GREMLIN Database
NQOR - NAD(P)H dehydrogenase (quinone)
UniProt: P0A8G6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11540
Length: 198 (191)
Sequences: 2683 (1491)
Seq/√Len: 107.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_E191_G3.2611.00
28_K187_E2.9661.00
73_I189_V2.8331.00
45_P49_E2.7321.00
109_S185_Q2.6841.00
18_M182_A2.6291.00
122_Q125_T2.4761.00
9_Y84_S2.4691.00
23_A27_S2.3951.00
26_A34_V2.3611.00
24_E183_R2.2051.00
73_I109_S2.0941.00
94_T134_H2.0721.00
16_E20_R1.9741.00
3_K33_E1.9571.00
186_G190_A1.9481.00
112_S163_T1.9421.00
176_Q180_S1.9221.00
76_T84_S1.9201.00
4_V71_A1.9081.00
109_S189_V1.8931.00
107_L196_L1.8641.00
104_Y144_A1.8461.00
108_A131_L1.8411.00
158_T163_T1.8351.00
88_R130_T1.8091.00
97_L102_A1.8001.00
28_K183_R1.7921.00
147_E180_S1.7401.00
25_G186_G1.7311.00
21_A183_R1.7051.00
42_T89_T1.6931.00
139_V192_L1.6881.00
141_I181_I1.6531.00
110_V127_T1.6421.00
67_A97_L1.6381.00
64_Q67_A1.6111.00
35_V65_E1.6091.00
21_A179_L1.6041.00
21_A24_E1.6031.00
39_V87_M1.5981.00
88_R92_D1.5481.00
132_A140_P1.5451.00
162_A185_Q1.5271.00
67_A102_A1.5021.00
22_V111_F1.4981.00
16_E58_A1.4321.00
5_L69_Y1.4291.00
74_F127_T1.4181.00
8_Y58_A1.4141.00
75_G111_F1.3831.00
32_A194_V1.3631.00
76_T127_T1.3421.00
35_V69_Y1.3361.00
105_G188_Y1.3120.99
107_L189_V1.3080.99
18_M162_A1.3020.99
30_D194_V1.2950.99
191_G195_K1.2840.99
17_T20_R1.2830.99
128_W132_A1.2790.99
97_L103_L1.2700.99
105_G191_G1.2580.99
114_T120_Q1.2490.99
17_T179_L1.2470.99
101_G104_Y1.2400.99
108_A136_M1.2160.99
44_P47_L1.2100.99
82_N126_S1.2070.99
32_A190_A1.1980.99
113_S166_A1.1950.99
174_P179_L1.1680.99
6_V23_A1.1630.99
46_Q49_E1.1590.99
6_V26_A1.1520.99
72_I136_M1.1420.98
155_R177_E1.1420.98
112_S124_I1.1420.98
24_E27_S1.1280.98
5_L37_K1.1200.98
132_A138_I1.1170.98
155_R175_S1.1040.98
109_S162_A1.0950.98
182_A186_G1.0830.98
25_G190_A1.0820.98
4_V26_A1.0780.98
61_A65_E1.0610.97
83_M127_T1.0540.97
47_L51_A1.0530.97
66_L94_T1.0430.97
107_L193_A1.0390.97
4_V190_A1.0340.97
175_S178_E1.0330.97
115_G168_G1.0320.97
8_Y16_E1.0310.97
24_E28_K1.0240.97
26_A190_A1.0180.97
145_A181_I1.0180.97
27_S34_V1.0110.97
82_N130_T1.0110.97
37_K65_E1.0080.97
64_Q68_D1.0070.96
48_F53_G1.0030.96
67_A100_S1.0000.96
83_M88_R0.9920.96
36_V58_A0.9870.96
47_L50_K0.9810.96
87_M91_L0.9790.96
65_E68_D0.9770.96
71_A189_V0.9710.96
91_L130_T0.9620.95
192_L196_L0.9600.95
82_N88_R0.9560.95
179_L183_R0.9480.95
137_V192_L0.9450.95
110_V124_I0.9380.95
185_Q189_V0.9380.95
63_P93_Q0.9360.95
27_S33_E0.9360.95
110_V128_W0.9200.94
86_Q92_D0.9170.94
76_T83_M0.9100.94
176_Q179_L0.9060.94
20_R36_V0.9050.94
40_P60_V0.9020.94
20_R27_S0.9000.94
122_Q126_S0.8950.93
125_T160_Y0.8900.93
114_T165_I0.8890.93
62_T65_E0.8820.93
184_Y188_Y0.8800.93
78_T123_T0.8790.93
83_M130_T0.8790.93
22_V25_G0.8790.93
43_M51_A0.8770.93
85_G89_T0.8720.92
110_V131_L0.8710.92
146_Q149_F0.8630.92
152_S177_E0.8550.92
25_G182_A0.8550.92
18_M164_T0.8490.91
3_K68_D0.8470.91
3_K70_D0.8430.91
167_G170_G0.8350.91
20_R57_T0.8350.91
22_V186_G0.8350.91
63_P94_T0.8330.91
3_K35_V0.8320.91
74_F91_L0.8280.90
