ZUPT - ECOLI - GREMLIN Contacts

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ZUPT - Zinc transporter ZupT

UniProt:	P0A8H3	Sequences: MSVPLILTILAGAATFIGAFLGVLGQKPSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSPVLGYGMFIFGLLGYFGLDRMLPHAHPQDLMQKSVQPLPKSIKRTAILLTLGISLHNFPEGIATFVTASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAILWAGISGLAEILGGVLAWLILGSMISPVVMAAIMAAVAGIMVALSVDELMPLAKEIDPNNNPSYGVLCGMSVMGFSLVLLQTAGIG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11167
Length:	257 (235)
Sequences:	5457 (3678)
Seq/√Len:	239.9

ECOLI - ZUPT
HALSA - Q9HQZ1
SULSO - Q97UE9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_F	236_G	4.560	1.00
77_G	207_A	4.267	1.00
56_A	206_A	3.760	1.00
39_F	243_V	3.719	1.00
121_F	184_G	3.431	1.00
125_I	188_A	3.087	1.00
8_T	185_G	2.914	1.00
53_L	71_F	2.818	1.00
71_F	213_V	2.559	1.00
16_F	175_G	2.524	1.00
70_M	203_A	2.482	1.00
166_S	169_T	2.409	1.00
172_L	176_I	2.234	1.00
75_L	238_L	2.218	1.00
168_R	172_L	2.014	1.00
46_L	50_M	1.997	1.00
19_A	22_G	1.975	1.00
44_M	212_M	1.951	1.00
49_L	213_V	1.936	1.00
45_L	237_V	1.909	1.00
242_S	246_F	1.888	1.00
68_Y	242_S	1.800	1.00
238_L	242_S	1.732	1.00
41_A	220_L	1.724	1.00
69_G	203_A	1.683	1.00
8_T	12_G	1.667	1.00
9_I	13_A	1.642	1.00
46_L	245_G	1.611	1.00
11_A	14_A	1.607	1.00
117_S	180_A	1.599	1.00
69_G	73_F	1.599	1.00
51_E	244_M	1.585	1.00
150_I	212_M	1.574	1.00
139_F	143_L	1.573	1.00
119_H	148_H	1.547	1.00
17_I	150_I	1.545	1.00
72_I	242_S	1.527	1.00
50_M	245_G	1.506	1.00
15_T	19_A	1.486	1.00
130_T	141_I	1.484	1.00
113_T	173_W	1.464	1.00
55_A	58_A	1.449	1.00
45_L	216_S	1.443	1.00
47_I	51_E	1.435	1.00
156_V	177_S	1.432	1.00
15_T	22_G	1.427	1.00
70_M	74_G	1.426	1.00
187_L	190_L	1.424	1.00
70_M	206_A	1.419	1.00
21_L	150_I	1.416	1.00
160_V	165_G	1.414	1.00
79_F	83_R	1.409	1.00
48_S	213_V	1.408	1.00
56_A	67_G	1.392	1.00
149_N	212_M	1.388	1.00
70_M	73_F	1.385	1.00
100_P	103_K	1.373	1.00
86_P	90_P	1.363	1.00
123_E	149_N	1.357	1.00
15_T	18_G	1.356	1.00
32_L	35_F	1.353	1.00
142_A	146_A	1.344	1.00
20_F	171_I	1.343	1.00
75_L	217_V	1.336	1.00
35_F	232_N	1.335	1.00
14_A	146_A	1.334	1.00
221_M	237_V	1.333	1.00
82_D	214_A	1.319	1.00
120_N	177_S	1.311	1.00
149_N	153_G	1.308	1.00
125_I	191_I	1.302	1.00
37_L	224_A	1.300	1.00
