GREMLIN Database
RUVX - Putative Holliday junction resolvase
UniProt: P0A8I1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13290
Length: 138 (133)
Sequences: 3574 (2295)
Seq/√Len: 199.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_E135_E3.3171.00
31_P44_I3.2031.00
69_E77_R3.1531.00
80_A93_L3.1461.00
56_E92_K3.0041.00
65_M98_L2.2121.00
94_H132_S2.2041.00
70_Q73_T2.1901.00
46_E87_F2.0541.00
64_N68_T1.9911.00
46_E86_R1.9881.00
5_L56_E1.9221.00
59_V80_A1.8981.00
49_L57_I1.8981.00
35_A41_D1.8861.00
12_T75_R1.8621.00
44_I47_R1.8431.00
61_L77_R1.7841.00
32_A123_S1.7071.00
69_E73_T1.6731.00
56_E90_E1.6591.00
99_S128_I1.6511.00
8_F17_V1.6111.00
104_R121_V1.5701.00
49_L87_F1.5521.00
17_V48_L1.5501.00
19_V30_L1.5331.00
94_H136_Q1.5241.00
65_M97_R1.5021.00
10_F59_V1.4901.00
72_L75_R1.4881.00
61_L93_L1.4641.00
47_R51_E1.4581.00
80_A84_H1.4531.00
46_E50_K1.4511.00
108_F114_R1.4381.00
57_I89_V1.4051.00
81_N84_H1.3951.00
15_I35_A1.3771.00
23_I26_T1.3691.00
6_L54_P1.3441.00
14_S34_K1.3081.00
102_E128_I1.3051.00
19_V52_W1.2981.00
76_A80_A1.2971.00
61_L69_E1.2851.00
12_T72_L1.2801.00
30_L52_W1.2731.00
10_F79_F1.2671.00
92_K133_Y1.2461.00
124_A127_V1.2171.00
64_N70_Q1.2131.00
4_T52_W1.2001.00
42_W82_R1.1991.00
19_V54_P1.1731.00
77_R93_L1.1551.00
72_L76_A1.1511.00
15_I41_D1.1431.00
5_L133_Y1.1331.00
105_S109_E1.1001.00
107_L120_K1.1001.00
99_S102_E1.0951.00
17_V31_P1.0911.00
27_A131_E1.0831.00
98_L101_V1.0731.00
20_G24_T1.0591.00
15_I79_F1.0561.00
29_P123_S1.0511.00
31_P123_S1.0031.00
71_P74_A0.9991.00
42_W86_R0.9911.00
36_Q40_P0.9781.00
104_R117_N0.9740.99
33_I44_I0.9700.99
57_I87_F0.9600.99
20_G134_F0.9580.99
120_K123_S0.9540.99
106_G124_A0.9350.99
108_F111_G0.9210.99
108_F117_N0.9130.99
4_T22_R0.8890.99
73_T93_L0.8830.99
74_A78_K0.8830.99
10_F72_L0.8790.99
4_T21_Q0.8700.99
59_V83_I0.8680.99
6_L48_L0.8670.99
102_E132_S0.8630.99
57_I83_I0.8470.99
43_N47_R0.8430.99
108_F113_Y0.8380.98
107_L124_A0.8380.98
43_N86_R0.8300.98
64_N71_P0.8250.98
14_S121_V0.8220.98
24_T55_D0.8210.98
114_R117_N0.8160.98
61_L73_T0.8130.98
81_N85_G0.8080.98
106_G131_E0.8020.98
10_F41_D0.7950.98
63_L67_G0.7940.98
38_G82_R0.7900.98
5_L58_I0.7870.98
104_R107_L0.7820.98
71_P75_R0.7820.98
7_A58_I0.7770.97
77_R80_A0.7740.97
18_A126_A0.7740.97
103_A124_A0.7730.97
30_L48_L0.7690.97
113_Y116_L0.7680.97
101_V105_S0.7650.97
48_L52_W0.7550.97
44_I48_L0.7450.97
76_A93_L0.7440.97
43_N46_E0.7340.96
128_I132_S0.7230.96
72_L100_T0.7230.96
58_I92_K0.7200.96
6_L17_V0.7190.96
102_E106_G0.7140.96
59_V76_A0.7110.96
63_L69_E0.7100.96
20_G25_G0.7090.96
29_P127_V0.7040.96
103_A128_I0.7000.95
49_L89_V0.6970.95
84_H88_G0.6970.95
58_I129_I0.6940.95
132_S136_Q0.6930.95
69_E74_A0.6930.95
45_I79_F0.6860.95
14_S32_A0.6740.94
79_F83_I0.6730.94
59_V91_V0.6690.94
23_I28_R0.6630.94
77_R81_N0.6610.94
103_A121_V0.6600.94
104_R108_F0.6510.93
82_R85_G0.6500.93
112_G117_N0.6480.93
112_G116_L0.6480.93
37_D40_P0.6480.93
14_S122_D0.6480.93
100_T121_V0.6460.93
40_P43_N0.6330.92
58_I94_H0.6300.92
78_K85_G0.6280.92
106_G128_I0.6270.92
5_L55_D0.6260.92
59_V93_L0.6240.92
45_I83_I0.6170.91
7_A130_L0.6160.91
78_K82_R0.6160.91
100_T104_R0.6040.90
111_G114_R0.6020.90
82_R86_R0.5990.90
22_R53_Q0.5990.90
112_G120_K0.5980.90
55_D90_E0.5960.90
64_N72_L0.5950.90
63_L70_Q0.5950.90
132_S135_E0.5930.90
107_L112_G0.5920.89
8_F14_S0.5910.89
43_N50_K0.5820.89
4_T19_V0.5780.88
6_L49_L0.5720.88
92_K136_Q0.5720.88
12_T100_T0.5710.88
42_W87_F0.5700.88
28_R52_W0.5670.87
98_L102_E0.5660.87
62_P97_R0.5630.87
6_L30_L0.5620.87
8_F59_V0.5620.87
17_V33_I0.5610.87
56_E133_Y0.5530.86
4_T28_R0.5520.86
46_E49_L0.5490.86
41_D79_F0.5480.86
73_T76_A0.5480.86
120_K124_A0.5430.85
21_Q24_T0.5380.85
106_G110_Q0.5370.84
105_S108_F0.5210.83
50_K53_Q0.5200.83
5_L134_F0.5200.83
21_Q25_G0.5180.82
103_A106_G0.5160.82
84_H91_V0.5130.82
49_L54_P0.5100.81
50_K87_F0.5090.81
58_I133_Y0.5090.81
116_L120_K0.5090.81
13_K34_K0.5050.81
4_T54_P0.5040.81
42_W46_E0.5030.80
7_A18_A0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.9493 100 0.195 Contact Map
1vhxA 2 0.9928 100 0.219 Contact Map
1iv0A 1 0.7101 99.9 0.464 Contact Map
4ep4A 2 0.942 98.6 0.768 Contact Map
1hjrA 2 0.942 97.5 0.822 Contact Map
3bzcA 1 0.942 97.4 0.826 Contact Map
3psiA 1 0.913 96.6 0.845 Contact Map
3psfA 1 0.8768 96.5 0.846 Contact Map
3ohrA 2 0.8913 96.1 0.853 Contact Map
2gupA 2 0.9275 93.4 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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