GREMLIN Database
UXAC - Uronate isomerase
UniProt: P0A8G3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12737
Length: 470 (446)
Sequences: 1198 (854)
Seq/√Len: 40.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A121_P4.0081.00
260_R271_E3.4751.00
82_R125_D3.2801.00
39_Q43_E3.1131.00
158_D182_P2.9481.00
48_K52_D2.9421.00
230_A235_K2.8631.00
125_D129_N2.8581.00
44_D141_S2.8461.00
89_A119_L2.8441.00
433_I453_V2.8411.00
214_R217_D2.8311.00
87_A90_A2.8041.00
49_N81_D2.7441.00
116_G123_T2.7361.00
253_E274_Q2.6891.00
116_G126_E2.6661.00
455_N459_N2.6411.00
86_D125_D2.6341.00
152_K462_R2.6081.00
68_N405_R2.5171.00
387_K441_E2.5031.00
110_R423_E2.4681.00
306_L335_S2.4551.00
250_N253_E2.4191.00
114_I127_I2.3791.00
198_N262_L2.3171.00
391_E431_Q2.3021.00
130_E134_L2.2791.00
82_R86_D2.2721.00
143_R173_D2.2631.00
168_A232_H2.1950.99
34_C419_Y2.1940.99
168_A172_K2.1930.99
216_A251_E2.1860.99
230_A292_W2.1820.99
202_A262_L2.1420.99
15_F438_E2.1290.99
267_L272_V2.0980.99
109_R115_T2.0910.99
170_I180_V2.0790.99
362_M365_N2.0660.99
74_L87_A2.0630.99
166_H169_E2.0600.99
147_Q177_T2.0450.99
348_L359_L2.0230.99
18_R444_A1.9970.99
12_D431_Q1.9850.99
228_H232_H1.9830.99
114_I130_E1.9660.99
320_S365_N1.9380.99
73_R78_D1.9330.99
122_S447_N1.9140.99
44_D143_R1.9060.99
42_A169_E1.8900.98
18_R22_D1.8770.98
227_D290_R1.8690.98
155_G236_V1.8260.98
347_I407_V1.8170.98
88_W100_L1.7910.98
155_G183_S1.7760.98
432_M436_W1.7700.98
111_P149_M1.7690.98
120_S123_T1.7510.97
14_E17_R1.7470.97
226_L287_Y1.7410.97
236_V293_V1.7110.97
27_Q459_N1.7100.97
372_P405_R1.7000.97
30_F467_I1.6940.97
285_A340_E1.6650.96
286_E289_R1.6600.96
92_V104_T1.6580.96
331_S362_M1.6580.96
205_G208_S1.6410.96
201_M218_L1.6410.96
255_D258_L1.6270.96
94_H455_N1.6260.96
454_K459_N1.6180.96
270_H274_Q1.6150.96
52_D81_D1.6130.96
223_T289_R1.5980.96
184_W222_L1.5940.95
360_G400_L1.5910.95
213_R217_D1.5900.95
92_V95_T1.5880.95
268_S271_E1.5810.95
183_S236_V1.5750.95
205_G211_D1.5660.95
95_T402_L1.5610.95
155_G181_L1.5540.95
307_R338_N1.5540.95
30_F152_K1.5540.95
129_N133_E1.5480.95
216_A255_D1.5470.95
394_M432_M1.5320.94
193_E276_K1.5230.94
219_Q282_F1.5200.94
223_T286_E1.5140.94
46_R138_D1.5130.94
39_Q166_H1.5040.94
210_T224_K1.5040.94
308_Q318_F1.4820.93
153_M181_L1.4590.93
357_E392_R1.4580.93
97_G436_W1.4530.93
146_M178_I1.4450.92
67_T400_L1.4350.92
13_T435_R1.4330.92
133_E137_Q1.4320.92
226_L286_E1.4310.92
299_G350_C1.4240.92
82_R129_N1.4180.92
161_I207_V1.4010.91
26_D454_K1.3990.91
146_M149_M1.3910.91
40_Q45_Y1.3890.91
285_A342_L1.3870.91
161_I208_S1.3860.91
254_L278_A1.3850.91
44_D138_D1.3800.91
215_F278_A1.3780.90
330_L334_L1.3760.90
170_I173_D1.3740.90
86_D121_P1.3730.90
300_A351_L1.3710.90
450_G454_K1.3600.90
80_S83_E1.3540.90
257_I274_Q1.3540.90
123_T126_E1.3520.90
