GREMLIN Database
YAAA - UPF0246 protein YaaA
UniProt: P0A8I3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10011
Length: 258 (240)
Sequences: 2256 (1584)
Seq/√Len: 102.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_N150_I4.4551.00
52_I56_L3.3751.00
92_Q95_T3.3391.00
241_D244_S3.2581.00
142_D145_Q3.1751.00
100_D221_E2.8351.00
60_N63_R2.7531.00
97_S100_D2.7291.00
81_L101_F2.7281.00
149_D153_N2.6901.00
3_I219_I2.5621.00
4_L167_V2.5211.00
10_T84_K2.5031.00
104_A220_I2.5021.00
217_R221_E2.4641.00
168_I219_I2.4541.00
17_L77_R2.4491.00
226_K229_Q2.4391.00
47_S54_D2.4051.00
100_D223_R2.3991.00
246_S249_E2.2681.00
187_E248_G2.1271.00
96_F217_R2.1231.00
192_V249_E2.1061.00
38_A64_F2.0251.00
13_Y82_A2.0031.00
26_E154_K1.9961.00
228_E231_T1.9881.00
151_I178_S1.9871.00
96_F100_D1.9861.00
103_F107_H1.9571.00
61_A65_H1.9191.00
5_I216_S1.8261.00
131_M178_S1.8061.00
105_Q121_L1.7811.00
62_A66_D1.7711.00
31_S67_W1.7531.00
75_N125_Q1.7121.00
214_L236_E1.6691.00
141_K145_Q1.6601.00
227_P250_L1.6361.00
37_E135_L1.6181.00
100_D220_I1.6131.00
5_I108_L1.5951.00
5_I87_V1.5901.00
103_F220_I1.5691.00
84_K94_E1.5681.00
231_T250_L1.5531.00
196_E201_F1.5451.00
219_I230_L1.5361.00
15_S77_R1.5121.00
219_I224_L1.4921.00
86_D206_F1.4851.00
154_K157_E1.4601.00
191_P250_L1.4461.00
46_I52_I1.4361.00
8_A11_L1.4241.00
104_A216_S1.4191.00
96_F104_A1.4161.00
58_G62_A1.4111.00
59_I63_R1.4071.00
18_T81_L1.3981.00
2_L165_N1.3390.99
27_L154_K1.3340.99
151_I179_V1.3290.99
90_G210_K1.3180.99
148_G180_K1.3160.99
240_F250_L1.3110.99
224_L229_Q1.3080.99
117_V154_K1.3060.99
4_L155_L1.3040.99
118_L124_M1.2850.99
33_Q146_F1.2800.99
96_F101_F1.2780.99
76_A123_L1.2690.99
2_L109_R1.2570.99
208_A212_R1.2540.99
95_T217_R1.2480.99
168_I191_P1.2410.99
91_L216_S1.2380.99
77_R82_A1.2360.99
37_E41_L1.2310.99
99_D223_R1.2300.99
113_G131_M1.2190.99
12_D84_K1.2100.99
96_F221_E1.1990.99
30_N146_F1.1850.99
32_Q36_H1.1760.98
156_N185_N1.1660.98
80_I91_L1.1640.98
52_I57_A1.1630.98
43_P61_A1.1550.98
13_Y124_M1.1480.98
225_T229_Q1.1370.98
166_V187_E1.1340.98
221_E235_S1.1190.98
47_S57_A1.1140.98
37_E138_A1.0790.97
196_E199_G1.0740.97
35_I64_F1.0730.97
43_P58_G1.0630.97
33_Q37_E1.0630.97
216_S220_I1.0600.97
194_L201_F1.0540.97
144_Y177_K1.0530.97
12_D77_R1.0500.97
47_S52_I1.0350.96
166_V227_P1.0320.96
247_N250_L1.0310.96
109_R117_V1.0310.96
203_I208_A1.0300.96
131_M174_E1.0280.96
165_N185_N1.0280.96
134_R142_D1.0170.96
229_Q232_G1.0120.96
30_N139_R1.0120.96
95_T221_E1.0040.96
22_Y78_Q1.0010.96
53_S56_L0.9990.96
80_I120_P0.9860.95
101_F121_L0.9820.95