199_V	203_A	1.288	1.00
100_P	104_S	1.286	1.00
32_L	36_S	1.284	1.00
5_L	9_I	1.280	1.00
39_F	239_C	1.279	1.00
186_V	190_L	1.278	1.00
127_T	145_V	1.271	1.00
217_V	237_V	1.266	1.00
221_M	225_K	1.261	1.00
113_T	156_V	1.248	1.00
208_V	211_I	1.246	1.00
152_E	212_M	1.240	1.00
86_P	89_H	1.239	1.00
16_F	178_G	1.226	1.00
46_L	241_M	1.225	1.00
153_G	174_A	1.200	1.00
179_L	183_L	1.192	1.00
49_L	53_L	1.190	1.00
10_L	142_A	1.180	1.00
56_A	202_A	1.178	1.00
79_F	214_A	1.169	1.00
11_A	15_T	1.159	1.00
72_I	76_L	1.155	1.00
21_L	25_G	1.153	1.00
101_L	104_S	1.150	1.00
99_Q	103_K	1.147	1.00
161_Y	167_K	1.137	1.00
149_N	177_S	1.136	1.00
57_L	67_G	1.136	1.00
12_G	22_G	1.133	1.00
125_I	184_G	1.128	1.00
15_T	21_L	1.125	1.00
6_I	10_L	1.122	1.00
7_L	11_A	1.121	1.00
18_G	22_G	1.104	1.00
55_A	59_A	1.102	1.00
19_A	157_A	1.097	1.00
189_W	192_L	1.096	1.00
146_A	212_M	1.091	1.00
74_G	78_Y	1.080	1.00
8_T	189_W	1.076	1.00
116_I	123_E	1.075	1.00
119_H	124_G	1.066	1.00
242_S	245_G	1.062	1.00
113_T	160_V	1.060	1.00
8_T	11_A	1.054	1.00
47_I	148_H	1.028	1.00
66_L	203_A	1.022	1.00
121_F	187_L	1.015	1.00
188_A	191_I	1.013	1.00
117_S	121_F	1.010	1.00
14_A	150_I	1.007	1.00
116_I	119_H	1.001	1.00
11_A	16_F	1.000	1.00
29_S	32_L	0.999	1.00
66_L	69_G	0.992	1.00
66_L	73_F	0.981	1.00
57_L	68_Y	0.981	1.00
112_L	115_G	0.976	1.00
19_A	25_G	0.975	1.00
149_N	152_E	0.972	1.00
43_I	217_V	0.970	1.00
19_A	174_A	0.964	1.00
34_A	229_P	0.962	1.00
169_T	172_L	0.958	1.00
48_S	51_E	0.953	1.00
25_G	28_P	0.952	1.00
225_K	233_P	0.950	1.00
59_A	179_L	0.948	1.00
38_G	233_P	0.947	1.00
149_N	211_I	0.933	1.00
41_A	115_G	0.932	1.00
7_L	14_A	0.930	1.00
11_A	18_G	0.927	1.00
14_A	19_A	0.923	1.00
56_A	209_A	0.922	1.00
141_I	152_E	0.915	1.00
179_L	182_I	0.914	1.00
20_F	23_V	0.905	1.00
45_L	49_L	0.904	1.00
61_G	64_P	0.903	1.00
47_I	141_I	0.901	1.00
81_L	118_L	0.898	1.00
217_V	221_M	0.898	1.00
196_I	200_V	0.897	1.00
127_T	142_A	0.894	1.00
152_E	156_V	0.888	0.99
149_N	156_V	0.879	0.99
49_L	54_P	0.876	0.99
81_L	86_P	0.876	0.99
48_S	212_M	0.876	0.99
43_I	244_M	0.873	0.99
12_G	18_G	0.869	0.99
110_I	114_L	0.867	0.99
207_A	211_I	0.864	0.99
114_L	140_G	0.861	0.99
126_A	211_I	0.860	0.99
51_E	248_L	0.855	0.99
152_E	177_S	0.855	0.99
53_L	209_A	0.855	0.99
74_G	86_P	0.849	0.99
116_I	156_V	0.844	0.99
