GREMLIN Database
URK - Uridine kinase
UniProt: P0A8F4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11701
Length: 213 (183)
Sequences: 4699 (2854)
Seq/√Len: 210.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A88_S4.9271.00
96_S103_M4.6201.00
49_Y80_H4.2081.00
79_E83_A3.0051.00
12_G132_L2.9751.00
89_A108_T2.9281.00
76_L80_H2.9151.00
146_L169_Q2.9041.00
77_L117_L2.7561.00
129_R186_Y2.5111.00
85_K133_N2.2381.00
91_D108_T2.1081.00
89_A110_E2.0551.00
173_R177_L2.0421.00
29_Y116_I2.0311.00
160_S163_S1.9611.00
128_L132_L1.8731.00
52_D55_H1.8471.00
144_I147_M1.8431.00
46_E122_L1.8281.00
40_H113_K1.8271.00
55_H58_M1.8101.00
91_D106_T1.7841.00
73_D102_R1.7831.00
54_S101_T1.7241.00
57_S61_R1.7211.00
117_L132_L1.7101.00
82_Q131_E1.7041.00
14_A123_L1.6871.00
82_Q127_R1.6631.00
172_V175_M1.6571.00
29_Y43_V1.6441.00
139_D184_K1.6441.00
53_Q64_T1.6411.00
96_S99_E1.6331.00
92_L107_V1.6291.00
80_H83_A1.6081.00
151_K155_N1.5921.00
11_I114_V1.5721.00
146_L150_I1.5671.00
27_T30_R1.5471.00
95_Y100_H1.4841.00
33_R39_E1.4731.00
82_Q86_R1.4601.00
52_D101_T1.4591.00
134_F189_I1.4411.00
123_L135_S1.4201.00
173_R176_F1.4131.00
16_A145_C1.3871.00
48_C92_L1.3791.00
24_I138_V1.3721.00
141_P144_I1.3651.00
135_S188_D1.3491.00
174_P178_Q1.3281.00
147_M151_K1.3251.00
55_H59_E1.3091.00
53_Q66_Y1.3051.00
68_H179_F1.3021.00
142_L177_L1.3021.00
58_M64_T1.2991.00
161_M165_M1.2931.00
10_I85_K1.2761.00
33_R38_D1.2701.00
9_V114_V1.2681.00
78_L127_R1.2571.00
164_V167_Q1.2541.00
51_K55_H1.2481.00
58_M62_V1.2321.00
78_L82_Q1.2211.00
45_P48_C1.1991.00
163_S166_A1.1771.00
42_G112_K1.1731.00
75_S127_R1.1431.00
25_A116_I1.1311.00
159_R167_Q1.1191.00
146_L165_M1.1021.00
24_I28_L1.0991.00
181_E184_K1.0881.00
25_A43_V1.0681.00
166_A171_T1.0681.00
9_V134_F1.0641.00
46_E74_H1.0601.00
159_R163_S1.0371.00
84_L115_I1.0251.00
139_D192_P1.0251.00
99_E103_M1.0141.00
46_E72_M1.0051.00
10_I132_L1.0021.00
53_Q100_H0.9951.00
154_V164_V0.9941.00
172_V176_F0.9911.00
94_V107_V0.9901.00
40_H110_E0.9881.00
69_P124_T0.9781.00
78_L128_L0.9721.00
94_V105_E0.9691.00
163_S167_Q0.9671.00
168_Y171_T0.9671.00
50_Y72_M0.9611.00
83_A86_R0.9591.00
73_D76_L0.9591.00
177_L181_E0.9561.00
13_I25_A0.9501.00
123_L187_A0.9501.00
75_S79_E0.9491.00
24_I191_V0.9250.99
53_Q101_T0.9230.99
97_Y100_H0.9180.99
56_L71_A0.9160.99
13_I24_I0.8990.99
29_Y41_I0.8930.99
33_R41_I0.8920.99
145_C176_F0.8800.99
44_I109_V0.8740.99
153_D157_R0.8570.99
162_D166_A0.8560.99
40_H112_K0.8540.99
76_L104_K0.8540.99
76_L93_P0.8470.99
80_H90_I0.8410.99
184_K190_I0.8330.99
45_P107_V0.8280.99
165_M169_Q0.8130.98
154_V161_M0.8110.98
80_H92_L0.8090.98
7_Q85_K0.8090.98
70_S126_A0.8080.98
51_K73_D0.8020.98
150_I165_M0.8010.98
11_I116_I0.7940.98
29_Y42_G0.7900.98
17_S172_V0.7850.98
25_A29_Y0.7820.98
91_D103_M0.7770.98
97_Y103_M0.7750.98
142_L145_C0.7730.98
126_A130_D0.7620.98
56_L64_T0.7600.98
27_T31_E0.7560.98
124_T183_S0.7520.97
171_T175_M0.7510.97
10_I115_I0.7510.97
89_A111_P0.7490.97
59_E63_K0.7470.97
93_P102_R0.7430.97
