GREMLIN Database
RLMH - Ribosomal RNA large subunit methyltransferase H
UniProt: P0A8I8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11254
Length: 155 (153)
Sequences: 2676 (1831)
Seq/√Len: 148.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_P124_A3.4471.00
67_N99_S2.5141.00
19_G134_V2.4431.00
85_A147_T2.2841.00
71_T108_L2.2001.00
6_V60_M2.1371.00
15_W19_G2.1301.00
110_P114_A2.0961.00
145_S150_H2.0961.00
128_P131_L2.0311.00
79_W118_Q2.0171.00
87_E118_Q2.0021.00
4_Q34_E1.9921.00
71_T116_A1.9551.00
17_Q21_T1.9521.00
61_L115_A1.9301.00
57_G112_C1.9231.00
127_L135_L1.9121.00
24_L33_F1.8671.00
123_S127_L1.8601.00
61_L112_C1.8351.00
89_E147_T1.7621.00
69_I101_L1.7571.00
74_I121_S1.7541.00
80_D83_Q1.7521.00
58_E111_A1.7451.00
57_G109_S1.7341.00
54_D109_S1.7301.00
87_E91_W1.6911.00
54_D111_A1.6601.00
84_L143_A1.6241.00
122_L132_V1.6041.00
48_D51_R1.5651.00
83_Q124_A1.5621.00
73_D113_K1.5551.00
14_D18_T1.5231.00
55_K58_E1.4771.00
30_D150_H1.4671.00
64_A69_I1.4631.00
41_G59_Q1.4401.00
7_A133_R1.4151.00
58_E62_A1.4081.00
4_Q97_D1.4061.00
89_E93_L1.4011.00
4_Q67_N1.4011.00
16_V19_G1.3991.00
68_R117_E1.3981.00
8_V38_I1.3961.00
31_M144_W1.3811.00
20_F137_A1.3751.00
86_A89_E1.3471.00
67_N97_D1.3381.00
5_L136_V1.3051.00
53_L113_K1.3031.00
69_I115_A1.3011.00
2_K34_E1.2761.00
68_R118_Q1.2671.00
113_K119_S1.2561.00
132_V135_L1.2301.00
60_M101_L1.2271.00
120_W125_L1.2191.00
20_F24_L1.1991.00
18_T21_T1.1871.00
51_R54_D1.1871.00
106_E154_R1.1771.00
75_P113_K1.1641.00
77_K118_Q1.1611.00
96_R117_E1.1541.00
77_K83_Q1.1491.00
21_T24_L1.1411.00
20_F134_V1.1310.99
49_I53_L1.1270.99
100_L136_V1.1160.99
71_T113_K1.0960.99
4_Q36_I1.0950.99
70_V91_W1.0900.99
73_D119_S1.0890.99
16_V134_V1.0850.99
4_Q99_S1.0760.99
20_F35_L1.0520.99
74_I82_P1.0330.99
68_R91_W1.0260.99
51_R55_K1.0130.99
22_E26_R1.0130.99
72_L136_V1.0040.99
57_G111_A1.0000.99
71_T119_S1.0000.99
79_W87_E0.9910.99
111_A114_A0.9840.99
110_P113_K0.9840.99
54_D58_E0.9740.98
5_L33_F0.9690.98
11_K20_F0.9620.98
92_K147_T0.9390.98
87_E90_R0.9300.98
2_K32_P0.9240.98
105_P154_R0.9210.98
8_V104_G0.9160.98
52_I106_E0.9080.98
36_I63_A0.9070.98
90_R94_D0.9030.97
66_K115_A0.8950.97
37_E133_R0.8910.97
83_Q86_A0.8860.97
79_W84_L0.8730.97
5_L102_I0.8670.97
74_I154_R0.8520.96
72_L132_V0.8510.96
69_I117_E0.8430.96
5_L140_L0.8420.96
30_D145_S0.8400.96
15_W18_T0.8330.96
145_S151_P0.8300.96
57_G61_L0.8280.96
81_T146_I0.8240.96
134_V137_A0.8230.96
24_L28_P0.8130.95
141_Y145_S0.8100.95
35_L133_R0.8080.95
13_P19_G0.7860.94
101_L108_L0.7860.94
