GREMLIN Database
ZUPT - Zinc transporter ZupT
UniProt: P0A8H3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11167
Length: 257 (235)
Sequences: 5457 (3678)
Seq/√Len: 239.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_F236_G4.5601.00
77_G207_A4.2671.00
56_A206_A3.7601.00
39_F243_V3.7191.00
121_F184_G3.4311.00
125_I188_A3.0871.00
8_T185_G2.9141.00
53_L71_F2.8181.00
71_F213_V2.5591.00
16_F175_G2.5241.00
70_M203_A2.4821.00
166_S169_T2.4091.00
172_L176_I2.2341.00
75_L238_L2.2181.00
168_R172_L2.0141.00
46_L50_M1.9971.00
19_A22_G1.9751.00
44_M212_M1.9511.00
49_L213_V1.9361.00
45_L237_V1.9091.00
242_S246_F1.8881.00
68_Y242_S1.8001.00
238_L242_S1.7321.00
41_A220_L1.7241.00
69_G203_A1.6831.00
8_T12_G1.6671.00
9_I13_A1.6421.00
46_L245_G1.6111.00
11_A14_A1.6071.00
117_S180_A1.5991.00
69_G73_F1.5991.00
51_E244_M1.5851.00
150_I212_M1.5741.00
139_F143_L1.5731.00
119_H148_H1.5471.00
17_I150_I1.5451.00
72_I242_S1.5271.00
50_M245_G1.5061.00
15_T19_A1.4861.00
130_T141_I1.4841.00
113_T173_W1.4641.00
55_A58_A1.4491.00
45_L216_S1.4431.00
47_I51_E1.4351.00
156_V177_S1.4321.00
15_T22_G1.4271.00
70_M74_G1.4261.00
187_L190_L1.4241.00
70_M206_A1.4191.00
21_L150_I1.4161.00
160_V165_G1.4141.00
79_F83_R1.4091.00
48_S213_V1.4081.00
56_A67_G1.3921.00
149_N212_M1.3881.00
70_M73_F1.3851.00
100_P103_K1.3731.00
86_P90_P1.3631.00
123_E149_N1.3571.00
15_T18_G1.3561.00
32_L35_F1.3531.00
142_A146_A1.3441.00
20_F171_I1.3431.00
75_L217_V1.3361.00
35_F232_N1.3351.00
14_A146_A1.3341.00
221_M237_V1.3331.00
82_D214_A1.3191.00
120_N177_S1.3111.00
149_N153_G1.3081.00
125_I191_I1.3021.00
37_L224_A1.3001.00
199_V203_A1.2881.00
100_P104_S1.2861.00
32_L36_S1.2841.00
5_L9_I1.2801.00
39_F239_C1.2791.00
186_V190_L1.2781.00
127_T145_V1.2711.00
217_V237_V1.2661.00
221_M225_K1.2611.00
113_T156_V1.2481.00
208_V211_I1.2461.00
152_E212_M1.2401.00
86_P89_H1.2391.00
16_F178_G1.2261.00
46_L241_M1.2251.00
153_G174_A1.2001.00
179_L183_L1.1921.00
49_L53_L1.1901.00
10_L142_A1.1801.00
56_A202_A1.1781.00
79_F214_A1.1691.00
11_A15_T1.1591.00
72_I76_L1.1551.00
21_L25_G1.1531.00
101_L104_S1.1501.00
99_Q103_K1.1471.00
161_Y167_K1.1371.00
149_N177_S1.1361.00
57_L67_G1.1361.00
12_G22_G1.1331.00
125_I184_G1.1281.00
15_T21_L1.1251.00
6_I10_L1.1221.00
7_L11_A1.1211.00
18_G22_G1.1041.00
55_A59_A1.1021.00
19_A157_A1.0971.00
189_W192_L1.0961.00
146_A212_M1.0911.00
74_G78_Y1.0801.00
8_T189_W1.0761.00
116_I123_E1.0751.00
119_H124_G1.0661.00
242_S245_G1.0621.00
113_T160_V1.0601.00
8_T11_A1.0541.00