281_V336_K1.3450.89
218_L275_F1.3390.89
27_Q454_K1.3360.89
146_M176_F1.3360.89
46_R142_A1.3350.89
186_P239_H1.3330.89
173_D176_F1.3310.89
34_C146_M1.3230.89
282_F286_E1.3200.88
204_L222_L1.3090.88
44_D147_Q1.2970.88
279_V283_L1.2950.87
193_E272_V1.2930.87
295_Q349_Y1.2910.87
68_N91_T1.2890.87
146_M154_V1.2880.87
43_E169_E1.2840.87
406_F425_F1.2810.87
27_Q152_K1.2780.87
356_N377_F1.2770.87
335_S339_E1.2750.87
286_E290_R1.2670.86
34_C154_V1.2660.86
433_I437_V1.2660.86
152_K458_F1.2610.86
334_L375_M1.2610.86
226_L290_R1.2600.86
450_G455_N1.2540.86
140_F145_I1.2470.85
146_M419_Y1.2440.85
116_G127_I1.2430.85
348_L375_M1.2400.85
104_T119_L1.2290.85
42_A170_I1.2230.84
435_R439_A1.2210.84
88_W91_T1.2150.84
46_R141_S1.2130.84
458_F462_R1.2110.84
215_F279_V1.2080.83
73_R79_A1.2050.83
386_Q399_Q1.2020.83
70_V91_T1.1970.83
50_L132_N1.1960.83
283_L287_Y1.1920.83
92_V105_H1.1900.83
20_Y25_K1.1880.82
327_A358_V1.1880.82
212_I217_D1.1870.82
116_G130_E1.1850.82
214_R255_D1.1800.82
260_R267_L1.1640.81
306_L339_E1.1640.81
304_N331_S1.1630.81
388_D399_Q1.1620.81
249_A254_L1.1620.81
134_L137_Q1.1600.81
188_K315_D1.1590.81
67_T363_I1.1540.81
43_E166_H1.1530.81
331_S365_N1.1470.80
303_N309_F1.1460.80
255_D259_A1.1430.80
96_I452_M1.1400.80
387_K428_I1.1390.80
215_F254_L1.1330.79
15_F437_V1.1320.79
126_E130_E1.1250.79
196_T199_D1.1240.79
380_G383_F1.1240.79
228_H231_A1.1210.79
282_F285_A1.1160.78
106_L110_R1.1140.78
134_L140_F1.1070.78
114_I131_C1.1030.77
108_L127_I1.0980.77
54_W107_E1.0900.77
391_E435_R1.0850.76
303_N315_D1.0850.76
155_G293_V1.0840.76
18_R446_I1.0820.76
140_F148_Q1.0780.76
192_I261_R1.0780.76
12_D435_R1.0740.76
332_K335_S1.0710.75
288_A342_L1.0700.75
171_A232_H1.0650.75
132_N136_A1.0650.75
64_A100_L1.0620.75
216_A220_T1.0620.75
71_A74_L1.0600.75
82_R124_A1.0490.74
12_D439_A1.0440.73
387_K391_E1.0400.73
298_I326_M1.0380.73
394_M403_L1.0340.73
93_P121_P1.0330.73
168_A228_H1.0260.72
41_I180_V1.0260.72
153_M467_I1.0220.72
44_D144_G1.0220.72
387_K439_A1.0220.72
51_Y81_D1.0210.72
227_D231_A1.0210.72
170_I176_F1.0200.72
210_T220_T1.0120.71
247_A270_H1.0100.71
247_A274_Q1.0100.71
15_F434_G1.0050.71
452_M455_N0.9980.70
184_W204_L0.9930.70
198_N202_A0.9880.69
68_N402_L0.9840.69
119_L123_T0.9830.69
13_T431_Q0.9800.69
403_L407_V0.9720.68
50_L131_C0.9710.68
106_L423_E0.9690.68
199_D202_A0.9640.67
76_T84_K0.9630.67
27_Q30_F0.9600.67
161_I203_K0.9590.67
139_N148_Q0.9580.67
217_D220_T0.9490.66
36_L154_V0.9480.66
176_F180_V0.9470.66
181_L236_V0.9460.66
285_A337_Q0.9450.66
108_L114_I0.9430.66
350_C377_F0.9400.65
92_V404_S0.9350.65
318_F371_M0.9340.65
189_A222_L0.9290.64
248_E336_K0.9260.64
219_Q286_E0.9240.64
209_D224_K0.9220.64
88_W92_V0.9200.64
261_R267_L0.9160.63
304_N320_S0.9150.63
442_A448_L0.9100.63
260_R265_E0.9070.63
45_Y56_K0.9050.62
337_Q342_L0.9030.62