36_H39_R0.9760.95
231_T240_F0.9720.95
80_I101_F0.9610.95
195_D205_S0.9580.95
190_K249_E0.9540.94
86_D90_G0.9530.94
28_L31_S0.9480.94
190_K250_L0.9480.94
21_R102_D0.9440.94
226_K250_L0.9320.94
210_K214_L0.9320.94
14_Q82_A0.9310.94
31_S35_I0.9230.93
153_N183_K0.9190.93
102_D106_Q0.9180.93
152_T180_K0.9170.93
31_S146_F0.9080.93
91_L217_R0.9080.93
54_D58_G0.9050.93
149_D180_K0.9000.93
195_D204_I0.8990.93
218_F233_F0.8980.92
168_I230_L0.8970.92
173_D190_K0.8930.92
214_L235_S0.8870.92
218_F222_N0.8870.92
115_Y125_Q0.8770.92
82_A126_P0.8720.91
10_T89_T0.8710.91
152_T181_P0.8670.91
87_V170_L0.8630.91
39_R65_H0.8610.91
63_R126_P0.8600.91
103_F223_R0.8560.91
62_A65_H0.8560.91
30_N33_Q0.8540.90
45_Q48_T0.8470.90
84_K89_T0.8460.90
109_R120_P0.8380.90
27_L196_E0.8370.90
4_L176_F0.8350.89
113_G175_Y0.8340.89
35_I114_L0.8310.89
180_K183_K0.8260.89
91_L96_F0.8220.89
26_E119_R0.8210.89
24_L123_L0.8200.89
83_F118_L0.8160.88
38_A41_L0.8160.88
83_F127_Y0.8150.88
42_T45_Q0.8140.88
152_T156_N0.8130.88
111_L179_V0.8120.88
8_A88_Y0.8090.88
119_R122_D0.8080.88
97_S221_E0.8070.88
27_L117_V0.8040.88
113_G130_E0.8020.88
87_V206_F0.7980.87
36_H68_Q0.7950.87
80_I104_A0.7950.87
18_T94_E0.7930.87
46_I61_A0.7920.87
76_A125_Q0.7920.87
108_L216_S0.7890.87
89_T206_F0.7810.86
18_T101_F0.7810.86
190_K194_L0.7750.86
25_P118_L0.7750.86
50_M64_F0.7710.85
28_L67_W0.7700.85
6_S169_N0.7600.85
192_V203_I0.7590.84
169_N190_K0.7550.84
98_E102_D0.7490.84
205_S208_A0.7450.83
41_L46_I0.7420.83
9_K130_E0.7410.83
169_N176_F0.7410.83
38_A135_L0.7400.83
131_M175_Y0.7390.83
31_S114_L0.7390.83
38_A133_I0.7380.83
103_F224_L0.7350.83
239_F247_N0.7310.82
23_T105_Q0.7300.82
231_T242_E0.7300.82
124_M151_I0.7250.82
18_T21_R0.7240.82
93_A96_F0.7240.82
44_P48_T0.7230.82
14_Q77_R0.7180.81
29_D32_Q0.7180.81
150_I153_N0.7170.81
11_L83_F0.7160.81
128_R147_W0.7130.81
34_L143_L0.7130.81
7_P175_Y0.7120.81
181_P188_I0.7110.80
54_D57_A0.7090.80
81_L96_F0.7050.80
201_F241_D0.7040.80
35_I68_Q0.6990.79
152_T183_K0.6980.79
194_L203_I0.6930.79
49_L132_G0.6890.78
130_E133_I0.6870.78
83_F132_G0.6870.78
79_A88_Y0.6850.78
149_D183_K0.6840.78
131_M208_A0.6820.78
28_L32_Q0.6790.77
140_G145_Q0.6770.77
109_R154_K0.6740.77
57_A61_A0.6730.77
67_W125_Q0.6710.76
165_N187_E0.6700.76
194_L249_E0.6690.76
195_D207_Y0.6670.76
148_G153_N0.6640.76
35_I46_I0.6610.75
32_Q68_Q0.6580.75
188_I193_F0.6580.75
101_F105_Q0.6550.75
29_D33_Q0.6540.75
200_K203_I0.6530.75
37_E142_D0.6520.74
67_W201_F0.6510.74
202_K205_S0.6460.74
75_N123_L0.6450.74
117_V151_I0.6440.74
37_E40_K0.6430.73
169_N172_S0.6360.73