47_I148_H1.0281.00
66_L203_A1.0221.00
121_F187_L1.0151.00
188_A191_I1.0131.00
117_S121_F1.0101.00
14_A150_I1.0071.00
116_I119_H1.0011.00
11_A16_F1.0001.00
29_S32_L0.9991.00
66_L69_G0.9921.00
66_L73_F0.9811.00
57_L68_Y0.9811.00
112_L115_G0.9761.00
19_A25_G0.9751.00
149_N152_E0.9721.00
43_I217_V0.9701.00
19_A174_A0.9641.00
34_A229_P0.9621.00
169_T172_L0.9581.00
48_S51_E0.9531.00
25_G28_P0.9521.00
225_K233_P0.9501.00
59_A179_L0.9481.00
38_G233_P0.9471.00
149_N211_I0.9331.00
41_A115_G0.9321.00
7_L14_A0.9301.00
11_A18_G0.9271.00
14_A19_A0.9231.00
56_A209_A0.9221.00
141_I152_E0.9151.00
179_L182_I0.9141.00
20_F23_V0.9051.00
45_L49_L0.9041.00
61_G64_P0.9031.00
47_I141_I0.9011.00
81_L118_L0.8981.00
217_V221_M0.8981.00
196_I200_V0.8971.00
127_T142_A0.8941.00
152_E156_V0.8880.99
149_N156_V0.8790.99
49_L54_P0.8760.99
81_L86_P0.8760.99
48_S212_M0.8760.99
43_I244_M0.8730.99
12_G18_G0.8690.99
110_I114_L0.8670.99
207_A211_I0.8640.99
114_L140_G0.8610.99
126_A211_I0.8600.99
51_E248_L0.8550.99
152_E177_S0.8550.99
53_L209_A0.8550.99
74_G86_P0.8490.99
116_I156_V0.8440.99
51_E148_H0.8410.99
170_A174_A0.8370.99
73_F203_A0.8360.99
46_L247_S0.8330.99
38_G236_G0.8250.99
120_N182_I0.8220.99
200_V203_A0.8190.99
31_R232_N0.8160.99
123_E152_E0.8130.99
67_G206_A0.8010.99
145_V152_E0.7990.99
234_S237_V0.7970.99
74_G207_A0.7940.99
12_G16_F0.7940.99
38_G224_A0.7930.99
128_F208_V0.7900.99
34_A224_A0.7860.99
175_G178_G0.7840.99
116_I153_G0.7830.99
18_G153_G0.7820.99
77_G81_L0.7750.99
160_V170_A0.7710.99
91_Q98_V0.7690.99
12_G175_G0.7680.99
12_G149_N0.7660.99
138_G142_A0.7620.98
187_L191_I0.7610.98
27_K30_N0.7600.98
224_A233_P0.7570.98
5_L186_V0.7550.98
166_S170_A0.7550.98
11_A22_G0.7550.98
55_A248_L0.7530.98
49_L72_I0.7530.98
122_P152_E0.7500.98
12_G182_I0.7460.98
149_N181_E0.7450.98
147_L157_A0.7440.98
37_L109_A0.7430.98
129_V192_L0.7380.98
109_A163_A0.7380.98
202_A210_G0.7380.98
10_L14_A0.7370.98
227_I230_N0.7330.98
8_T186_V0.7300.98
116_I152_E0.7280.98
126_A141_I0.7270.98
155_A159_P0.7260.98
236_G242_S0.7210.98
153_G212_M0.7210.98
47_I211_I0.7200.98
136_E140_G0.7180.98
172_L175_G0.7170.98
68_Y246_F0.7110.98
239_C243_V0.7090.98
18_G21_L0.7090.98
112_L156_V0.7080.98
11_A51_E0.7060.97
19_A23_V0.7060.97
84_M88_A0.7040.97
102_P106_K0.7000.97
76_L237_V0.6960.97
176_I180_A0.6920.97
144_A244_M0.6920.97
211_I220_L0.6870.97
73_F77_G0.6870.97
30_N227_I0.6810.97
22_G25_G0.6790.97
55_A148_H0.6770.97
11_A21_L0.6710.97
122_P126_A0.6700.97
66_L70_M0.6680.96
47_I208_V0.6670.96
