GREMLIN Database
UPP - Uracil phosphoribosyltransferase
UniProt: P0A8F0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11332
Length: 208 (203)
Sequences: 3067 (1609)
Seq/√Len: 113.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_Q55_E4.0891.00
108_L191_G3.8211.00
167_A171_K3.6411.00
161_A180_T3.4091.00
53_T60_P3.3671.00
51_K62_E3.1851.00
139_V156_V2.7821.00
16_G63_I2.7701.00
33_S89_E2.7461.00
166_I183_I2.6511.00
140_I172_A2.5411.00
140_I168_A2.4791.00
143_I169_L2.4151.00
26_K30_E2.3951.00
59_G185_Q2.3571.00
53_T62_E2.2461.00
51_K64_D2.2361.00
168_A172_A2.1951.00
73_V129_V2.1591.00
144_D148_K2.1541.00
163_P167_A2.1451.00
50_E65_Q2.1141.00
40_T87_V2.0701.00
52_V65_Q1.9821.00
87_V157_L1.9011.00
147_K173_H1.8561.00
55_E60_P1.8341.00
156_V169_L1.7961.00
102_Y111_V1.7771.00
24_S27_R1.7751.00
18_M32_A1.7601.00
58_N194_I1.7581.00
33_S85_D1.7551.00
59_G194_I1.7391.00
144_D172_A1.7371.00
12_K64_D1.7181.00
104_N111_V1.6861.00
125_M153_S1.6361.00
11_V35_V1.6361.00
188_N194_I1.6271.00
50_E67_K1.6071.00
46_D155_K1.5711.00
163_P185_Q1.5561.00
167_A170_E1.5561.00
166_I178_L1.5421.00
74_V97_S1.5251.00
42_E45_A1.5041.00
75_P81_L1.4821.00
146_L151_C1.4641.00
36_G83_M1.4441.00
5_E183_I1.4391.00
14_K34_E1.4311.00
37_S89_E1.4221.00
88_L96_I1.4041.00
141_A144_D1.3801.00
15_L181_A1.3671.00
32_A159_L1.3111.00
43_A157_L1.2970.99
158_V180_T1.2940.99
140_I144_D1.2730.99
147_K175_D1.2700.99
145_L149_A1.2650.99
73_V87_V1.2650.99
47_L71_I1.2600.99
185_Q194_I1.2490.99
54_I61_V1.2370.99
186_G194_I1.2360.99
110_P137_G1.2350.99
70_K124_R1.2270.99
44_T91_V1.2140.99
155_K177_E1.2020.99
143_I154_I1.1930.99
23_I203_K1.1800.99
29_R88_L1.1770.99
39_L43_A1.1770.99
18_M31_L1.1670.99
72_T121_I1.1660.99
144_D173_H1.1580.99
99_V142_T1.1270.99
126_A151_C1.1160.98
105_E190_H1.1150.98
115_Q145_L1.1150.98
101_M138_S1.1030.98
39_L157_L1.0860.98
115_Q149_A1.0790.98
145_L148_K1.0760.98
97_S118_V1.0750.98
6_V11_V1.0700.98
152_S175_D1.0650.98
18_M35_V1.0630.98
112_P115_Q1.0540.98
48_E67_K1.0490.98
71_I124_R1.0430.98
35_V181_A1.0430.98
109_E168_A1.0420.98
72_T126_A1.0380.97
164_E186_G1.0350.97
110_P113_Y1.0260.97
44_T47_L1.0080.97
169_L178_L1.0050.97
184_D193_I0.9990.97
163_P186_G0.9990.97
27_R30_E0.9980.97
125_M155_K0.9760.96
40_T86_G0.9730.96
128_I146_L0.9670.96
110_P116_K0.9640.96
17_L65_Q0.9460.96
20_E54_I0.9430.96
40_T73_V0.9420.96
186_G189_E0.9420.96
112_P145_L0.9400.95
11_V38_L0.9300.95
7_K12_K0.9280.95
114_F118_V0.9160.95
81_L98_V0.9130.95
107_T110_P0.9120.95
141_A145_L0.8690.93
82_G204_I0.8640.93
37_S90_N0.8620.93
143_I176_V0.8570.93
113_Y116_K0.8560.93
14_K31_L0.8550.93
121_I151_C0.8490.92
155_K179_Y0.8450.92
153_S177_E0.8410.92
49_T64_D0.8410.92
40_T90_N0.8400.92
73_V91_V0.8370.92
140_I169_L0.8370.92
4_V179_Y0.8240.91
120_N124_R0.8180.91
168_A171_K0.8080.90
111_V116_K0.8060.90
121_I126_A0.8010.90
114_F117_L0.8000.90
128_I143_I0.7970.90
111_V117_L0.7920.89
15_L160_V0.7850.89
84_M98_V0.7850.89
132_M193_I0.7840.89
17_L27_R0.7830.89
113_Y117_L0.7830.89
52_V63_I0.7790.89
33_S37_S0.7780.89
16_G65_Q0.7770.89
43_A127_L0.7710.88
6_V39_L0.7710.88
112_P116_K0.7660.88
74_V117_L0.7620.88
164_E167_A0.7620.88
170_E177_E0.7620.88
127_L155_K0.7610.87
40_T43_A0.7590.87
79_A132_M0.7570.87
104_N109_E0.7550.87
103_R201_G0.7520.87
180_T183_I0.7470.86
