_L0.7230.98
74_F78_N0.7180.98
43_S259_W0.7170.98
33_T36_A0.7160.98
124_L262_V0.7080.98
38_N119_S0.7070.98
132_R139_S0.7060.98
210_A269_T0.6940.97
180_V183_I0.6940.97
142_V145_M0.6910.97
41_Y45_L0.6900.97
79_F84_G0.6870.97
76_F88_Q0.6820.97
112_T119_S0.6800.97
72_R76_F0.6790.97
81_P84_G0.6790.97
203_I273_G0.6750.97
64_F69_I0.6720.97
46_S113_A0.6680.97
17_W216_V0.6670.97
53_V109_L0.6660.97
221_F255_V0.6660.97
70_Q74_F0.6650.97
49_P243_G0.6600.96
231_Y236_P0.6600.96
189_S218_A0.6580.96
57_L102_T0.6540.96
220_L224_G0.6540.96
118_Y122_S0.6540.96
221_F244_V0.6540.96
264_L267_E0.6530.96
157_S188_L0.6500.96
222_E226_K0.6440.96
128_W201_P0.6430.96
118_Y121_D0.6430.96
44_L239_Q0.6430.96
55_F123_A0.6430.96
40_A252_F0.6420.96
112_T115_L0.6420.96
130_S203_I0.6400.96
132_R202_T0.6370.96
186_L222_E0.6350.95
49_P110_I0.6350.95
54_V57_L0.6330.95
224_G261_I0.6330.95
174_N177_I0.6330.95
230_L233_T0.6300.95
217_A261_I0.6290.95
97_N241_I0.6280.95
39_L46_S0.6250.95
114_L143_Y0.6250.95
196_L262_V0.6250.95
189_S225_K0.6240.95
256_Y261_I0.6220.95
33_T256_Y0.6200.95
121_D140_F0.6190.95
146_I200_V0.6180.95
19_W271_T0.6170.95
107_C233_T0.6140.95
53_V151_P0.6120.94
152_L156_A0.6110.94
161_S182_R0.6090.94
244_V248_I0.6090.94
113_A267_E0.6060.94
216_V219_L0.6060.94
189_S222_E0.6050.94
52_A249_P0.6040.94
135_P140_F0.6030.94
213_G216_V0.6020.94
172_D176_V0.6020.94
183_I187_L0.6020.94
23_L27_I0.6020.94
128_W270_V0.6000.94
47_L220_L0.5980.94
55_F68_S0.5970.94
105_G260_C0.5960.94
41_Y115_L0.5940.94
117_M193_F0.5920.93
238_Y242_Y0.5920.93
228_F231_Y0.5910.93
59_A63_M0.5870.93
270_V274_E0.5870.93
69_I72_R0.5850.93
151_P155_G0.5850.93
164_L177_I0.5840.93
98_S102_T0.5830.93
53_V117_M0.5810.93
169_W177_I0.5800.93
251_L255_V0.5800.93
121_D249_P0.5800.93
149_L246_A0.5790.93
110_I156_A0.5780.93
91_I95_V0.5770.93
42_V111_V0.5770.93
236_P250_I0.5760.93
29_E131_K0.5750.92
193_F210_A0.5740.92
122_S126_T0.5740.92
115_L240_L0.5730.92
91_I119_S0.5710.92
187_L206_P0.5700.92
153_L157_S0.5680.92
155_G167_L0.5670.92
31_N252_F0.5650.92
103_A110_I0.5620.92
175_T178_D0.5600.91
75_I84_G0.5600.91
161_S225_K0.5590.91
43_S53_V0.5580.91
217_A258_T0.5570.91
30_D256_Y0.5570.91
90_Y108_G0.5550.91
118_Y143_Y0.5550.91
84_G88_Q0.5550.91
234_M237_S0.5540.91
125_N134_R0.5510.91
111_V261_I0.5510.91
162_S225_K0.5510.91
221_F225_K0.5490.91
213_G217_A0.5480.91
205_V273_G0.5480.91
120_I146_I0.5470.90
89_R93_Q0.5460.90
235_F239_Q0.5430.90
93_Q97_N0.5420.90
117_M146_I0.5420.90
44_L249_P0.5410.90
59_A62_P0.5410.90
56_A101_M0.5390.90
167_L170_A0.5380.90
73_H77_A0.5370.90
40_A245_L0.5370.90
111_V212_V0.5360.90
41_Y44_L0.5340.89
173_L177_I0.5340.89
58_F63_M0.5330.89
184_F187_L0.5330.89
38_N118_Y0.5330.89
174_N178_D0.5310.89
42_V164_L0.5310.89
246_A249_P0.5300.89
271_T275_Y0.5300.89
47_L87_I0.5280.89
172_D175_T0.5250.89
151_P192_S0.5250.89
156_A175_T0.5250.89
94_F97_N0.5230.88
53_V95_V0.5200.88
64_F68_S0.5200.88
79_F82_A0.5200.88
40_A260_C0.5200.88
25_Q208_R0.5180.88
21_K28_D0.5170.88
41_Y262_V0.5140.88
111_V114_L0.5130.87
236_P240_L0.5120.87
239_Q244_V0.5090.87
199_I207_N0.5070.87
145_M164_L0.5070.87
208_R223_A0.5050.87
19_W275_Y0.5040.87
118_Y136_K0.5030.86
23_L26_R0.5020.86
102_T162_S0.5020.86
37_G253_V0.5010.86
45_L235_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlfF 1 0.4517 25.5 0.947 Contact Map
4p02A 1 0.4379 23 0.948 Contact Map
4rp9A 2 0.8345 22.3 0.948 Contact Map
3effK 4 0.3931 20.5 0.949 Contact Map
3giaA 1 0.7379 17.1 0.951 Contact Map
3dh4A 3 0.869 15.7 0.952 Contact Map
4humA 1 0.769 12.3 0.954 Contact Map
2xq2A 2 0.869 12.2 0.954 Contact Map
4ltoA 3 0.3379 11.3 0.955 Contact Map
4he8J 1 0.5069 10.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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