GREMLIN Database
PSD - Phosphatidylserine decarboxylase proenzyme
UniProt: P0A8K1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10775
Length: 322 (254)
Sequences: 1849 (1236)
Seq/√Len: 77.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_K59_S4.5241.00
130_N262_P4.3681.00
61_R65_E4.3631.00
151_N242_L4.3201.00
53_Q70_P3.9421.00
242_L245_Q3.4311.00
89_A146_V3.4061.00
155_R190_D3.0581.00
91_G136_T2.6751.00
42_V57_T2.4931.00
205_I252_L2.4301.00
78_I243_K2.4181.00
89_A136_T2.3681.00
191_T196_M2.3591.00
48_D51_E2.3191.00
195_P261_A2.3151.00
42_V49_M2.2921.00
116_A177_N2.2481.00
78_I86_V2.1391.00
127_L261_A2.1271.00
29_R61_R2.1111.00
87_M277_T2.0741.00
98_K132_T2.0681.00
153_I190_D2.0221.00
55_P72_R2.0081.00
210_E251_K1.9841.00
188_L197_A1.9801.00
79_D84_V1.9771.00
87_M283_L1.9631.00
152_G189_F1.9141.00
128_F131_G1.9111.00
201_V255_T1.9061.00
84_V282_P1.9001.00
79_D86_V1.8781.00
85_L260_F1.8571.00
53_Q73_D1.8161.00
49_M52_A1.7881.00
126_D129_R1.7461.00
153_I240_A1.7381.00
79_D282_P1.7321.00
62_T65_E1.7191.00
52_A71_L1.7081.00
52_A60_Y1.7071.00
31_G34_T1.6831.00
127_L195_P1.6121.00
101_E129_R1.6001.00
86_V243_K1.5991.00
150_C196_M1.5470.99
15_K204_T1.5320.99
19_T23_G1.5220.99
71_L75_V1.5040.99
146_V256_V1.4970.99
124_M156_E1.4950.99
11_Y165_F1.4910.99
55_P59_S1.4900.99
27_S251_K1.4630.99
198_Q247_M1.4630.99
160_V186_I1.4450.99
124_M188_L1.4380.99
23_G26_A1.4320.99
145_R246_E1.4310.99
196_M260_F1.4300.99
89_A256_V1.4290.99
157_M185_V1.4220.99
190_D195_P1.4180.99
81_D285_V1.4050.99
210_E249_R1.3650.99
78_I244_G1.3650.99
261_A264_K1.3510.98
212_V249_R1.3490.98
164_L207_G1.3460.98
81_D84_V1.3430.98
268_V282_P1.3330.98
282_P285_V1.3290.98
198_Q258_N1.3050.98
93_I134_V1.2900.98
68_V249_R1.2810.98
110_H176_P1.2790.98
115_E121_N1.2790.98
23_G27_S1.2610.97
22_A205_I1.2580.97
89_A279_I1.2560.97
85_L150_C1.2560.97
136_T258_N1.2550.97
93_I277_T1.2540.97
258_N283_L1.2470.97
148_M154_L1.2430.97
266_N285_V1.2380.97
159_Y183_E1.2370.97
113_S116_A1.2240.97
123_L126_D1.2170.97
70_P249_R1.2130.97
97_G133_F1.1950.97
118_L197_A1.1910.96
124_M127_L1.1900.96
150_C193_F1.1900.96
119_A160_V1.1840.96
134_V267_L1.1720.96
28_K31_G1.1700.96
271_L275_S1.1680.96
71_L74_E1.1600.96
102_D114_L1.1580.96
22_A26_A1.1570.96
260_F265_V1.1520.96
151_N192_E1.1510.96
127_L188_L1.1500.96
85_L265_V1.1480.96
30_A34_T1.1390.95
172_A179_F1.1380.95
153_I238_S1.1280.95
55_P60_Y1.1260.95
47_V66_F1.1230.95
272_E275_S1.1210.95
143_Y147_H1.1200.95
54_K65_E1.1120.95
33_L37_V1.0920.94
36_L40_L1.0880.94
60_Y70_P1.0810.94
16_L19_T1.0790.94
151_N240_A1.0770.94
92_V169_H1.0670.94
151_N245_Q1.0670.94
159_Y185_V1.0640.93
152_G191_T1.0600.93
26_A252_L1.0600.93
212_V246_E1.0580.93
65_E68_V1.0570.93
41_F63_F1.0540.93