14_D17_Q0.7850.94
41_G52_I0.7850.94
2_K97_D0.7800.94
88_L143_A0.7700.94
86_A90_R0.7630.93
78_P121_S0.7590.93
64_A67_N0.7570.93
4_Q65_G0.7540.93
65_G97_D0.7440.93
50_K53_L0.7370.92
56_E104_G0.7270.92
53_L104_G0.7260.92
82_P85_A0.7230.91
41_G55_K0.7220.91
53_L106_E0.7180.91
27_F31_M0.7180.91
33_F137_A0.7170.91
43_R52_I0.7140.91
89_E92_K0.7140.91
27_F140_L0.7120.91
21_T25_R0.7090.91
27_F144_W0.7070.91
71_T101_L0.7060.91
49_I106_E0.7060.91
24_L35_L0.7060.91
77_K124_A0.7050.90
74_I105_P0.7040.90
131_L134_V0.7030.90
84_L125_L0.7020.90
122_L125_L0.7000.90
70_V98_V0.6980.90
70_V87_E0.6960.90
47_A51_R0.6950.90
121_S124_A0.6890.89
6_V99_S0.6840.89
72_L122_L0.6690.88
92_K148_T0.6640.88
68_R96_R0.6620.87
146_I153_H0.6610.87
18_T22_E0.6590.87
75_P119_S0.6570.87
88_L98_V0.6500.87
112_C115_A0.6440.86
120_W136_V0.6440.86
70_V120_W0.6420.86
116_A119_S0.6420.86
125_L135_L0.6380.86
50_K54_D0.6330.85
43_R151_P0.6260.84
88_L92_K0.6250.84
92_K144_W0.6250.84
11_K16_V0.6210.84
68_R94_D0.6210.84
69_I99_S0.6190.84
82_P146_I0.6180.84
16_V131_L0.6130.83
56_E60_M0.6120.83
84_L120_W0.6010.82
79_W125_L0.5970.82
79_W83_Q0.5920.81
105_P132_V0.5860.80
13_P16_V0.5860.80
26_R141_Y0.5840.80
3_L144_W0.5810.80
12_M40_A0.5810.80
23_Y139_S0.5810.80
59_Q62_A0.5800.80
122_L135_L0.5780.79
43_R49_I0.5750.79
77_K87_E0.5750.79
73_D116_A0.5740.79
74_I119_S0.5720.79
23_Y134_V0.5710.79
82_P86_A0.5690.78
24_L137_A0.5660.78
70_V118_Q0.5650.78
3_L31_M0.5650.78
81_T85_A0.5650.78
143_A147_T0.5630.78
44_G105_P0.5620.78
38_I60_M0.5590.77
11_K17_Q0.5580.77
101_L112_C0.5570.77
9_G133_R0.5490.76
70_V100_L0.5450.75
144_W148_T0.5420.75
7_A35_L0.5380.74
128_P132_V0.5380.74
52_I55_K0.5360.74
79_W120_W0.5340.74
56_E64_A0.5330.74
78_P123_S0.5270.73
50_K110_P0.5260.73
136_V140_L0.5260.73
38_I59_Q0.5240.73
25_R29_K0.5230.72
85_A89_E0.5220.72
131_L135_L0.5200.72
69_I116_A0.5190.72
55_K59_Q0.5170.72
12_M130_P0.5160.71
105_P130_P0.5160.71
7_A37_E0.5100.71
13_P22_E0.5050.70
52_I105_P0.5050.70
31_M92_K0.5030.70
41_G44_G0.5030.70
108_L112_C0.5030.70
15_W22_E0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ns5A 2 1 100 0.006 Contact Map
1to0A 2 0.9548 100 0.024 Contact Map
4fakA 2 0.9935 100 0.033 Contact Map
1o6dA 2 0.929 100 0.038 Contact Map
3oiiA 2 0.8774 99.7 0.669 Contact Map
3o7bA 2 0.8645 94.5 0.891 Contact Map
1oy5A 2 0.9032 93 0.898 Contact Map
3iefA 2 0.9226 92.3 0.9 Contact Map
3ky7A 2 0.871 92 0.901 Contact Map
3knuA 2 0.9097 91.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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