83_M126_S0.8250.90
131_L136_M0.8230.90
45_P50_K0.8230.90
126_S129_T0.8210.90
4_V32_A0.8210.90
46_Q50_K0.8160.90
43_M48_F0.8090.89
144_A184_Y0.8050.89
121_E129_T0.7920.88
16_E38_R0.7910.88
43_M47_L0.7900.88
164_T174_P0.7860.88
48_F55_T0.7850.88
107_L192_L0.7840.88
35_V68_D0.7840.88
20_R58_A0.7820.88
110_V138_I0.7820.88
78_T114_T0.7780.87
44_P49_E0.7630.86
71_A107_L0.7630.86
145_A184_Y0.7600.86
63_P67_A0.7590.86
107_L137_V0.7530.86
153_Q177_E0.7490.85
147_E181_I0.7480.85
124_I127_T0.7450.85
23_A34_V0.7440.85
85_G92_D0.7340.84
22_V185_Q0.7330.84
48_F51_A0.7260.84
139_V189_V0.7220.83
30_D190_A0.7210.83
26_A32_A0.7150.83
19_A111_F0.7150.83
48_F58_A0.7080.82
44_P93_Q0.7070.82
66_L103_L0.7010.81
15_I111_F0.7000.81
145_A148_L0.6950.81
183_R187_E0.6940.81
23_A36_V0.6910.80
20_R23_A0.6890.80
63_P97_L0.6890.80
142_G188_Y0.6870.80
17_T173_Q0.6790.79
39_V42_T0.6740.79
115_G170_G0.6720.79
117_G121_E0.6720.79
117_G160_Y0.6630.78
180_S183_R0.6630.78
22_V182_A0.6620.77
148_L181_I0.6600.77
90_F94_T0.6590.77
38_R41_E0.6580.77
15_I75_G0.6540.77
32_A70_D0.6520.76
16_E54_K0.6510.76
4_V193_A0.6510.76
43_M53_G0.6480.76
188_Y192_L0.6450.76
42_T85_G0.6420.75
8_Y55_T0.6390.75
72_I108_A0.6370.75
22_V73_I0.6340.74
132_A142_G0.6340.74
77_P123_T0.6340.74
76_T82_N0.6310.74
15_I76_T0.6270.74
95_G99_A0.6240.73
133_H160_Y0.6220.73
101_G135_G0.6210.73
3_K32_A0.6210.73
43_M89_T0.6180.73
68_D176_Q0.6170.72
121_E125_T0.6130.72
21_A25_G0.6120.72
155_R163_T0.6060.71
20_R24_E0.6050.71
130_T134_H0.6030.71
120_Q165_I0.6000.70
128_W138_I0.5970.70
137_V195_K0.5950.70
7_L61_A0.5800.68
121_E160_Y0.5750.67
3_K61_A0.5750.67
96_G99_A0.5740.67
10_S13_G0.5730.67
44_P48_F0.5730.67
51_A55_T0.5720.67
145_A188_Y0.5700.66
42_T51_A0.5700.66
26_A193_A0.5690.66
172_R178_E0.5640.66
180_S184_Y0.5620.65
141_I162_A0.5620.65
88_R127_T0.5590.65
9_Y77_P0.5580.65
11_M53_G0.5580.65
101_G144_A0.5580.65
11_M41_E0.5560.65
137_V196_L0.5540.64
22_V162_A0.5540.64
83_M87_M0.5530.64
5_L61_A0.5490.64
117_G155_R0.5480.63
125_T129_T0.5480.63
142_G184_Y0.5440.63
76_T112_S0.5430.63
37_K69_Y0.5430.63
91_L94_T0.5410.62
137_V140_P0.5350.62
117_G163_T0.5350.62
133_H159_P0.5330.61
121_E158_T0.5320.61
71_A193_A0.5300.61
94_T97_L0.5300.61
76_T110_V0.5280.61
22_V75_G0.5250.60
54_K57_T0.5250.60
141_I149_F0.5210.60
64_Q97_L0.5200.59
120_Q157_G0.5160.59
176_Q183_R0.5130.58
166_A179_L0.5120.58
89_T93_Q0.5120.58
19_A36_V0.5110.58
127_T130_T0.5110.58
76_T87_M0.5100.58
155_R181_I0.5100.58
174_P178_E0.5080.58
143_Y159_P0.5070.58
79_R114_T0.5070.58
73_I107_L0.5060.57
53_G57_T0.5040.57
172_R175_S0.5030.57
80_F94_T0.5020.57
54_K58_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lafA 4 0.9949 100 0.485 Contact Map
1ydgA 4 0.9596 100 0.488 Contact Map
3zhoA 4 0.9798 100 0.491 Contact Map
3d7nA 4 0.7778 100 0.499 Contact Map
2a5lA 4 0.8788 100 0.501 Contact Map
2zkiA 7 0.9646 100 0.52 Contact Map
2arkA 4 0.8283 100 0.573 Contact Map
2fzvA 5 0.899 99.9 0.606 Contact Map
2q62A 4 0.8939 99.9 0.609 Contact Map
1sqsA 2 0.8636 99.9 0.622 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.