198_Q256_V1.0460.93
22_A27_S1.0440.93
146_V248_G1.0370.93
106_Q178_L1.0240.92
117_L199_I1.0170.92
24_W28_K1.0060.91
146_V200_L0.9920.91
128_F188_L0.9720.90
81_D282_P0.9710.90
128_F197_A0.9620.89
200_L247_M0.9610.89
117_L257_I0.9600.89
132_T267_L0.9520.89
15_K163_D0.9380.88
149_P196_M0.9370.88
120_G158_I0.9280.88
164_L183_E0.9250.87
150_C192_E0.9200.87
103_K111_N0.9190.87
166_S169_H0.9190.87
21_L24_W0.9070.86
79_D82_P0.9000.86
182_N203_A0.8980.86
38_I66_F0.8960.86
51_E278_K0.8920.86
136_T277_T0.8890.85
107_A135_T0.8860.85
78_I282_P0.8740.84
265_V284_A0.8730.84
146_V211_T0.8680.84
157_M211_T0.8650.84
29_R62_T0.8600.83
150_C189_F0.8600.83
202_G208_S0.8590.83
200_L211_T0.8450.82
23_G251_K0.8400.82
64_N68_V0.8400.82
154_L213_W0.8380.82
35_K58_A0.8320.81
166_S171_T0.8240.81
18_L205_I0.8230.81
87_M136_T0.8230.81
148_M200_L0.8220.81
16_L20_R0.8160.80
185_V208_S0.8160.80
115_E129_R0.8130.80
98_K130_N0.8130.80
118_L259_L0.8120.80
187_C200_L0.8090.79
92_V142_D0.8030.79
207_G248_G0.7980.79
167_V203_A0.7920.78
156_E188_L0.7840.77
236_D239_V0.7820.77
80_T86_V0.7800.77
146_V198_Q0.7780.77
21_L25_G0.7700.76
155_R195_P0.7690.76
241_L247_M0.7680.76
23_G205_I0.7670.76
164_L202_G0.7640.75
107_A257_I0.7620.75
131_G262_P0.7600.75
13_L37_V0.7600.75
93_I136_T0.7500.74
110_H177_N0.7500.74
154_L187_C0.7490.74
157_M187_C0.7480.74
71_L90_D0.7450.74
93_I96_L0.7440.73
15_K207_G0.7440.73
27_S62_T0.7350.73
154_L157_M0.7340.72
104_I111_N0.7240.71
142_D167_V0.7200.71
129_R262_P0.7190.71
158_I188_L0.7180.71
137_Y203_A0.7170.71
11_Y14_P0.7110.70
154_L189_F0.7110.70
34_T38_I0.7060.70
167_V206_V0.7030.69
246_E280_G0.7030.69
187_C247_M0.7010.69
77_P279_I0.7010.69
100_E130_N0.7000.69
19_T22_A0.6980.69
158_I161_P0.6980.69
105_L114_L0.6970.69
185_V200_L0.6970.69
131_G152_G0.6960.68
65_E70_P0.6950.68
114_L199_I0.6950.68
79_D243_K0.6900.68
161_P183_E0.6890.68
268_V277_T0.6880.68
105_L117_L0.6870.67
114_L257_I0.6850.67
211_T247_M0.6830.67
34_T267_L0.6830.67
15_K172_A0.6830.67
197_A209_I0.6820.67
100_E111_N0.6800.67
278_K281_Q0.6800.67
135_T255_T0.6790.67
185_V211_T0.6770.66
20_R23_G0.6760.66
10_Q171_T0.6740.66
179_F255_T0.6700.66
41_F171_T0.6670.65
23_G31_G0.6640.65
138_L143_Y0.6640.65
71_L76_R0.6640.65
189_F196_M0.6630.65
136_T256_V0.6630.65
148_M189_F0.6620.65
41_F110_H0.6570.64
22_A209_I0.6540.64
96_L267_L0.6540.64
205_I251_K0.6500.63
279_I285_V0.6470.63
74_E279_I0.6460.63
92_V171_T0.6460.63
165_F200_L0.6430.62
171_T252_L0.6420.62
105_L136_T0.6410.62
82_P192_E0.6380.62
22_A204_T0.6370.62
34_T208_S0.6360.62
96_L275_S0.6340.61
54_K61_R0.6310.61
268_V275_S0.6260.60
52_A55_P0.6250.60
10_Q16_L0.6230.60
128_F152_G0.6210.60
189_F213_W0.6170.59
154_L241_L0.6140.59
78_I279_I0.6130.59
212_V247_M0.6120.59