104_N107_T0.7470.86
117_L149_A0.7460.86
95_R124_R0.7420.86
7_K45_A0.7410.86
72_T97_S0.7410.86
103_R132_M0.7390.86
127_L157_L0.7360.86
160_V182_S0.7340.86
32_A35_V0.7260.85
38_L41_Y0.7250.85
71_I125_M0.7250.85
84_M96_I0.7250.85
15_L182_S0.7250.85
184_D195_P0.7240.85
165_G187_L0.7240.85
110_P114_F0.7230.85
23_I27_R0.7210.85
103_R131_P0.7200.84
170_E178_L0.7160.84
73_V84_M0.7110.84
169_L176_V0.7110.84
137_G168_A0.7090.84
75_P129_V0.7060.83
17_L23_I0.7010.83
16_G54_I0.6920.82
36_G86_G0.6900.82
128_I142_T0.6830.81
166_I170_E0.6820.81
17_L31_L0.6810.81
110_P118_V0.6800.81
128_I169_L0.6790.81
19_R184_D0.6760.81
103_R138_S0.6760.81
97_S117_L0.6760.81
132_M192_Y0.6710.80
33_S36_G0.6700.80
103_R134_A0.6690.80
110_P117_L0.6620.79
59_G186_G0.6570.79
81_L84_M0.6550.78
132_M138_S0.6530.78
32_A36_G0.6530.78
112_P117_L0.6500.78
125_M152_S0.6500.78
103_R199_D0.6500.78
126_A146_L0.6460.77
4_V177_E0.6450.77
111_V114_F0.6410.77
144_D147_K0.6400.77
71_I91_V0.6390.77
132_M197_L0.6390.77
23_I57_W0.6390.77
158_V161_A0.6380.77
38_L90_N0.6370.76
32_A204_I0.6340.76
173_H176_V0.6330.76
56_G61_V0.6300.76
19_R195_P0.6290.76
18_M43_A0.6250.75
48_E69_K0.6240.75
32_A200_A0.6220.75
54_I60_P0.6220.75
34_E41_Y0.6200.75
101_M141_A0.6130.74
164_E185_Q0.6110.73
192_Y200_A0.6100.73
46_D177_E0.6090.73
143_I147_K0.6090.73
101_M145_L0.6070.73
20_E52_V0.6070.73
105_E137_G0.6050.73
11_V181_A0.6020.72
193_I197_L0.6010.72
10_L38_L0.6000.72
109_E141_A0.5980.72
195_P198_G0.5970.72
118_V203_K0.5970.72
6_V180_T0.5950.71
79_A192_Y0.5930.71
108_L190_H0.5920.71
184_D196_G0.5890.71
90_N93_S0.5880.71
57_W203_K0.5840.70
22_D55_E0.5830.70
84_M129_V0.5810.70
24_S93_S0.5800.70
54_I63_I0.5800.70
158_V166_I0.5760.69
146_L150_G0.5740.69
27_R155_K0.5730.69
14_K38_L0.5720.69
140_I173_H0.5640.67
193_I199_D0.5630.67
85_D89_E0.5600.67
99_V115_Q0.5600.67
31_L34_E0.5570.66
147_K176_V0.5570.66
30_E89_E0.5540.66
138_S141_A0.5530.66
28_F200_A0.5530.66
37_S40_T0.5530.66
40_T157_L0.5530.66
16_G32_A0.5520.66
131_P134_A0.5520.66
10_L90_N0.5510.66
41_Y86_G0.5510.66
72_T117_L0.5490.65
16_G20_E0.5420.64
83_M159_L0.5410.64
79_A200_A0.5390.64
142_T207_T0.5380.64
12_K182_S0.5380.64
166_I180_T0.5370.64
100_G113_Y0.5370.64
25_T29_R0.5360.64
28_F57_W0.5350.63
32_A83_M0.5350.63
33_S204_I0.5340.63
79_A201_G0.5320.63
24_S95_R0.5320.63
43_A126_A0.5300.63
13_H17_L0.5300.63
48_E65_Q0.5290.63
69_K123_E0.5290.63
79_A193_I0.5290.63
4_V7_K0.5260.62
33_S40_T0.5240.62
107_T137_G0.5240.62
110_P141_A0.5230.62
84_M87_V0.5220.62
12_K49_T0.5210.61
103_R202_D0.5210.61
112_P149_A0.5180.61
13_H34_E0.5140.60
72_T124_R0.5140.60
86_G94_A0.5140.60
46_D179_Y0.5130.60
23_I118_V0.5130.60
131_P138_S0.5120.60
45_A90_N0.5110.60
164_E191_G0.5110.60
19_R196_G0.5080.59
75_P100_G0.5070.59
24_S91_V0.5060.59
26_K83_M0.5030.59
33_S180_T0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xttA 3 0.9856 100 0.23 Contact Map
3dmpA 4 0.9808 100 0.267 Contact Map
2ehjA 3 1 100 0.27 Contact Map
1o5oA 3 1 100 0.273 Contact Map
1bd3D 3 0.9952 100 0.276 Contact Map
1v9sA 3 1 100 0.276 Contact Map
2e55A 3 0.9904 100 0.295 Contact Map
1i5eA 2 1 100 0.348 Contact Map
3s5jB 2 0.9135 99.8 0.738 Contact Map
1qb7A 2 0.9087 99.7 0.763 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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