51_E	148_H	0.841	0.99
170_A	174_A	0.837	0.99
73_F	203_A	0.836	0.99
46_L	247_S	0.833	0.99
38_G	236_G	0.825	0.99
120_N	182_I	0.822	0.99
200_V	203_A	0.819	0.99
31_R	232_N	0.816	0.99
123_E	152_E	0.813	0.99
67_G	206_A	0.801	0.99
145_V	152_E	0.799	0.99
234_S	237_V	0.797	0.99
74_G	207_A	0.794	0.99
12_G	16_F	0.794	0.99
38_G	224_A	0.793	0.99
128_F	208_V	0.790	0.99
34_A	224_A	0.786	0.99
175_G	178_G	0.784	0.99
116_I	153_G	0.783	0.99
18_G	153_G	0.782	0.99
77_G	81_L	0.775	0.99
160_V	170_A	0.771	0.99
91_Q	98_V	0.769	0.99
12_G	175_G	0.768	0.99
12_G	149_N	0.766	0.99
138_G	142_A	0.762	0.98
187_L	191_I	0.761	0.98
27_K	30_N	0.760	0.98
224_A	233_P	0.757	0.98
5_L	186_V	0.755	0.98
166_S	170_A	0.755	0.98
11_A	22_G	0.755	0.98
55_A	248_L	0.753	0.98
49_L	72_I	0.753	0.98
122_P	152_E	0.750	0.98
12_G	182_I	0.746	0.98
149_N	181_E	0.745	0.98
147_L	157_A	0.744	0.98
37_L	109_A	0.743	0.98
129_V	192_L	0.738	0.98
109_A	163_A	0.738	0.98
202_A	210_G	0.738	0.98
10_L	14_A	0.737	0.98
227_I	230_N	0.733	0.98
8_T	186_V	0.730	0.98
116_I	152_E	0.728	0.98
126_A	141_I	0.727	0.98
155_A	159_P	0.726	0.98
236_G	242_S	0.721	0.98
153_G	212_M	0.721	0.98
47_I	211_I	0.720	0.98
136_E	140_G	0.718	0.98
172_L	175_G	0.717	0.98
68_Y	246_F	0.711	0.98
239_C	243_V	0.709	0.98
18_G	21_L	0.709	0.98
112_L	156_V	0.708	0.98
11_A	51_E	0.706	0.97
19_A	23_V	0.706	0.97
84_M	88_A	0.704	0.97
102_P	106_K	0.700	0.97
76_L	237_V	0.696	0.97
176_I	180_A	0.692	0.97
144_A	244_M	0.692	0.97
211_I	220_L	0.687	0.97
73_F	77_G	0.687	0.97
30_N	227_I	0.681	0.97
22_G	25_G	0.679	0.97
55_A	148_H	0.677	0.97
11_A	21_L	0.671	0.97
122_P	126_A	0.670	0.97
66_L	70_M	0.668	0.96
47_I	208_V	0.667	0.96
130_T	137_L	0.665	0.96
161_Y	164_T	0.660	0.96
153_G	156_V	0.653	0.96
23_V	171_I	0.652	0.96
147_L	248_L	0.650	0.96
41_A	79_F	0.645	0.96
136_E	168_R	0.645	0.96
42_G	49_L	0.645	0.96
236_G	239_C	0.641	0.96
169_T	173_W	0.639	0.95
203_A	207_A	0.639	0.95
138_G	157_A	0.639	0.95
214_A	235_Y	0.638	0.95
116_I	155_A	0.638	0.95
23_V	168_R	0.636	0.95
102_P	105_I	0.635	0.95
129_V	133_S	0.634	0.95
156_V	160_V	0.631	0.95
64_P	69_G	0.631	0.95
7_L	19_A	0.630	0.95
146_A	149_N	0.625	0.95
76_L	80_G	0.622	0.95
54_P	58_A	0.620	0.95
49_L	241_M	0.620	0.95
125_I	204_I	0.619	0.95
47_I	244_M	0.619	0.95
63_S	239_C	0.616	0.95