81_L117_L0.7430.97
94_V103_M0.7380.97
77_L81_L0.7380.97
57_S60_E0.7370.97
81_L128_L0.7320.97
142_L181_E0.7310.97
81_L132_L0.7300.97
94_V102_R0.7300.97
32_L41_I0.7290.97
143_D147_M0.7250.97
162_D165_M0.7250.97
17_S176_F0.7210.97
126_A179_F0.7200.97
52_D102_R0.7130.96
89_A106_T0.7120.96
141_P192_P0.7060.96
48_C94_V0.7010.96
177_L185_Q0.7000.96
12_G123_L0.6980.96
79_E82_Q0.6970.96
121_L124_T0.6920.96
48_C107_V0.6880.96
65_N175_M0.6870.96
12_G128_L0.6830.96
149_R172_V0.6820.95
51_K56_L0.6810.95
42_G115_I0.6730.95
15_G20_G0.6700.95
65_N68_H0.6700.95
33_R40_H0.6680.95
32_L114_V0.6660.95
42_G109_V0.6650.95
161_M164_V0.6610.95
47_D152_R0.6590.95
50_Y149_R0.6530.94
147_M165_M0.6510.94
29_Y33_R0.6500.94
125_D130_D0.6500.94
11_I136_I0.6490.94
137_F184_K0.6490.94
169_Q174_P0.6460.94
76_L79_E0.6450.94
97_Y157_R0.6410.94
84_L90_I0.6390.94
19_S145_C0.6350.93
51_K91_D0.6280.93
65_N178_Q0.6270.93
97_Y149_R0.6260.93
159_R164_V0.6210.93
54_S57_S0.6200.93
72_M97_Y0.6190.93
16_A176_F0.6170.92
76_L102_R0.6140.92
56_L59_E0.6120.92
26_S29_Y0.6100.92
94_V106_T0.6090.92
10_I131_E0.6050.92
95_Y157_R0.6020.91
26_S30_R0.5990.91
78_L132_L0.5940.91
150_I161_M0.5920.91
13_I189_I0.5890.91
25_A45_P0.5890.91
74_H78_L0.5880.91
52_D104_K0.5870.90
48_C105_E0.5850.90
60_E63_K0.5830.90
156_E164_V0.5820.90
78_L81_L0.5800.90
44_I92_L0.5800.90
156_E159_R0.5790.90
146_L173_R0.5780.90
48_C176_F0.5760.90
130_D186_Y0.5760.90
154_V160_S0.5750.90
164_V168_Y0.5750.90
50_Y56_L0.5740.89
62_V100_H0.5700.89
74_H122_L0.5690.89
142_L173_R0.5670.89
155_N162_D0.5650.89
53_Q62_V0.5640.89
46_E77_L0.5620.88
50_Y97_Y0.5610.88
127_R130_D0.5600.88
18_A46_E0.5580.88
53_Q56_L0.5580.88
33_R113_K0.5540.88
149_R153_D0.5540.88
66_Y172_V0.5530.88
122_L132_L0.5500.87
66_Y95_Y0.5500.87
10_I81_L0.5490.87
15_G19_S0.5480.87
85_K131_E0.5450.87
59_E62_V0.5430.87
23_L47_D0.5430.87
95_Y101_T0.5420.87
137_F183_S0.5410.87
26_S43_V0.5410.87
143_D192_P0.5380.86
63_K66_Y0.5380.86
28_L116_I0.5370.86
17_S50_Y0.5360.86
97_Y120_I0.5360.86
48_C120_I0.5340.86
17_S47_D0.5330.86
8_C113_K0.5330.86
120_I149_R0.5320.86
166_A169_Q0.5310.86
53_Q61_R0.5300.85
17_S149_R0.5300.85
15_G21_K0.5260.85
69_P126_A0.5240.85
16_A137_F0.5230.85
74_H125_D0.5200.84
11_I113_K0.5160.84
84_L151_K0.5150.84
72_M121_L0.5150.84
17_S97_Y0.5140.84
44_I80_H0.5110.83
16_A140_T0.5050.83
143_D188_D0.5040.82
150_I164_V0.5040.82
110_E113_K0.5030.82
78_L130_D0.5020.82
26_S130_D0.5000.82
7_Q38_D0.5000.82
169_Q173_R0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ga8A 1 0.9155 100 0.424 Contact Map
2jeoA 3 0.9531 100 0.434 Contact Map
3tqcA 2 0.9671 100 0.44 Contact Map
1a7jA 5 0.9343 100 0.48 Contact Map
1rz3A 1 0.7793 100 0.509 Contact Map
1uj2A 3 0.9718 100 0.511 Contact Map
3w34A 2 0.9531 99.9 0.525 Contact Map
4bfzA 2 0.9671 99.9 0.543 Contact Map
2qt1A 1 0.8779 99.9 0.547 Contact Map
4ne2A 2 0.9624 99.9 0.548 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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