100_E121_N0.6080.58
90_D280_G0.6060.58
154_L247_M0.6040.58
9_L132_T0.6030.57
46_K141_R0.6020.57
266_N278_K0.6010.57
46_K100_E0.6000.57
169_H204_T0.5990.57
140_P147_H0.5970.57
67_F138_L0.5960.57
63_F160_V0.5950.56
167_V182_N0.5950.56
62_T153_I0.5940.56
148_M211_T0.5910.56
131_G263_G0.5890.56
162_G207_G0.5880.56
137_Y140_P0.5880.56
63_F168_N0.5880.56
96_L273_S0.5850.55
93_I283_L0.5830.55
161_P175_V0.5810.55
63_F166_S0.5800.55
10_Q18_L0.5800.55
148_M247_M0.5800.55
54_K60_Y0.5800.55
24_W274_L0.5790.54
92_V105_L0.5770.54
80_T83_N0.5770.54
166_S252_L0.5760.54
199_I257_I0.5760.54
139_S142_D0.5760.54
150_C187_C0.5750.54
40_L43_K0.5740.54
85_L193_F0.5740.54
14_P22_A0.5730.54
155_R188_L0.5710.53
157_M208_S0.5700.53
25_G28_K0.5680.53
23_G29_R0.5680.53
23_G204_T0.5670.53
25_G37_V0.5660.53
83_N99_I0.5660.53
137_Y171_T0.5650.53
80_T84_V0.5650.53
22_A207_G0.5630.52
165_F208_S0.5620.52
137_Y167_V0.5610.52
199_I259_L0.5600.52
53_Q59_S0.5600.52
117_L135_T0.5590.52
263_G281_Q0.5580.52
45_Y49_M0.5560.51
169_H208_S0.5550.51
121_N273_S0.5550.51
145_R249_R0.5550.51
145_R208_S0.5520.51
243_K265_V0.5510.51
38_I47_V0.5500.51
53_Q60_Y0.5500.51
41_F64_N0.5490.51
271_L283_L0.5480.50
166_S211_T0.5480.50
64_N251_K0.5470.50
182_N255_T0.5460.50
95_Q133_F0.5460.50
26_A205_I0.5440.50
92_V273_S0.5430.50
91_G94_S0.5430.50
20_R207_G0.5420.50
68_V251_K0.5410.50
118_L188_L0.5400.49
153_I192_E0.5400.49
16_L164_L0.5390.49
104_I114_L0.5390.49
163_D181_R0.5350.49
193_F279_I0.5340.49
264_K284_A0.5340.49
20_R24_W0.5340.49
246_E249_R0.5330.49
76_R90_D0.5330.49
70_P246_E0.5330.49
127_L155_R0.5320.48
209_I257_I0.5310.48
84_V243_K0.5300.48
15_K164_L0.5300.48
135_T257_I0.5300.48
116_A181_R0.5290.48
94_S166_S0.5290.48
51_E75_V0.5270.48
43_K262_P0.5250.48
146_V209_I0.5250.48
186_I199_I0.5230.47
84_V285_V0.5230.47
40_L44_Y0.5220.47
203_A255_T0.5210.47
204_T252_L0.5190.47
133_F172_A0.5170.47
63_F89_A0.5170.47
15_K19_T0.5170.47
100_E103_K0.5160.46
11_Y176_P0.5140.46
167_V255_T0.5140.46
16_L22_A0.5140.46
182_N207_G0.5120.46
18_L23_G0.5120.46
23_G207_G0.5110.46
32_W43_K0.5100.46
28_K204_T0.5090.46
79_D83_N0.5080.45
95_Q137_Y0.5060.45
92_V141_R0.5030.45
119_A158_I0.5020.45
147_H154_L0.5020.45
66_F202_G0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gprA 1 0.4534 95.1 0.94 Contact Map
2d5dA 1 0.2143 80.4 0.956 Contact Map
1dczA 1 0.236 78.6 0.957 Contact Map
1ax3A 1 0.4317 61.7 0.961 Contact Map
1bdoA 2 0.2453 58.1 0.962 Contact Map
1z6hA 1 0.2205 58.1 0.962 Contact Map
2kccA 1 0.2609 57.2 0.962 Contact Map
1f3zA 2 0.3944 50.7 0.964 Contact Map
2k7vA 2 0.2609 49.6 0.964 Contact Map
1ghjA 1 0.2422 46.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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