10_L	146_A	0.616	0.95
193_G	196_I	0.614	0.94
120_N	149_N	0.613	0.94
9_I	182_I	0.609	0.94
213_V	216_S	0.606	0.94
48_S	241_M	0.604	0.94
216_S	220_L	0.598	0.94
42_G	208_V	0.598	0.94
128_F	189_W	0.597	0.94
71_F	206_A	0.596	0.94
48_S	216_S	0.596	0.94
120_N	181_E	0.595	0.93
34_A	38_G	0.593	0.93
120_N	153_G	0.592	0.93
159_P	212_M	0.591	0.93
246_F	249_V	0.590	0.93
61_G	197_S	0.587	0.93
152_E	155_A	0.586	0.93
126_A	210_G	0.585	0.93
45_L	213_V	0.583	0.93
21_L	24_L	0.582	0.93
64_P	68_Y	0.581	0.93
175_G	179_L	0.580	0.93
78_Y	115_G	0.579	0.93
15_T	119_H	0.578	0.92
116_I	174_A	0.576	0.92
152_E	174_A	0.573	0.92
34_A	233_P	0.569	0.92
41_A	45_L	0.567	0.92
82_D	216_S	0.567	0.92
67_G	71_F	0.561	0.91
72_I	80_G	0.561	0.91
48_S	177_S	0.560	0.91
116_I	120_N	0.559	0.91
181_E	212_M	0.559	0.91
37_L	40_A	0.558	0.91
17_I	20_F	0.558	0.91
208_V	247_S	0.557	0.91
16_F	174_A	0.556	0.91
168_R	239_C	0.554	0.91
137_L	192_L	0.553	0.91
98_V	104_S	0.552	0.91
50_M	55_A	0.552	0.91
211_I	215_L	0.550	0.91
170_A	177_S	0.544	0.90
165_G	169_T	0.542	0.90
48_S	56_A	0.542	0.90
186_V	189_W	0.540	0.90
11_A	185_G	0.539	0.90
61_G	196_I	0.537	0.89
59_A	198_P	0.537	0.89
119_H	123_E	0.537	0.89
55_A	180_A	0.533	0.89
98_V	101_L	0.532	0.89
161_Y	170_A	0.531	0.89
44_M	151_P	0.528	0.89
48_S	248_L	0.523	0.88
176_I	179_L	0.522	0.88
218_D	222_P	0.522	0.88
112_L	220_L	0.522	0.88
12_G	15_T	0.520	0.88
80_G	91_Q	0.518	0.88
54_P	57_L	0.518	0.88
7_L	192_L	0.516	0.88
91_Q	239_C	0.516	0.88
6_I	183_L	0.516	0.88
33_L	36_S	0.515	0.87
87_H	91_Q	0.511	0.87
241_M	245_G	0.510	0.87
127_T	181_E	0.509	0.87
169_T	179_L	0.508	0.87
153_G	157_A	0.508	0.87
65_V	69_G	0.507	0.87
104_S	135_L	0.507	0.87
120_N	244_M	0.507	0.87
31_R	110_I	0.506	0.87
217_V	225_K	0.501	0.86
73_F	246_F	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g1uA	2	0.4591	53.1	0.929	Contact Map
3dh4A	3	0.3385	35.6	0.936	Contact Map
4dveA	3	0.537	25.8	0.94	Contact Map
3giaA	1	0.358	21.5	0.942	Contact Map
4av3A	2	0.8327	18.5	0.944	Contact Map
4tkrA	2	0.4786	17.2	0.945	Contact Map
3rlbA	1	0.4708	16.4	0.945	Contact Map
4gc0A	1	0.5759	15.2	0.946	Contact Map
4oo9A	1	0.3113	14.1	0.947	Contact Map
4tnwA	3	0.3502	13.8	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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