52_D56_K0.9020.62
223_T285_A0.9020.62
24_A453_V0.8970.62
184_W226_L0.8850.61
247_A273_A0.8850.61
130_E133_E0.8850.61
141_S144_G0.8830.60
79_A84_K0.8820.60
331_S335_S0.8810.60
320_S362_M0.8800.60
390_M394_M0.8790.60
367_Q375_M0.8760.60
208_S224_K0.8760.60
113_G134_L0.8750.60
51_Y84_K0.8730.60
223_T227_D0.8710.59
308_Q311_L0.8700.59
391_E395_T0.8670.59
197_F218_L0.8660.59
24_A457_C0.8640.59
296_Y346_T0.8630.59
246_F277_T0.8630.59
88_W95_T0.8610.58
403_L433_I0.8600.58
64_A95_T0.8590.58
403_L429_L0.8590.58
100_L104_T0.8580.58
280_L296_Y0.8540.58
118_L443_P0.8510.58
188_K314_P0.8500.57
118_L442_A0.8500.57
397_L401_G0.8470.57
202_A206_E0.8440.57
15_F444_A0.8430.57
66_R371_M0.8410.57
190_F279_V0.8370.56
183_S293_V0.8370.56
202_A211_D0.8360.56
30_F462_R0.8360.56
257_I267_L0.8350.56
429_L456_I0.8340.56
137_Q140_F0.8340.56
249_A278_A0.8340.56
275_F279_V0.8270.55
68_N372_P0.8250.55
89_A127_I0.8230.55
198_N261_R0.8210.55
388_D395_T0.8150.54
104_T123_T0.8150.54
34_C149_M0.8140.54
66_R305_N0.8140.54
205_G262_L0.8130.54
51_Y55_L0.8110.54
155_G467_I0.8110.54
299_G365_N0.8100.54
41_I170_I0.8080.54
143_R176_F0.8080.54
345_K466_A0.8080.54
145_I416_F0.8070.54
348_L363_I0.8020.53
357_E396_Q0.8010.53
242_D328_E0.8010.53
89_A123_T0.8000.53
110_R420_T0.8000.53
212_I258_L0.8000.53
160_P188_K0.7980.53
49_N52_D0.7980.53
203_K206_E0.7970.53
165_E169_E0.7970.53
149_M419_Y0.7960.53
119_L127_I0.7930.52
78_D84_K0.7930.52
461_A465_F0.7850.52
24_A430_C0.7830.51
333_L337_Q0.7830.51
215_F258_L0.7810.51
190_F283_L0.7790.51
55_L84_K0.7780.51
398_A436_W0.7780.51
201_M262_L0.7770.51
101_Y105_H0.7760.51
96_I433_I0.7760.51
363_I375_M0.7760.51
245_M277_T0.7700.50
243_V273_A0.7700.50
82_R121_P0.7700.50
281_V285_A0.7670.50
325_P328_E0.7660.50
259_A262_L0.7640.50
244_V333_L0.7630.49
144_G148_Q0.7630.49
392_R395_T0.7620.49
304_N365_N0.7620.49
308_Q316_V0.7600.49
392_R396_Q0.7590.49
347_I464_Y0.7570.49
169_E172_K0.7550.49
96_I437_V0.7530.49
457_C461_A0.7520.48
334_L348_L0.7510.48
88_W104_T0.7470.48
149_M420_T0.7420.48
288_A340_E0.7410.47
451_E455_N0.7400.47
173_D178_I0.7400.47
223_T290_R0.7390.47
95_T386_Q0.7390.47
159_D188_K0.7370.47
138_D141_S0.7370.47
251_E255_D0.7310.47
66_R318_F0.7270.46
256_S260_R0.7260.46
37_P40_Q0.7250.46
45_Y52_D0.7250.46
13_T16_A0.7240.46
327_A362_M0.7230.46
359_L384_N0.7210.46
226_L230_A0.7200.46
97_G395_T0.7200.46
183_S380_G0.7150.45
211_D217_D0.7130.45
67_T360_G0.7110.45
144_G147_Q0.7100.45
153_M183_S0.7100.45
171_A174_G0.7090.45
123_T130_E0.7090.45
96_I442_A0.7080.44
227_D230_A0.7080.44
301_L332_K0.7060.44
254_L258_L0.7050.44
388_D392_R0.7010.44
226_L283_L0.7000.44
446_I450_G0.7000.44
61_K100_L0.7000.44
306_L310_K0.6990.44
384_N398_A0.6930.43
379_S410_L0.6900.43
325_P329_E0.6890.43
145_I420_T0.6890.43
49_N132_N0.6880.43
118_L448_L0.6870.43
