GREMLIN Database
EX7S - Exodeoxyribonuclease 7 small subunit
UniProt: P0A8G9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11098
Length: 80 (72)
Sequences: 617 (423)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E41_R6.2051.00
31_P35_A3.6641.00
14_A49_G2.5681.00
24_R38_E2.3591.00
24_R34_E2.3531.00
39_F64_L2.1851.00
36_L43_V2.0971.00
51_A55_Q2.0761.00
30_L38_E1.8450.99
10_S13_K1.7220.99
39_F46_A1.6650.98
11_F15_L1.6040.98
61_Q72_L1.5840.98
34_E37_N1.5040.97
13_K16_S1.4790.96
37_N40_E1.4020.95
33_E52_K1.3040.93
65_S70_A1.2840.92
31_P34_E1.2780.92
62_I73_T1.2200.90
10_S52_K1.2050.89
40_E44_Q1.1840.88
33_E66_D1.1810.88
35_A56_A1.1600.87
59_R68_E1.1600.87
23_T54_Q1.1480.87
8_P71_S1.0940.84
37_N47_R1.0570.82
54_Q58_Q1.0030.78
12_E49_G0.9950.78
40_E59_R0.9820.77
14_A50_Q0.9680.76
10_S15_L0.9650.76
11_F39_F0.9620.75
15_L30_L0.9520.75
50_Q58_Q0.9380.74
59_R73_T0.9370.73
43_V46_A0.9310.73
64_L73_T0.9230.72
14_A48_Q0.9190.72
65_S68_E0.9120.71
7_A27_S0.8770.68
21_I38_E0.8720.68
21_I52_K0.8640.67
37_N54_Q0.8600.67
36_L39_F0.8300.64
19_E23_T0.8270.64
47_R50_Q0.8200.63
55_Q60_V0.8080.62
10_S51_A0.8070.62
27_S63_L0.8070.62
51_A60_V0.8060.62
42_G49_G0.8050.62
21_I50_Q0.7990.61
67_N70_A0.7990.61
32_L72_L0.7740.59
50_Q56_A0.7690.58
13_K73_T0.7570.57
17_E45_L0.7450.56
36_L46_A0.7440.56
13_K44_Q0.7400.55
48_Q60_V0.7380.55
19_E60_V0.7350.55
59_R62_I0.7190.53
36_L47_R0.7170.53
68_E71_S0.7150.53
61_Q74_P0.7150.53
20_Q55_Q0.6970.51
40_E60_V0.6860.50
50_Q54_Q0.6830.49
66_D69_D0.6790.49
7_A20_Q0.6730.48
36_L56_A0.6670.48
33_E46_A0.6640.48
40_E57_E0.6560.47
20_Q71_S0.6430.45
30_L56_A0.6430.45
38_E43_V0.6410.45
6_E23_T0.6340.44
16_S43_V0.6310.44
43_V47_R0.6300.44
40_E56_A0.6280.44
25_L77_P0.6200.43
51_A62_I0.6190.43
33_E76_T0.6110.42
6_E68_E0.6090.42
47_R66_D0.6020.41
39_F43_V0.5940.40
47_R58_Q0.5920.40
15_L36_L0.5880.40
27_S34_E0.5870.40
33_E47_R0.5800.39
62_I75_F0.5790.39
10_S35_A0.5700.38
26_E32_L0.5670.38
22_V40_E0.5660.38
16_S20_Q0.5600.37
11_F18_L0.5580.37
17_E20_Q0.5570.37
34_E59_R0.5530.37
43_V50_Q0.5490.36
7_A48_Q0.5420.35
19_E54_Q0.5290.34
18_L22_V0.5280.34
60_V74_P0.5260.34
67_N73_T0.5250.34
36_L52_K0.5110.33
56_A60_V0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vp7A 2 0.95 99.8 0.297 Contact Map
2f9yA 2 0.75 30.9 0.887 Contact Map
4w9rA 2 0.8 12.5 0.906 Contact Map
4tptA 2 0.6125 11.7 0.907 Contact Map
2psqA 2 0.3375 11 0.908 Contact Map
2w1iA 1 0.3375 10 0.91 Contact Map
4cqeA 1 0.3 9.9 0.91 Contact Map
2ozoA 1 0.475 9.5 0.911 Contact Map
3ob4A 2 0.9375 8.9 0.912 Contact Map
3lxpA 1 0.3375 8.3 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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