GREMLIN Database
YACL - UPF0231 protein YacL
UniProt: P0A8E5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12605
Length: 120 (118)
Sequences: 230 (152)
Seq/√Len: 14.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_M109_V4.5531.00
93_Y96_E3.8481.00
19_M96_E3.1790.98
67_M72_V3.0060.97
19_M93_Y2.9440.97
64_T77_N2.6150.94
35_N38_L2.5790.94
41_E58_R2.3340.89
1_M5_F2.3030.89
50_K107_L2.2500.88
45_A49_L2.1040.84
4_E9_I2.0910.83
3_Y17_M2.0150.81
73_M113_Y1.8820.76
18_S21_H1.8800.76
28_F32_V1.7820.72
15_V109_V1.7200.69
72_V106_F1.6840.67
60_G106_F1.6440.66
25_G30_E1.6030.64
59_A64_T1.5630.61
34_E113_Y1.5600.61
3_Y25_G1.5520.61
3_Y76_A1.5490.61
49_L67_M1.5430.60
3_Y108_Q1.5360.60
19_M97_S1.5080.59
2_D20_G1.4710.57
23_V63_Y1.4500.56
28_F112_A1.4350.55
93_Y97_S1.3920.52
15_V110_V1.3470.50
8_D12_V1.3420.50
21_H25_G1.3420.50
74_V96_E1.3410.50
28_F109_V1.3170.48
13_V113_Y1.3150.48
37_A58_R1.3140.48
19_M74_V1.3060.48
32_V110_V1.2830.46
34_E65_L1.2610.45
36_L117_V1.2100.43
22_E93_Y1.1710.41
42_V56_W1.1690.40
104_E109_V1.1610.40
62_E71_E1.1290.38
46_A110_V1.1240.38
17_M24_V1.1100.37
42_V77_N1.0910.36
25_G109_V1.0900.36
39_L43_E1.0890.36
87_E90_M1.0770.36
27_W46_A1.0480.34
48_A115_N1.0100.32
17_M110_V0.9900.32
33_K113_Y0.9900.32
51_G99_S0.9880.31
82_A85_E0.9860.31
68_D89_G0.9760.31
67_M79_L0.9700.31
6_L16_R0.9650.30
13_V29_N0.9610.30
13_V53_E0.9530.30
45_A48_A0.9410.29
10_T107_L0.9310.29
65_L82_A0.9150.28
83_G86_M0.9090.28
104_E108_Q0.9090.28
9_I14_K0.9080.28
75_R109_V0.8910.27
20_G93_Y0.8910.27
63_Y76_A0.8850.27
57_Q104_E0.8720.26
54_R61_H0.8720.26
72_V103_V0.8520.25
37_A42_V0.8380.25
24_V109_V0.8370.25
66_W74_V0.8340.25
18_S22_E0.8120.24
24_V28_F0.7930.23
78_Q113_Y0.7870.23
20_G108_Q0.7860.23
44_Q104_E0.7800.23
25_G90_M0.7750.22
27_W70_E0.7690.22
22_E96_E0.7590.22
5_F11_G0.7550.22
8_D29_N0.7540.22
26_H63_Y0.7500.21
86_M104_E0.7500.21
42_V69_G0.7490.21
41_E110_V0.7470.21
28_F65_L0.7450.21
83_G92_Y0.7430.21
26_H74_V0.7410.21
102_G105_D0.7290.21
101_C105_D0.7290.21
103_V107_L0.7290.21
38_L106_F0.7290.21
30_E41_E0.7260.21
20_G96_E0.7240.21
2_D5_F0.7230.20
48_A80_E0.7120.20
83_G99_S0.7110.20
37_A118_Q0.7040.20
18_S99_S0.6950.20
49_L56_W0.6900.19
14_K88_E0.6900.19
27_W60_G0.6880.19
10_T77_N0.6870.19
51_G90_M0.6800.19
28_F59_A0.6750.19
73_M100_L0.6660.19
29_N113_Y0.6650.19
103_V117_V0.6630.18
57_Q67_M0.6620.18
4_E85_E0.6540.18
2_D10_T0.6470.18
36_L118_Q0.6470.18
40_D82_A0.6460.18
32_V92_Y0.6440.18
50_K103_V0.6400.18
8_D55_S0.6370.18
49_L103_V0.6340.18
91_N117_V0.6230.17
34_E55_S0.6220.17
55_S68_D0.6210.17
80_E83_G0.6170.17
9_I12_V0.6150.17
23_V41_E0.6130.17
23_V78_Q0.6130.17
30_E33_K0.6080.17
6_L15_V0.6080.17
42_V110_V0.6030.17
20_G92_Y0.6000.16
50_K98_L0.5990.16
52_S80_E0.5970.16
3_Y112_A0.5960.16
53_E117_V0.5960.16
54_R72_V0.5930.16
54_R75_R0.5890.16
15_V24_V0.5870.16
18_S23_V0.5860.16
31_E76_A0.5850.16
23_V47_H0.5790.16
35_N109_V0.5770.16
21_H70_E0.5760.16
26_H62_E0.5750.16
37_A91_N0.5750.16
29_N62_E0.5750.16
108_Q111_A0.5730.16
76_A97_S0.5670.16
19_M22_E0.5660.15
13_V68_D0.5560.15
44_Q59_A0.5540.15
49_L112_A0.5540.15
32_V38_L0.5490.15
15_V29_N0.5480.15
59_A83_G0.5420.15
42_V84_D0.5410.15
63_Y106_F0.5370.15
55_S99_S0.5330.15
54_R98_L0.5330.15
44_Q61_H0.5300.14
34_E61_H0.5290.14
74_V93_Y0.5240.14
45_A89_G0.5200.14
17_M49_L0.5180.14
45_A111_A0.5170.14
11_G19_M0.5160.14
8_D75_R0.5150.14
16_R109_V0.5130.14
103_V115_N0.5100.14
26_H30_E0.5090.14
17_M25_G0.5040.14
99_S112_A0.5040.14
70_E91_N0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b6hA 1 0.3667 10.4 0.943 Contact Map
2lydA 1 0.3667 9.5 0.944 Contact Map
4fe2A 2 0.375 7.6 0.947 Contact Map
1dvoA 1 0.3917 7.5 0.947 Contact Map
1q67A 2 0.4167 6.6 0.948 Contact Map
4kmdA 2 0.575 5.3 0.95 Contact Map
2jq6A 1 0.8583 5.3 0.95 Contact Map
1nwdB 2 0.2083 5.2 0.95 Contact Map
3erxA 3 0.5 4.6 0.952 Contact Map
1pd3A 2 0.45 4.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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