GREMLIN Database
RHLB - ATP-dependent RNA helicase RhlB
UniProt: P0A8J8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10844
Length: 421 (341)
Sequences: 57117 (33559)
Seq/√Len: 1817.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_T87_A3.7241.00
64_L104_A3.5521.00
284_G307_L3.2921.00
301_E306_D2.9291.00
43_T195_M2.8531.00
101_H105_E2.8131.00
284_G301_E2.7641.00
273_W277_A2.6581.00
300_D304_R2.6361.00
273_W285_L2.6331.00
273_W283_V2.5351.00
297_R301_E2.5291.00
114_K136_D2.4941.00
248_Q279_D2.4731.00
116_G135_V2.4191.00
259_A327_H2.3861.00
266_K289_D2.3801.00
270_E285_L2.3181.00
44_L69_H2.3091.00
91_A100_I2.2481.00
282_R308_D2.2421.00
167_A196_L2.1761.00
263_A269_C2.1551.00
101_H117_L2.1451.00
63_F197_F2.1421.00
275_H279_D2.1391.00
257_D326_T2.1381.00
296_L300_D2.1131.00
263_A272_I2.0281.00
177_K180_R2.0091.00
284_G298_I2.0071.00
291_A294_K1.9351.00
140_G145_L1.9051.00
246_L249_T1.8931.00
258_R324_A1.8821.00
87_A161_V1.8411.00
37_A41_P1.8411.00
86_R160_Q1.8231.00
176_I179_I1.8191.00
176_I180_R1.8141.00
178_D181_W1.7861.00
85_P160_Q1.7801.00
233_E344_I1.7301.00
70_Y161_V1.7111.00
101_H115_L1.6931.00
244_M275_H1.6931.00
35_I51_G1.6831.00
248_Q252_E1.6771.00
43_T66_S1.6671.00
269_C285_L1.6661.00
98_V102_A1.6641.00
344_I356_S1.6541.00
246_L250_L1.6501.00
116_G130_V1.6391.00
39_A62_A1.6381.00
47_R217_E1.6301.00
263_A311_V1.6301.00
98_V296_L1.6221.00
328_V347_T1.6191.00
276_L311_V1.6091.00
269_C287_T1.5971.00
103_D321_H1.5971.00
330_N344_I1.5941.00
208_L213_M1.5931.00
204_R207_E1.5631.00
268_R332_D1.5571.00
252_E279_D1.5541.00
63_F163_V1.5541.00
327_H357_I1.5531.00
272_I331_Y1.5371.00
103_D106_P1.5341.00
277_A283_V1.5131.00
294_K297_R1.5071.00
208_L212_Q1.4991.00
268_R271_E1.4921.00
148_Y153_H1.4871.00
312_A316_A1.4661.00
175_F179_I1.4561.00
177_K181_W1.4471.00
123_G126_K1.4451.00
265_T268_R1.4251.00
316_A320_L1.4241.00
43_T49_V1.4171.00
208_L214_N1.4131.00
206_R210_F1.4131.00
104_A137_I1.4071.00
71_L87_A1.4051.00
234_E355_H1.4031.00
41_P45_A1.3971.00
51_G197_F1.3921.00
259_A329_F1.3721.00
125_D129_K1.3641.00
232_K355_H1.3631.00
290_V298_I1.3571.00
247_L329_F1.3561.00
42_L49_V1.3501.00
99_Q321_H1.3471.00
298_I310_L1.3181.00
168_D318_R1.3161.00
179_I182_L1.3091.00
294_K298_I1.2991.00
250_L253_E1.2981.00
88_L159_I1.2971.00
208_L211_E1.2951.00
104_A115_L1.2861.00
71_L136_D1.2851.00
301_E307_L1.2851.00
96_L319_G1.2841.00
70_Y160_Q1.2811.00
53_A57_T1.2751.00
175_F180_R1.2681.00
124_Y128_L1.2661.00
68_F72_L1.2661.00
162_V194_N1.2571.00
259_A309_I1.2531.00
209_A213_M1.2531.00
180_R184_R1.2401.00
102_A106_P1.2401.00
281_H309_I1.2401.00
258_R305_G1.2401.00
273_W311_V1.2371.00
67_T161_V1.2371.00
68_F108_A1.2361.00
183_F186_M1.2341.00
324_A352_A1.2311.00
