GREMLIN Database
YACG - DNA gyrase inhibitor YacG
UniProt: P0A8H8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12314
Length: 65 (52)
Sequences: 472 (262)
Seq/√Len: 36.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_K33_Q4.4571.00
39_E45_K3.2491.00
49_S52_D2.2130.99
16_V22_S2.1050.99
39_E44_E1.8700.98
33_Q41_A1.7570.96
7_V16_V1.7560.96
6_T15_T1.7270.96
8_N15_T1.6950.96
11_T35_I1.5380.93
19_G23_P1.5230.92
17_V22_S1.5040.92
7_V22_S1.4940.92
34_L39_E1.4110.89
17_V21_I1.2960.84
52_D56_S1.2880.84
5_I8_N1.2700.83
8_N13_G1.1670.77
31_R37_L1.1570.77
25_R33_Q1.1300.75
43_E46_R1.0860.72
34_L50_S1.0760.71
24_F41_A1.0720.71
24_F46_R1.0650.71
34_L45_K1.0610.70
47_I50_S1.0330.68
46_R56_S1.0330.68
33_Q45_K1.0100.67
7_V17_V1.0060.66
51_G54_S0.9470.61
8_N14_K0.9300.60
39_E48_P0.9270.60
23_P30_K0.8820.56
20_E23_P0.8740.55
6_T16_V0.8640.54
5_I52_D0.8330.52
39_E47_I0.8280.51
24_F43_E0.8010.49
5_I13_G0.7830.47
41_A48_P0.7820.47
19_G22_S0.7670.46
31_R46_R0.7640.46
6_T52_D0.7550.45
14_K53_L0.7180.42
46_R49_S0.7110.41
13_G34_L0.7010.40
25_R39_E0.6970.40
16_V20_E0.6860.39
39_E54_S0.6810.39
39_E49_S0.6700.38
18_W33_Q0.6680.38
8_N50_S0.6670.37
13_G55_E0.6660.37
25_R44_E0.6600.37
48_P51_G0.6580.37
16_V33_Q0.6250.34
5_I15_T0.6200.34
5_I16_V0.6110.33
35_I38_G0.6060.33
17_V44_E0.6030.32
5_I20_E0.6000.32
6_T55_E0.5990.32
15_T18_W0.5860.31
11_T44_E0.5820.31
6_T22_S0.5810.31
48_P56_S0.5740.30
7_V55_E0.5720.30
49_S54_S0.5720.30
8_N17_V0.5630.29
14_K46_R0.5450.28
11_T31_R0.5420.28
23_P53_L0.5400.28
20_E56_S0.5310.27
14_K55_E0.5280.27
50_S53_L0.5250.27
15_T52_D0.5120.26
7_V47_I0.5110.26
35_I39_E0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tmaI 1 0.8769 99.9 0.204 Contact Map
3i2dA 1 0.7231 58.3 0.88 Contact Map
3u52A 2 0.9692 51.4 0.885 Contact Map
1mtyD 2 1 45.6 0.889 Contact Map
2incA 2 0.9538 39.5 0.893 Contact Map
3ge3A 2 0.9692 36.2 0.895 Contact Map
3wwlA 1 0.7692 31.7 0.898 Contact Map
4wuyA 1 0.9231 30.3 0.899 Contact Map
3h2yA 1 0.3538 28.8 0.9 Contact Map
3cngA 4 0.9077 19.4 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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