459_N463_D0.6850.42
379_S407_V0.6840.42
305_N371_M0.6840.42
223_T282_F0.6840.42
30_F458_F0.6840.42
305_N318_F0.6810.42
237_S292_W0.6810.42
97_G294_Q0.6810.42
301_L327_A0.6790.42
153_M179_K0.6790.42
391_E428_I0.6780.42
301_L328_E0.6760.42
79_A83_E0.6750.41
259_A263_A0.6750.41
350_C365_N0.6740.41
377_F380_G0.6740.41
305_N338_N0.6730.41
250_N274_Q0.6730.41
216_A259_A0.6720.41
154_V306_L0.6700.41
97_G398_A0.6700.41
134_L138_D0.6680.41
246_F336_K0.6640.40
42_A166_H0.6620.40
160_P236_V0.6620.40
327_A365_N0.6620.40
312_L315_D0.6600.40
202_A205_G0.6600.40
437_V446_I0.6600.40
430_C461_A0.6560.40
244_V330_L0.6530.40
82_R128_W0.6530.40
206_E224_K0.6520.39
248_E329_E0.6520.39
197_F275_F0.6520.39
89_A104_T0.6510.39
128_W367_Q0.6490.39
59_H157_T0.6460.39
305_N339_E0.6450.39
246_F249_A0.6440.39
220_T224_K0.6430.39
110_R149_M0.6420.39
309_F314_P0.6410.38
349_Y379_S0.6410.38
13_T438_E0.6410.38
147_Q178_I0.6400.38
158_D162_D0.6400.38
25_K169_E0.6390.38
433_I452_M0.6360.38
331_S355_D0.6360.38
50_L56_K0.6350.38
218_L279_V0.6340.38
27_Q458_F0.6340.38
257_I275_F0.6340.38
320_S327_A0.6340.38
225_R228_H0.6340.38
271_E274_Q0.6330.38
86_D124_A0.6330.38
218_L283_L0.6330.38
357_E386_Q0.6330.38
82_R123_T0.6330.38
50_L82_R0.6320.38
284_G337_Q0.6310.38
20_Y423_E0.6310.38
91_T100_L0.6290.37
242_D276_K0.6290.37
192_I257_I0.6280.37
67_T318_F0.6270.37
218_L258_L0.6260.37
191_N276_K0.6260.37
17_R435_R0.6260.37
163_S332_K0.6250.37
102_H428_I0.6230.37
315_D416_F0.6210.37
191_N194_Q0.6210.37
291_G466_A0.6170.36
437_V442_A0.6160.36
86_D90_A0.6140.36
135_L144_G0.6140.36
425_F429_L0.6130.36
14_E18_R0.6110.36
201_M261_R0.6100.36
247_A277_T0.6080.36
122_S126_E0.6070.36
64_A67_T0.6070.36
19_L24_A0.6070.36
254_L274_Q0.6070.36
431_Q439_A0.6060.35
83_E165_E0.6060.35
89_A116_G0.6050.35
125_D131_C0.6050.35
51_Y56_K0.6040.35
284_G296_Y0.6040.35
215_F282_F0.6030.35
249_A274_Q0.6020.35
336_K339_E0.6020.35
158_D183_S0.6000.35
442_A452_M0.5990.35
128_W436_W0.5990.35
75_C84_K0.5990.35
253_E256_S0.5990.35
52_D132_N0.5980.35
302_R315_D0.5980.35
183_S350_C0.5980.35
350_C384_N0.5980.35
120_S451_E0.5970.35
280_L333_L0.5950.35
87_A121_P0.5950.35
360_G363_I0.5940.34
226_L292_W0.5930.34
368_G371_M0.5920.34
434_G438_E0.5920.34
96_I446_I0.5890.34
350_C359_L0.5890.34
198_N208_S0.5890.34
345_K376_Q0.5890.34
394_M398_A0.5880.34
251_E282_F0.5870.34
197_F201_M0.5870.34
244_V334_L0.5870.34
194_Q303_N0.5860.34
53_I417_L0.5840.34
203_K207_V0.5840.34
360_G377_F0.5840.34
208_S211_D0.5840.34
230_A236_V0.5830.34
236_V349_Y0.5830.34
284_G333_L0.5820.33
118_L445_D0.5820.33
312_L316_V0.5820.33
198_N201_M0.5790.33
32_Y464_Y0.5790.33
20_Y109_R0.5780.33
201_M258_L0.5760.33
219_Q223_T0.5750.33
168_A171_A0.5720.33
72_E312_L0.5720.33
189_A200_Y0.5710.33
191_N240_A0.5710.33
205_G217_D0.5700.32