130_T137_L0.6650.96
161_Y164_T0.6600.96
153_G156_V0.6530.96
23_V171_I0.6520.96
147_L248_L0.6500.96
41_A79_F0.6450.96
136_E168_R0.6450.96
42_G49_L0.6450.96
236_G239_C0.6410.96
169_T173_W0.6390.95
203_A207_A0.6390.95
138_G157_A0.6390.95
214_A235_Y0.6380.95
116_I155_A0.6380.95
23_V168_R0.6360.95
102_P105_I0.6350.95
129_V133_S0.6340.95
156_V160_V0.6310.95
64_P69_G0.6310.95
7_L19_A0.6300.95
146_A149_N0.6250.95
76_L80_G0.6220.95
54_P58_A0.6200.95
49_L241_M0.6200.95
125_I204_I0.6190.95
47_I244_M0.6190.95
63_S239_C0.6160.95
10_L146_A0.6160.95
193_G196_I0.6140.94
120_N149_N0.6130.94
9_I182_I0.6090.94
213_V216_S0.6060.94
48_S241_M0.6040.94
216_S220_L0.5980.94
42_G208_V0.5980.94
128_F189_W0.5970.94
71_F206_A0.5960.94
48_S216_S0.5960.94
120_N181_E0.5950.93
34_A38_G0.5930.93
120_N153_G0.5920.93
159_P212_M0.5910.93
246_F249_V0.5900.93
61_G197_S0.5870.93
152_E155_A0.5860.93
126_A210_G0.5850.93
45_L213_V0.5830.93
21_L24_L0.5820.93
64_P68_Y0.5810.93
175_G179_L0.5800.93
78_Y115_G0.5790.93
15_T119_H0.5780.92
116_I174_A0.5760.92
152_E174_A0.5730.92
34_A233_P0.5690.92
41_A45_L0.5670.92
82_D216_S0.5670.92
67_G71_F0.5610.91
72_I80_G0.5610.91
48_S177_S0.5600.91
116_I120_N0.5590.91
181_E212_M0.5590.91
37_L40_A0.5580.91
17_I20_F0.5580.91
208_V247_S0.5570.91
16_F174_A0.5560.91
168_R239_C0.5540.91
137_L192_L0.5530.91
98_V104_S0.5520.91
50_M55_A0.5520.91
211_I215_L0.5500.91
170_A177_S0.5440.90
165_G169_T0.5420.90
48_S56_A0.5420.90
186_V189_W0.5400.90
11_A185_G0.5390.90
61_G196_I0.5370.89
59_A198_P0.5370.89
119_H123_E0.5370.89
55_A180_A0.5330.89
98_V101_L0.5320.89
161_Y170_A0.5310.89
44_M151_P0.5280.89
48_S248_L0.5230.88
176_I179_L0.5220.88
218_D222_P0.5220.88
112_L220_L0.5220.88
12_G15_T0.5200.88
80_G91_Q0.5180.88
54_P57_L0.5180.88
7_L192_L0.5160.88
91_Q239_C0.5160.88
6_I183_L0.5160.88
33_L36_S0.5150.87
87_H91_Q0.5110.87
241_M245_G0.5100.87
127_T181_E0.5090.87
169_T179_L0.5080.87
153_G157_A0.5080.87
65_V69_G0.5070.87
104_S135_L0.5070.87
120_N244_M0.5070.87
31_R110_I0.5060.87
217_V225_K0.5010.86
73_F246_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.4591 53.1 0.929 Contact Map
3dh4A 3 0.3385 35.6 0.936 Contact Map
4dveA 3 0.537 25.8 0.94 Contact Map
3giaA 1 0.358 21.5 0.942 Contact Map
4av3A 2 0.8327 18.5 0.944 Contact Map
4tkrA 2 0.4786 17.2 0.945 Contact Map
3rlbA 1 0.4708 16.4 0.945 Contact Map
4gc0A 1 0.5759 15.2 0.946 Contact Map
4oo9A 1 0.3113 14.1 0.947 Contact Map
4tnwA 3 0.3502 13.8 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.