245_S250_L0.6360.73
103_F225_T0.6330.72
171_A175_Y0.6300.72
111_L131_M0.6280.72
234_N239_F0.6250.71
20_T102_D0.6250.71
113_G132_G0.6250.71
84_K219_I0.6240.71
207_Y212_R0.6240.71
58_G61_A0.6230.71
219_I227_P0.6200.71
35_I39_R0.6190.71
131_M144_Y0.6190.71
167_V186_A0.6150.70
189_I227_P0.6150.70
194_L241_D0.6140.70
203_I249_E0.6110.70
203_I206_F0.6070.69
33_Q139_R0.6070.69
80_I93_A0.6070.69
120_P233_F0.6050.69
107_H220_I0.6030.69
67_W114_L0.6030.69
108_L220_I0.6010.68
173_D203_I0.6010.68
201_F244_S0.6000.68
113_G144_Y0.6000.68
5_I104_A0.5990.68
36_H40_K0.5980.68
219_I250_L0.5980.68
90_G132_G0.5980.68
131_M143_L0.5950.68
242_E245_S0.5950.68
109_R155_L0.5900.67
98_E230_L0.5900.67
52_I61_A0.5890.67
130_E174_E0.5870.67
197_K237_G0.5870.67
135_L203_I0.5870.67
147_W172_S0.5860.66
6_S171_A0.5860.66
41_L45_Q0.5800.66
170_L215_M0.5800.66
105_Q120_P0.5790.65
218_F221_E0.5780.65
204_I207_Y0.5770.65
170_L212_R0.5750.65
43_P54_D0.5740.65
194_L244_S0.5710.64
130_E175_Y0.5700.64
240_F247_N0.5680.64
18_T77_R0.5660.64
33_Q138_A0.5650.64
82_A124_M0.5640.63
93_A217_R0.5640.63
40_K43_P0.5640.63
134_R141_K0.5620.63
55_K59_I0.5590.63
13_Y77_R0.5570.62
176_F179_V0.5550.62
99_D102_D0.5540.62
128_R172_S0.5530.62
113_G178_S0.5520.62
87_V204_I0.5510.62
53_S132_G0.5500.62
38_A129_L0.5500.62
222_N234_N0.5480.61
97_S104_A0.5470.61
32_Q69_P0.5470.61
38_A42_T0.5450.61
27_L150_I0.5450.61
22_Y123_L0.5440.61
110_M124_M0.5440.61
26_E157_E0.5430.61
35_I38_A0.5420.60
195_D238_Y0.5420.60
11_L86_D0.5400.60
27_L64_F0.5390.60
152_T179_V0.5380.60
136_E141_K0.5360.60
113_G172_S0.5330.59
84_K110_M0.5330.59
164_D187_E0.5330.59
13_Y63_R0.5310.59
8_A60_N0.5290.59
48_T51_R0.5280.58
9_K174_E0.5270.58
6_S172_S0.5250.58
132_G174_E0.5240.58
15_S20_T0.5240.58
42_T58_G0.5220.58
25_P69_P0.5210.57
4_L117_V0.5190.57
11_L206_F0.5180.57
89_T210_K0.5160.57
136_E139_R0.5140.56
43_P57_A0.5130.56
91_L220_I0.5110.56
100_D103_F0.5100.56
33_Q36_H0.5080.56
156_N184_L0.5080.56
184_L188_I0.5040.55
115_Y174_E0.5040.55
2_L164_D0.5020.55
194_L202_K0.5000.54
41_L49_L0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ou0A 1 0.2287 28.5 0.96 Contact Map
4glxA 1 0.3256 13.7 0.966 Contact Map
3c65A 1 0.0233 10.6 0.967 Contact Map
4gfjA 1 0.0736 10.5 0.967 Contact Map
2yfvC 1 0.2326 9.8 0.968 Contact Map
3eyiA 1 0.2287 8.9 0.968 Contact Map
3sgiA 1 0 8.4 0.969 Contact Map
4rb5B 1 0.469 7.6 0.969 Contact Map
4pj0U 1 0.3566 6.3 0.971 Contact Map
2duyA 1 0.2481 5.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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