21_H24_A0.5700.32
386_Q404_S0.5690.32
236_V467_I0.5680.32
380_G386_Q0.5670.32
248_E332_K0.5670.32
162_D203_K0.5650.32
36_L323_D0.5650.32
127_I130_E0.5640.32
377_F397_L0.5630.32
19_L453_V0.5620.32
285_A336_K0.5610.32
219_Q279_V0.5590.32
72_E311_L0.5590.32
245_M273_A0.5580.32
226_L372_P0.5570.31
197_F258_L0.5570.31
86_D129_N0.5560.31
253_E257_I0.5540.31
326_M358_V0.5540.31
349_Y410_L0.5540.31
199_D261_R0.5540.31
364_G400_L0.5540.31
392_R399_Q0.5540.31
284_G342_L0.5520.31
284_G294_Q0.5520.31
43_E165_E0.5520.31
146_M457_C0.5510.31
26_D150_N0.5510.31
159_D200_Y0.5500.31
326_M329_E0.5500.31
149_M154_V0.5490.31
294_Q436_W0.5490.31
288_A341_N0.5490.31
267_L271_E0.5480.31
318_F338_N0.5450.30
192_I275_F0.5440.30
76_T79_A0.5430.30
390_M428_I0.5430.30
330_L348_L0.5420.30
96_I448_L0.5420.30
254_L257_I0.5420.30
290_R399_Q0.5410.30
360_G365_N0.5410.30
394_M425_F0.5410.30
171_A231_A0.5400.30
380_G393_Q0.5400.30
296_Y329_E0.5390.30
355_D362_M0.5390.30
15_F450_G0.5390.30
357_E400_L0.5390.30
161_I218_L0.5380.30
104_T108_L0.5370.30
198_N264_G0.5360.30
264_G335_S0.5350.30
428_I431_Q0.5350.30
22_D446_I0.5340.30
395_T398_A0.5340.30
21_H25_K0.5330.30
134_L150_N0.5330.30
289_R342_L0.5330.30
91_T405_R0.5330.30
205_G212_I0.5330.30
226_L261_R0.5330.30
30_F188_K0.5320.29
63_R422_H0.5310.29
49_N128_W0.5300.29
188_K196_T0.5280.29
210_T217_D0.5280.29
248_E278_A0.5270.29
84_K345_K0.5240.29
74_L80_S0.5240.29
269_E273_A0.5230.29
13_T17_R0.5230.29
463_D466_A0.5230.29
152_K459_N0.5230.29
139_N144_G0.5220.29
87_A300_A0.5220.29
393_Q397_L0.5220.29
163_S166_H0.5220.29
62_W72_E0.5220.29
79_A87_A0.5210.29
301_L331_S0.5190.28
193_E267_L0.5180.28
155_G432_M0.5180.28
146_M416_F0.5170.28
159_D207_V0.5170.28
219_Q291_G0.5160.28
362_M377_F0.5150.28
396_Q428_I0.5150.28
203_K444_A0.5140.28
53_I145_I0.5140.28
78_D211_D0.5130.28
104_T393_Q0.5120.28
384_N436_W0.5110.28
113_G116_G0.5110.28
121_P125_D0.5100.28
153_M466_A0.5100.28
40_Q56_K0.5100.28
206_E407_V0.5100.28
95_T404_S0.5090.28
240_A314_P0.5090.28
307_R311_L0.5090.28
200_Y205_G0.5080.28
86_D120_S0.5080.28
169_E260_R0.5070.28
282_F290_R0.5070.28
140_F176_F0.5070.28
47_F53_I0.5070.28
38_P166_H0.5060.28
459_N462_R0.5040.27
431_Q435_R0.5040.27
183_S226_L0.5040.27
350_C362_M0.5020.27
380_G461_A0.5010.27
120_S445_D0.5010.27
265_E271_E0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iacA 3 0.9936 100 0.14 Contact Map
2q01A 3 0.9702 100 0.228 Contact Map
1j5sA 3 0.9532 100 0.25 Contact Map
4i6vA 3 0.8957 100 0.382 Contact Map
2qeeA 5 0.8553 100 0.41 Contact Map
2qpxA 3 0.7638 100 0.645 Contact Map
3irsA 3 0.5617 97.3 0.964 Contact Map
3nurA 2 0.5894 95.8 0.969 Contact Map
4mupA 1 0.5638 95.7 0.97 Contact Map
3gg7A 1 0.5021 95.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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