209_A212_Q1.2121.00
40_L44_L1.2111.00
29_F61_M1.2061.00
211_E214_N1.2061.00
42_L217_E1.2011.00
205_V208_L1.2001.00
91_A97_A1.1951.00
269_C273_W1.1911.00
228_G231_I1.1901.00
85_P158_A1.1841.00
97_A117_L1.1741.00
181_W184_R1.1731.00
215_N218_Y1.1691.00
245_R248_Q1.1641.00
84_Q158_A1.1641.00
67_T163_V1.1471.00
86_R136_D1.1371.00
216_A220_E1.1281.00
70_Y193_L1.1241.00
250_L329_F1.1151.00
135_V138_L1.1121.00
290_V294_K1.1111.00
303_T324_A1.1111.00
146_I181_W1.1101.00
336_D339_D1.1101.00
333_L358_S1.1091.00
302_F310_L1.1071.00
368_L372_E1.1021.00
39_A51_G1.1021.00
101_H139_I1.1001.00
298_I301_E1.0931.00
330_N343_R1.0891.00
300_D303_T1.0841.00
175_F178_D1.0821.00
34_P38_L1.0801.00
330_N358_S1.0791.00
275_H278_A1.0781.00
38_L42_L1.0751.00
247_L331_Y1.0741.00
248_Q275_H1.0721.00
244_M248_Q1.0711.00
269_C311_V1.0691.00
233_E340_Y1.0601.00
102_A105_E1.0591.00
90_M140_G1.0571.00
298_I307_L1.0551.00
40_L65_T1.0501.00
297_R300_D1.0441.00
204_R208_L1.0371.00
60_T100_I1.0361.00
243_K246_L1.0331.00
69_H72_L1.0291.00
161_V195_M1.0251.00
54_Q57_T1.0241.00
52_Q220_E1.0221.00
287_T290_V1.0201.00
305_G308_D1.0161.00
116_G138_L1.0131.00
27_K106_P1.0101.00
127_Q130_V1.0071.00
364_Y368_L1.0051.00
305_G324_A1.0031.00
242_E245_R0.9971.00
181_W185_R0.9971.00
97_A139_I0.9941.00
49_V195_M0.9881.00
261_I329_F0.9861.00
169_R172_D0.9791.00
272_I311_V0.9771.00
244_M331_Y0.9771.00
327_H355_H0.9731.00
169_R318_R0.9711.00
286_L315_V0.9711.00
334_P340_Y0.9681.00
34_P37_A0.9661.00
226_K229_H0.9651.00
244_M279_D0.9611.00
210_F214_N0.9611.00
292_Q296_L0.9511.00
146_I178_D0.9511.00
61_M103_D0.9501.00
206_R218_Y0.9461.00
180_R211_E0.9431.00
270_E287_T0.9371.00
249_T253_E0.9361.00
286_L316_A0.9341.00
104_A139_I0.9291.00
370_A374_Y0.9251.00
179_I186_M0.9231.00
42_L45_A0.9221.00
317_A339_D0.9181.00
31_N37_A0.9181.00
274_G277_A0.9161.00
96_L99_Q0.9151.00
90_M145_L0.9081.00
26_K109_E0.8981.00
125_D128_L0.8941.00
221_V224_E0.8931.00
179_I183_F0.8921.00
218_Y222_E0.8911.00
372_E376_G0.8861.00
236_F246_L0.8831.00
251_I259_A0.8791.00
228_G233_E0.8781.00
274_G278_A0.8751.00
256_P308_D0.8721.00
209_A214_N0.8721.00
176_I183_F0.8711.00
356_S360_A0.8681.00
268_R331_Y0.8671.00
354_G357_I0.8621.00
267_H271_E0.8591.00
293_K297_R0.8581.00
67_T137_I0.8581.00
262_F343_R0.8561.00
257_D327_H0.8521.00
367_N370_A0.8491.00
182_L186_M0.8491.00
249_T252_E0.8461.00
216_A221_V0.8401.00
178_D182_L0.8401.00
281_H308_D0.8361.00
160_Q192_R0.8361.00
206_R209_A0.8351.00
98_V117_L0.8331.00
220_E223_P0.8321.00
62_A66_S0.8291.00
38_L41_P0.8281.00
71_L113_L0.8261.00
234_E237_Y0.8261.00
122_D126_K0.8221.00
365_A369_P0.8121.00
161_V193_L0.8111.00
369_P372_E0.8081.00
250_L357_I0.8071.00
127_Q131_L0.8061.00
302_F325_V0.8041.00
299_L303_T0.7921.00
142_T164_L0.7921.00
143_G146_I0.7911.00
252_E281_H0.7911.00
207_E210_F0.7911.00
277_A282_R0.7871.00
370_A373_T0.7851.00
65_T68_F0.7851.00
261_I309_I0.7841.00
207_E211_E0.7831.00
225_Q228_G0.7811.00
256_P259_A0.7801.00
180_R183_F0.7781.00
119_Y122_D0.7781.00
314_D339_D0.7781.00
229_H233_E0.7771.00
258_R326_T0.7771.00
89_I104_A0.7771.00
243_K250_L0.7751.00
66_S161_V0.7731.00
35_I38_L0.7721.00
198_S201_L0.7721.00
108_A111_T0.7701.00
122_D127_Q0.7701.00
257_D352_A0.7691.00
87_A163_V0.7671.00
98_V101_H0.7651.00
147_D151_Q0.7641.00
113_L136_D0.7641.00
357_I361_C0.7641.00
51_G62_A0.7621.00
140_G144_R0.7611.00
217_E220_E0.7591.00
368_L371_I0.7591.00
86_R158_A0.7581.00
217_E221_V0.7581.00
261_I311_V0.7561.00
232_K353_S0.7551.00
270_E274_G0.7551.00
162_V183_F0.7541.00
205_V209_A0.7531.00
177_K184_R0.7411.00
245_R249_T0.7411.00
184_R213_M0.7371.00
146_I150_K0.7361.00
243_K332_D0.7321.00
271_E275_H0.7321.00
55_T199_A0.7301.00
210_F213_M0.7281.00
227_T230_R0.7271.00
375_I378_S0.7271.00
177_K183_F0.7261.00
244_M247_L0.7251.00
126_K129_K0.7251.00
261_I331_Y0.7211.00
126_K130_V0.7211.00
87_A137_I0.7181.00
258_R308_D0.7161.00
88_L162_V0.7141.00
63_F100_I0.7111.00
51_G195_M0.7101.00
103_D107_L0.7091.00
325_V347_T0.7081.00
243_K247_L0.7081.00
233_E237_Y0.7071.00
216_A219_I0.7061.00
150_K181_W0.7061.00
42_L47_R0.7031.00
162_V186_M0.7021.00
202_S205_V0.7011.00
245_R275_H0.7001.00
122_D130_V0.6991.00
156_L159_I0.6981.00
35_I222_E0.6981.00
371_I375_I0.6981.00
230_R233_E0.6971.00
64_L108_A0.6961.00
366_L370_A0.6941.00
41_P44_L0.6941.00
32_C40_L0.6931.00
228_G232_K0.6911.00
67_T104_A0.6901.00
177_K182_L0.6881.00
163_V195_M0.6871.00
326_T352_A0.6851.00
266_K270_E0.6851.00
53_A62_A0.6841.00
61_M65_T0.6821.00
130_V135_V0.6811.00
98_V300_D0.6801.00
250_L327_H0.6791.00
67_T89_I0.6781.00
89_I100_I0.6771.00
105_E109_E0.6761.00
262_F316_A0.6751.00
98_V119_Y0.6721.00
282_R307_L0.6711.00
178_D185_R0.6701.00
247_L251_I0.6681.00
261_I272_I0.6681.00
149_A185_R0.6641.00
358_S361_C0.6621.00
239_S242_E0.6611.00
244_M271_E0.6601.00
264_N332_D0.6581.00
231_I236_F0.6561.00
175_F183_F0.6551.00
182_L185_R0.6531.00
372_E375_I0.6531.00
374_Y378_S0.6501.00
216_A222_E0.6491.00
215_N219_I0.6471.00
102_A303_T0.6471.00
330_N334_P0.6471.00
344_I358_S0.6461.00
138_L159_I0.6441.00
363_E366_L0.6411.00
168_D342_H0.6391.00
285_L290_V0.6381.00
260_I325_V0.6381.00
243_K248_Q0.6341.00
301_E305_G0.6341.00
247_L261_I0.6331.00
244_M250_L0.6311.00
170_M175_F0.6311.00
295_R299_L0.6301.00
203_Y207_E0.6301.00
247_L272_I0.6281.00
40_L66_S0.6271.00
200_T342_H0.6251.00
226_K230_R0.6241.00
48_D196_L0.6221.00
314_D343_R0.6221.00
183_F187_P0.6181.00
114_K134_G0.6181.00
46_G70_Y0.6151.00
97_A119_Y0.6151.00
144_R147_D0.6141.00
46_G193_L0.6141.00
118_A127_Q0.6131.00
61_M107_L0.6131.00
303_T323_P0.6131.00
371_I374_Y0.6121.00
369_P373_T0.6101.00
260_I347_T0.6081.00
180_R187_P0.6071.00
354_G358_S0.6061.00
373_T377_H0.6051.00
229_H232_K0.6051.00
71_L137_I0.6041.00
354_G361_C0.6031.00
263_A331_Y0.6021.00
132_E135_V0.6021.00
88_L140_G0.6011.00
177_K186_M0.5981.00
374_Y377_H0.5981.00
264_N335_D0.5981.00
187_P191_Q0.5971.00
260_I312_A0.5951.00
227_T233_E0.5931.00
234_E357_I0.5911.00
154_I157_G0.5911.00
220_E224_E0.5901.00
128_L153_H0.5881.00
286_L299_L0.5871.00
40_L62_A0.5871.00
100_I139_I0.5861.00
184_R187_P0.5841.00
84_Q136_D0.5841.00
175_F182_L0.5831.00
271_E274_G0.5811.00
229_H234_E0.5811.00
365_A368_L0.5811.00
124_Y151_Q0.5801.00
368_L378_S0.5791.00
55_T345_G0.5771.00
299_L322_I0.5751.00
117_L122_D0.5741.00
176_I186_M0.5741.00
286_L290_V0.5731.00
163_V197_F0.5711.00
273_W276_L0.5711.00
355_H358_S0.5711.00
232_K235_L0.5701.00
199_A345_G0.5691.00
367_N371_I0.5681.00
188_P191_Q0.5671.00
326_T354_G0.5671.00
226_K231_I0.5661.00
102_A296_L0.5661.00
100_I103_D0.5621.00
270_E273_W0.5621.00
282_R301_E0.5621.00
218_Y221_V0.5611.00
262_F328_V0.5611.00
180_R186_M0.5571.00
231_I235_L0.5571.00
124_Y127_Q0.5551.00
215_N221_V0.5531.00
330_N333_L0.5531.00
47_R193_L0.5481.00
299_L302_F0.5481.00
372_E378_S0.5481.00
235_L360_A0.5451.00
63_F195_M0.5441.00
102_A300_D0.5441.00
227_T231_I0.5441.00
219_I222_E0.5411.00
25_E30_H0.5381.00
235_L238_P0.5381.00
39_A43_T0.5371.00
231_I348_G0.5371.00
104_A108_A0.5331.00
364_Y367_N0.5321.00
52_Q201_L0.5301.00
270_E289_D0.5291.00
33_T350_A0.5281.00
293_K296_L0.5271.00
178_D183_F0.5271.00
117_L120_G0.5251.00
148_Y151_Q0.5221.00
286_L298_I0.5211.00
148_Y152_N0.5171.00
176_I184_R0.5161.00
48_D193_L0.5161.00
205_V212_Q0.5151.00
167_A201_L0.5141.00
176_I181_W0.5141.00
48_D194_N0.5131.00
179_I185_R0.5131.00
187_P192_R0.5131.00
114_K135_V0.5121.00
266_K269_C0.5111.00
345_G348_G0.5111.00
32_C37_A0.5101.00
204_R209_A0.5091.00
264_N268_R0.5081.00
284_G308_D0.5081.00
179_I187_P0.5081.00
292_Q295_R0.5071.00
89_I139_I0.5061.00
230_R353_S0.5061.00
118_A138_L0.5051.00
106_P109_E0.5051.00
245_R279_D0.5021.00
228_G235_L0.5021.00
176_I185_R0.5011.00
303_T322_I0.5011.00
373_T376_G0.5001.00
366_L369_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.9287 100 0.23 Contact Map
4nhoA 1 0.9145 100 0.243 Contact Map
2db3A 1 0.9121 100 0.247 Contact Map
4c9bA 1 0.9002 100 0.248 Contact Map
4d25A 1 0.9192 100 0.253 Contact Map
4ljyA 1 0.9501 100 0.256 Contact Map
3eiqA 1 0.8551 100 0.26 Contact Map
1s2mA 1 0.8955 100 0.263 Contact Map
4ct4B 1 0.8955 100 0.268 Contact Map
4kbfA 2 0.867 100 0.272 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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